Research Topics
| Jeff S HealeySummaryCountry: Canada Publications
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Detail Information
Publications
Pacemaker-detected atrial fibrillation in patients with pacemakers: prevalence, predictors, and current use of oral anticoagulationJeff S Healey
Population Health Research Institute, Hamilton, Ontario, Canada
Can J Cardiol 29:224-8. 2013..This study sought to determine the prevalence and predictors of pacemaker-detected AF and to document current oral anticoagulant use...- A randomized-controlled pilot study comparing ICD implantation with and without intraoperative defibrillation testing in patients with heart failure and severe left ventricular dysfunction: a substudy of the RAFT trialJeff S Healey
Population Health Research Institute, Barton St East, Hamilton, Ontario, Canada
J Cardiovasc Electrophysiol 23:1313-6. 2012..The need to perform defibrillation testing (DT) at the time of implantable cardioverter defibrillator (ICD) insertion is controversial. In the absence of randomized trials, some regions now perform more than half of ICD implants without DT... - Relevance of electrical remodeling in human atrial fibrillation: results of the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial mechanisms of atrial fibrillation studyJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Canada
Circ Arrhythm Electrophysiol 5:626-31. 2012..In animal models of atrial fibrillation (AF), changes in atrial electrophysiological properties are associated with the development of AF. Their relevance to human AF is unclear... - The rationale and design of the Shockless IMPLant Evaluation (SIMPLE) trial: a randomized, controlled trial of defibrillation testing at the time of defibrillator implantationJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Am Heart J 164:146-52. 2012..5-year mean follow-up will provide sufficient statistical power to demonstrate noninferiority. The study is being performed at approximately 90 centers in Canada, Europe, Israel, and Asia Pacific with final results expected in 2013... - Periprocedural bleeding and thromboembolic events with dabigatran compared with warfarin: results from the Randomized Evaluation of Long-Term Anticoagulation Therapy (RE-LY) randomized trialJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Canada
Circulation 126:343-8. 2012..Dabigatran reduces ischemic stroke in comparison with warfarin; however, given the lack of antidote, there is concern that it might increase bleeding when surgery or invasive procedures are required... - Canadian Cardiovascular Society/Canadian Anesthesiologists' Society/Canadian Heart Rhythm Society joint position statement on the perioperative management of patients with implanted pacemakers, defibrillators, and neurostimulating devicesJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Can J Cardiol 28:141-51. 2012..It reviews the relative merits of intraoperative magnet use vs reprogramming of devices and gives examples of situations where one or the other approach is preferable... - Does catheter ablation for atrial fibrillation increase or reduce neurological insult?Jeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Curr Opin Cardiol 27:36-40. 2012..This article will review the periprocedural and long-term risk of stroke and other adverse neurological outcomes in patients having catheter ablation of atrial fibrillation... - Society position statement : Canadian Cardiovascular Society/Canadian Anesthesiologists' Society/Canadian Heart Rhythm Society joint position statement on the perioperative management of patients with implanted pacemakers, defibrillators, and neurostimulaJeff S Healey
Population Health Research Institute, McMaster University, Room C3 121, David Braley CVSRI, 237 Barton St East, Hamilton, ON, L8L 2X2, Canada
Can J Anaesth 59:394-407. 2012.... - Canadian Cardiovascular Society atrial fibrillation guidelines 2010: etiology and initial investigationsJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
Can J Cardiol 27:31-7. 2011..Additional investigations may then be undertaken, with the decision guided by the initial evaluation. A comprehensive and systematic initial evaluation forms the foundation for a patient-specific plan for the management of AF... 
