Pierre Guertin

Summary

Country: Canada

Publications

  1. ncbi request reprint A valuable animal model of spinal cord injury to study motor dysfunctions, comorbid conditions, and aging associated diseases
    Pascal Rouleau
    Neuroscience Unit, Laval University Medical Center CHUQ CHUL, Quebec City, Quebec, Canada
    Curr Pharm Des 19:4437-47. 2013
  2. ncbi request reprint Pharmacological approaches to chronic spinal cord injury
    Inge Steuer
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    Curr Pharm Des 19:4423-36. 2013
  3. doi request reprint Preliminary evidence of safety following administration of L-DOPA and buspirone in an incomplete monoplegic patient
    P A Guertin
    CHUL Research Center, Neuroscience Unit, Quebec City, Quebec, Canada
    Spinal Cord 47:91-2. 2009
  4. doi request reprint A technological platform to optimize combinatorial treatment design and discovery for chronic spinal cord injury
    Pierre A Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    J Neurosci Res 86:3039-51. 2008
  5. doi request reprint Can the spinal cord learn and remember?
    Pierre Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    ScientificWorldJournal 8:757-61. 2008
  6. doi request reprint Key central pattern generators of the spinal cord
    Pierre A Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec, Canada
    J Neurosci Res 87:2399-405. 2009
  7. ncbi request reprint Recovery of locomotor function with combinatory drug treatments designed to synergistically activate specific neuronal networks
    Pierre A Guertin
    Laval University Medical Center CHUL CHUQ, Neuroscience Unit, RC 9800, 2705 Laurier Blvd, Quebec City, Quebec, G1V 4G2, Canada
    Curr Med Chem 16:1366-71. 2009
  8. doi request reprint The mammalian central pattern generator for locomotion
    Pierre A Guertin
    Laval University Medical Center, Quebec City, Quebec, Canada
    Brain Res Rev 62:45-56. 2009
  9. doi request reprint Oral administration of a tri-therapy for central pattern generator activation in paraplegic mice: proof-of-concept of efficacy
    Pierre A Guertin
    Laval University Medical Centre CHUQ CHUL, Quebec City, Canada
    Biotechnol J 5:421-6. 2010
  10. doi request reprint Effects on locomotion, muscle, bone, and blood induced by a combination therapy eliciting weight-bearing stepping in nonassisted spinal cord-transected mice
    Pierre A Guertin
    Laval University Medical Center, Quebec City, QC, Canada
    Neurorehabil Neural Repair 25:234-42. 2011

Collaborators

  • J P Brown
  • PETER HEDLUND
  • Nicolas P Lapointe
  • Pascal Rouleau
  • Roth Visal Ung
  • Inge Steuer
  • Eric S Landry
  • Sylvain Picard
  • Roth V Ung
  • Claude Rouillard
  • Magali Grob
  • Eric Landry
  • Maxime Bergeron
  • Daniel Levesque
  • Martin Cote
  • Jérôme Frenette

