Paul M Gorman

Summary

Country: Canada

Publications

  1. pmc Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
    Paul M Gorman
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    BMC Neurosci 9:17. 2008
  2. ncbi Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates
    David Frost
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Eur J Biochem 270:654-63. 2003
  3. ncbi Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides
    Meng Guo
    Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada M5G 2M9
    FEBS Lett 579:3574-8. 2005
  4. ncbi Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH
    Paul M Gorman
    Division of Molecular and Structural Biology, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Mol Biol 325:743-57. 2003
  5. ncbi Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization
    Douglas V Laurents
    Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas, Serrano 119, 28006 Madrid, Spain
    J Biol Chem 280:3675-85. 2005

Collaborators

  • Meng Guo
  • J McLaurin
  • Douglas V Laurents
  • Avijit Chakrabartty
  • David Frost
  • Manuel Rico
  • Marta Bruix
  • Christopher M Yip

Detail Information

Publications5

  1. pmc Dimerization of the transmembrane domain of amyloid precursor proteins and familial Alzheimer's disease mutants
    Paul M Gorman
    Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 2M9, Canada
    BMC Neurosci 9:17. 2008
    ..The transmembrane domain (TM) of APP contains the known dimerization motif GXXXA. We have investigated the dimerization of both wild type and FAD mutant APP transmembrane domains...
  2. ncbi Co-incorporation of A beta 40 and A beta 42 to form mixed pre-fibrillar aggregates
    David Frost
    Division of Molecular and Structural Biology, Ontario Cancer Institute and Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada
    Eur J Biochem 270:654-63. 2003
    ..A change in the local A beta variant ratio can therefore have a significant impact on A beta aggregation; indeed such a change has been reported in some types of familial AD...
  3. ncbi Charge substitution shows that repulsive electrostatic interactions impede the oligomerization of Alzheimer amyloid peptides
    Meng Guo
    Department of Medical Biophysics, University of Toronto, Toronto, Ont, Canada M5G 2M9
    FEBS Lett 579:3574-8. 2005
    ..The strong negative correlation between net charge and oligomerization indicates that electrostatic repulsion between A beta monomers impedes their association...
  4. ncbi Alternate aggregation pathways of the Alzheimer beta-amyloid peptide: Abeta association kinetics at endosomal pH
    Paul M Gorman
    Division of Molecular and Structural Biology, Ontario Cancer Institute, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Mol Biol 325:743-57. 2003
    ..However, after two weeks beta-structure is observed and is attributable to the insoluble portion of the sample. After two months, mature amyloid fibrils appear and the spherical aggregates are significantly diminished...
  5. ncbi Alzheimer's Abeta40 studied by NMR at low pH reveals that sodium 4,4-dimethyl-4-silapentane-1-sulfonate (DSS) binds and promotes beta-ball oligomerization
    Douglas V Laurents
    Instituto de Quimica Fisica Rocasolano, Consejo Superior de Investigaciones Cientificas, Serrano 119, 28006 Madrid, Spain
    J Biol Chem 280:3675-85. 2005
    ..DSS binds beta-balls more strongly and caused them to double in size. Plausible micelle-like models for the beta-ball structure with and without bound DSS are presented...