Research Topics
| Clement HamaniSummaryCountry: Canada Publications
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Publications
Spontaneous recurrent seizures and neuropathology in the chronic phase of the pilocarpine and picrotoxin model epilepsyClement Hamani
Department of Physiology, UNIFESP-EPM, R. Botucatu 862, , Brazil
Neurol Res 24:199-209. 2002..Future experiments conducted in this sense, might lead to important results in regard to the elucidation of mechanisms of epileptogenesis...- Deep brain stimulation in the treatment of dyskinesia and dystoniaHiroki Toda
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University of Toronto, Ontario, Cananda
Neurosurg Focus 17:E2. 2004..Discrimination between the diverse forms of dystonia and a better understanding of the pathophysiological features of this condition will serve as a platform for improved outcomes... 
Pedunculopontine nucleus microelectrode recordings in movement disorder patientsMoran Weinberger
Department of Physiology, University of Toronto, Med Sci Bldg 3302, 1 King s College Circle, M5S 1A8, Toronto, ON, Canada
Exp Brain Res 188:165-74. 2008..It remains to be seen to what extent the physiological characteristics of the neurons and the stimulation-evoked effects will permit reliable identification of PPN and determination of the optimal target for DBS therapy...- Correspondence of microelectrode mapping with magnetic resonance imaging for subthalamic nucleus proceduresClement Hamani
Division of Neurosurgery, University of Toronto, Toronto, ON M5T 2S8, Canada
Surg Neurol 63:249-53; discussion 253. 2005..Little is known about the correlation between the position of the STN as seen on MRI and that as determined by MER mapping. We compared these in 10 patients with Parkinson's disease... - The subthalamic nucleus in the context of movement disordersClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute, Ontario, Canada
Brain 127:4-20. 2004..The aim of the present article is to review briefly the major anatomical, pharmacological and physiological aspects of the STN, as well as its involvement in the pathophysiology and treatment of Parkinson's disease... - Contribution of decreased serotonin release to the antidyskinetic effects of deep brain stimulation in a rodent model of tardive dyskinesia: comparison of the subthalamic and entopeduncular nucleiMeaghan C Creed
Department of Pharmacology and Toxicology, Toronto Western Hospital, University of Toronto, Ontario M5T 1R8, Canada
J Neurosci 32:9574-81. 2012..While decreasing 5-HT function is sufficient to suppress HAL-induced VCMs, 5-HT decrease is not necessary for the beneficial motor effects of DBS in this model... 
Stimulation of the subthalamic nucleus and impulsivity: release your horsesBenedicte Ballanger
Division of Brain, Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 66:817-24. 2009....- A phase I trial of deep brain stimulation of memory circuits in Alzheimer's diseaseAdrian W Laxton
Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 68:521-34. 2010..We hypothesized that fornix/hypothalamus deep brain stimulation (DBS) could modulate neurophysiological activity in these pathological circuits and possibly produce clinical benefits... - Movement related potentials and oscillatory activities in the human internal globus pallidus during voluntary movementsEric W Tsang
Division of Brain Imaging and Behaviour Systems Neuroscience, Toronto Western Research Institute, University Health Network, Toronto, Canada
J Neurol Neurosurg Psychiatry 83:91-7. 2012..To study internal globus pallidus (GPi) activities and the interactions among the bilateral GPi and motor cortical areas during voluntary movements... - Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human ponsAndrew S Lim
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 66:110-4. 2009..This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114... - Early gene mapping after deep brain stimulation in a rat model of tardive dyskinesia: comparison with transient local inactivationMeaghan C Creed
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
Eur Neuropsychopharmacol 22:506-17. 2012..The divergent effects of STN vs. EPN manipulations on HAL-induced zif268 changes suggest that similar behavioral outcomes of DBS in these two areas may involve different neuroanatomical mechanisms... - The nature and time course of cortical activation following subthalamic stimulation in Parkinson's diseaseRenju Kuriakose
Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada M5T 2S8
Cereb Cortex 20:1926-36. 2010..Cortical activation may be related to the clinical effects of STN DBS in PD... - Deep brain stimulation of the anterior nucleus of the thalamus: effects of electrical stimulation on pilocarpine-induced seizures and status epilepticusClement Hamani
