P Hamet

Summary

Country: Canada

Publications

  1. pmc Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse
    Majid Nikpay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertens Res 35:585-91. 2012
  2. doi Increased renal epithelial na channel expression and activity correlate with elevation of blood pressure in spontaneously hypertensive rats
    Mounsif Haloui
    CRCHUM Technopôle Angus, 2901, Rachel est, Montreal, QC H1W 4A4, Canada
    Hypertension 62:731-7. 2013
  3. ncbi The burden of blood pressure: where are we and where should we go?
    P Hamet
    Research Centre, Centre Hospitalier de l Universite de Montreal CHUM, Montreal, Canada
    Can J Cardiol 16:1483-7. 2000
  4. ncbi Current status of genome-wide scanning for hypertension
    Pavel Hamet
    Research Centre, Centre Hospitalier de l Universite de Montreal, Canada
    Curr Opin Cardiol 22:292-7. 2007
  5. ncbi Genetics and genomics of depression
    Pavel Hamet
    Departement de Medecine, Faculte de Medecine, Universite de Montreal, and Centre de recherche, Centre Hospitalier de l Universite de Montreal CHUM, Quebec, Canada
    Metabolism 54:10-5. 2005
  6. doi What matters in ADVANCE and ADVANCE-ON
    P Hamet
    CRCHUM Technopôle Angus, 2901 rue Rachel est, Montreal, Quebec H1W 4A4, Canada
    Diabetes Obes Metab 14:20-9. 2012
  7. pmc Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension
    P Hamet
    Laboratory of Molecular Medicine, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Monteal, Quebec, Canada
    Am J Hum Genet 76:815-32. 2005
  8. ncbi Genetics of the sleep-wake cycle and its disorders
    Pavel Hamet
    Centre de recherche du centre hospitalier de l Université de Montréal CHUM, Montreal, Quebec, Canada H2W 1T7
    Metabolism 55:S7-12. 2006
  9. ncbi Workshop: excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells?
    P Hamet
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 37:760-6. 2001
  10. ncbi Newborn and adult recombinant inbred strains: a tool to search for genetic determinants of target organ damage in hypertension
    P Hamet
    Centre de Recherche du C H U M, Universite de Montreal, Quebec, Canada
    Kidney Int 53:1488-92. 1998

Collaborators

Detail Information

Publications135 found, 100 shown here

  1. pmc Genetic mapping of habitual substance use, obesity-related traits, responses to mental and physical stress, and heart rate and blood pressure measurements reveals shared genes that are overrepresented in the neural synapse
    Majid Nikpay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertens Res 35:585-91. 2012
    ....
  2. doi Increased renal epithelial na channel expression and activity correlate with elevation of blood pressure in spontaneously hypertensive rats
    Mounsif Haloui
    CRCHUM Technopôle Angus, 2901, Rachel est, Montreal, QC H1W 4A4, Canada
    Hypertension 62:731-7. 2013
    ..We suggest that spontaneously hypertensive rats display an intact negative feed-back between renin-angiotensin-system and epithelial Na channel activity whose upregulated expression is supported by a yet unknown mechanism. ..
  3. ncbi The burden of blood pressure: where are we and where should we go?
    P Hamet
    Research Centre, Centre Hospitalier de l Universite de Montreal CHUM, Montreal, Canada
    Can J Cardiol 16:1483-7. 2000
    ..However, the supreme goal is universal - to lower blood pressure and other risk factors to reduce the risk of cardiovascular disease with its fatal consequences...
  4. ncbi Current status of genome-wide scanning for hypertension
    Pavel Hamet
    Research Centre, Centre Hospitalier de l Universite de Montreal, Canada
    Curr Opin Cardiol 22:292-7. 2007
    ..The current review focuses on new trends in genome-wide assessment of the inherited component of blood pressure variation...
  5. ncbi Genetics and genomics of depression
    Pavel Hamet
    Departement de Medecine, Faculte de Medecine, Universite de Montreal, and Centre de recherche, Centre Hospitalier de l Universite de Montreal CHUM, Quebec, Canada
    Metabolism 54:10-5. 2005
    ..This type of analysis has led us to uncover significant loci for the stress response and anxiety in rats and mice...
  6. doi What matters in ADVANCE and ADVANCE-ON
    P Hamet
    CRCHUM Technopôle Angus, 2901 rue Rachel est, Montreal, Quebec H1W 4A4, Canada
    Diabetes Obes Metab 14:20-9. 2012
    ..The potential long-term benefit, particularly that of initial tight blood glucose control, suggested by recent post-trial evidence is currently being evaluated in the ADVANCE-ON study...
  7. pmc Quantitative founder-effect analysis of French Canadian families identifies specific loci contributing to metabolic phenotypes of hypertension
    P Hamet
    Laboratory of Molecular Medicine, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Monteal, Quebec, Canada
    Am J Hum Genet 76:815-32. 2005
    ..These methods should accelerate the uncovering of causal haplotypes in complex diseases such as hypertension and metabolic syndrome...
  8. ncbi Genetics of the sleep-wake cycle and its disorders
    Pavel Hamet
    Centre de recherche du centre hospitalier de l Université de Montréal CHUM, Montreal, Quebec, Canada H2W 1T7
    Metabolism 55:S7-12. 2006
    ..Beyond sleep, light/dark cycles and sleep deprivation appear also to be associated with eating habits, and epidemics of obesity have to be evaluated in the context of shortened sleep duration...
