Tamas Fulop

Summary

Country: Canada

Publications

  1. ncbi request reprint The role of lipid rafts in T lymphocyte signal transduction with aging
    Tamas Fulop
    Institut Universitaire de Geriatrie de Sherbrooke, Center on Aging Research, Faculty of Medicine, Université de Shebrooke, Sherbrooke, QC, J1H, 4C4 Canada
    Ann N Y Acad Sci 973:302-4. 2002
  2. ncbi request reprint Cytokine receptor signalling and aging
    T Fulop
    Centre de recherche sur le vieillissement, Service de Geriatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Mech Ageing Dev 127:526-37. 2006
  3. ncbi request reprint The metabolic syndrome
    T Fulop
    Research Centre on Aging, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 54:375-86. 2006
  4. doi request reprint Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
    Aurelie Le Page
    Research Center on Aging, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, J1H 4C4, Quebec, Canada
    Cell Commun Signal 12:2. 2014
  5. pmc Slower immune system aging in women versus men in the Japanese population
    Katsuiku Hirokawa
    Institute for Health and Life Sciences, Tokyo Medical and Dental University Open Laboratory, Medical Research Institute Surugadai Bldg, 2 3 10, Surugadai, Kanda, Chiyoda ku, Tokyo 101 0062, Japan
    Immun Ageing 10:19. 2013
  6. pmc Immunosenescence in vertebrates and invertebrates
    Ludmila Muller
    Max Planck Institute for Human Development, Berlin, Germany
    Immun Ageing 10:12. 2013
  7. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
  8. doi request reprint Immunology of aging and cancer development
    Tamas Fulop
    Research Center on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Interdiscip Top Gerontol 38:38-48. 2013
  9. ncbi request reprint Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Discov Med 15:33-42. 2013
  10. ncbi request reprint Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Discov Med 15:23-32. 2013

Collaborators

Detail Information

Publications64

  1. ncbi request reprint The role of lipid rafts in T lymphocyte signal transduction with aging
    Tamas Fulop
    Institut Universitaire de Geriatrie de Sherbrooke, Center on Aging Research, Faculty of Medicine, Université de Shebrooke, Sherbrooke, QC, J1H, 4C4 Canada
    Ann N Y Acad Sci 973:302-4. 2002
  2. ncbi request reprint Cytokine receptor signalling and aging
    T Fulop
    Centre de recherche sur le vieillissement, Service de Geriatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Mech Ageing Dev 127:526-37. 2006
    ..In this review we summarise our present knowledge on cytokine signalling with ageing, mainly focusing on IL-2 and IL-6 receptors signalling...
  3. ncbi request reprint The metabolic syndrome
    T Fulop
    Research Centre on Aging, Immunology Graduate Programme, Faculty of Medicine, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 54:375-86. 2006
    ..More research is needed to bring new therapies to be able to decrease the incidence and prevalence of the MS among the population and thus increasing their quality of life...
  4. doi request reprint Downregulation of inhibitory SRC homology 2 domain-containing phosphatase-1 (SHP-1) leads to recovery of T cell responses in elderly
    Aurelie Le Page
    Research Center on Aging, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, J1H 4C4, Quebec, Canada
    Cell Commun Signal 12:2. 2014
    ..Such conditions tip the immune balance in favor of altered T cell activation and a related decreased response in aging...
  5. pmc Slower immune system aging in women versus men in the Japanese population
    Katsuiku Hirokawa
    Institute for Health and Life Sciences, Tokyo Medical and Dental University Open Laboratory, Medical Research Institute Surugadai Bldg, 2 3 10, Surugadai, Kanda, Chiyoda ku, Tokyo 101 0062, Japan
    Immun Ageing 10:19. 2013
    ..The proliferative activities and cytokine-producing capacities of T cells in response to anti-CD3 monoclonal antibody stimulation were also assessed...
  6. pmc Immunosenescence in vertebrates and invertebrates
    Ludmila Muller
    Max Planck Institute for Human Development, Berlin, Germany
    Immun Ageing 10:12. 2013
    ..is not necessarily "senescence" if it is not deleterious). Indeed, under certain circumstances, or potentially even as a rule, this adaptation to the individual host environment may confer an actual survival advantage...
  7. pmc CMV and Immunosenescence: from basics to clinics
    Rafael Solana
    Immunology Unit, Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Reina Sofia University Hospital University of Cordoba, Cordoba, Spain
    Immun Ageing 9:23. 2012
    ..Here we summarize the major findings of this workshop...
