Hugh-James Freeman

Summary

Country: Canada

Publications

  1. ncbi request reprint Temporal and geographic evolution of longstanding Crohn's disease over more than 50 years
    Hugh James Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 17:696-700. 2003
  2. pmc Limitations in assessment of mucosal healing in inflammatory bowel disease
    Hugh James Freeman
    Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W5, Canada
    World J Gastroenterol 16:15-20. 2010
  3. pmc An appendiceal neoplastic lesion: case report and implications for colonoscopic screening and surveillance
    Hugh J Freeman
    University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 23:379-81. 2009
  4. pmc "Melanosis" in the small and large intestine
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:4296-9. 2008
  5. pmc Recent developments on the role of Clostridium difficile in inflammatory bowel disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:2794-6. 2008
  6. pmc Selected luminal mucosal complications of adult celiac disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Clin Exp Gastroenterol 2:9-12. 2009
  7. pmc Hepatic manifestations of celiac disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Exp Gastroenterol 3:33-9. 2010
  8. pmc Adult celiac disease and its malignant complications
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    Gut Liver 3:237-46. 2009
  9. ncbi request reprint Natural history and long-term outcomes of patients treated for early stage colorectal cancer
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Gastroenterol 27:409-13. 2013
  10. ncbi request reprint Detection of adult celiac disease with duodenal screening biopsies over a 30-year period
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Gastroenterol 27:405-8. 2013