  9. ncbi Workshop: excess growth and apoptosis: is hypertension a case of accelerated aging of cardiovascular cells?
    P Hamet
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 37:760-6. 2001
    ..These studies suggest that cardiovascular cells from hypertensive animals are subject to accelerated turnover, potentially leading to their accelerated aging...
  10. ncbi Newborn and adult recombinant inbred strains: a tool to search for genetic determinants of target organ damage in hypertension
    P Hamet
    Centre de Recherche du C H U M, Universite de Montreal, Quebec, Canada
    Kidney Int 53:1488-92. 1998
    ..To better understand their role in the pathogenesis of hypertension, studies at different ages are needed, which are uniquely feasible in RIS...
  11. ncbi Apoptosis in serum-deprived vascular smooth muscle cells: evidence for cell volume-independent mechanism
    S N Orlov
    Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, PQ, Canada
    Apoptosis 9:55-66. 2004
    ..In contrast to hyperosmotic medium, the modest cell volume decrease occurring in serum-deprived VSMC does not contribute to triggering of the apoptotic machinery...
  12. ncbi Chromosomal mapping of HCaRG, a novel hypertension-related, calcium-regulated gene
    N Solban
    Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    Folia Biol (Praha) 48:9-14. 2002
    ..Furthermore, a search of ESTs in Genbank for homologous sequences showed that HCaRG is expressed only in eukaryotes, particularly in mammals...
  13. ncbi Increased Na(+)/H(+) exchanger isoform 1 activity in spontaneously hypertensive rats: lack of mutations within the coding region of NHE1
    S N Orlov
    Centre de Recherche, CHUM, University of Montreal, Montreal, Canada
    Biochim Biophys Acta 1500:169-80. 2000
    ....
  14. ncbi RAS blockade decreases blood pressure and proteinuria in transgenic mice overexpressing rat angiotensinogen gene in the kidney
    S Sachetelli
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Pavillon Masson, Montreal, Quebec, Canada
    Kidney Int 69:1016-23. 2006
    ..RAS blockers prevent these abnormalities. These data support the role of the intrarenal RAS in the development of hypertension and renal injury...
  15. ncbi Evidence of an altered in vivo vascular cell turnover in spontaneously hypertensive rats and its modulation by long-term antihypertensive treatment
    N Thorin-Trescases
    Research Centre, , University of Montreal, Montreal, Quebec, Canada
    J Cardiovasc Pharmacol 38:764-74. 2001
    ..We propose that the altered cell turnover is a component of aortic remodeling observed in hypertension. Our data also suggest that it is possible to modulate in vivo cell turnover and affect vascular remodeling by pharmacologic therapy...
  16. ncbi Antiproliferative effect of brief exposure to cholera toxin in vascular smooth muscle cells: role of cAMP and protein kinase A
    N Thorin-Trescases
    Centre de Recherche, , QC, Canada
    Can J Physiol Pharmacol 79:471-80. 2001
    ..In conclusion, brief exposure to CTX leads to full-scale activation of cAMP signaling and evokes VSMC arrest in the G1 phase...
  17. ncbi Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach
    T Ueno
    Centre de recherche Centre hospitalier de l Université de Montréal Hôtel Dieu, Quebec, Canada
    Physiol Res 52:689-700. 2003
    ..Concordance of the identified locus for KW/BW and BP through the SNS on Chr8 with the PKD locus revealed the importance of this region for renal complications in various diseases...
  18. ncbi Activation of cAMP signaling transiently inhibits apoptosis in vascular smooth muscle cells in a site upstream of caspase-3
    S N Orlov
    Centre de Recherche du CHUM, Campus Hotel Dieu, University of Montreal, Montreal, Quebec, Canada
    Cell Death Differ 6:661-72. 1999
    ....
  19. pmc Dynamic genetic linkage of intermediate blood pressure phenotypes during postural adaptations in a founder population
    I A Arenas
    Centre de Recherche, Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec, Canada
    Physiol Genomics 45:138-50. 2013
    ..Supine and standing BPs have distinct genetic signatures. Standardized maneuvers influence the results of genetic investigations into BP, thus reflecting its dynamic regulation...
  20. ncbi Inversion of the intracellular Na(+)/K(+) ratio blocks apoptosis in vascular smooth muscle cells by induction of RNA synthesis
    S N Orlov
    Centre de Recherche du CHUM, Campus Hotel Dieu, University of Montreal, Montreal, PQ, Canada
    Hypertension 35:1062-8. 2000
    ..Thus, our results demonstrate that the antiapoptotic effect of the inverted [Na(+)](i)/[K(+)](i) ratio is mediated by MAPK-independent induction of de novo synthesis of RNA species encoding inhibitor(s) of programmed cell death...
  21. doi A 52-week prospective, cohort study of the effects of losartan with or without hydrochlorothiazide (HCTZ) in hypertensive patients with metabolic syndrome
    N Racine
    Department of Medicine, Montreal Heart Institute, Montreal, Quebec, Canada
    J Hum Hypertens 24:739-48. 2010
    ....
  22. ncbi Inhibition of Na+,K+ pump affects nucleic acid synthesis and smooth muscle cell proliferation via elevation of the [Na+]i/[K+]i ratio: possible implication in vascular remodelling
    S N Orlov
    Centre de Recherche, , , , , Canada
    J Hypertens 19:1559-65. 2001
    ....