Detail Information

Publications30

  1. ncbi request reprint A valuable animal model of spinal cord injury to study motor dysfunctions, comorbid conditions, and aging associated diseases
    Pascal Rouleau
    Neuroscience Unit, Laval University Medical Center CHUQ CHUL, Quebec City, Quebec, Canada
    Curr Pharm Des 19:4437-47. 2013
    ..g., stereotyped motor behaviours such as locomotion, sexual response, defecation and micturition) largely related with 'command centers' located in lumbosacral areas of the spinal cord...
  2. ncbi request reprint Pharmacological approaches to chronic spinal cord injury
    Inge Steuer
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    Curr Pharm Des 19:4423-36. 2013
    ..Understanding further pharmacological approaches to chronic spinal cord injury may improve both life expectancy and overall quality of life while reducing unsustainable cost increases associated with this debilitation condition...
  3. doi request reprint Preliminary evidence of safety following administration of L-DOPA and buspirone in an incomplete monoplegic patient
    P A Guertin
    CHUL Research Center, Neuroscience Unit, Quebec City, Quebec, Canada
    Spinal Cord 47:91-2. 2009
    ..Case report...
  4. doi request reprint A technological platform to optimize combinatorial treatment design and discovery for chronic spinal cord injury
    Pierre A Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    J Neurosci Res 86:3039-51. 2008
    ....
  5. doi request reprint Can the spinal cord learn and remember?
    Pierre Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    ScientificWorldJournal 8:757-61. 2008
    ..This mini-review reports, mainly, animal data that support the idea that other areas of the central nervous system, such as the spinal cord, can also learn and remember...
  6. doi request reprint Key central pattern generators of the spinal cord
    Pierre A Guertin
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec, Canada
    J Neurosci Res 87:2399-405. 2009
    ..This review provides a brief update on CPG organization and function in the spinal cord and focuses on similarities and differences between these networks and their pharmacological modulation...
  7. ncbi request reprint Recovery of locomotor function with combinatory drug treatments designed to synergistically activate specific neuronal networks
    Pierre A Guertin
    Laval University Medical Center CHUL CHUQ, Neuroscience Unit, RC 9800, 2705 Laurier Blvd, Quebec City, Quebec, G1V 4G2, Canada
    Curr Med Chem 16:1366-71. 2009
    ....
  8. doi request reprint The mammalian central pattern generator for locomotion
    Pierre A Guertin
    Laval University Medical Center, Quebec City, Quebec, Canada
    Brain Res Rev 62:45-56. 2009
    ..This article constitutes a comprehensive review summarizing key findings on the organization and properties of this network...
  9. doi request reprint Oral administration of a tri-therapy for central pattern generator activation in paraplegic mice: proof-of-concept of efficacy
    Pierre A Guertin
    Laval University Medical Centre CHUQ CHUL, Quebec City, Canada
    Biotechnol J 5:421-6. 2010
    ....
  10. doi request reprint Effects on locomotion, muscle, bone, and blood induced by a combination therapy eliciting weight-bearing stepping in nonassisted spinal cord-transected mice
    Pierre A Guertin
    Laval University Medical Center, Quebec City, QC, Canada
    Neurorehabil Neural Repair 25:234-42. 2011
    ..The health benefits associated with physical activity-based rehabilitation in patients with no lower-extremity motor function after a spinal cord injury (SCI) is uncertain...
  11. ncbi request reprint Synergistic activation of the central pattern generator for locomotion by l-beta-3,4-dihydroxyphenylalanine and quipazine in adult paraplegic mice
    Pierre A Guertin
    Department of Anatomy and Physiology, Laval University, Neuroscience Research Center of Laval University Medical Center, Quebec City, Quebec, G1V4G2, Canada
    Neurosci Lett 358:71-4. 2004
    ....
  12. ncbi request reprint Ionotropic 5-HT3 receptor agonist-induced motor responses in the hindlimbs of paraplegic mice
    Pierre A Guertin
    Department of Anatomy and Physiology, Laval University and Laval University Medical Center, Quebec City, Quebec, Canada
    J Neurophysiol 94:3397-405. 2005
    ....
  13. pmc Specific role of dopamine D1 receptors in spinal network activation and rhythmic movement induction in vertebrates
    Nicolas P Lapointe
    Laval University Medical Center, Quebec City, Canada
    J Physiol 587:1499-511. 2009
    ..Overall, the results clearly show in mice the existence of a role for D1 receptors in spinal network activation and corresponding rhythmic movement generation...
  14. ncbi request reprint Differential effects of 5-HT1 and 5-HT2 receptor agonists on hindlimb movements in paraplegic mice
    Eric S Landry
    Department of Anatomy and Physiology, Laval University, Research Centre of the Laval University Research Hospital CRCHUL CHUQ, 2705 Bld Laurier, RC 9800, Quebec City, Quebec, G1V4G2, Canada
    Prog Neuropsychopharmacol Biol Psychiatry 28:1053-60. 2004
    ..These results suggest that only subsets of spinal 5-HT receptors are specific to locomotor rhythmogenesis and should be activated to successfully induce stepping movements after spinal cord injury...
  15. doi request reprint Role of spinal 5-HT2 receptor subtypes in quipazine-induced hindlimb movements after a low-thoracic spinal cord transection
    Roth V Ung
    Neuroscience Unit, Laval University Medical Center, Quebec City, QC, Canada
    Eur J Neurosci 28:2231-42. 2008
    ..These findings may contribute to design drug treatments aimed at promoting locomotor function recovery in chronic spinal cord-injured patients...
  16. ncbi request reprint Body weight, limb size, and muscular properties of early paraplegic mice
    Eric Landry
    Neuroscience Research Center of Laval University Medical Center, Quebec City, Quebec, Canada
    J Neurotrauma 21:1008-16. 2004
