Robert G Hart

Summary

Country: Canada

Publications

  1. doi request reprint Predictors of stroke recurrence in patients with recent lacunar stroke and response to interventions according to risk status: secondary prevention of small subcortical strokes trial
    Robert G Hart
    Department of Medicine Neurology, McMaster University, Hamilton, Ontario, Canada Electronic address
    J Stroke Cerebrovasc Dis 23:618-24. 2014
  2. doi request reprint Embolic strokes of undetermined source: the case for a new clinical construct
    Robert G Hart
    McMaster University and Population Health Research Institute, Hamilton, ON, Canada Electronic address
    Lancet Neurol 13:429-38. 2014
  3. doi request reprint Stroke prevention in atrial fibrillation patients with chronic kidney disease
    Robert G Hart
    Department of Medicine Neurology, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:S71-8. 2013
  4. doi request reprint Anticoagulants in atrial fibrillation patients with chronic kidney disease
    Robert G Hart
    Division of Neurology, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Nat Rev Nephrol 8:569-78. 2012
  5. doi request reprint Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial
    Robert G Hart
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Stroke 43:1511-7. 2012
  6. pmc Warfarin in atrial fibrillation patients with moderate chronic kidney disease
    Robert G Hart
    Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Clin J Am Soc Nephrol 6:2599-604. 2011
  7. doi request reprint The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy
    Michiel Coppens
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 34:170-6. 2013
  8. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
  9. doi request reprint Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada
    J Stroke Cerebrovasc Dis 21:429-35. 2012
  10. doi request reprint Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable
    Stuart J Connolly
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 155:579-86. 2011

Detail Information

Publications48

  1. doi request reprint Predictors of stroke recurrence in patients with recent lacunar stroke and response to interventions according to risk status: secondary prevention of small subcortical strokes trial
    Robert G Hart
    Department of Medicine Neurology, McMaster University, Hamilton, Ontario, Canada Electronic address
    J Stroke Cerebrovasc Dis 23:618-24. 2014
    ....
  2. doi request reprint Embolic strokes of undetermined source: the case for a new clinical construct
    Robert G Hart
    McMaster University and Population Health Research Institute, Hamilton, ON, Canada Electronic address
    Lancet Neurol 13:429-38. 2014
    ..Randomised trials testing direct-acting oral anticoagulants for secondary prevention of embolic strokes of undetermined source are warranted. ..
  3. doi request reprint Stroke prevention in atrial fibrillation patients with chronic kidney disease
    Robert G Hart
    Department of Medicine Neurology, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:S71-8. 2013
    ..Anticoagulation options for hemodialysis patients require testing in randomized trials...
  4. doi request reprint Anticoagulants in atrial fibrillation patients with chronic kidney disease
    Robert G Hart
    Division of Neurology, Department of Medicine, McMaster University, 1280 Main Street West, Hamilton, ON L8S 4L8, Canada
    Nat Rev Nephrol 8:569-78. 2012
    ..Although much remains to be learned about the optimal use of these new agents in patients with CKD, they are attractive anticoagulation options that are likely to replace warfarin in coming years...
  5. doi request reprint Intracranial hemorrhage in atrial fibrillation patients during anticoagulation with warfarin or dabigatran: the RE-LY trial
    Robert G Hart
    Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada
    Stroke 43:1511-7. 2012
    ..Intracranial hemorrhage is the most devastating complication of anticoagulation. Outcomes associated with different sites of intracranial bleeding occurring with warfarin versus dabigatran have not been defined...
  6. pmc Warfarin in atrial fibrillation patients with moderate chronic kidney disease
    Robert G Hart
    Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Clin J Am Soc Nephrol 6:2599-604. 2011
    ..The efficacy of adjusted-dose warfarin for prevention of stroke in atrial fibrillation patients with stage 3 chronic kidney disease (CKD) is unknown...
  7. doi request reprint The CHA2DS2-VASc score identifies those patients with atrial fibrillation and a CHADS2 score of 1 who are unlikely to benefit from oral anticoagulant therapy
    Michiel Coppens
    Population Health Research Institute, McMaster University, Hamilton, Ontario, Canada
    Eur Heart J 34:170-6. 2013
    ..e. CHADS(2) score of 1)...