Division of Neurosurgery, Toronto Western Hospital and University Health Network, University of Toronto, Toronto, Ontario, Canada
Epilepsy Res 78:117-23. 2008..As the optimal stimulation settings remain elusive, we studied the effects of different stimulation parameters against pilocarpine induced seizures and status epilepticus (SE)... - Cerebral blood flow changes induced by pedunculopontine nucleus stimulation in patients with advanced Parkinson's disease: a [(15)O] H2O PET studyBenedicte Ballanger
Toronto Western Research Institute Division of Brain, Imaging and Behaviour Systems Neuroscience, UHN, University of Toronto, Toronto, Ontario, Canada
Hum Brain Mapp 30:3901-9. 2009..Whether these findings are associated with the DBS-PPN clinical effect remains to be proven. However, they suggest that PPN modulation may induce functional changes in neural networks associated with the control of lower limb movements... - A multicenter pilot study of subcallosal cingulate area deep brain stimulation for treatment-resistant depressionAndres M Lozano
Division of Neurosurgery, University of Toronto, Canada
J Neurosurg 116:315-22. 2012..They conducted a 3-center prospective open-label trial of SCG DBS for 12 months in patients with treatment-resistant depression... - Unilateral subdural motor cortex stimulation improves essential tremor but not Parkinson's diseaseElena Moro
Movement Disorders Centre, Division of Neurology, Department of Medicine, University of Toronto, Toronto Western Hospital, University Health Network, Toronto, ON M5T2S8, Canada
Brain 134:2096-105. 2011..These findings suggest that unilateral subdural motor cortex stimulation may be useful for contralateral hand tremor in selected patients with essential tremor but was not effective in improving parkinsonian signs in our series... - Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depressionAndres M Lozano
Division of Neurosurgery, University of Toronto, Toronto, Canada
Biol Psychiatry 64:461-7. 2008..We now report the results of these and an additional 14 patients with extended follow-up... - Somatosensory evoked potentials recorded from the human pedunculopontine nucleus regionI Jin Yeh
Toronto Western Research Institute, University Health Network, Toronto, Ontario, Canada
Mov Disord 25:2076-83. 2010..Among the 10 recordings with HFOs, only 1 had possible phase reversal in the bipolar derivation. Our results suggest that there are direct somatosensory inputs to the PPNR. The slow components and HFOs of the SEP have different origins... - Deep brain stimulation of the subcallosal cingulate gyrus for depression: anatomical location of active contacts in clinical responders and a suggested guideline for targetingClement Hamani
Division of Neurosurgery, Toronto Western Hospital, 399 Bathurst Street, WW 4 447 Toronto, Ontario M5T2S8 Canada
J Neurosurg 111:1209-15. 2009..Based on the location of the active contacts used for long-term stimulation in responders, the authors suggest a standardized method of targeting the SCG in patients with MDD... - Unilateral pedunculopontine stimulation improves falls in Parkinson's diseaseElena Moro
Division of Neurosurgery, 4 447 Toronto Western Hospital, 399 Bathurst Street, Toronto, ON, M5T 2S8 Canada
Brain 133:215-24. 2010..Our results suggest that pedunculopontine nucleus deep-brain stimulation may be effective in preventing falls in patients with advanced Parkinson's disease but that further evaluation of this procedure is required... - Neural stimulation successfully treats depression in patients with prior ablative cingulotomyJoseph S Neimat
Toronto Western Hospital, 399 Bathurst St, WW4-425, Toronto, Ontario M5T 2S8, Canada
Am J Psychiatry 165:687-93. 2008 - Comparison of 2-dimensional magnetic resonance imaging and 3-planar reconstruction methods for targeting the subthalamic nucleus in Parkinson diseaseYuri M Andrade-Souza
Division of Neurosurgery, Department of Surgery, University of Toronto and University Health Network, Toronto, Ontario, M5T 2S8, Canada
Surg Neurol 63:357-62; discussion 362-3. 2005..012). CONCLUSION: Indirect and direct targets chosen using 3P reconstruction more closely approximate the position of the clinically optimal contact than targets chosen using 2D MRI... - Deep brain stimulation reverses anhedonic-like behavior in a chronic model of depression: role of serotonin and brain derived neurotrophic factorClement Hamani
Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto Western Hospital, 250 College Street, Toronto, Ontario, Canada