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Temporal and geographic evolution of longstanding Crohn's disease over more than 50 years
    Hugh James Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 17:696-700. 2003
    ....
  2. pmc Limitations in assessment of mucosal healing in inflammatory bowel disease
    Hugh James Freeman
    Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W5, Canada
    World J Gastroenterol 16:15-20. 2010
    ..This likely reflects the dynamic nature of this evolving and individualized inflammatory process that tends to be focused, but not limited, to the mucosa of the intestinal tract...
  3. pmc An appendiceal neoplastic lesion: case report and implications for colonoscopic screening and surveillance
    Hugh J Freeman
    University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 23:379-81. 2009
    ..Although endoscopic removal of the appendix has been reported, treatment of these localized appendiceal lesions requires a wide surgical excision...
  4. pmc "Melanosis" in the small and large intestine
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:4296-9. 2008
    ..If detected, removal and further histopathologic analysis of the polyp may be facilitated...
  5. pmc Recent developments on the role of Clostridium difficile in inflammatory bowel disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:2794-6. 2008
    ..Finally, refractory or treatment-resistant pouchitis may occur with CD infection...
  6. pmc Selected luminal mucosal complications of adult celiac disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Clin Exp Gastroenterol 2:9-12. 2009
    ..Detection of collagenous disorders that affect the luminal mucosa of the stomach or intestinal tract may result in recognition of underlying celiac disease...
  7. pmc Hepatic manifestations of celiac disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Clin Exp Gastroenterol 3:33-9. 2010
    ..In addition, celiac disease may be associated with rare hepatic complications, such as hepatic T-cell lymphoma...
  8. pmc Adult celiac disease and its malignant complications
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    Gut Liver 3:237-46. 2009
    ....
  9. ncbi request reprint Natural history and long-term outcomes of patients treated for early stage colorectal cancer
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Gastroenterol 27:409-13. 2013
    ..In the present long-term evaluation up to 25 years, metachronous neoplasia, including both advanced adenomas and carcinomas, was defined...
  10. ncbi request reprint Detection of adult celiac disease with duodenal screening biopsies over a 30-year period
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Gastroenterol 27:405-8. 2013
    ..Serological studies suggest that celiac disease may be present in approximately 0.5% to 1% of the North American population. Screening data based on small intestinal biopsy performed during routine endoscopic evaluations are not available...
  11. pmc Long-term follow-up of patients with malignant pedunculated colon polyps after colonoscopic polypectomy
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 27:20-4. 2013
    ..Current screening guidelines recommend intense surveillance by colonoscopy for the initial five years after the initial colon cancer has been resected. Information regarding endoscopically removed malignant polyps is limited...
  12. pmc Long-term natural history and complications of collagenous colitis
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 26:627-30. 2012
    ..Neoplastic disorders of the colon may also occur during the course of collagenous colitis, including colon carcinoma and neuroendocrine tumours (ie, carcinoids). Finally, lymphoproliferative disease has been reported...
  13. doi request reprint Celiac disease and selected long-term health issues
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Maturitas 73:206-11. 2012
    ..Some with biopsy features suggestive of celiac disease may not respond to a gluten-free diet. These may not have celiac disease at all, but instead, a sprue-like intestinal disease, or so-called unclassified sprue...
  14. pmc Colitis associated with biological agents
    Hugh James Freeman
    Division of Gastroenterology, Department of Medicine, University of British Columbia Hospital, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 18:1871-4. 2012
    ..Other agents include rituximab (an anti-CD20 monoclonal antibody), bevacizumab (a monoclonal antibody against the vascular endothelial growth factor) and anti-tumor necrosis factor agents, including infliximab, adalimumab and etanercept...
  15. pmc Tropheryma whipplei infection
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 15:2078-80. 2009
    ..Although rare, it is a systemic infection that may mimic a wide spectrum of clinical disorders and may have a fatal outcome. If recognized, prolonged antibiotic therapy may be a very successful form of treatment...
  16. pmc Malignancy in adult celiac disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, Vancouver, Canada
    World J Gastroenterol 15:1581-3. 2009
    ....
  17. pmc Long-term natural history of Crohn's disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 15:1315-8. 2009
    ..Long-term studies on the natural history have also suggested that discrete events (or agents) may precipitate this granulomatous inflammatory process...
  18. pmc Crypt region localization of intestinal stem cells in adults
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:7160-2. 2008
    ..These studies raise the possibility that there may be separate stem cell lines or different states of stem cell activation involved in the renewal of normal mammalian intestinal tract...
  19. pmc Adult celiac disease in the elderly
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 14:6911-4. 2008
    ..Osteopenia may also be associated with an increased risk of fractures. Finally, elderly celiacs have an increased risk of malignant intestinal disease, especially lymphoma...
  20. pmc Adult eosinophilic gastroenteritis and hypereosinophilic syndromes
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:6771-3. 2008
    ..Future evaluation and treatment of EGE may depend on precise serological biomarkers to aid in definition of the long-term natural history of the disorder and its response to pharmacological or biological forms of therapy...
  21. pmc Segmental colitis associated with diverticulosis syndrome
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:6442-3. 2008
    ....
  22. pmc Neurological disorders in adult celiac disease
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    Can J Gastroenterol 22:909-11. 2008
    ..Further studies are needed, however, to determine if a gluten-free diet will lead to improvement in the associated neurological disorder...
  23. pmc Use of the Crohn's disease activity index in clinical trials of biological agents
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 1W5, Canada
    World J Gastroenterol 14:4127-30. 2008
