Jean Francois Gagnon

Summary

Country: Canada

Publications

  1. ncbi Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Ann Neurol 66:39-47. 2009
  2. ncbi The Montreal Cognitive Assessment: a screening tool for mild cognitive impairment in REM sleep behavior disorder
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Mov Disord 25:936-40. 2010
  3. ncbi Neurobiology of sleep disturbances in neurodegenerative disorders
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, H4J 1C5, Canada
    Curr Pharm Des 14:3430-45. 2008
  4. ncbi Sleep spindles and rapid eye movement sleep as predictors of next morning cognitive performance in healthy middle-aged and older participants
    Marjolaine Lafortune
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Montreal, QC, Canada Centre de recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada Département de psychologie, Universite de Montreal, Montreal, QC, Canada
    J Sleep Res 23:159-67. 2014
  5. ncbi Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment
    Jessica Rodrigues Brazète
    Center for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Montreal, Quebec, Canada Department of Psychology, Universite de Montreal, Montreal, Quebec, Canada
    Sleep Med 14:1059-63. 2013
  6. doi Brain perfusion anomalies in rapid eye movement sleep behavior disorder with mild cognitive impairment
    Melanie Vendette
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Mov Disord 27:1255-61. 2012
  7. ncbi REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Qudbec, Canada
    Sleep 29:1321-5. 2006
  8. ncbi Mild cognitive impairment in patients with Parkinson's disease is associated with increased cortical degeneration
    Alexandru Hanganu
    Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Mov Disord 28:1360-9. 2013
  9. doi Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 26:1529-33. 2011
  10. doi Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 25:2304-10. 2010