Biol Psychiatry 71:30-5. 2012..We have studied the effects of ventromedial prefrontal cortex (vmPFC) stimulation in a chronic model of depression and assessed the involvement of the serotonergic system and brain derived neurotrophic factor (BDNF) in a DBS response... - The subcallosal cingulate gyrus in the context of major depressionClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
Biol Psychiatry 69:301-8. 2011..Particular attention is given to the regional and downstream structures that could be influenced by the application of deep brain stimulation in this region... - The dominant-STN phenomenon in bilateral STN DBS for Parkinson's diseaseAnna Castrioto
Movement Disorders Center, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, ON, Canada
Neurobiol Dis 41:131-7. 2011..In our sample 50% of the patients presented with a dominant-STN, suggesting that a non-negligible part of PD patients might not need bilateral STN-DBS surgery... - The pedunculopontine nucleus as a target for deep brain stimulationClement Hamani
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital, University Health Network, University of Toronto, 399 Bathurst Street WW 4 447, Toronto, ON, M5T2S8, Canada
J Neural Transm 118:1461-8. 2011..In this article, we review some of the basic aspects of the PPN as a target and the outcome of the recently published clinical trials... - Deep brain stimulation for the treatment of epilepsyClement Hamani
Division of Neurosurgery Toronto Western Hospital University of Toronto, Division of Neurosurgery, Toronto Western Hospital, Toronto, ON, Canada
Int J Neural Syst 19:213-26. 2009..We review the published literature on DBS, cortical and cerebellar stimulation for the treatment of epilepsy focusing predominantly on the rationale and clinical outcome in each target... - Anterior thalamus deep brain stimulation at high current impairs memory in ratsClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada
Exp Neurol 225:154-62. 2010..Though translating data from animals to humans has to be considered with caution, our study underscores the need for carefully monitoring memory function while selecting stimulation parameters during the clinical evaluation of AN DBS... - Memory rescue and enhanced neurogenesis following electrical stimulation of the anterior thalamus in rats treated with corticosteroneClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
Exp Neurol 232:100-4. 2011.... - Dravet syndrome and deep brain stimulation: seizure control after 10 years of treatmentDanielle M Andrade
Division of Neurology, Toronto Western Hospital, Krembil Neuroscience Centre, University of Toronto, Toronto, Ontario, Canada
Epilepsia 51:1314-6. 2010..We speculate that the results of DBS for epilepsy in patients with Dravet syndrome may be related to age at initiation of DBS treatment and seizure type... - Basal ganglia physiology and deep brain stimulationAndres M Lozano
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, UHN, Toronto, Ontario, Canada
Mov Disord 25:S71-5. 2010..In addition we review the recent work on pedunculopontine nucleus neurophysiology and trials of deep brain stimulation in that region for gait disturbances in Parkinson's disease... - The regulation of adult rodent hippocampal neurogenesis by deep brain stimulationHiroki Toda
Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
J Neurosurg 108:132-8. 2008..To examine the influence of deep brain stimulation on hippocampal neurogenesis in an adult rodent model... - Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulationLili Naz Hazrati
Department of Pathology, University of Toronto, University Health Network, Toronto, Ontario, Canada
Mov Disord 27:1304-7. 2012..However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP)... - Location of active contacts in patients with primary dystonia treated with globus pallidus deep brain stimulationClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, University Health Network, Toronto, Canada
Neurosurgery 62:217-23; discussion 223-5. 2008..We compared the location of the contacts being used for stimulation (active contacts) in patients with cervical dystonia, generalized dystonia, and Parkinson's disease and correlated the results with clinical outcome... - Deep brain stimulation in clinical trials and animal models of depressionClement Hamani
Neuroimaging Research Section, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON, M5T 1R8, Canada
Eur J Neurosci 32:1109-17. 2010..Particular emphasis will be given to aspects involved in the translation of data from animal models to humans and in our findings on the potential substrates involved in the antidepressant effects of DBS in rats... - Memory enhancement induced by hypothalamic/fornix deep brain stimulationClement Hamani
