Nachar A, Saleem A, Arnason J, Haddad P. Regulation of liver cell glucose homeostasis by dehydroabietic acid, abietic acid and squalene isolated from balsam fir (Abies balsamea (L.) Mill.) a plant of the Eastern James Bay Cree traditional pharmacopeia. Phytochemistry. 2015;117:373-9 pubmed publisher
..Dehydroabietic acid stood out for its strongest effect in all the experiments close to that of the crude extract. These compounds may have potential applications in the treatment of type 2 diabetes and insulin resistance. ..
Kasangana P, Haddad P, Stevanovic T. Study of Polyphenol Content and Antioxidant Capacity of Myrianthus Arboreus (Cecropiaceae) Root Bark Extracts. Antioxidants (Basel). 2015;4:410-26 pubmed publisher
..9. According to the present study, EAc fraction and EtOH extract should be further studied for the potential use in the pharmaceutical and food industry. ..
Li S, Pasquin S, Eid H, Gauchat J, Saleem A, Haddad P. Anti-apoptotic potential of several antidiabetic medicinal plants of the eastern James Bay Cree pharmacopeia in cultured kidney cells. BMC Complement Altern Med. 2018;18:37 pubmed publisher
..We conclude that several Cree antidiabetic plants exert anti-apoptotic activity that may be relevant in the context of diabetic nephropathy (DN) that affects a significant proportion of Cree diabetics. ..
Nachar A, Eid H, Vinqvist Tymchuk M, Vuong T, Kalt W, Matar C, et al
. Phenolic compounds isolated from fermented blueberry juice decrease hepatocellular glucose output and enhance muscle glucose uptake in cultured murine and human cells. BMC Complement Altern Med. 2017;17:138 pubmed publisher
..5??M. This study identifies novel potential antidiabetic compounds that can help standardize FJ. ..
Sánchez Villavicencio M, Vinqvist Tymchuk M, Kalt W, Matar C, Alarcon Aguilar F, Escobar Villanueva M, et al
. Fermented blueberry juice extract and its specific fractions have an anti-adipogenic effect in 3 T3-L1 cells. BMC Complement Altern Med. 2017;17:24 pubmed publisher
Ouchfoun M, Eid H, Musallam L, Brault A, Li S, Vallerand D, et al
. Labrador tea (Rhododendron groenlandicum) attenuates insulin resistance in a diet-induced obesity mouse model. Eur J Nutr. 2016;55:941-54 pubmed publisher
..They validate the safety and efficacy of this plant, a promising candidate for culturally relevant complementary treatment in Cree diabetics. ..
Eid H, Ouchfoun M, Saleem A, Guerrero Analco J, Walshe Roussel B, Musallam L, et al
. A combination of (+)-catechin and (-)-epicatechin underlies the in vitro adipogenic action of Labrador tea (Rhododendron groenlandicum), an antidiabetic medicinal plant of the Eastern James Bay Cree pharmacopeia. J Ethnopharmacol. 2016;178:251-7 pubmed publisher
..This brings further evidence for the antidiabetic potential of R. groenlandicum and provides new opportunities to profile active principles in biological fluids or in traditional preparations. ..
Kasangana P, Nachar A, Eid H, Stevanovic T, Haddad P. Root bark extracts of Myrianthus arboreus P. Beauv. (Cecropiaceae) exhibit anti-diabetic potential by modulating hepatocyte glucose homeostasis. J Ethnopharmacol. 2018;211:117-125 pubmed publisher
..Overall, these data support the traditional antidiabetic uses of the root bark of M. arboreus. ..