  8. doi request reprint Immunology of aging and cancer development
    Tamas Fulop
    Research Center on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Interdiscip Top Gerontol 38:38-48. 2013
    ..Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions in the elderly...
  9. ncbi request reprint Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 2: new immune paradigm
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Discov Med 15:33-42. 2013
    ....
  10. ncbi request reprint Elusive Alzheimer's disease: can immune signatures help our understanding of this challenging disease? Part 1: clinical and historical background
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Discov Med 15:23-32. 2013
    ....
  11. doi request reprint The role of elastin peptides in modulating the immune response in aging and age-related diseases
    T Fulop
    Research Center on Aging, University of Sherbrooke, 1036, rue Belvedere Sud, Sherbrooke, QC, J1H 4C4, Canada
    Pathol Biol (Paris) 60:28-33. 2012
    ..This review will describe the putative contribution of elastin peptides to inflamm-aging and extend on their role on immunosenescence, as well as on age-associated chronic inflammatory diseases...
  12. ncbi request reprint Dysregulation of T-cell function in the elderly : scientific basis and clinical implications
    Tamas Fulop
    Immunology Program, Geriatric Division, Research Center on Aging, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Drugs Aging 22:589-603. 2005
    ..Considering the public health consequences of decreased immune competence in old age, strategies for immune response modulation are desirable to decrease the health burden for the elderly and improve their quality of life...
  13. ncbi request reprint Potential role of immunosenescence in cancer development
    Tamas Fulop
    Research Center on Aging, Department of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Ann N Y Acad Sci 1197:158-65. 2010
    ..Understanding the contribution of immunosenescence to cancer development and progression may lead to better interventions for the elderly...
  14. doi request reprint Aging, frailty and age-related diseases
    T Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, QC, Canada
    Biogerontology 11:547-63. 2010
    ..This review will focus on the relationship between aging, frailty and age-related diseases, and will highlight possible interventions to reduce the occurrence and effects of frailty in elderly people...
  15. ncbi request reprint Elastin peptides induced oxidation of LDL by phagocytic cells
    Tamas Fulop
    Centre de recherche sur le vieillissement, Faculte de Medecine, Universite de Sherbrooke, Que, Canada
    Pathol Biol (Paris) 53:416-23. 2005
    ..In our present study, the HDL was able to decrease the LDL oxidation by KE. This is a new mechanism by which elastin peptides might participate in the initiation and progression of the atherosclerotic process...
  16. pmc Immunosupportive therapies in aging
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Clin Interv Aging 2:33-54. 2007
    ..We will then discuss possible interventions that might one day become applicable in an appropriate ethical environment...
  17. pmc Ageing, autoimmunity and arthritis: Perturbations of TCR signal transduction pathways with ageing - a biochemical paradigm for the ageing immune system
    Tamas Fulop
    Research Center on Ageing, Sherbrooke Geriatric University Institute, University of Sherbrooke, Quebec, Canada
    Arthritis Res Ther 5:290-302. 2003
    ..The putative contribution of altered T-cell signalling with ageing in the development of autoimmune diseases will be also discussed...
  18. ncbi request reprint Insulin receptor and ageing
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Service de Geriatrie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada J1H 4C4
    Pathol Biol (Paris) 51:574-80. 2003
    ..The understanding of the IR physiology with ageing will help to develop more adequate preventive and therapeutic strategies in order to decrease the burden of the complications related to insulin resistance...
  19. ncbi request reprint Effects of methyl-beta-cyclodextrin on T lymphocytes lipid rafts with aging
    Anis Larbi
    Research Center on Aging, Sherbrooke Geriatric University Institute, University of Sherbrooke, Sherbrooke, Que, Canada J1H 5N4
    Exp Gerontol 39:551-8. 2004
    ..Altogether these results suggest that defects in cholesterol cellular homeostasis may be part of T-cell immunosenescence via lipid rafts dysfunction...
  20. ncbi request reprint Acute in vivo elevation of intravascular triacylglycerol lipolysis impairs peripheral T cell activation in humans
    Anis Larbi
    Division of Geriatrics, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Clin Nutr 82:949-56. 2005
    ..Previous studies have shown suppressive effects of polyunsaturated fatty acids (PUFAs) on T cell proliferation, but the precise mechanism for this effect has not been fully investigated in vivo in humans...