Division of Neurosurgery, Toronto Western Hospital and Research Institute, University of Toronto, Toronto, Ontario, Canada
Ann Neurol 63:119-23. 2008..This shows that hypothalamic stimulation in this patient modulates limbic activity and improves certain memory functions... - Comparison of three methods of targeting the subthalamic nucleus for chronic stimulation in Parkinson's diseaseYuri M Andrade-Souza
Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 56:360-8; discussion 360-8. 2005..CONCLUSION: The use of the RN as an internal fiducial marker for targeting the optimal region of STN stimulation was reliable and closely approximates the position of the electrode contact that provides the optimal clinical results... - Deep brain stimulation of the subthalamic or entopeduncular nucleus attenuates vacuous chewing movements in a rodent model of tardive dyskinesiaMeaghan Creed
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada
Eur Neuropsychopharmacol 21:393-400. 2011..The chronic HAL VCM model preparation may be useful to explore mechanisms underlying DBS effects in drug-induced dyskinesias... - Bilateral subthalamic nucleus stimulation for Parkinson's disease: a systematic review of the clinical literatureClement Hamani
Division of Neurosurgery, University of Toronto, Toronto Western Hospital, Toronto, Ontario, Canada
Neurosurgery 56:1313-21; discussion 1321-4. 2005..CONCLUSION: Bilateral subthalamic nucleus stimulation is effective in the treatment of PD. Further refinements in patient selection and surgical technique may lessen the incidence of complications associated with this procedure... - The motor thalamus in neurosurgeryClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 58:146-58; discussion 146-58. 2006..The aim of the present article is to briefly review the major anatomic and physiological aspects of the motor thalamus as well as the electrophysiological findings described in humans undergoing surgical procedures... - Deep brain stimulation: current and future perspectivesNasir Raza Awan
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Canada
Neurosurg Focus 27:E2. 2009..This review will discuss some of the areas of current investigation and potential new applications of DBS... - Characterization of REM-sleep associated ponto-geniculo-occipital waves in the human ponsAndrew S Lim
Division of Neurology, Department of Medicine, University of Toronto, Ontario, Canada
Sleep 30:823-7. 2007..We sought to identify and characterize human PGO waves... - Special lecture: Brain stimulation: perspectives for the futureClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
Clin Neurosurg 51:271-4. 2004 - The pedunculopontine nucleus and movement disorders: anatomy and the role for deep brain stimulationClement Hamani
Division of Neurosurgery, Department of Surgery, Toronto Western Hospital Research Institute, University of Toronto, Toronto, Canada
Parkinsonism Relat Disord 13:S276-80. 2007..We review the anatomical features of the PPN, its role in motor control, and its potential role as a target for PD surgery, including the results of recently published clinical studies... - Saccade-related potentials recorded from human subthalamic nucleusAdrian P Fawcett
Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ont, Canada
Clin Neurophysiol 118:155-63. 2007..To investigate an ocular motor role for the STN in Parkinson's disease (PD) patients... - Deep brain stimulation for chronic neuropathic pain: long-term outcome and the incidence of insertional effectClement Hamani
Division of Neurosurgery, Toronto Western Hospital, Toronto, Ont, Canada
Pain 125:188-96. 2006..The relatively low efficacy of DBS for the treatment of neuropathic pain stresses the need for further investigation and the exploration of new surgical targets... - Surgery for other movement disorders: dystonia, ticsClement Hamani
Division of Neurosurgery, Toronto Western Hospital, UHN, Toronto, Ontario, Canada
Curr Opin Neurol 20:470-6. 2007..We review the neurosurgical treatment of dystonias and tics, focusing mainly on the surgical aspects and outcome of deep brain stimulation... - Antidepressant-like effects of medial prefrontal cortex deep brain stimulation in ratsClement Hamani
Neuroimaging Research Section, Centre for Addiction and Mental Health, Toronto, Ontario M5T 1R8, Canada
Biol Psychiatry 67:117-24. 2010..We report on the effects of ventromedial prefrontal cortex (vmPFC) DBS in rats, focusing on possible mechanisms involved in an antidepressant-like response in the forced swim test (FST)... - Treatment options for epileptic myoclonus and epilepsy syndromes associated with myoclonusDanielle M Andrade