  8. doi request reprint Irbesartan in patients with atrial fibrillation
    Salim Yusuf
    Population Health Research Institute, McMaster University, Hamilton, ON, Canada
    N Engl J Med 364:928-38. 2011
    ..The risk of cardiovascular events among patients with atrial fibrillation is high. We evaluated whether irbesartan, an angiotensin-receptor blocker, would reduce this risk...
  9. doi request reprint Stroke risk and efficacy of apixaban in atrial fibrillation patients with moderate chronic kidney disease
    John W Eikelboom
    Population Health Research Institute, Hamilton Health Sciences and McMaster University, Hamilton, Canada
    J Stroke Cerebrovasc Dis 21:429-35. 2012
    ..Apixaban is superior to aspirin for the prevention of stroke in patients with atrial fibrillation. Apixaban is partially renally excreted and may accumulate in patients with renal impairment...
  10. doi request reprint Net clinical benefit of adding clopidogrel to aspirin therapy in patients with atrial fibrillation for whom vitamin K antagonists are unsuitable
    Stuart J Connolly
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 155:579-86. 2011
    ..Adding clopidogrel to aspirin therapy reduces stroke in patients with atrial fibrillation (AF) but increases hemorrhage...
  11. ncbi request reprint Avoiding central nervous system bleeding during antithrombotic therapy: recent data and ideas
    Robert G Hart
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Stroke 36:1588-93. 2005
    ..We review the incidence, risk factors, and predictors of ICH in patients receiving long-term anticoagulation or antiplatelet therapy...
  12. doi request reprint Risks and benefits of oral anticoagulation compared with clopidogrel plus aspirin in patients with atrial fibrillation according to stroke risk: the atrial fibrillation clopidogrel trial with irbesartan for prevention of vascular events (ACTIVE-W)
    Jeff S Healey
    Population Health Research Institute, McMaster University, 237 Barton St E, Hamilton, Ontario, Canada
    Stroke 39:1482-6. 2008
    ..However, because OAC carries important bleeding complications, risk stratification schemes have been devised to identify patients for whom the absolute benefits of OAC exceed its risks...
  13. ncbi request reprint Lessons from the Stroke Prevention in Atrial Fibrillation trials
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, 7703 Floyd Curl Drive MC 7883, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 138:831-8. 2003
    ..For patients at moderate risk for stroke, patient preferences and access to reliable anticoagulation monitoring are particularly relevant...
  14. doi request reprint Clinical features and racial/ethnic differences among the 3020 participants in the Secondary Prevention of Small Subcortical Strokes (SPS3) trial
    Carole L White
    School of Nursing, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas, USA
    J Stroke Cerebrovasc Dis 22:764-74. 2013
    ..Among the racially/ethnically diverse SPS3 participants, important differences in patient features and vascular risk factors could influence prognosis for recurrent stroke and response to interventions...
  15. doi request reprint Balancing the benefits and risks of 2 doses of dabigatran compared with warfarin in atrial fibrillation
    John W Eikelboom
    Population Health Research Institute, McMaster University, 237 Barton St East, Hamilton, Ontario, Canada
    J Am Coll Cardiol 62:900-8. 2013
    ..This study sought to compare the net clinical benefit of dabigatran 110 mg bid and 150 mg bid with that of warfarin in patients with atrial fibrillation (AF)...
  16. doi request reprint ASA failure: does the combination ASA/clopidogrel confer better long-term vascular protection?
    Robert Cote
    From the Department of Neurology, Neurosurgery and Medicine R C, McGill University, Montreal, Canada Department of Biostatistics Y Z, L A M, University of Alabama at Birmingham Department of Medicine Neurology R G H, McMaster University, Hamilton, Canada Hennepin County Medical Center Neurology D C A, University of Minnesota Medical School, Minneapolis Department of Clinical Pharmacy R L T, University of Texas, Austin and Department of Medicine O R B, Brain Research Center, University of British Columbia, Vancouver, Canada
    Neurology 82:382-9. 2014
    ..To assess whether adding clopidogrel to acetylsalicylic acid (ASA) has a long-term protective vascular effect in patients with lacunar stroke while taking ASA...