  21. ncbi request reprint Low-grade inflammation with aging has consequences for T-lymphocyte signaling
    Anis Larbi
    Research Center on Aging, University of Sherbrooke Geriatric Institute, Sherbrooke, Quebec, Canada
    Ann N Y Acad Sci 1030:125-33. 2004
    ..In conclusion, we show a link between aging, T-lymphocyte lipid rafts, immune senescence, and low-grade inflammation...
  22. ncbi request reprint Modulation of human lymphocyte proliferative response with aging
    Nadine Douziech
    Centre de recherche en gérontologie et gériatrie, Institut Universitaire de Geriatrie de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, Quebec, Canada J1H 4C4
    Exp Gerontol 37:369-87. 2002
    ..The direct activation of certain molecules or the modulation of the cholesterol content of the membrane seems to be effective immunomodulatory interventions with aging...
  23. ncbi request reprint Differential role of lipid rafts in the functions of CD4+ and CD8+ human T lymphocytes with aging
    Anis Larbi
    Research Center on Aging, 1036 Belvedere Street South, Sherbrooke, Quebec, Canada
    Cell Signal 18:1017-30. 2006
    ..This study emphasizes the differential role of lipid rafts in CD4+ and CD8+ T-cell activation in aging and suggests that the differential localization of CD28 may explain disparities in response to stimulation in human aging...
  24. ncbi request reprint Impairment of SHP-1 down-regulation in the lipid rafts of human neutrophils under GM-CSF stimulation contributes to their age-related, altered functions
    Carl F Fortin
    Laboratory for Immunology, Research Center on Aging, Clinical Research Center, and Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    J Leukoc Biol 79:1061-72. 2006
    ..Our results suggest an alteration of the SHP-1 modulation by GM-CSF in lipid rafts of PMN with aging. These alterations could contribute to the decreased GM-CSF effects on PMN...
  25. ncbi request reprint Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functions
    Carl F Fortin
    Immunology Graduate Program, Clinical Research Center, University of Sherbrooke, 3001, 12eme Avenue Nord, Sherbrooke, Que, Canada J1H 5N4
    FEBS Lett 581:1173-8. 2007
    ..The observed alterations in TREM-1 response are possibly an important contributing factor in the higher incidence of sepsis-related deaths in the elderly population...
  26. ncbi request reprint Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytes
    Anis Larbi
    Research Center on Aging, Geriatric Institute, Clinical Research Center, University of Sherbrooke, 1036 Belvédère St South, Sherbrooke, QC, Canada J1H 4C4
    J Leukoc Biol 75:373-81. 2004
    ..Our data suggest that some properties of lipid rafts are altered in aging, and this finding may be part of the causes for the decline in T cell functions that are observed in elderly individuals...
  27. ncbi request reprint Signal transduction and functional changes in neutrophils with aging
    Tamas Fulop
    Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Programme d Immunologie, Universite de Sherbrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Aging Cell 3:217-26. 2004
    ..Alterations were also found in the neutrophil membrane lipid rafts. These alterations in neutrophil functions and signal transduction that occur during aging might contribute to the significant increase in infections in old age...
  28. doi request reprint Antioxidant-rich food intakes and their association with blood total antioxidant status and vitamin C and E levels in community-dwelling seniors from the Quebec longitudinal study NuAge
    Abdelouahed Khalil
    Research Centre on Aging, Department of Medicine, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Canada
    Exp Gerontol 46:475-81. 2011
    ..25, P<0.025). These results highlight associations between ARF consumption and circulating levels of antioxidants in the elderly and suggest benefits from antioxidant-rich foods during aging...
  29. ncbi request reprint Do membrane rafts contribute to human immunosenescence?
    Andru Tomoiu
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, 1036 rue Belvedere sud, Sherbrooke J1H 4C4, Quebec, Canada
    Ann N Y Acad Sci 1100:98-110. 2007
    ..The alterations in membrane rafts composition and function can underline this altered activation of T cells with aging and then contribute to human immunosenescence. The experimental data in favor of this hypothesis will be reviewed...
  30. ncbi request reprint Presence and active synthesis of the 67 kDa elastin-receptor in human circulating white blood cells
    Anis Larbi
    Laboratoire de Bio gérontologie, Centre de recherche sur le vieillissement, Institut Universitaire de Gériatrie, Departement de Medecine, Universite de Sherbrooke, Sherbrooke, Que, Canada
    Biochem Biophys Res Commun 332:787-92. 2005
    ..The presence of El-R is very important for the interaction of circulating cell with the matrix as these cells intervene during atherosclerosis and in host defence...