Division of Neurology, Krembil Neuroscience Centre, University of Toronto, Toronto Western Hospital, Toronto, Canada
Expert Opin Pharmacother 10:1549-60. 2009..Myoclonus is a brief shock-like movement that has many different etiologies. The degree to which it disturbs quality of life is extremely variable, as is its response to treatment... - The future of deep brain stimulationAndres M Lozano
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
J Clin Neurophysiol 21:68-9. 2004..This will act as a driving force to increase the efforts to improve the technology applied to design and manufacture new hardware... - Neural stimulation for Parkinson's disease: current therapies and future directionsJoseph S Neimat
Toronto Western Hospital, Toronto, Ontario M5T 2S8, Canada
Expert Rev Neurother 6:101-9. 2006.... - Tremor cells in the human thalamus: differences among neurological disordersJason A Brodkey
Division of Neurosurgery, Toronto Western Hospital, Ontario, Canada
J Neurosurg 101:43-7. 2004..CONCLUSIONS: There was an increased incidence of TRA in the thalamus of patients with PD. The location of thalamic TRA cells in patients with basal ganglia and other tremor disorders was similar... - Longevity of batteries in internal pulse generators used for deep brain stimulationMohammed Bin-Mahfoodh
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
Stereotact Funct Neurosurg 80:56-60. 2003..In our series of patients who needed battery replacement, battery longevity varied with stimulation parameters but was longer than expected from the manufacturer's specifications... - Deep brain stimulation for treatment-resistant depressionHelen S Mayberg
Rotman Research Institute at Baycrest Centre, and Departments of Psychiatry and Neurology, University of Toronto, Toronto, Ontario, M6A 2E1, Canada
Neuron 45:651-60. 2005.... - Hardware-related complications of deep brain stimulation: a review of the published literatureClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Canada
Stereotact Funct Neurosurg 84:248-51. 2006..3% of the patients). Refinements in surgical technique, technological improvements, and a greater experience with the procedures will likely decrease the incidence of hardware-related side effects in the future... - Bilateral anterior thalamic nucleus lesions and high-frequency stimulation are protective against pilocarpine-induced seizures and status epilepticusClement Hamani
Division of Neurosurgery, University of Toronto, Toronto, Ontario, Canada
Neurosurgery 54:191-5; discussion 195-7. 2004..CONCLUSION: Bilateral anterior thalamic nuclear complex stimulation and thalamotomies were protective against SE induced by pilocarpine... - Preclinical studies modeling deep brain stimulation for depressionClement Hamani
Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada Electronic address
Biol Psychiatry 72:916-23. 2012.... - Neuromodulation: a more comprehensive concept beyond deep brain stimulationClement Hamani
Behavioural Neurobiology Laboratory, Centre for Addiction and Mental Health, Toronto, Ontario, Canada Division of Neurosurgery, University Health Network, Toronto Western Hospital, Toronto, Ontario, Canada Electronic address
Int Rev Neurobiol 107:1-3. 2012..As the number of indications and studies increases, so does research in associated fields. This chapter provides a brief introduction and discusses the overall contents of this volume of the International Review of Neurobiology... - Physiology and pathophysiology of Parkinson's diseaseClement Hamani
Division of Neurosurgery, Toronto Western Hospital, University of Toronto, Toronto, Ontario, Canada
Ann N Y Acad Sci 991:15-21. 2003..With this abnormal neuronal activity neutralized, normal movements can in many cases be restored... - Cingulotomy for psychiatric disease: microelectrode guidance, a callosal reference system for documenting lesion location, and clinical resultsErich O Richter
Department of Neurosurgery, University of Florida, Gainesville, Florida, USA
Neurosurgery 54:622-28; discussion 628-30. 2004..CONCLUSION: Microelectrode recording is useful for lesion placement. Our system for reporting location in anterior cingulate cortex normalizes for differences in callosal morphometry. These techniques may aid future study... - Inhibitory role of the zona incerta in the pilocarpine model of epilepsyClement Hamani
Depto de Fisiologia, EPM UNIFESP, SP 04023 900, Sao Paulo, Brazil
Epilepsy Res 49:73-80. 2002..Our results contribute to the further characterisation of the regulatory role of the zona incerta in seizure-related phenomena, suggesting that its modulation might be a relevant target for anticonvulsant strategies...