  23. ncbi Longitudinal analysis of motor activity and coordination, anxiety, and spatial learning in mice with altered blood pressure
    S Thifault
    , , Centre de Recherche, , 3840 rue St-Urbain, , H2W 1T8, , Canada
    Brain Res 910:99-105. 2001
    ..Both groups with abnormal BP values were deficient during visuomotor guidance in the water maze. These results indicate strain-, age-, and test-specific abnormalities in mice with uncontrolled hypertension or hypotension...
  24. ncbi Replacement of (alpha)1-Na-K-ATPase of Dahl rats by Milan rats lowers blood pressure but does not affect its activity
    S N Orlov
    Research Centre, , , Montreal, Quebec, H2W 1T8, Canada
    Physiol Genomics 7:171-7. 2001
    ..Thus the BP-lowering effects observed in S.M5 and S.M6 could not be attributed to the alpha(1)-Na-K-ATPase activity or its stoichiometry. Atp1a1 is not supported as a candidate to be a BP QTL...
  25. ncbi Smooth muscle apoptosis during vascular regression in spontaneously hypertensive rats
    D deBlois
    Centre de Recherche de l Hôtel Dieu de Montréal, Quebec, Canada
    Hypertension 29:340-9. 1997
    ..Thus, smooth muscle cell apoptosis represents a novel therapeutic target for the control of hypertensive vessel remodeling in response to therapeutic agents...
  26. ncbi Heritability estimates of obesity measures in siblings with and without hypertension
    Z Pausova
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Canada
    Hypertension 38:41-7. 2001
    ..This, in turn, suggests that a genetic link exists between obesity and hypertension in these families...
  27. ncbi Contribution of autosomal loci and the Y chromosome to the stress response in rats
    P Dumas
    Centre de Recherche du CHUM, Universite de Montreal, Montreal, Quebec, Canada
    Hypertension 35:568-73. 2000
    ....
  28. ncbi Apoptosis and vascular wall remodeling in hypertension
    P Hamet
    Centre de Recherche Hôtel Dieu de Montréal, Universite de Montreal, Canada
    Can J Physiol Pharmacol 74:850-61. 1996
    ..The identification of biochemical markers of apoptosis and other methodological advances will ultimately help in understanding the role of apoptotic cell death in vascular remodeling and hypertensive end-organ damage...
  29. ncbi Thermosensitivity, a possible new locus involved in genetic hypertension
    D Malo
    Clinical Research Institute of Montreal, Quebec, Canada
    Hypertension 14:121-8. 1989
    ..The results support the possibility that the increased thermosensitivity seen in hypertensive mice is associated with one of the genes that contributes to their high blood pressure...
  30. ncbi The Sp transcription factor family is involved in the cellular expression of the human GIP-R gene promoter
    V Baldacchino
    Laboratory of Endocrine Pathophysiology, Department of Medicine, Hôtel Dieu du Centre hospitalier de l Université de Montréal, Montreal, Canada
    Endocr Res 30:805-6. 2004
  31. ncbi Increase of calmodulin activator in hypertension. Modulation by dietary sodium and calcium
    E Chang
    Clinical Research Institute of Montreal, Quebec, Canada
    Am J Hypertens 3:210S-215S. 1990
    ..In the presence of exogenously added CaM, lipidic extracts from the SHM heart showed augmented CaM-PDE activity relative to normotensive preparations. This difference was eliminated by trifluoperazine.(ABSTRACT TRUNCATED AT 250 WORDS)..
  32. ncbi [Na+]i/[K+]i -independent death of ouabain-treated renal epithelial cells is not mediated by Na+,K+ -ATPase internalization and de novo gene expression
    Olga A Akimova
    Research Centre, Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel East, Montreal, Quebec H1W 4A4, Canada
    Pflugers Arch 455:711-9. 2008
    ..Our results show that neither Na(+),K(+)-ATPase endocytosis nor de novo gene expression contributes to Na(+)(i), K(+)(i)-independent cell death signaling evoked by prolonged exposure to CTS...
  33. ncbi Endothelial and myocyte apoptosis--role of angiotensin II
    P Hamet
    Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Canada
    Can J Cardiol 17:26A-8A. 2001
    ..More recent in vivo studies have shown the prevention and regression of vascular lesions by apoptosis induction with medications (including AT1 receptor inhibitor)...
  34. ncbi Characterization of a primate model of hypertension. The response of hypertensive and normotensive male vervets (Cercopithecus aethiops) to cold pressor stress, captopril administration, and acute bolus of atrial natriuretic factor
    S Martin
    Department of Psychiatry, McGill University School of Medicine, Montreal, Quebec, Canada
    Am J Hypertens 3:27-32. 1990
    ..Additional studies are required to complete the endocrine and pharmacological characterization of individual animals with HBP...
  35. ncbi Novel genetic approaches to the resolution of complex diseases
    P Hamet
    Research Centre, Centre hospitalier de l Université de Montreal CHUM Montreal, Quebec, Canada
    Cas Lek Cesk 143:651-6; discussion 656. 2004
    ..Foreseeably, genetics will be part of this novel medicine in which the prediction of diseases will be based on individual genomic makeup...