Cardiac resynchronization therapy in patients with permanent atrial fibrillation: results from the Resynchronization for Ambulatory Heart Failure Trial (RAFT)Jeff S Healey
Population Health Research Institute, Hamilton, Ontario, Canada
Circ Heart Fail 5:566-70. 2012..Cardiac resynchronization (CRT) prolongs survival in patients with systolic heart failure and QRS prolongation. However, most trials excluded patients with permanent atrial fibrillation...- Irbesartan in patients with atrial fibrillationSalim Yusuf
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
N Engl J Med 364:928-38. 2011..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk... - Prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers: a meta-analysisJeff S Healey
Population Health Research Institute, McMaster University, and Hamilton Health Sciences, Hamilton, Ontario, Canada
J Am Coll Cardiol 45:1832-9. 2005.... - Risk of bleeding with 2 doses of dabigatran compared with warfarin in older and younger patients with atrial fibrillation: an analysis of the randomized evaluation of long-term anticoagulant therapy (RE-LY) trialJohn W Eikelboom
Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Ontario, Canada
Circulation 123:2363-72. 2011..The purpose of this study was to compare their risks of bleeding in the Randomized Evaluation of Long-Term Anticoagulant Therapy (RE-LY) trial... - Canadian Registry of ICD Implant Testing procedures (CREDIT): current practice, risks, and costs of intraoperative defibrillation testingJeff S Healey
The Population Health Research Institute, McMaster University, Hamilton, Canada
J Cardiovasc Electrophysiol 21:177-82. 2010..There is uncertainty about the proper role of defibrillation testing (DT) at the time of implantable cardioverter defibrillator (ICD) insertion... - Postoperative low-molecular-weight heparin bridging is associated with an increase in wound hematoma following surgery for pacemakers and implantable defibrillatorsMarlene Robinson
Department of Medicine, McMaster University, 237 Barton Street East, Hamilton, Ontario, Canada
Pacing Clin Electrophysiol 32:378-82. 2009..Low-molecular-weight heparin (LMWH) is often used; however, wound hematoma is a common complication... - The effect of atrial-based pacing on exercise capacity as measured by the 6-minute walk test: a substudy of the Canadian Trial of Physiological Pacing (CTOPP)Adrian Baranchuk
Queen s University, Kingston, Ontario, Canada
Heart Rhythm 4:1024-8. 2007.... - Subclinical atrial fibrillation and the risk of strokeJeff S Healey
Population Health Research Institute, McMaster University, Hamilton, ON, Canada
N Engl J Med 366:120-9. 2012..We evaluated whether subclinical episodes of rapid atrial rate detected by implanted devices were associated with an increased risk of ischemic stroke in patients who did not have other evidence of atrial fibrillation... - Atrial overdrive pacing in sleep apnoea: a meta-analysisAdrian Baranchuk
Cardiac Electrophysiology and Pacing, Kingston General Hospital, Queen s University, FAPC 3, 76 Stuart Street, Kingston, ON, Canada
Europace 11:1037-40. 2009.... - Focused 2012 update of the Canadian Cardiovascular Society atrial fibrillation guidelines: recommendations for stroke prevention and rate/rhythm controlAllan C Skanes
Arrhythmia Service, University Hospital, University of Western Ontario, London, Ontario, Canada
Can J Cardiol 28:125-36. 2012..This report presents the details of the new recommendations, along with the background and rationale... - Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)Jeff S Healey
Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
Stroke 39:1482-6. 2008..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks... 
