Kasumba D, Grandvaux N. Therapeutic Targeting of RIG-I and MDA5 Might Not Lead to the Same Rome. Trends Pharmacol Sci. 2019;40:116-127 pubmed publisher
Grandvaux N, McCormick C. CSV2018: The 2nd Symposium of the Canadian Society for Virology. Viruses. 2019;11: pubmed publisher
..TWIV featured interviews of CSV co-founders Nathalie Grandvaux (Université de Montréal) and Craig McCormick (Dalhousie University), who discussed the origins and ..
Robitaille A, Mariani M, Fortin A, Grandvaux N. A High Resolution Method to Monitor Phosphorylation-dependent Activation of IRF3. J Vis Exp. 2016;:e53723 pubmed publisher
..This experimental strategy constitutes an affordable and sensitive approach to acquire all the necessary information for a complete analysis of the phosphorylation-mediated activation of IRF3. ..
Zamorano Cuervo N, Osseman Q, Grandvaux N. Virus Infection Triggers MAVS Polymers of Distinct Molecular Weight. Viruses. 2018;10: pubmed publisher
..Altogether, our data suggest that RIG-I-dependent MAVS activation involves the coexistence of MAVS polymers with distinct molecular weights. ..
Grandvaux N. [The IKK? kinase in breast cancer: from oncogenesis to treatment resistance]. Med Sci (Paris). 2011;27:619-25 pubmed publisher
..Interestingly, IKK? is involved in the development of resistance to Tamoxifène. Thus, IKK? is a promising therapeutic target for newly developed breast cancer treatment. ..
Mukawera E, Chartier S, Williams V, Pagano P, Lapointe R, Grandvaux N. Redox-modulating agents target NOX2-dependent IKKε oncogenic kinase expression and proliferation in human breast cancer cell lines. Redox Biol. 2015;6:9-18 pubmed publisher
..Taken together, our results suggest that redox-modulating compounds targeting NOX2 could present a particular therapeutic interest in combination therapy against breast carcinomas exhibiting IKKε amplification. ..
Cervantes Ortiz S, Zamorano Cuervo N, Grandvaux N. Respiratory Syncytial Virus and Cellular Stress Responses: Impact on Replication and Physiopathology. Viruses. 2016;8: pubmed publisher
..We summarize the evidence linking these stress responses with the regulation of RSV replication and the associated pathogenesis. ..
McCormick C, Grandvaux N. 1st Workshop of the Canadian Society for Virology. Viruses. 2017;9: pubmed publisher
..The workshop also featured a variety of trainee oral and poster presentations, and a panel discussion on the topic of the future of the CSV and virus research in Canada. ..
Williams V, Grosset A, Zamorano Cuervo N, St Pierre Y, Sylvestre M, Gaboury L, et al
. Detection of IKKÎµ by immunohistochemistry in primary breast cancer: association with EGFR expression and absence of lymph node metastasis. BMC Cancer. 2017;17:356 pubmed publisher
..This study suggests that breast cancer tumors expressing EGFR and IKKÎµ may be potential targets for drugs aiming at inhibiting IKKÎµ activity or expression. ..