Collaborators

Detail Information

Publications41

  1. ncbi Mild cognitive impairment in rapid eye movement sleep behavior disorder and Parkinson's disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Ann Neurol 66:39-47. 2009
    ..To investigate the frequency and subtypes of mild cognitive impairment (MCI) in idiopathic rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease (PD) in association with RBD...
  2. ncbi The Montreal Cognitive Assessment: a screening tool for mild cognitive impairment in REM sleep behavior disorder
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Montreal, Quebec, Canada
    Mov Disord 25:936-40. 2010
    ..The MoCA is superior to the MMSE in detecting MCI in idiopathic RBD patients, showing good sensitivity and very good specificity...
  3. ncbi Neurobiology of sleep disturbances in neurodegenerative disorders
    J F Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, 5400 Boul Gouin Ouest, Montreal, Quebec, H4J 1C5, Canada
    Curr Pharm Des 14:3430-45. 2008
    ..The cause of sleep disturbances in neurodegenerative disorders may be attributed to several factors, including age-related modifications, symptoms of the disease, comorbid conditions and the neurodegenerative process itself...
  4. ncbi Sleep spindles and rapid eye movement sleep as predictors of next morning cognitive performance in healthy middle-aged and older participants
    Marjolaine Lafortune
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Montreal, QC, Canada Centre de recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada Département de psychologie, Universite de Montreal, Montreal, QC, Canada
    J Sleep Res 23:159-67. 2014
    ..Rapid eye movement sleep may be a marker of age-related changes in acetylcholine transmission, which plays a role in new information encoding. ..
  5. ncbi Electroencephalogram slowing in rapid eye movement sleep behavior disorder is associated with mild cognitive impairment
    Jessica Rodrigues Brazète
    Center for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Montreal, Quebec, Canada Department of Psychology, Universite de Montreal, Montreal, Quebec, Canada
    Sleep Med 14:1059-63. 2013
    ..Moreover, approximately 50% of iRBD patients have mild cognitive impairment (MCI). The purpose of our study was to investigate waking electroencephalogram (EEG) abnormalities specific to iRBD patients with MCI...
  6. doi Brain perfusion anomalies in rapid eye movement sleep behavior disorder with mild cognitive impairment
    Melanie Vendette
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Mov Disord 27:1255-61. 2012
    ..This suggests the presence of an identifiable neuroimaging marker of synucleinopathy in REM sleep behavior disorder with mild cognitive impairment. © 2012 Movement Disorder Society...
  7. ncbi REM sleep behavior disorder and REM sleep without atonia in probable Alzheimer disease
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Qudbec, Canada
    Sleep 29:1321-5. 2006
    ..To determine the frequency of rapid eye movement (REM) sleep behavior disorder (RBD) and REM sleep without atonia among patients with Alzheimer disease and control subjects...
  8. ncbi Mild cognitive impairment in patients with Parkinson's disease is associated with increased cortical degeneration
    Alexandru Hanganu
    Centre de Recherche, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Mov Disord 28:1360-9. 2013
    ....
  9. doi Cardiac autonomic denervation in Parkinson's disease is linked to REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 26:1529-33. 2011
    ..In this study we examined the relationship between rapid eye movement sleep behavior disorder and autonomic dysfunction in Parkinson's disease as measured by cardiac beat-to-beat variability...
  10. doi Cardiac autonomic dysfunction in idiopathic REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 25:2304-10. 2010
    ..This suggests that autonomic dysfunction is linked with RBD independent of associated Parkinson's disease or Lewy body dementia...
  11. pmc Antidepressants and REM sleep behavior disorder: isolated side effect or neurodegenerative signal?
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada Centre d Études Avancées en Médecine du Sommeil, Hôpital du Sacré Cœur de Montréal, Montreal, Quebec, Canada
    Sleep 36:1579-85. 2013
    ..It is therefore critically important to understand whether antidepressant-associated RBD is an independent pharmacologic syndrome or a sign of possible prodromal neurodegeneration...
  12. ncbi Slowing of electroencephalogram in rapid eye movement sleep behavior disorder
    Maria Livia Fantini
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré Coeur, Quebec, Canada
    Ann Neurol 53:774-80. 2003
    ..The topographical distribution of EEG slowing and possible pathophysiological mechanisms are discussed in light of the known association between RBD and neurodegenerative disorders...
  13. doi Rapid eye movement sleep behavior disorder and subtypes of Parkinson's disease
    Silvia Rios Romenets
    Department of Neurology, McGill University, Montreal General Hospital, 1650 Cedar Avenue, Montreal, Quebec, Canada
    Mov Disord 27:996-1003. 2012
    ..009). Our results support previous findings that RBD is a multifaceted phenomenon in PD. Patients with PD who have RBD tend to have specific motor and nonmotor manifestations, especially orthostatic hypotension...