  36. ncbi Apoptosis in cardiovascular remodeling--effect of medication
    D deBlois
    Department of Pharmacology, University of Montreal, 2nd Centre de recherche, , Quebec, Canada
    Cardiovasc Drugs Ther 15:539-45. 2001
    ....
  37. ncbi The diversity of abnormal hormone receptors in adrenal Cushing's syndrome allows novel pharmacological therapies
    A Lacroix
    Division of Endocrinology, Department of Medicine, Research Center, Hôtel Dieu du Centre Hospitalier, Universite de Montreal, Montreal, Canada
    Braz J Med Biol Res 33:1201-9. 2000
    ....
  38. ncbi In vivo variability of TMA oxidation is partially mediated by polymorphisms of the FMO3 gene
    D M Lambert
    Biochemical Genetics, Montreal Children's Hospital, Montreal, Quebec, Canada
    Mol Genet Metab 73:224-9. 2001
    ..quot; With the use of substrate loading or with the interaction of other known modulators of FMO3 activity such as hormonal influences, these genotypes may predispose to mild TMAU...
  39. ncbi Regression of neointimal lesions in the carotid artery of nifedipine-treated SHR and WKY rats: possible role of apoptosis
    J Lemay
    Laboratory of Pharmacology of Vascular Pathologies, CHUM Research Center, Montreal, Quebec, Canada
    J Vasc Res 38:462-70. 2001
    ..Thus, the antihypertrophic action of nifedipine is amplified in the neointima of SHR and WKY rat carotids, where histological evidence suggests SMC deletion via apoptosis...
  40. doi Cardiotonic steroid-resistant alpha1-Na+,K+-ATPase rescues renal epithelial cells from the cytotoxic action of ouabain: evidence for a Nai+,Ki+ -independent mechanism
    Olga A Akimova
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Technopole Angus, 2901 Rachel Est, Montreal, QC H1W 4A4, Canada
    Apoptosis 15:55-62. 2010
    ..Our results show that the alpha1R subunit rescues MDCK cells from the cytotoxic action of CTS independently of inhibition of Na(+),K(+)-ATPase-mediated Na(+) and K(+) fluxes and inversion of the [Na(+)](i)/[K(+)](i) ratio...
  41. ncbi Diet-induced obesity delays cardiovascular recovery from stress in spontaneously hypertensive rats
    Lucie Sedova
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Obes Res 12:1951-8. 2004
    ....
  42. ncbi Renal effects of immersion in essential hypertension. Carvedilol Study Group
    P Larochelle
    Centre de Recherche, , , Canada
    Am J Hypertens 7:120-8. 1994
    ..29 +/- 0.58 to 1.63 +/- 0.55 ng/mL/h) and to a greater degree in patients with EH (1.62 +/- 0.52 to 0.77 +/- 0.19 ng/mL/h, P < .05) by HOI.(ABSTRACT TRUNCATED AT 250 WORDS)..
  43. ncbi [3H]-thymidine labelling of DNA triggers apoptosis potentiated by E1A-adenoviral protein
    S N Orlov
    Centre de recherche du centre hospitalier de l Université de Montréal CHUM, PQ, Canada
    Apoptosis 8:199-208. 2003
    ....
  44. ncbi The rapid decline of MTT reduction is not a marker of death signaling in ouabain-treated cells
    O A Akimova
    Centre de Recherche, CHUM Hotel Dieu, Montreal, Quebec, Canada
    Cell Mol Biol (Noisy-le-grand) 52:71-7. 2006
    ..We speculate that altered endo- and exocytoses evoked by cardiotonic steroids contribute to decreased MTT reduction...
  45. ncbi The angiotensin II type 1 receptor and receptor-associated proteins
    D F Guo
    Research Centre, Hotel Dieu of CHUM and Department of Medicine, University of Montreal, Quebec, Canada
    Cell Res 11:165-80. 2001
    ..These novel proteins will advance our understanding of how the receptor is internalized and recycled as they provide molecular mechanisms for the activation and regulation of G-protein-coupled receptors...
  46. ncbi Hypertension: genes and environment
    P Hamet
    Centre de Recherche du C H U M, Pavillon Hôtel Dieu, Universite de Montreal, Quebec, Canada
    J Hypertens 16:397-418. 1998
    ..Finally, we discuss the significance of environmental factors, such as stress and diet, in the pathogenesis of hypertension, and we describe their interactions with specific hypertension susceptibility genes...
  47. ncbi The death of cardiotonic steroid-treated cells: evidence of Na+i,K+i-independent H+i-sensitive signalling
    S N Orlov
    Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Montreal, Quebec, Canada
    Acta Physiol (Oxf) 187:231-40. 2006
    ..The molecular origin of intracellular Na+ and H+ sensor involvement in the development of apoptosis and oncosis is currently under investigation...
  48. ncbi Ectopic and abnormal hormone receptors in adrenal Cushing's syndrome
    A Lacroix
    Department of Medicine, Research Center, H tel du Centre Hospitalier de l Université de Montréal, Quebec, Canada
    Endocr Rev 22:75-110. 2001
    ....
  49. ncbi Distinct quantitative trait loci for kidney, cardiac, and aortic mass dissociated from and associated with blood pressure in Dahl congenic rats
    Chenda Duong
    Research Centre, Centre Hospitalier de l Universite de Montreal CHUM, Montreal, Quebec, Canada
    Mamm Genome 17:1147-61. 2006
    ..The discovery of individual Km and Cakm QTLs will likely facilitate the identification of mechanisms underlying renal, cardiac, and/or aortic hypertrophy independent of hypertension...