  17. doi request reprint Assessment of anticoagulation intensity and management of bleeding with old and new oral anticoagulants
    Aaron Liew
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Can J Cardiol 29:S34-44. 2013
    ..PCCs and recombinant factor VIIa may improve hemostasis in patients in whom bleeding develops during treatment with a NOAC, but their efficacy is unproven. ..
  18. ncbi request reprint Meta-analysis: antithrombotic therapy to prevent stroke in patients who have nonvalvular atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Ann Intern Med 146:857-67. 2007
    ..Atrial fibrillation is a strong independent risk factor for stroke...
  19. doi request reprint Effect of addition of clopidogrel to aspirin on mortality: systematic review of randomized trials
    Santiago Palacio
    Department of Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Stroke 43:2157-62. 2012
    ..We assessed the effect of the addition of clopidogrel to aspirin on mortality in a meta-analysis of published randomized trials...
  20. doi request reprint The Secondary Prevention of Small Subcortical Strokes (SPS3) study
    Oscar R Benavente
    Department of Medicine, Brain Research Center, Division of Neurology, University of British Columbia, Vancouver, BC, Canada
    Int J Stroke 6:164-75. 2011
    ..The aim of the Secondary Prevention of Small Subcortical Strokes study (Trial registration: NCT00059306) is to define strategies for reducing stroke recurrence, cognitive decline, and major vascular events...
  21. doi request reprint Anticoagulants in patients with atrial fibrillation and end-stage renal disease
    K Scott Brimble
    Department of Medicine Nephrology, McMaster University, Hamilton, Ontario, Canada
    Postgrad Med 124:17-25. 2012
    ..Randomized controlled trials are needed to clarify the role of warfarin or other anticoagulants in preventing stroke in patients with ESRD and AF...
  22. ncbi request reprint Transient ischemic attacks in patients with atrial fibrillation: implications for secondary prevention: the European Atrial Fibrillation Trial and Stroke Prevention in Atrial Fibrillation III trial
    Robert G Hart
    Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Dr, MSC 7883, San Antonio, TX 78229 3900, USA
    Stroke 35:948-51. 2004
    ..Transient ischemic attacks (TIAs) are infrequent in patients with atrial fibrillation, and little is known about the long-term prognosis and response to antithrombotic therapy...
  23. ncbi request reprint What's new in stroke? The top 10 for 2004/05
    Silvina B Tonarelli
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas 78229, USA
    J Am Geriatr Soc 54:674-9. 2006
    ..The practical management implications of these studies refine and improve care of geriatric patients with cerebrovascular disease...
  24. ncbi request reprint What's new in stroke? The top 10 studies of 2006-2008. Part I
    Robert G Hart
    Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Pol Arch Med Wewn 118:650-7. 2008
    ..These trials, together involving 39,742 participants, have influenced 2008 European and North American guidelines for secondary prevention of noncardioembolic stroke, and these guideline recommendations are reviewed...
  25. doi request reprint Aspirin therapy and risk of subdural hematoma: meta-analysis of randomized clinical trials
    Ben J Connolly
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Stroke Cerebrovasc Dis 22:444-8. 2013
    ..Subdural hematomas are an important bleeding complication of antithrombotic therapies. We sought to characterize the risk of subdural hematoma associated with antiplatelet therapy...
  26. doi request reprint Clopidogrel and aspirin versus aspirin alone for the prevention of stroke in patients with a history of atrial fibrillation: subgroup analysis of the CHARISMA randomized trial
    Robert G Hart
    Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Cerebrovasc Dis 25:344-7. 2008
    ..Aspirin offers modest reduction in stroke in patients with atrial fibrillation. Whether combination of aspirin with clopidogrel offers additional protection is unclear...