Stroke prevention in patients with atrial fibrillation: the diagnosis and management of hypertension by specialistsJeff S Healey
McMaster University, Hamilton, Ontario
Can J Cardiol 22:485-8. 2006..Hypertension is common in patients with atrial fibrillation (AF) and is an important cause of stroke...- Left Atrial Appendage Occlusion Study (LAAOS): results of a randomized controlled pilot study of left atrial appendage occlusion during coronary bypass surgery in patients at risk for strokeJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Am Heart J 150:288-93. 2005..This pilot study assessed the safety and efficacy of left atrial appendage (LAA) occlusion, performed at the time of coronary artery bypass grafting (CABG)... - Implantable cardioverter-defibrillator shock prevention does not reduce mortality: a systemic reviewAndrew H Ha
McMaster University, Hamilton, Ontario, Canada
Heart Rhythm 9:2068-74. 2012..Antiarrhythmic medications, catheter ablation, and enhanced ICD programming all may reduce ICD shocks, but whether shock reduction decreases mortality is unknown... - The burden of atrial fibrillation on the hospital sector in CanadaDaria J O'Reilly
Programs for Assessment of Technology in Health PATH Research Institute, St Joseph s Healthcare Hamilton, Hamilton, Ontario, Canada
Can J Cardiol 29:229-35. 2013..The purpose of this study was to estimate the cost of AF related to hospital-based care in Canada... - Interventions for preventing post-operative atrial fibrillation in patients undergoing heart surgeryKyle A Arsenault
Department of Surgery, McMaster University, Hamilton, Canada
Cochrane Database Syst Rev 1:CD003611. 2013..We conducted an update to a 2004 Cochrane systematic review and meta-analysis of the literature to gain a better understanding of the effectiveness of these interventions... - Right ventricular apical pacing: a necessary evil?Jeff S Healey
McMaster University, Hamilton, Canada
Curr Opin Cardiol 22:33-8. 2007..Clinical trial evidence suggests that traditional right ventricular apical pacing may be harmful. This review summarizes the existing evidence and outlines the major avenues of ongoing research in this field... - New pharmacotherapy for stroke prevention in atrial fibrillation: update 2010Luciana Armaganijan
Department of Medicine, Cardiology Division, Arrhythmia Service, McMaster University, HHSC, David Braley CVSRI, Hamilton, Ontario, Canada
Adv Ther 26:1058-71. 2009..This review focuses on new antithrombotic therapies for stroke prevention in patients with AF... - Role of the renin-angiotensin-aldosterone system in atrial fibrillation and cardiac remodelingJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Curr Opin Cardiol 20:31-7. 2005..Ongoing research will establish whether ACE inhibitors or ARBs have specific benefits in patients with atrial fibrillation... - Predictors of atrio-ventricular conduction disease, long-term outcomes in patients with myotonic dystrophy types I and IIAndrew H Ha
McMaster University, Hamilton, Ontario, Canada
Pacing Clin Electrophysiol 35:1262-9. 2012..Patients with myotonic dystrophy (DM) have an annual mortality of approximately 3.5%, one-third of which is sudden cardiac death. The predictors of cardiac conduction disease in these patients are incompletely defined... - Bidirectional ventricular tachycardia secondary to subacute myocarditisAshley Chin
McMaster University, Departments of Medicine and Pathology and Molecular Medicine, Hamilton, Ontario, Canada
Can J Cardiol 29:254.e13-4. 2013..The patient had an episode of bidirectional ventricular tachycardia during the acute admission. Subacute myocarditis should be added to the limited differential diagnosis of bidirectional ventricular tachycardia... - Comparative effectiveness of catheter ablation strategies for rhythm control in patients with atrial fibrillation: a meta-analysisNazila Assasi
Programs for Assessment of Technology in Health PATH Research Institute, McMaster University, 2000 25 Main St W, Hamilton, ON, Canada, L8P 1H1
J Interv Card Electrophysiol 35:259-75. 2012..Ablation of additional sites has been used to increase the efficacy of ablation procedures in restoring and maintaining normal sinus rhythm... - Cost-effectiveness of physiologic pacing: results of the Canadian Health Economic Assessment of Physiologic PacingGordon Blackhouse
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Ontario, Canada
Heart Rhythm 2:270-5. 2005..The selective use of these devices in patients likely to be pacemaker dependent appears to be cost-effective. Further studies with longer follow-up and which consider the benefit of reducing nonfatal cardiac events would be valuable... - Atrial fibrillation: hypertension as a causative agent, risk factor for complications, and potential therapeutic targetJeff S Healey
McMaster University, Hamilton, Ontario, Canada
Am J Cardiol 91:9G-14G. 2003..Specific pharmacotherapy could potentially play a major role in the primary and secondary prevention of atrial fibrillation and its complications...