  50. doi Altered phosphorylation of RRXS*/T* motif in ouabain-treated renal epithelial cells is not mediated by inversion of the [Na](i)/[K+](i) ratio
    Olga A Akimova
    Research Centre, Centre hospitalier de l Université de Montréal CHUM Technopôle Angus, Montreal, Quebec, Canada
    Cell Physiol Biochem 21:315-24. 2008
    ..The molecular origin of serine-threonine kinases and/or phosphatases involved in phosphorylation of ouabain-sensitive proteins and their role in cell death signaling should be examined further...
  51. ncbi Inhibition of Na+,K+-ATPase by ouabain triggers epithelial cell death independently of inversion of the [Na+]i/[K+]i ratio
    Dimitri Pchejetski
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, PQ, Canada
    Biochem Biophys Res Commun 301:735-44. 2003
    ..Our results show for the first time that the death of ouabain-treated renal epithelial cells is independent of the inhibition of Na(+)/K(+) pump-mediated ion fluxes and the [Na(+)](i)]/[K(+)](i) ratio...
  52. pmc c-Fos expression in ouabain-treated vascular smooth muscle cells from rat aorta: evidence for an intracellular-sodium-mediated, calcium-independent mechanism
    Sebastien Taurin
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, PQ, Canada
    J Physiol 543:835-47. 2002
    ....
  53. ncbi HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation
    N Solban
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec H2W 1T8, Canada
    J Biol Chem 275:32234-43. 2000
    ..Taken together, our results suggest that HCaRG is a nuclear protein potentially involved in the control of cell proliferation...
  54. ncbi Upregulation of osteopontin gene expression in diabetic rat proximal tubular cells revealed by microarray profiling
    T J Hsieh
    Research Centre, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    Kidney Int 69:1005-15. 2006
    ....
  55. ncbi Partial characterisation of the 5' flanking region of the human GIP receptor (GIPR) gene
    V Baldacchino
    Laboratory of Endocrine Pathophysiology, Dept of Medicine, Hôtel Dieu du Centre hospitalier de l Université de Montréal CHUM, Montreal, Canada, H2W 1T8
    Endocr Res 28:577. 2002
  56. ncbi [Na/K pump and intracellular monovalent cations: novel mechanism of excitation-transcription coupling involved in inhibition of apoptosis]
    S Taurin
    Research Centre, University of Montreal Hospital CHUM, Canada
    Mol Biol (Mosk) 37:371-81. 2003
    ....
  57. doi Central role of guanylyl cyclase in natriuretic peptide signaling in hypertension and metabolic syndrome
    G Martel
    Laboratory of Cellular Biology of Hypertension, Centre for Ecogenomic Models of Human Diseases, Centre de Recherche, Centre hospitalier de l Université de Montréal CRCHUM, Technopole Angus, 2901 rue Rachel est, bureau 314, Montreal, QC H1W 4A4, Canada
    Mol Cell Biochem 334:53-65. 2010
    ..A new era is now on its way targeting the NP system to not only treat high blood pressure, but to also assist in the fight against the obesity pandemic. Here, we summarize recent data on the role of NPs in hypertension and MetS...
  58. ncbi Intracellular monovalent ions as second messengers
    S N Orlov
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, CHUM Hotel Dieu, Montreal, Quebec, Canada
    J Membr Biol 210:161-72. 2006
    ..With the exception of HCO (3) (-) -sensitive soluble adenylyl cyclase, the molecular origin of sensors involved in the function of monovalent ions as second messengers remains unknown...
  59. ncbi What is apoptosis and what is its relevance to vascular biology?
    P Hamet
    Universite de Montreal, Montreal, Canada
    Can J Cardiol 15:5B-7B. 1999
    ..In these models, apoptosis was effectively upregulated by three of the four antihypertensive agents studied. Work to identify the gene that controls apoptosis is ongoing...
  60. ncbi Can we use erythrocytes for the study of the activity of the ubiquitous Na+/H+ exchanger (NHE-1) in essential hypertension?
    S N Orlov
    Laboratory of Biomembranes, Faculty of Biology, MV Lomonosov Moscow State University, Russia
    Am J Hypertens 11:774-83. 1998
    ....
  61. ncbi Development of hypertension and kidney hypertrophy in transgenic mice overexpressing ARAP1 gene in the kidney
    Deng Fu Guo
    Research Centre, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, Pavillon Masson, 3850 Saint Urbain St, Montreal, Quebec, Canada H2W 1T8
    Hypertension 48:453-9. 2006
    ....
  62. ncbi The alpha1-Na/K pump does not mediate the involvement of ouabain in the development of hypertension in rats
    Sergei N Orlov
    Centre de Recherche, Centre hospitalier de l Université de Montréal Hĵtel Dieu, PQ, Canada
    Blood Press 11:56-62. 2002
    ..Alternative mechanisms of the involvement of EO and ouabain-like factors in the development of hypertension are considered...
  63. doi Pharmacogenomics of metabolic effects of rosiglitazone
    Ondrej Seda
    Centre Hospitalier de l Universite de Montreal, Centre de Recherche, Technopole Angus, 2901 Rachel East, Office 314, Montreal, Quebec H1W 4A4, Canada
    Pharmacogenomics 9:141-55. 2008
    ..SHR4 inbred rat strains, with their insulin-sensitive, normolipidemic counterpart, the Brown Norway (BN) rat...