  31. ncbi request reprint GM-CSF activates the Jak/STAT pathway to rescue polymorphonuclear neutrophils from spontaneous apoptosis in young but not elderly individuals
    Carl F Fortin
    Department of Medicine, Research Center on Aging, Laboratory of Biogerontology, Sherbrooke Geriatric University Institute, 1036, rue Belvedere Sud, J1H 4C4 Sherbrooke, QC, Canada
    Biogerontology 8:173-87. 2007
    ....
  32. ncbi request reprint Immunosenescence and cancer
    Tamas Fulop
    Research Center on Aging, Department of Medicine, Geriatrics Division, University of Sherbrooke, Sherbrooke, QC, Canada
    Crit Rev Oncog 18:489-513. 2013
    ..In this context, the study of the interrelation of the immune response and the tumor at various stages is essential to enhance our capacity for intervention in elderly cancer patients. ..
  33. doi request reprint Aging and neutrophils: there is still much to do
    Carl F Fortin
    Pulmonary Division, Faculty of Medicine, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Rejuvenation Res 11:873-82. 2008
    ..Furthermore, we discuss how aging potentially affects the production and release of mediators by human neutrophils in ways that may contribute to the development of these pathologies...
  34. doi request reprint Impairment of the ABCA1 and SR-BI-mediated cholesterol efflux pathways and HDL anti-inflammatory activity in Alzheimer's disease
    Abdelouahed Khalil
    Research Centre on Aging, University of Sherbrooke, Sherbrooke, Quebec, Canada
    Mech Ageing Dev 133:20-9. 2012
    ..In conclusion, our study provides evidence for the first time that the functionality of HDL is impaired in AD and that this alteration might be caused by AD-associated oxidative stress and inflammation...
  35. ncbi request reprint Aging, immunity, and cancer
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Quebec, Canada
    Discov Med 11:537-50. 2011
    ..Future research will unravel new aspects of the immune response against tumors which will be modulable to decrease the burden of cancer in elderly individuals...
  36. doi request reprint Sepsis, leukocytes, and nitric oxide (NO): an intricate affair
    Carl F Fortin
    Pulmonary Division and Groupe de Physiopathologie Respiratoire, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Shock 33:344-52. 2010
    ..Consequently, the manipulation of NO distribution in septic patients, used in conjunction with conventional treatments aimed at restoring normal immune functions, may represent a valuable therapeutic strategy...
  37. ncbi request reprint Effects of TREM-1 activation in human neutrophils: activation of signaling pathways, recruitment into lipid rafts and association with TLR4
    Carl F Fortin
    Immunology Graduate Program, Clinical Research Center, Faculty of Medicine, University of Sherbrooke, Quebec J1H 4C4, Canada
    Int Immunol 19:41-50. 2007
    ..These data shed a new light on how various receptors implicated in the innate immune response could interact to insure an efficient inflammatory response upon pathogens-associated aggression...
  38. ncbi request reprint T cell response in aging: influence of cellular cholesterol modulation
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, J1H 4C4, Quebec, Canada
    Adv Exp Med Biol 584:157-69. 2006
  39. ncbi request reprint Interrelated factors favoring physical performance and activity in older adults from the NuAge cohort study
    Joane Matta
    Division of Geriatric Medicine, McGill University, Quebec, Canada School of Human Nutrition and Dietetics, McGill University, Quebec, Canada
    Exp Gerontol 55:37-43. 2014
    ..Contribute evidence towards the complex interrelationships of body composition, physical performance and physical activity (PA) in an older population to assist in decisions for maintaining functional capacity in older adults...
  40. ncbi request reprint Role of lipid rafts in activation-induced cell death: the fas pathway in aging
    Anis Larbi
    Research Center on Aging, Immunological Graduate Programme, Department of Medicine, University of Sherbrooke, Sherbrooke, J1H 4C4, Quebec, Canada
    Adv Exp Med Biol 584:137-55. 2006
  41. pmc MT6-MMP is present in lipid rafts and faces inward in living human PMNs but translocates to the cell surface during neutrophil apoptosis
    Carl F Fortin
    Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    Int Immunol 22:637-49. 2010
    ..Collectively, these results provide new insights on the role of MT6-MMP in the physiology of human PMNs...
