D Gautrin

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..43 to 0.78). It is concluded that apprentices in animal health show a high incidence of probable OA, and that preexposure airway caliber and responsiveness as well as sensitization to pets are associated with an increased risk...

..This subject is also examined from a socioeconomic perspective...

..The cumulative incidences for skin sensitization, probable occupational RC, and occupational asthma to latex were 6.4%, 1.8%, and 4.5%, respectively...

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..The clinical outcome of asymptomatic airway hyperresponsiveness (AHR) remains unclear. A study was undertaken to evaluate the incidence of respiratory symptoms in a cohort of asymptomatic subjects with AHR at baseline...

..4% on average. The significance of these early pulmonary function changes in relation to possible chronic effects of exposure to welding fumes and gases remains to be explored...

..CONCLUSION: Of the three potential factors for the development of respiratory symptoms that we considered, i.e. RC symptoms, having a measurable PC20 and atopy, having a measurable PC20 is the most significant one...

..4%. Sensitization, symptoms and diseases occur maximally in the first 2-3 yrs after starting exposure to laboratory animals. Skin reactivity to work-related allergens and rhinoconjuctivitis symptoms have low positive predictive values...

..The current prospective study investigated the hypothesis of metal fume fever (MFF) being a predictor for the development of respiratory symptoms and functional abnormalities...

..The results support the hypothesis that opportunity for early infections reduces the risk of asthma...

..Isocyanates are the main cause of occupational asthma in most countries. Study of immunological markers of diisocyanate asthma may identify individuals at risk...

..Risk factors and prevalence of occupational asthma (OA) and occupational allergy (OAl) in the snow crab-processing industry have been poorly studied...

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..Skin prick test reactivity to wheat flour and persistent allergic rhinitis on starting exposure to flour are significant determinants for the development of work-related RC symptoms...

..In conclusion, the determinants for the development of specific skin sensitization, symptoms and disease are different between atopic and nonatopic apprentices starting occupational exposure to laboratory-animal-derived allergens...

..As such, MFF could be viewed as a pre-marker of welding related OA, a hypothesis that requires further investigation...

..Occupational asthma can be used as a satisfactory model for the development of adult-onset asthma. There is a great need to develop intervention strategies through adequate surveillance programmes in high-risk workplaces...

..The occurrence of OC is relatively high. Knowledge of factors leading to increased risk could facilitate the targetting of patients who need timely intervention, under conditions of normal use...

..A study was undertaken to objectively assess, in the context of specific inhalation challenge (SIC) testing, the concomitance of bronchial and nasal reaction in the investigation of OR and OA...

..Exposure to laboratory animals often causes the appearance of immunologic sensitization and symptoms...

..Workers exposed to chlorine may be at risk of deterioration in FEV1...

..Genetic susceptibility is explored. New diagnostic means are described. Surveillance programs are conducted and preventive measures are proposed...

..We conducted a long-term (8-yr) follow-up of 408 apprentices entering programs involving exposure to high-molecular-weight allergens...

..However, SES differences in hospitalization may suggest differential management and/or treatment practices according to socioeconomic status at the emergency departments...

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..This review updates existing knowledge on occupational rhinitis based on epidemiological and clinical research studies published from 2003 to 2005...

..In clinical practice a perforation of the nasal septum secondary to an occupational exposure to corrosive chemicals is not considered a sequel of rhinitis...

..An ancillary objective was to assess the reproducibility of NAL in the context of two different SIC methodologies...

..To assess the transportability of an existing diagnostic questionnaire model for the sensitization to laboratory animal (LA) allergens...

..The reproducibility of acoustic rhinometry measurements in the setting of occupational challenges has never been examined. This study assessed the reproducibility of acoustic rhinometry during SIC investigation of occupational rhinitis...

..Our results suggest a predominant nasal eosinophilic inflammatory response after occupational allergen challenge...

..Subjects with new occupational sensitization are at a greater risk of development of sensitization to common aeroallergens than subjects without sensitization...

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..To examine recent publications on the types of agents involved in occupational asthma, the mechanisms by which they induce asthma, and how best to evaluate and treat workers suspected of this respiratory condition...

..We conclude that chlorine exposure causes functional and pathological changes in the airways associated with oxidative stress. Inducible nitric oxide synthase is involved in the induction of changes in responsiveness to methacholine...