Jean Philippe Gratton


Country: Canada


  1. Chidiac R, Zhang Y, Tessier S, Faubert D, Delisle C, Gratton J. Comparative Phosphoproteomics Analysis of VEGF and Angiopoietin-1 Signaling Reveals ZO-1 as a Critical Regulator of Endothelial Cell Proliferation. Mol Cell Proteomics. 2016;15:1511-25 pubmed publisher
    ..In conclusion, we uncovered ZO-1 as part of a signaling node activated by VEGF, but not Ang-1, that specifically modulates EC proliferation during angiogenesis. ..
  2. Zhang Y, Chidiac R, Delisle C, Gratton J. Endothelial NO Synthase-Dependent S-Nitrosylation of ?-Catenin Prevents Its Association with TCF4 and Inhibits Proliferation of Endothelial Cells Stimulated by Wnt3a. Mol Cell Biol. 2017;37: pubmed publisher
    ..Thus, our data define the mechanism responsible for the repressive effects of NO on the transcriptional activity of ?-catenin and link eNOS-derived NO to the modulation by VEGF of Wnt/?-catenin-induced endothelial cell proliferation. ..