  27. ncbi request reprint Oral anticoagulants vs. aspirin for stroke prevention in patients with non-valvular atrial fibrillation: the verdict is in
    Carl van Walraven
    Clinical Epidemiology Unit Ottawa Health Research Institute, Ottawa, Ontario, Canada
    Card Electrophysiol Rev 7:374-8. 2003
    ..Since high-risk AF patients appear to benefit most from OAC, determining stroke risk in AF patients is very important...
  28. doi request reprint Antithrombotic therapy for stroke prevention in atrial fibrillation and mechanical heart valves
    John W Eikelboom
    Department of Medicine, McMaster University, Hamilton, ON, Canada
    Am J Hematol 87:S100-7. 2012
    ....
  29. ncbi request reprint Occurrence and characteristics of stroke events in the Atrial Fibrillation Follow-up Investigation of Sinus Rhythm Management (AFFIRM) study
    David G Sherman
    University of Texas Health Science Center, San Antonio, USA
    Arch Intern Med 165:1185-91. 2005
    ..The Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Study was a multicenter comparison of high-risk patients with AF who were randomized to either a sinus rhythm control or a rate control strategy...
  30. ncbi request reprint Anticoagulation in atrial fibrillation: selected controversies including optimal anticoagulation intensity, treatment of intracerebral hemorrhage
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    J Thromb Thrombolysis 25:26-32. 2008
    ..A wide range of acute treatments to urgently reverse anticoagulation have been recommended by experts, but prevention is a far better option than treatment of this devastating problem...
  31. ncbi request reprint What's new in stroke? The top 10 studies of 2006-2008. Part II
    Robert G Hart
    Vascular Neurology, Department of Neurology, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Pol Arch Med Wewn 118:747-55. 2008
    ..These recent studies add important pieces to the complex puzzle of optimal stroke prevention and treatment...
  32. ncbi request reprint Reliability and validity of blood pressure measurement in the Secondary Prevention of Small Subcortical Strokes study
    Pablo E Pergola
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    Blood Press Monit 12:1-8. 2007
    ..Reliable and unbiased blood pressure measurement is critical to successful completion of the trial...
  33. ncbi request reprint A clinical prediction rule to identify patients with atrial fibrillation and a low risk for stroke while taking aspirin
    Carl van Walraven
    Clinical Epidemiology Unit, Ottawa Health Research Institute, Ottawa Hospital, Ontario, Canada
    Arch Intern Med 163:936-43. 2003
    ....
  34. ncbi request reprint Treatment of warfarin-associated intracerebral hemorrhage: literature review and expert opinion
    Maria I Aguilar
    Department of Neurology, Mayo Clinic College of Medicine, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA
    Mayo Clin Proc 82:82-92. 2007
    ..Reasonable management based on expert opinion includes a wide range of additional measures to reverse anticoagulation in the absence of solid evidence...
  35. ncbi request reprint Aspirin dosage and thromboxane synthesis in patients with vascular disease
    Robert G Hart
    University of Texas Health Science Center, San Antonio 78229 3900, USA
    Pharmacotherapy 23:579-84. 2003
    ..To determine whether urinary 11-dehydrothromboxane B2 (d-TXB2) is a marker of aspirin resistance and define the relationship between aspirin dosage and concentrations of this thromboxane metabolite...
  36. pmc Thrombolysis for acute stroke in hemodialysis: international survey of expert opinion
    Santiago Palacio
    Department of Neurology, University of Texas Health Science Center, 8300 Floyd Curl Drive MC 7883, San Antonio, TX 78229 3900, USA
    Clin J Am Soc Nephrol 6:1089-93. 2011
    ..The objective of this study was for stroke experts to define the range of management concerning thrombolytic treatment of acute stroke in hemodialysis...
  37. doi request reprint Cognitive impairment in lacunar strokes: the SPS3 trial
    Claudia Jacova
    Division of Neurology, Department of Medicine, Brain Research Center, University of British Columbia, Vancouver, British Columbia, Canada
    Ann Neurol 72:351-62. 2012
    ..However, adequate characterization of cognitive impairment is lacking. The aim of this study was to estimate the prevalence and characterize the neuropsychological impairment in lacunar stroke patients...
