- Endothelial cell injury by high glucose and heparanase is prevented by insulin, heparin and basic fibroblast growth factorJuying Han
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5B4, Canada
Cardiovasc Diabetol 4:12. 2005..Heparanase production, induced by hyperglycemia, and subsequent degradation of heparan sulfate may contribute to endothelial injury. Little is known about endothelial injury by heparanase and possible means of preventing this injury...
- Heparanase upregulation in high glucose-treated endothelial cells is prevented by insulin and heparinJuying Han
Department of Veterinary Biomedical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada
Exp Biol Med (Maywood) 232:927-34. 2007..Reactive oxygen species, but not changes in osmolarity, may be involved in the upregulation of heparanase...
- Changes in cultured endothelial cell glycosaminoglycans under hyperglycemic conditions and the effect of insulin and heparinJuying Han
Department of Veterinary Biomedical Sciences, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada
Cardiovasc Diabetol 8:46. 2009..Decreased HSPG may contribute to diabetic endothelial injury. Decreased tissue HS in diabetes has been reported, however, endothelial HS changes are poorly studied...