  64. ncbi Biochemistry and physiology of the natriuretic peptide receptor guanylyl cyclases
    Johanne Tremblay
    Research Centre, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Mol Cell Biochem 230:31-47. 2002
    ..The structure and regulation of GC-B is similar to that of GC-A. This chapter reviews the structure and roles of GC-A and GC-B in blood pressure regulation and cardiac and renal pathophysiology...
  65. ncbi Genetics of programmed cell death and proliferation
    Sergei N Orlov
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Universite de Montreal, Montreal, Quebec, Canada
    Semin Nephrol 22:161-71. 2002
    ..In the present article, we summarize the results of these studies with an emphasis on the relative impact of genetic determinants and the environment...
  66. ncbi Identification and chromosomal localization of ecogenetic components of electrolyte excretion
    Pierre Dumas
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, Quebec, Canada
    J Hypertens 20:209-17. 2002
    ..To determine to what extent urinary excretion of blood pressure-modulating electrolytes is genetically determined, and to identify their chromosomal localization...
  67. ncbi Apoptosis vs. oncosis: role of cell volume and intracellular monovalent cations
    Sergei N Orlov
    Centre de recherche du Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, 3850, rue Saint Urbain, Montreal, Quebec H2W 1T7, Canada
    Adv Exp Med Biol 559:219-33. 2004
    ..fmk. In these cells, the death signal was mediated by interaction of ouabain with the Na(+)-K(+)-ATPase alpha-subunit but was independent of the inhibition of Na(+)-K+ pump-mediated ion fluxes and elevation of the [Na+]i/[K+]i ratio...
  68. doi Systematic, genome-wide, sex-specific linkage of cardiovascular traits in French Canadians
    Ondrej Seda
    Centre de Recherche, Centre hospitalier de l Université de Montréal Technopôle Angus, Montreal, Quebec, Canada
    Hypertension 51:1156-62. 2008
    ..Many of these would have been missed in a traditional, sex-adjusted setting...
  69. doi Impact of genetic and epigenetic factors from early life to later disease
    Johanne Tremblay
    Gene Medicine Service, Research Center, Centre Hospitalier de l Universite de Montreal CHUM, Montreal, Quebec, Canada H1W 4A4
    Metabolism 57:S27-31. 2008
    ..Evolutionally acquired genomic susceptibilities and environmentally induced epigenomic modulations occurring early in life impact on later development of human diseases...
  70. ncbi Aberrant G-protein coupled receptor expression in relation to adrenocortical overfunction
    Andre Lacroix
    Division of Endocrinology, Department of Medicine, Centre de recherche du Centre Hospitalier de l Universite de Montreal, Universite de Montreal, Montreal, QC, Canada
    Clin Endocrinol (Oxf) 73:1-15. 2010
    ....
  71. pmc Decreased NKCC1 activity in erythrocytes from African Americans with hypertension and dyslipidemia
    Sergei N Orlov
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM Technopôle Angus, Montreal, Quebec, Canada
    Am J Hypertens 23:321-6. 2010
    ..We examined the impact of race, gender, and plasma lipid on NKCC1 activity in French Canadians and African Americans with hypertension and dyslipidemia...
  72. doi NKCC1 and hypertension: a novel therapeutic target involved in the regulation of vascular tone and renal function
    Sergei N Orlov
    Research Centre, Centre Hospitalier de l Université de Montréal CHUM Technôpole Angus and Department of Medicine, Universite de Montreal, Montreal, Quebec, Canada
    Curr Opin Nephrol Hypertens 19:163-8. 2010
    ..The present review summarizes recent advances in our understanding of the mechanisms involving the housekeeping Na+, K+, 2Cl(-) cotransporter (NKCC1) in blood pressure (BP) regulation...
  73. doi Genetics of pain, opioids, and opioid responsiveness
    Johanne Tremblay
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM Technopôle Angus, Montreal, Quebec, Canada
    Metabolism 59:S5-8. 2010
    ....
  74. ncbi Regulation of therapeutic apoptosis: a potential target in controlling hypertensive organ damage
    Denis Deblois
    University of Montreal Hospital Research Center, Montreal, QC, Canada
    Can J Physiol Pharmacol 83:29-41. 2005
    ..We propose that the presence of a cell subpopulation with defective cell cycle regulation may determine organ susceptibility to undergo therapeutic apoptosis...
  75. ncbi A genealogical study of essential hypertension with and without obesity in French Canadians
    Zdenka Pausova
    University of Montreal Health Centre, Canada
    Obes Res 10:463-70. 2002
    ....
  76. ncbi Proteome analysis and functional expression identify mortalin as an antiapoptotic gene induced by elevation of [Na+]i/[K+]i ratio in cultured vascular smooth muscle cells
    Sebastien Taurin
    Centre de Recherche de l Hôpital Sainte Justine, Montreal, Quebec, Canada
    Circ Res 91:915-22. 2002
    ..Our studies therefore define a new [Na+]i/[K+]i-responsive signaling pathway that may play an important role in the regulation of programmed cell death in VSMCs...