  42. doi request reprint Brain glucose and acetoacetate metabolism: a comparison of young and older adults
    Scott Nugent
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada Department of Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Neurobiol Aging 35:1386-95. 2014
    ..05 false discovery rate correction). This study provides new information about glucose and ketone metabolism in the human brain and a comparison of the extent to which their regional use changes during normal aging...
  43. ncbi request reprint The role of Mcl-1 and Bax expression alteration in the decreased rescue of human neutrophils from apoptosis by GM-CSF with aging
    Tamas Fulop
    Institut Unversitiare de Gériatire de Sherbrooke, Center on Aging Research, Department of Medicine, Service de Geriatrie, Faculty of Medicine, Université de Shebrooke, Sherbrooke, Quebec J1H 4C4, Canada
    Ann N Y Acad Sci 973:305-8. 2002
  44. doi request reprint Frailty in the elderly is associated with insulin resistance of glucose metabolism in the postabsorptive state only in the presence of increased abdominal fat
    Eric D B Goulet
    McGill Nutrition and Food Science Centre, MUHC Royal Victoria Hospital, Montreal, Que, Canada
    Exp Gerontol 44:740-4. 2009
    ..5% and 8.5% of the variance in IS. Increased abdominal obesity is associated with IR in frail elderly. Non-obese frail persons are not more IR than their healthy counterparts...
  45. ncbi request reprint On the immunological theory of aging
    Tamas Fulop
    Research Center on Aging, University of Sherbrooke, Sherbrooke, Que, Canada
    Interdiscip Top Gerontol 39:163-76. 2014
    ..Explanatory power may be enhanced by combination with other theories such as the free radical theory. More longitudinal studies are needed to corroborate the immune theory of aging...
  46. ncbi request reprint Age-related decrease in high-density lipoproteins antioxidant activity is due to an alteration in the PON1's free sulfhydryl groups
    Leila Jaouad
    Centre de recherche sur le vieillissement, Institut Universitaire de Geriatrie de Sherbrooke, Sherbrooke, Que, Canada J1H4C4
    Atherosclerosis 185:191-200. 2006
    ..There was a significant decrease in the number of free sulfhydryls between Y-PON1 and E-PON1 with respect to cysteine-284 amino acid residues (p<0.0092)...
  47. ncbi request reprint Modulation of T-cell signalling by non-esterified fatty acids
    Pascal Brassard
    Department of Medicine and Centre de recherche Clinique Etienne Le Bel, Faculty of Medicine, Universite de Sherbrooke, QC, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:337-43. 2007
    ..Further mechanistic studies and randomized controlled clinical trials are needed to assess more accurately their effects in healthy and pathological states...
  48. ncbi request reprint Effects of vitamin C supplementation on antioxidants and lipid peroxidation markers in elderly subjects with type 2 diabetes
    Daniel M Tessier
    Biogerontology Laboratory, Research Center on Aging, Sherbrooke Geriatric University Institute, 375 Rue Argyll, Sherbrooke, QC J1J 3H5, Canada
    Arch Gerontol Geriatr 48:67-72. 2009
    ..These changes are not sufficient to decrease the LDL susceptibility to peroxidation...
  49. doi request reprint Assessment of inflammation in large arteries with 18F-FDG-PET in elderly
    Marlene Rossibel Montesino Orellana
    Centre du vieillissement, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Quebec, Canada
    Comput Med Imaging Graph 37:459-65. 2013
    ....
  50. doi request reprint A novel statistical approach shows evidence for multi-system physiological dysregulation during aging
    Alan A Cohen
    Groupe de recherche Primus, Department of Family Medicine, University of Sherbrooke, CHUS Fleurimont, 3001 12e Avenue North, Sherbrooke, QC J1H 5N4, Canada
    Mech Ageing Dev 134:110-7. 2013
    ..Biomarkers from multiple systems were implicated. These results support hypotheses of simultaneous dysregulation in multiple systems and confirm the need for longitudinal, multivariate approaches to understanding biomarkers in aging...
  51. pmc Brain fuel metabolism, aging, and Alzheimer's disease
    Stephen Cunnane
    Research Center on Aging, Health and Social Services Center Sherbrooke University Geriatrics Institute, Universite de Sherbrooke, Sherbrooke, QC, Canada
    Nutrition 27:3-20. 2011
    ....