  14. ncbi Rapid eye movement sleep behavior disorder and risk of dementia in Parkinson's disease: a prospective study
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 27:720-6. 2012
    ..In this prospective study, RBD was associated with increased risk of dementia. This indicates that RBD may be a marker of a relatively diffuse, complex subtype of PD...
  15. ncbi Idiopathic REM sleep behavior disorder in the transition to degenerative disease
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 24:2225-32. 2009
    ..The indistinguishability of dementia and PD in all ancillary measures suggests a single unitary "RBD-then-neurodegeneration" process, the clinical presentation of which depends upon selective neuronal vulnerability...
  16. doi Normative data for the Dementia Rating Scale-2 in the French-Quebec population
    Monica Lavoie
    a Département de réadaptation, Universite Laval, Quebec, Canada
    Clin Neuropsychol 27:1150-66. 2013
    ....
  17. doi Association between waking electroencephalography and cognitive event-related potentials in patients with obstructive sleep apnea
    Andrée Ann Baril
    Center for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Montreal, Quebec, Canada
    Sleep Med 14:685-7. 2013
    ..Our study aimed at evaluating if an association exists between the severity of ERP abnormalities and EEG slowing to better understand cerebral dysfunctions in OSA...
  18. pmc Reduced slow-wave rebound during daytime recovery sleep in middle-aged subjects
    Marjolaine Lafortune
    Center for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Montreal, Quebec, Canada
    PLoS ONE 7:e43224. 2012
    ..Age-related changes in the quality of wake experience may underlie age-related reduction in markers of cortical synchronization enhancement after sustained wakefulness...
  19. doi REM sleep behavior disorder: from dreams to neurodegeneration
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Neurobiol Dis 46:553-8. 2012
    ....
  20. doi Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Ann Neurol 69:811-8. 2011
    ....
  21. ncbi Brain perfusion and markers of neurodegeneration in rapid eye movement sleep behavior disorder
    Melanie Vendette
    Centre d Études Avancées en Médecine du Sommeil, Hôpital du Sacré Cœur de Montréal, and Department of Psychology, University of Montreal, Montreal, Quebec, Canada
    Mov Disord 26:1717-24. 2011
    ..Moreover, regional cerebral blood flow anomalies were associated with markers of neurodegeneration...
  22. ncbi Sleep and quantitative EEG in neurodegenerative disorders
    Dominique Petit
    Centre d étude du sommeil et des rythmes diologiques, Hôpital du Sacré Coeur, Montreal, Quebec, Canada
    J Psychosom Res 56:487-96. 2004
    ..The study of sleep variables and that of the spectral composition of the EEG can provide valuable information for understanding the pathophysiology and for assisting the diagnosis of neurodegenerative diseases...
  23. ncbi Rapid-eye-movement sleep behaviour disorder and neurodegenerative diseases
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Lancet Neurol 5:424-32. 2006
    ..RBD might be a stage in the development of neurodegenerative disorders and increased awareness of this could lead to substantial advances in knowledge of mechanisms, diagnosis, and treatment of neurodegenerative disorders...
  24. doi Abnormal occipital event-related potentials in Parkinson's disease with concomitant REM sleep behavior disorder
    Pierre Olivier Gaudreault
    Center for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Montreal, QC, Canada
    Parkinsonism Relat Disord 19:212-7. 2013
    ..Our goal was to improve our understanding of the role of this sleep disorder in cerebral dysfunction occurring in Parkinson's disease using a visual cognitive task and event-related potentials...
  25. doi Mild cognitive impairment in moderate to severe COPD: a preliminary study
    Sylvia Villeneuve
    Departement de Psychologie, Universite de Montreal, Montreal, QC, Canada
    Chest 142:1516-23. 2012
    ....
  26. doi Non-rapid eye movement sleep characteristics in idiopathic REM sleep behavior disorder
    Véronique Latreille
    Centre for Advanced Research in Sleep Medicine, Hôpital du Sacré Cœur de Montréal, Quebec, Canada
    J Neurol Sci 310:159-62. 2011
    ..Results show no SW abnormalities in iRBD patients compared to healthy participants, which suggests similar level of synchronization of thalamo-cortical neurons during N-REM sleep...
  27. ncbi Sleep bruxism and oromandibular myoclonus in rapid eye movement sleep behavior disorder: a preliminary report
    Susumu Abe
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Montreal, Canada Faculté de Médecine Dentaire, Universite de Montreal, Canada Department of Oral Care and Clinical Education, The Tokushima University Hospital, Japan
    Sleep Med 14:1024-30. 2013
    ....
  28. doi Color discrimination deficits in Parkinson's disease are related to cognitive impairment and white-matter alterations
    Josie Anne Bertrand
    Center for Advanced Research in Sleep Medicine, Sacre Coeur Hospital, Montreal, Quebec, Canada
    Mov Disord 27:1781-8. 2012
    ..Poor performance on the Farnsworth-Munsell 100 hue test was also associated with white-matter alterations in right posterior brain regions...