  77. ncbi Na+/K+ pump and endothelial cell survival: [Na+]i/[K+]i-independent necrosis triggered by ouabain, and protection against apoptosis mediated by elevation of [Na+]i
    Sergei N Orlov
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Hotel Dieu, 3850 Rue St Urbain, Montreal, Quebec, H2W 1T7, Canada
    Pflugers Arch 448:335-45. 2004
    ..The role of Na+/K+ pump-mediated regulation of endothelial cell survival and vascular remodelling seen in hypertension should be investigated further in context of EOLS and chronic treatment with digitalis...
  78. ncbi Segment of rat chromosome 20 regulates diet-induced augmentations in adiposity, glucose intolerance, and blood pressure
    Zdenka Pausova
    Laboratory of Functional Genomics, Centre de Recherche, CHUM Hôtel Die, 3850 St Urbain St, Montreal, Quebec H2W 1T7, Canada
    Hypertension 41:1047-55. 2003
    ....
  79. ncbi Cushing's syndrome variants secondary to aberrant hormone receptors
    Andre Lacroix
    Laboratories of Endocrine Pathophysiology, Cellular Biology of Hypertension, and Molecular Medicine, Department of Medicine, Hôtel Dieu du Centre hospitalier de l Université de Montréal CHUM, Montreal H2W 1T8, Canada
    Trends Endocrinol Metab 15:375-82. 2004
    ..The identification of aberrant adrenal GPCRs offers the potential for novel pharmacological therapies that either suppress the endogenous ligands or block the receptor with specific antagonists...
  80. ncbi Characterization of a cGMP-response element in the guanylyl cyclase/natriuretic peptide receptor A gene promoter
    David Hum
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, Montreal, Quebec, Canada
    Hypertension 43:1270-8. 2004
    ....
  81. ncbi TA repeat variation, Npr1 expression, and blood pressure: impact of the Ace locus
    Johanne Tremblay
    Laboratory of Cellular Biology of Hypertension, Centre de Recherche du Centre Hospitalier de l Université de Montréal Hôtel Dieu, Montreal, Quebec, Canada
    Hypertension 41:16-24. 2003
    ..In conclusion, the longer TA repeat unit in the promoter of Npr1 of SHR, in tandem with a putative cGMP responsive element, regulates the transcription of the Npr1 gene with consequences on diastolic blood pressure...
  82. ncbi Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems
    Takahiro Ueno
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal Hotel Dieu, 3850 Rue Saint Urbain, Montreal, Quebec, Canada
    J Mol Med (Berl) 81:51-60. 2003
    ..This pharmocogenetic approach enabled us to determine the main causative acute BP regulatory systems and should lead to better selection of suitable antihypertensive drugs for individual patients...
  83. ncbi Impact of diabetes on crash risks of truck-permit holders and commercial drivers
    C Laberge-Nadeau
    Department of Social and Preventive Medicine, University of Montreal, Quebec, Canada
    Diabetes Care 23:612-7. 2000
    ..Scientific evidence to support such regulations has been sparse. This article presents detailed analyses of crash risks for users and nonusers of insulin among diabetic truck-permit holders in Québec, Canada...
  84. pmc GREBP, a cGMP-response element-binding protein repressing the transcription of natriuretic peptide receptor 1 (NPR1/GCA)
    Guy Martel
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Quebec H1W 4A4, Canada
    J Biol Chem 285:20926-39. 2010
    ..GREBP is a nuclear protein mainly expressed in the heart. We report here the existence of a human-specific gene that acts as a transcriptional repressor of the NPR1/GCA gene...
  85. ncbi Whole genome expression profiling of glucose-dependent insulinotropic peptide (GIP)- and adrenocorticotropin-dependent adrenal hyperplasias reveals novel targets for the study of GIP-dependent Cushing's syndrome
    Antoine Lampron
    Department of Medicine, Hôtel Dieu du Centre hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 91:3611-8. 2006
    ..Chronic adrenal stimulation by ACTH in Cushing's disease or GIP in GIP-dependent ACTH-independent macronodular adrenal hyperplasia both lead to the induction of genes implicated in adrenal proliferation and steroidogenesis...
  86. ncbi Multiple quantitative trait loci for blood pressure interacting epistatically and additively on Dahl rat chromosome 2
    Julie Dutil
    Research Centre CHUM, 3840 rue St Urbain, Montreal, Quebec, Canada
    Hypertension 45:557-64. 2005
    ..These results suggest that BP QTLs closely linked in a segment interact epistatically and additively to one another on Chr 2...
  87. ncbi HCaRG is a novel regulator of renal epithelial cell growth and differentiation causing G2M arrest
    Alison M Devlin
    Laboratory of Cellular Biology of Hypertension, Centre de Recherche, Centre Hospitalier de l Universite de Montreal, University of Montreal, Montreal, Quebec, Canada
    Am J Physiol Renal Physiol 284:F753-62. 2003
    ..Taken together, our results suggest that HCaRG is a regulator of renal epithelial cell growth and differentiation causing G(2)M cell cycle arrest...
  88. doi The death of ouabain-treated renal epithelial cells: evidence against anoikis occurrence
    Olga A Akimova
    Research Centre, Centre hospitalier de l Université de Montréal CHUM Technopôle Angus, 2901 Rachel Est, Montreal, Quebec, Canada
    Apoptosis 13:670-80. 2008
    ..2 to 6.7 almost completely abolished the cytotoxic action of ouabain, but did not significantly affect anoikis. Our results show that the Na (i) + ,K (i) + -independent mode of MDCK cell death evoked by ouabain is not mediated by anoikis...
