Genomes and Genes

Species

Nathalie Grandvaux

Summary

Country: Canada

Publications

  1. Robitaille A, Mariani M, Fortin A, Grandvaux N. A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3. J Vis Exp. 2016;:e53723 pubmed publisher
    ..This experimental strategy constitutes an affordable and sensitive approach to acquire all the necessary information for a complete analysis of the phosphorylation-mediated activation of IRF3. ..
  2. Zamorano Cuervo N, Osseman Q, Grandvaux N. Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight. Viruses. 2018;10: pubmed publisher
    ..Altogether, our data suggest that RIG-I-dependent MAVS activation involves the coexistence of MAVS polymers with distinct molecular weights. ..
  3. Grandvaux N. [The IKK? kinase in breast cancer: from oncogenesis to treatment resistance]. Med Sci (Paris). 2011;27:619-25 pubmed publisher
    ..Interestingly, IKK? is involved in the development of resistance to Tamoxifène. Thus, IKK? is a promising therapeutic target for newly developed breast cancer treatment. ..
  4. Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKK? oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
    ..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKK? amplification. ..
  5. Cervantes Ortiz S, Zamorano Cuervo N, Grandvaux N. Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology. Viruses. 2016;8: pubmed publisher
    ..We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis. ..
  6. McCormick C, Grandvaux N. 1st Workshop of the Canadian Society for Virology. Viruses. 2017;9: pubmed publisher
    ..The workshop also featured a variety of trainee oral and poster presentations, and a panel discussion on the topic of the future of the CSV and virus research in Canada. ..
  7. Williams V, Grosset A, Zamorano Cuervo N, St Pierre Y, Sylvestre M, Gaboury L, et al. Detection of IKK? by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis. BMC Cancer. 2017;17:356 pubmed publisher
    ..This study suggests that breast cancer tumors expressing EGFR and IKK? may be potential targets for drugs aiming at inhibiting IKK? activity or expression. ..
  8. Robitaille A, Caron E, Zucchini N, Mukawera E, Adam D, Mariani M, et al. DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection. Sci Rep. 2017;7:17388 pubmed publisher
    ..Collectively, our data unveils a previously unrecognized selective role of DUSP1 in the regulation of tissue damage and repair during infections by RSV and SeV. ..

Detail Information

Publications8

  1. Robitaille A, Mariani M, Fortin A, Grandvaux N. A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3. J Vis Exp. 2016;:e53723 pubmed publisher
    ..This experimental strategy constitutes an affordable and sensitive approach to acquire all the necessary information for a complete analysis of the phosphorylation-mediated activation of IRF3. ..
  2. Zamorano Cuervo N, Osseman Q, Grandvaux N. Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight. Viruses. 2018;10: pubmed publisher
    ..Altogether, our data suggest that RIG-I-dependent MAVS activation involves the coexistence of MAVS polymers with distinct molecular weights. ..
  3. Grandvaux N. [The IKK? kinase in breast cancer: from oncogenesis to treatment resistance]. Med Sci (Paris). 2011;27:619-25 pubmed publisher
    ..Interestingly, IKK? is involved in the development of resistance to Tamoxifène. Thus, IKK? is a promising therapeutic target for newly developed breast cancer treatment. ..
  4. Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKK? oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
    ..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKK? amplification. ..
  5. Cervantes Ortiz S, Zamorano Cuervo N, Grandvaux N. Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology. Viruses. 2016;8: pubmed publisher
    ..We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis. ..
  6. McCormick C, Grandvaux N. 1st Workshop of the Canadian Society for Virology. Viruses. 2017;9: pubmed publisher
    ..The workshop also featured a variety of trainee oral and poster presentations, and a panel discussion on the topic of the future of the CSV and virus research in Canada. ..
  7. Williams V, Grosset A, Zamorano Cuervo N, St Pierre Y, Sylvestre M, Gaboury L, et al. Detection of IKK? by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis. BMC Cancer. 2017;17:356 pubmed publisher
    ..This study suggests that breast cancer tumors expressing EGFR and IKK? may be potential targets for drugs aiming at inhibiting IKK? activity or expression. ..
  8. Robitaille A, Caron E, Zucchini N, Mukawera E, Adam D, Mariani M, et al. DUSP1 regulates apoptosis and cell migration, but not the JIP1-protected cytokine response, during Respiratory Syncytial Virus and Sendai Virus infection. Sci Rep. 2017;7:17388 pubmed publisher
    ..Collectively, our data unveils a previously unrecognized selective role of DUSP1 in the regulation of tissue damage and repair during infections by RSV and SeV. ..