  52. ncbi request reprint Putative role of 67 kDa elastin-laminin receptor in tumor invasion
    Tamas Fulop
    Departement de Medecine, Center de recherché sur le vieillissement, Service de Geriatrie, Institut Universitaire de Geriatrie de Sherbrooke, 1036 rue Belvedere sud, Sherbrooke, Que, Canada J1H 4C4
    Semin Cancer Biol 12:219-29. 2002
    ..In this review we will concentrate on the putative role of the 67 kDa ELR subunit in tumor invasion...
  53. doi request reprint Electronic organiser and Alzheimer's disease: fact or fiction?
    Hélène Imbeault
    a Research Center on Aging, Sherbrooke Geriatric University Institute, Universite de Sherbrooke, Quebec, Canada
    Neuropsychol Rehabil 24:71-100. 2014
    ..These results suggest that persons with Alzheimer's disease can learn to use new technologies to compensate for their everyday memory problems, which opens up new rehabilitation possibilities in dementia care. ..
  54. doi request reprint Musical structural determinants of emotional judgments in dementia of the Alzheimer type
    Lise Gagnon
    Research Center on Aging, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Neuropsychology 23:90-7. 2009
    ..These results constitute a preliminary empirical demonstration that, in early DAT, musical emotional judgments appear to be based on normal structural analysis of musical input...
  55. doi request reprint Immunosenescence and vaccination in nursing home residents
    Tamas Fulop
    Research Center on Aging, Immunology Program, Geriatric Division, Faculty of Medicine, University of Sherbrooke, Quebec, Canada
    Clin Infect Dis 48:443-8. 2009
    ..Research efforts should continue attempts to elucidate the immunological basis of impaired immunity in nursing home residents to design improved prevention strategies for this vulnerable group...
  56. ncbi request reprint NF-kappaB, AP-1, Zinc-deficiency and aging
    Georges Herbein
    Department of Virology, IFR 133, EA 3186, Franche Comte University, F 25030, Besancon, France
    Biogerontology 7:409-19. 2006
    ..In this review we summarize our present knowledge on NF-kappaB and AP-1 activation and underline the role of Zn in this process, especially in the context of Zn deficiency observed in aged persons leading to immunosenescence...
  57. ncbi request reprint Host resistance and immune responses in advanced age
    Steven C Castle
    Geriatric Research Education and Clinical Center GRECC mail code 11G, VA Greater Los Angeles Healthcare System, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Clin Geriatr Med 23:463-79, v. 2007
    ....
  58. ncbi request reprint Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study
    Fiorella Marcellini
    Social Gerontology Unit, Res Dept, INRCA Italian National Research Centres on Ageing, Via S Margherita 5, 60100, Ancona, Italy
    Biogerontology 7:339-45. 2006
    ....
  59. ncbi request reprint Mediterranean diet and plasma concentration of inflammatory markers in old and very old subjects in the ZINCAGE population study
    George V Dedoussis
    Department of Nutrition Science and Dietetics, Harokopio University of Athens, Athens, Greece
    Clin Chem Lab Med 46:990-6. 2008
    ..The Mediterranean diet has been suggested as a determinant of longevity. In the current study, we investigated the impact of the Mediterranean diet on inflammatory status in old subjects...
  60. ncbi request reprint Engineering anticancer T cells for extended functional longevity
    Graham Pawelec
    Center for Medical Research, ZMF, University of Tubingen Medical School, Waldhornlestrasse 22, D 72072 Tuebingen, Germany
    Ann N Y Acad Sci 1019:178-85. 2004
    ....
  61. ncbi request reprint Study of factors influencing the decreased HDL associated PON1 activity with aging
    Ildiko Seres
    First Department of Medicine, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary
    Exp Gerontol 39:59-66. 2004
    ..Altogether our results suggest that the decrease in PON1 activity may be related to the development of oxidative stress conditions with aging and the increased HDL susceptibility to oxidation in elderly subjects...
  62. ncbi request reprint Zinc, metallothioneins, and longevity--effect of zinc supplementation: zincage study
    Eugenio Mocchegiani
    Immunology Center Section Nutrigenomic and Immunosenescence, Research Department, Italian National Research Center on Ageing, Ancona, Italy
    Ann N Y Acad Sci 1119:129-46. 2007
    ....
  63. ncbi request reprint Nef and TNFalpha are coplayers that favor HIV-1 replication in monocytic cells and primary macrophages
    Georges Herbein
    Department of Virology, University of Franche Comte, Besancon, France
    Curr HIV Res 6:117-29. 2008
    ....