  89. ncbi Dynamic genetic architecture of metabolic syndrome attributes in the rat
    Ondrej Seda
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Canada
    Physiol Genomics 21:243-52. 2005
    ....
  90. ncbi [Na]i -induced c-Fos expression is not mediated by activation of the 5' -promoter containing known transcriptional elements
    Mounsif Haloui
    Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Technopôle Angus, Montreal, PQ, Canada
    FEBS J 274:3557-67. 2007
    ..Our results reveal that Na(+) (i)-induced c-Fos expression is not mediated by the 5'-UTR containing transcriptional elements activated by growth factors and other 'classic stimuli'...
  91. ncbi Increased transcription of a major stress gene in spontaneously hypertensive mice
    P Hamet
    Clinical Research Institute of Montreal, Quebec, Canada
    Hypertension 15:904-8. 1990
    ..The present studies demonstrate that increased hsp70 gene expression is due to its heightened transcription rate. The genetic basis of environmental susceptibility to hypertension may thus involve an abnormal control of heat shock genes...
  92. ncbi Contribution of the TNF alpha gene region of rat chromosome 20 to the body temperature response to endotoxin
    Z Pausova
    Centre Hospitalier de l Universite de Montreal, Canada
    Transplant Proc 31:1622-3. 1999
  93. ncbi In vivo measurement of atrial natriuretic peptide receptors using nuclear imaging
    R Willenbrock
    Centre de Recherche, , , , Canada
    Am J Hypertens 5:832-6. 1992
    ..Since ANP receptor density and affinity are influenced by various physiological and pathological conditions, clinical and diagnostic applications seem possible...
  94. ncbi Comparisons between C57BL/6J and A/J mice in motor activity and coordination, hole-poking, and spatial learning
    S Thifault
    Laboratoire de médecine moléculaire and Service de neurologie, Centre de Recherche, Hôtel Dieu du Centre hospitalier de l Université de Montréal, Que, Montreal, Canada
    Brain Res Bull 58:213-8. 2002
    ..These results indicate that recombinant inbred or congenic strains derived from B6 and A/J mice offer considerable potential for discerning the genetic basis of several behavioral phenotypes...
  95. doi The impact of a multidisciplinary information technology-supported program on blood pressure control in primary care
    Stephane Rinfret
    Centre de recherche du Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Circ Cardiovasc Qual Outcomes 2:170-7. 2009
    ..Effective programs to address this problem are lacking. We hypothesized that an information technology-supported management program could help improve blood pressure (BP) control...
  96. ncbi Integrating genomics and transcriptomics with geo-ethnicity and the environment for the resolution of complex cardiovascular diseases
    Ondrej Seda
    Centre Hospitalier de l Universite de Montreal CHUM, Research Centre, Laboratory of Molecular Medicine, Montreal, Quebec, Canada
    Curr Opin Mol Ther 7:583-7. 2005
    ....
  97. ncbi Genetic determinants of the stress response in cardiovascular disease
    Pavel Hamet
    Laboratory of Molecular Medicine and Laboratory of Cellular Biology of Hypertension, Centre de Recherche, Centre hospitalier de l Université de Montréal CHUM Hôtel Dieu, Quebec, Canada
    Metabolism 51:15-24. 2002
    ..The high prevalence of cardiovascular diseases with traits of enhanced stress responsiveness is discussed here in the context of a paradigm, such as hypertension, in the general population...
  98. ncbi The Sp transcription factors are involved in the cellular expression of the human glucose-dependent insulinotropic polypeptide receptor gene and overexpressed in adrenals of patients with Cushing's syndrome
    Valérie Baldacchino
    Laboratory of Endocrine Pathophysiology, Department of Medicine, Centre Hospitalier de l Universite de Montreal, Quebec, Canada
    J Mol Endocrinol 35:61-71. 2005
    ..This study represents the first step in our understanding of the mechanisms involved in the regulation of the expression of the hGIP-R gene...
  99. ncbi Renal ischemia-reperfusion injury in the rat is prevented by a novel immune modulation therapy
    Johanne Tremblay
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec, Canada
    Transplantation 74:1425-33. 2002
    ..The therapy has been shown to have a beneficial effect in models of inflammation and vascular diseases. This study tested the hypothesis that IMT can prevent renal ischemia-reperfusion (I/R) injury in rats...
  100. ncbi Cardiotonic steroids differentially affect intracellular Na+ and [Na+]i/[K+]i-independent signaling in C7-MDCK cells
    Olga A Akimova
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, Montreal, Quebec H2W 1T7, Canada
    J Biol Chem 280:832-9. 2005
    ..Thus, our results show that CTS exhibit distinctly different potency in Na(+),K(+) pump inhibition and triggering of [Na(+)](i)/[K(+)](i)-independent signaling, including cell death...
  101. ncbi Modest intracellular acidification suppresses death signaling in ouabain-treated cells
    Olga A Akimova
    Centre de Recherche, Centre Hospitalier de l Universite de Montreal, CHUM Hotel Dieu, Montreal, Canada
    Pflugers Arch 451:569-78. 2006
    ..They also suggest that the protective action of acidification is mediated by de novo expression of genes involved in inhibition of the cell death machinery...