  38. ncbi request reprint Atrial fibrillation and stroke prevention
    Robert G Hart
    Department of Medicine, Division of Neurology, University of Texas Health Science Center, San Antonio, USA
    N Engl J Med 349:1015-6. 2003
  39. ncbi request reprint Antithrombotic therapies for stroke prevention in atrial fibrillation
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio, Texas, USA
    Adv Neurol 92:249-56. 2003
  40. doi request reprint Atrial fibrillation in ischemic stroke: predicting response to thrombolysis and clinical outcomes
    Gustavo Saposnik
    MSc, FAHA, FRCPC, Stroke Outcomes Research Center, Department of Medicine, St Michael s Hospital, University of Toronto, 55 Queen St E, Toronto, Ontario, M5C 1R6, Canada
    Stroke 44:99-104. 2013
    ..Atrial fibrillation (AF) increases the risk of stroke and is associated with poor stroke outcomes. Limited tools are available to evaluate clinical outcomes and response to thrombolysis in stroke patients with AF...
  41. doi request reprint Efficacy and safety of warfarin vs. antiplatelet therapy in patients with systolic heart failure and sinus rhythm: a systematic review and meta-analysis of randomized controlled trials
    Aaron Yl Liew
    Department of Medicine, McMaster University, East Hamilton, ON, Canada
    Int J Stroke 9:199-206. 2014
    ..We performed this meta-analysis to obtain the best estimates of the efficacy and safety of warfarin as compared with antiplatelet therapy in patients with systolic heart failure who are in sinus rhythm...
  42. ncbi request reprint What's new in stroke? The top 10 studies of 2009-2011: part II
    Robert G Hart
    Vascular Neurology, Department of Neurology, University of Texas Health Science Center, San Antonio, United States
    Pol Arch Med Wewn 121:200-7. 2011
    ..For younger patients, periprocedural risks were comparable with stenting or endarterectomy, but long-term outcomes are required to assess the relative merits of the two procedures...
  43. ncbi request reprint What's new in stroke? The top 10 studies of 2009-2011: part I
    Wiesław J Oczkowski
    Vascular Neurology, Division of Neurology, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    Pol Arch Med Wewn 121:193-9. 2011
    ....
  44. ncbi request reprint Atrial fibrillation, stroke, and acute antithrombotic therapy: analysis of randomized clinical trials
    Robert G Hart
    Department of Medicine Neurology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    Stroke 33:2722-7. 2002
    ..Until recently, the value of antithrombotic therapies for acute stroke management has been based on empiric evidence...
  45. doi request reprint Neuroprotection trials in Parkinson's disease: systematic review
    Robert G Hart
    Department of Neurology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Mov Disord 24:647-54. 2009
    ..Future trials should include participants with wider ranges of disease stages and assess broader neurological outcomes...
  46. ncbi request reprint National Stroke Association guidelines for the management of transient ischemic attacks
    S Claiborne Johnston
    Department of Neurology, University of California, San Francisco, CA 94143 0114, USA
    Ann Neurol 60:301-13. 2006
    ..Management varies widely, and most published guidelines have not been updated in several years. We sought to create comprehensive, unbiased, evidence-based guidelines for the management of patients with transient ischemic attacks...
  47. ncbi request reprint Late-developing cerebral arteropathy after pyogenic meningitis
    Santiago Palacio
    Department of Medicine Neurology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Dr, San Antonio, Texas 78229 3900, USA
    Arch Neurol 60:431-3. 2003
    ..Although vasculopathy is a recognized complication during acute meningitis, to our knowledge, no previous reports have been published of this phenomenon developing months after successful treatment...
  48. ncbi request reprint Headache improvement through TMD stabilization appliance and self-management therapies
    Edward F Wright
    University of Texas Health Science Center, San Antonio, USA
    Cranio 24:104-11. 2006
    ..722). These results suggest appliance and self-management therapies can be beneficial for many severe headache patients, irrespective of the headache type (tension-type, migraine without aura, and migraine with aura)...