Research Topics
| Jean François HardySummaryCountry: Canada Publications
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Detail Information
Publications
[Erythrocyte transfusions: an evidence-based approach]J F Hardy
Département d Anesthésiologie, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, QC, Canada
Ann Fr Anesth Reanim 31:617-25. 2012..Since then, a restrictive strategy aiming for a moderately anaemic threshold (7-8 g/dL) is appropriate under most circumstances...
Efficacy and safety of recombinant activated factor VII to control bleeding in nonhemophiliac patients: a review of 17 randomized controlled trialsJean François Hardy
Department of Anesthesiology, University of Montreal, Quebec, Canada
Ann Thorac Surg 86:1038-48. 2008..In addition, the safety of rFVIIa remains a concern. Consequently, we conclude that the generalized use of rFVIIa to prevent or to control bleeding in nonhemophiliac patients can not be recommended...
The coagulopathy of massive transfusionJ F Hardy
Département d Anesthésiologie, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
Vox Sang 89:123-7. 2005..Nevertheless, the level of evidence supporting specific treatment options is low and more studies are required to guide our management of massively transfused patients...
Endpoints in clinical trials on transfusion requirements: the need for a structured approachJean François Hardy
Department of Anesthesiology, University of Montreal, Notre Dame Hospital, Montreal, Quebec, Canada
Transfusion 45:9S-13S. 2005
Current status of transfusion triggers for red blood cell concentratesJean François Hardy
Département d anesthésiolgie, Universite de Montreal, CP 6128, Succursale Centre Ville, Canada, QC, 1H3C 3J7
Transfus Apher Sci 31:55-66. 2004..Future research and development should focus on the determination of optimal transfusion strategies in various patient populations and on reliable monitors to guide transfusion therapy...
Massive transfusion and coagulopathy: pathophysiology and implications for clinical managementJean François Hardy
Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, Montreal, Quebec, Canada
Can J Anaesth 51:293-310. 2004..To review the pathophysiology of coagulopathy in massively transfused, adult and previously hemostatically competent patients in both elective surgical and trauma settings, and to recommend the most appropriate treatment strategies...
Should we reconsider triggers for red blood cell transfusion?J Fr Hardy
Department of Anesthesiology, University of Montreal, C P 6128, Succursale Centre Ville, Montreal QC, Canada, H3C 3J7
Acta Anaesthesiol Belg 54:287-95. 2003..Reliable monitors to guide transfusion therapy and well conducted trials to determine optimal transfusion strategies are required...
Pharmacological strategies for blood conservation in cardiac surgery: erythropoietin and antifibrinolyticsJ F Hardy
Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
Can J Anaesth 48:S24-31. 2001....
Transfusions in patients undergoing cardiac surgery with autologous bloodJ F Hardy
Department of Anesthesiology, Montreal Heart Institute, University of Montreal, Quebec, Canada
Can J Anaesth 47:705-11. 2000..We verified if these variables also predicted the need for allogeneic transfusions when autologous blood is predonated...
Managing uncontrolled hemorrhage in trauma and surgery: a novel and promising approachJean François Hardy
Department of Anesthesiology, Centre hospitaler de l université de Montréal, Quebec, Canada
Can J Anaesth 49:S4-6. 2002
Anesthesiologists and perioperative hemostasis: should we feel concerned?Jean François Hardy
Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560, rue Sherbrooke Est, Montreal, Quebec H2L 4M1, Canada
Can J Anaesth 49:S4. 2002
Recombinant human activated factor VII is thrombogenic in a rabbit model of cyclic flow reduction and does not reduce intra-abdominal bleedingSonia Charbonneau
Department of Anesthesiology, CHUM, Hopital Notre Dame, Montreal, Canada
Thromb Haemost 97:296-303. 2007..rHuFVIIa increases thrombosis in a rabbit model of carotid artery injury. The bleeding from hepatic and splenic lesions is not reduced by administration of rHuFVIIa despite a hypercoagulable state confirmed by standard TEG analysis...
Postoperative anemia does not impede functional outcome and quality of life early after hip and knee arthroplastiesElise Vuille-Lessard
Department of Anesthesiology, CHUM Notre Dame, University of Montreal, Montreal, Quebec, Canada
Transfusion 52:261-70. 2012..Anemia may be associated with a decrease in postoperative vigor. We hypothesize that, in these patients, a threshold hemoglobin (Hb) concentration exists below which functional recovery and quality of life (QoL) become difficult...
Efficacy and safety of activated recombinant factor VII in cardiac surgical patientsJean François Hardy
Department of Anesthesiology, University of Montreal, Montreal, Quebec, Canada
Curr Opin Anaesthesiol 22:95-9. 2009..Recombinant activated factor VII (rFVIIa) is being used (off-label) increasingly after cardiac surgery to prevent or to control hemorrhage, but its efficacy and safety remain unclear...
Red blood cell transfusion practice in elective orthopedic surgery: a multicenter cohort studyElise Vuille-Lessard
Department of Anesthesiology, CHUM Notre Dame, University of Montreal, Montreal, Quebec, Canada
Transfusion 50:2117-24. 2010..The indications for red blood cell (RBC) transfusions remain unclear despite published guidelines. Our hypothesis was that the transfusion practice varies inside the Centre hospitalier de l'Université de Montréal (CHUM)...
Anesthetic technique does not affect the performance of a rabbit model of arterial cyclic flow reductions: a pilot studySonia Charbonneau
Department of Anesthesiology, Centre Hospitalier de l Universite de Montreal, Hopital Notre Dame, 1560 Sherbrooke East, Montreal, Quebec H2L 4M1, Canada
Can J Anaesth 54:269-75. 2007..Our initial observations, using a more complete and effective isoflurane-based anesthetic technique, failed to reproduce findings reported previously. Consequently, we compared the effects of these two anesthetic techniques in the model...
Blood conservation and the management of perioperative blood transfusions in a patient undergoing major vascular surgery: a Self-Assessment ProgramJean François Hardy
University of Montreal, Montreal, Canada
Can J Anaesth 52:344-5. 2005
Choosing the optimal endpoint(s) for a clinical trial on transfusionJean François Hardy
Department of Anesthesiology, University of Montreal, Notre Dame Hospital, Montreal, Quebec, Canada
Transfusion 45:1S. 2005
Clopidogrel induces an acute hemostatic deficit and increases intra abdominal bleeding in rabbitsElise Lortie
Department of Anesthesiology, of the Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
Thromb Res 123:869-73. 2009..We sought to determine the dose of clopidogrel which has a maximal antiplatelet and hemorrhagic effect in a rabbit model of non-cardiac surgery...