  29. doi Validity of the Mattis Dementia Rating Scale to detect mild cognitive impairment in Parkinson's disease and REM sleep behavior disorder
    Sylvia Villeneuve
    Departement de Psychologie, Universite de Montreal, Montreal, Quebec, Canada
    Dement Geriatr Cogn Disord 31:210-7. 2011
    ..Our aim was to evaluate the validity of the Mini-Mental State Examination (MMSE) and the Mattis Dementia Rating Scale (DRS-2) to detect MCI in PD and iRBD...
  30. doi Manifestations of Parkinson disease differ in association with REM sleep behavior disorder
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 23:1665-72. 2008
    ..These findings suggest that the pathophysiology of RBD and nonmotor manifestations of PD, particularly autonomic dysfunction, are linked...
  31. doi Rapid eye movement sleep behavior disorder as a biomarker for neurodegeneration: the past 10 years
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Sleep Med 14:763-7. 2013
    ....
  32. pmc Abnormal metabolic network activity in REM sleep behavior disorder
    Florian Holtbernd
    From the Center for Neurosciences F H, Y M, C C T, A F, V D, D E, The Feinstein Institute for Medical Research, Manhasset, NY Center for Advanced Research in Sleep Medicine J F G, R B P, M V, J M, Hôpital du Sacré Coeur de Montréal Department of Psychology J F G, M V, Université du Québec à Montréal Department of Neurology R B P, Montreal General Hospital Montreal Neurological Institute J P S, McGill University and Department of Psychiatry J M, University of Montreal, Montreal, Canada
    Neurology 82:620-7. 2014
    ....
  33. doi Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies
    Ronald B Postuma
    Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada
    Mov Disord 28:597-604. 2013
    ..2013 Movement Disorder Society...
  34. doi The impact of aging on gray matter structural covariance networks
    Maxime Montembeault
    Centre de recherche de l Institut universitaire de geriatrie de Montreal, 4545 Chemin Queen Mary, Montreal, QC, Canada
    Neuroimage 63:754-9. 2012
    ..Our results indicate that healthy aging alters the structural organization of cognitive networks, shifting from a more distributed (in young adulthood) to a more localized topological organization in older individuals...
  35. doi Polysomnographic diagnosis of idiopathic REM sleep behavior disorder
    Jacques Montplaisir
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Quebec, Canada
    Mov Disord 25:2044-51. 2010
    ..For the five RBD patients who did not show chin EMG abnormalities, it cannot be excluded that they had increased phasic EMG activity in the upper limbs and presented visible motor activity...
  36. ncbi Update on the pharmacology of REM sleep behavior disorder
    Jean Francois Gagnon
    Centre d Etude du Sommeil et des Rythmes Biologiques, Hopital du Sacre Coeur de Montreal, Institut Universitaire de Geriatrie de Montreal, Montreal, Quebec, Canada
    Neurology 67:742-7. 2006
    ..When these agents are prescribed to patients with neurodegenerative disorders or narcolepsy who are at risk of developing RBD, systematic follow-up may be warranted to detect the emergence of RBD symptoms...
  37. pmc Cardiac autonomic regulation during sleep in idiopathic REM sleep behavior disorder
    Paola A Lanfranchi
    Department of Medicine, Cardiology Division, Hopital du Sacre Coeur de Montreal, Montreal, Canada
    Sleep 30:1019-25. 2007
    ..We tested the hypothesis that REM-related cardiorespiratory activation is altered in subjects with RBD...
  38. doi Patterns of cortical thickness and surface area in early Parkinson's disease
    Thomas Jubault
    Unité de Neuroimagerie Fonctionelle, Institut Universitaire de Geriatrie de Montreal, Montreal, QC, Canada
    Neuroimage 55:462-7. 2011
    ..In the future, MRI-generated corticometry, combined with additional behavioral markers, may prove to be a useful diagnosis tool to characterize the evolution of motor and cognitive deficits in PD...
  39. pmc Alexithymia associated with nightmare distress in idiopathic REM sleep behavior disorder
    Isabelle Godin
    Center for Advanced Research in Sleep Medicine, Hopital du Sacre Coeur de Montreal, Quebec, Canada Department of Psychology, Universite de Montreal, Quebec, Canada
    Sleep 36:1957-62. 2013
    ..g., nightmares) and is a non-motor symptom of PD. We assessed alexithymia and disturbed dreaming in iRBD patients with the aim of determining if these two factors are elevated and interrelated among this population...
  40. ncbi Irinotecan inactivation is modulated by epigenetic silencing of UGT1A1 in colon cancer
    Jean Francois Gagnon
    Canada Research Chair in Pharmacogenomics, Centre Hospitalier de l Universite Laval Research Center, Faculty of Pharmacy, Laval University, Quebec, Canada
    Clin Cancer Res 12:1850-8. 2006
    ..Herein, we explored the role of DNA methylation in the silencing of UGT1A1 gene expression in colon cancer and its influence on cellular SN-38 detoxification...
  41. ncbi Identification of N-myc regulatory regions involved in embryonic expression
    Jean Charron
    Center of Research on Cancer, University Laval, CHUQ, L Hôtel Dieu de Québec, Quebec, Quebec G1R 2J6, Canada
    Pediatr Res 51:48-56. 2002
    ..Altogether, these findings indicated that the regulation of the spatiotemporal expression pattern of N-myc during development necessitates multiple regulatory DNA elements...