    ..The use of paraplegic mouse models may provide new therapeutic approaches to restore motor and locomotor functions after SCI...
  17. doi request reprint Synergistic effects of D1/5 and 5-HT1A/7 receptor agonists on locomotor movement induction in complete spinal cord-transected mice
    Nicolas P Lapointe
    Laval University Medical Centre, Quebec City, Quebec, Canada
    J Neurophysiol 100:160-8. 2008
    ..Although previous work from this laboratory has reported the partial rhythmogenic potential of monoamines in vivo, the present study shows that drug combinations such as SKF-81297 and 8-OH-DPAT can elicit weight-bearing stepping...
  18. ncbi request reprint Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord-transected mice
    Eric S Landry
    Laval University Medical Center, Quebec, Canada
    Eur J Neurosci 24:535-46. 2006
    ..The results, with selective antagonists and knockout animals, provide compelling evidence of a specific contribution of both receptor subtypes to spinal locomotor rhythmogenesis in vivo...
  19. doi request reprint Tail pinching-induced hindlimb movements are suppressed by clonidine in spinal cord injured mice
    Nicolas P Lapointe
    Laval University Medical Center, Neuroscience Unit, RC 9800, 2705 Laurier Blvd, Quebec City, Quebec, Canada, G1V 4G2
    Behav Neurosci 122:576-88. 2008
    ..Altogether, the results suggest that the prolocomotor effects of clonidine reported elsewhere must depend upon stimuli or factors that remain to be identified...
  20. doi request reprint Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice
    Nicolas P Lapointe
    Neuroscience Unit, RC 9800, Laval University Medical Center, 2705 Laurier Blvd, Quebec City, Quebec, Canada G1V 4G2
    J Pharmacol Exp Ther 325:994-1006. 2008
    ..g., no tail or perineal pinching) Tx mice, although repeated administration may progressively facilitate the expression of spontaneous hindlimb movements...
  21. ncbi request reprint Strain-dependent recovery of spontaneous hindlimb movement in spinal cord transected mice (CD1, C57BL/6, BALB/c)
    Nicolas P Lapointe
    Neuroscience Unit, Laval University Medical Center, Quebec City, PQ, Canada
    Behav Neurosci 120:826-34. 2006
    ..A. Guertin, 2005a) methods. Such spontaneous recovery in low-thoracic Tx mice is likely the result of neuronal plasticity at the lumbosacral spinal cord level, suggesting that these sublesional changes are strain dependent...
  22. doi request reprint Spinal cord injury research in mice: 2008 review
    Inge Steuer
    Faculty of Medicine, Department of Anatomy and Physiology, Laval University, Quebec City, Quebec, Canada
    ScientificWorldJournal 9:490-8. 2009
    ....
  23. doi request reprint Histomorphometric and densitometric changes in the femora of spinal cord transected mice
    Sylvain Picard
    Laval University Medical Center CHUL, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Anat Rec (Hoboken) 291:303-7. 2008
    ..Given the increasing availability of genetic and molecular research tools for research in mice, this murine model may be useful to study further the cellular and molecular mechanisms of demineralization associated with SCI...
  24. doi request reprint Effects of co-administration of clenbuterol and testosterone propionate on skeletal muscle in paraplegic mice
    Roth Visal Ung
    Neuroscience Unit, Laval University Medical Center CHUL CHUQ, Quebec City, Quebec, Canada
    J Neurotrauma 27:1129-42. 2010
    ..These results provide evidence suggesting that clenbuterol alone or combined with testosterone may constitute better clinically-relevant treatments than testosterone alone to decrease muscle atrophy (mass and fiber CSA) in SCI subjects...
  25. ncbi request reprint Early changes in deep vein diameter and biochemical markers associated with thrombi formation after spinal cord injury in mice
    Pascal Rouleau
    Neuroscience Unit, Laval University Medical Center, Quebec City, Quebec, Canada
    J Neurotrauma 24:1406-14. 2007
    ....
  26. ncbi request reprint Plasticity in sublesionally located neurons following spinal cord injury
    Nicolas P Lapointe
    Laval University Medical Center CHUL CHUQ Neuroscience Unit, RC 9800, Quebec City, Quebec G1V 4G2, Canada
    J Neurophysiol 98:2497-500. 2007
    ....
  27. ncbi request reprint Hormonal and immunological changes in mice after spinal cord injury
    Pascal Rouleau
    Neuroscience Unit, Laval University Medical Center CHUQ CHUL, Laval University, Quebec City, Quebec, Canada
    J Neurotrauma 24:367-78. 2007
    ..These results revealed significant changes occurring rapidly (<1-2 weeks) after Tx in both hormonal and immunological systems, providing compelling evidence of a role for anabolic hormones in SCI-related immune deficiencies...
  28. ncbi request reprint [The paraplegic mouse: a model with new perspectives for spinal cord injury research]
    Nicolas P Lapointe
    Med Sci (Paris) 22:102-3. 2006
  29. ncbi request reprint [Role of Ca(2+) in the pacemaker-like property of spinal motoneurons]
    Magali Grob
    Département d anatomie et de physiologie, Universite Laval, Centre hospitalier de l Universite Laval, Unité de Neuroscience RC 98002705, boulevard Laurier, Quebec G1V 4G2, Canada
    Med Sci (Paris) 23:64-6. 2007
    ..A detailed understanding of the complex role of Ca(2+) in mediating the auto-rhythmic property of spinal neurons may contribute to the development of novel therapeutic approaches to induce locomotion after spinal cord injury...
  30. ncbi request reprint Conditional intrinsic voltage oscillations in mature vertebrate neurons undergo specific changes in culture
    Pierre A Guertin
    Div of Neurophysiology, Dept of Medical Physiology, Panum Institute, University of Copenhagen, 2200 DK, Copenhagen N, Denmark
    J Neurophysiol 95:2024-7. 2006
    ..3 channel contribution to intrinsic oscillatory property expression may occur in culture. The results contribute also to understanding further the potential for plasticity of mature vertebrate neurons...