    ..Physicians caring for patients should be concerned about the positive results in clinical trials that are sponsored by industry, even if the trials involve respected centers and the results appear in highly ranked medical journals...
  24. pmc Heterogeneity of colorectal adenomas, the serrated adenoma, and implications for screening and surveillance
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:3461-3. 2008
    ....
  25. pmc Relevance of segmental colitis with diverticulosis (SCAD) to other forms of inflammatory bowel disease
    H J Freeman
    Department of Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 23:439-40. 2009
    ....
  26. pmc Free perforation of the small intestine in collagenous sprue
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 15:4446-8. 2009
    ..The dramatic findings here may reflect an underlying or early molecular event in the eventual clinical appearance of overt T-cell lymphoma...
  27. pmc Longstanding eosinophilic gastroenteritis of more than 20 years
    Hugh J Freeman
    Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Can J Gastroenterol 23:632-4. 2009
    ..In the future, treatment of EGE may involve monoclonal antibody agents that target the specific biological effects of the eosinophil, apparently central to this unusual inflammatory process...
  28. ncbi request reprint Complete histological resolution of collagenous sprue
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    Can J Gastroenterol 18:333-6. 2004
    ..Moreover, collagenous colitis may be a clinical signal that occult small intestinal disease is present. Finally, collagenous sprue may, in some instances, be a completely reversible small intestinal disorder...
  29. pmc Recurrent myopericarditis with extensive ulcerative colitis
    Hugh James Freeman
    Department of Medicine, University of British Columbia, Vancouver, British Columbia
    Can J Cardiol 26:549-50. 2010
    ..Recurrent myopericarditis with ulcerative colitis appears to be rare, but responsive to steroids. It may occur more often than is currently appreciated and may lead to fatal arrhythmias or cardiac failure...
  30. pmc Reproductive changes associated with celiac disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada
    World J Gastroenterol 16:5810-4. 2010
    ..Reports noting activation during pregnancy or the puerperium may be important, and suggest that celiac disease may also be hypothetically precipitated by maternal exposure to one or more fetal antigens...
  31. pmc Surveillance for colitis-associated colon neoplasia
    Hugh James Freeman
    Department of Medicine, University of British Columbia, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 16:4646-51. 2010
    ..Although the clinical challenge posed to even the most experienced clinicians remains significant, evolving methods of endoscopic imaging may facilitate better evaluation of this highly select group of patients...
  32. pmc Mesenteric lymph node cavitation syndrome
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W5, Canada
    World J Gastroenterol 16:2991-3. 2010
    ..Modern abdominal imaging modalities may permit earlier detection in celiac disease so that earlier diagnosis and improved understanding of its pathogenesis may result...
  33. ncbi request reprint Celiac disease (gluten-sensitive enteropathy)
    H J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Minerva Gastroenterol Dietol 56:245-9. 2010
    ..These have a sprue-like intestinal disorder, also labeled unclassified sprue. This represents a small, but likely, heterogeneous group, and in these, intractable symptoms may be present and, in some, lymphoma is eventually diagnosed...
  34. pmc Risk factors in familial forms of celiac disease
    Hugh James Freeman
    Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada
    World J Gastroenterol 16:1828-31. 2010
    ..Identification of celiac disease is important since recent long-term studies have shown that the mortality of celiac disease is increased, if it is unrecognized and untreated...
  35. pmc Sellar inflammatory mass with inflammatory bowel disease
    Hugh J Freeman
    University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 24:58-60. 2010
    ....
  36. pmc Update on collagenous sprue
    Hugh James Freeman
    Department of Medicine, University of British Columbia Hospital, Vancouver, BC, V6T 1W5, Canada
    World J Gastroenterol 16:296-8. 2010
    ..Studies showing either gastric or colonic involvement (or both) with this unusual collagenous inflammatory mucosal process may also reflect a far more extensive and heterogeneous process than previously appreciated...
  37. pmc Multifocal stenosing ulceration of the small intestine
    Hugh James Freeman
    Department of Medicine, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 15:4883-5. 2009
    ..With the development of newer imaging modalities to visualize the small-intestinal mucosa, such as double-balloon enteroscopy, improved understanding of the long-term natural history of this apparently distinctive disorder should emerge...
  38. pmc Adult celiac disease with acetylcholine receptor antibody positive myasthenia gravis
    Hugh J Freeman
    Department of Medicine Gastroenterology and Neurology, University of British Columbia, Vancouver, BC, Canada
    World J Gastroenterol 15:4741-4. 2009
    ..Celiac disease and myasthenia gravis may occur together more often than is currently appreciated. The presence of motor weakness in celiac disease may be a clue to occult myasthenia gravis, even in the absence of intestinal symptoms...
  39. pmc Intraductal papillary mucinous neoplasms and other pancreatic cystic lesions
    Hugh James Freeman
    Department of Medicine, University of British Columbia Hospital, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:2977-9. 2008
    ..Therefore, recognition of this entity is exceedingly important for the clinician involved in diagnosis and further evaluation of a potentially curable form of pancreatic cancer...
  40. ncbi request reprint Asymptomatic familial colon cancer with FDG-PET scanning for recurrent disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    Int J Gastrointest Cancer 36:163-9. 2005
    ..This case underscores the ongoing need for additional evidence-based studies on evolving imaging modalities used in the diagnosis and management of colonic cancer...
  41. pmc Resolution of paraneoplastic collagenous enterocolitis after resection of colon cancer
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver
    Can J Gastroenterol 20:357-60. 2006
    ..Collagenous enterocolitis is an inflammatory process that may represent a distinctive and reversible paraneoplastic phenomenon...
  42. ncbi request reprint Erythema nodosum and pyoderma gangrenosum in 50 patients with Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1W5
    Can J Gastroenterol 19:603-6. 2005
    ..This suggests that some components of the inflammatory process in Crohn's disease may be modulated by estrogen-mediated events, particularly in adolescents and young adults...
  43. ncbi request reprint Long-term clinical behavior of jejunoileal involvement in Crohn's disease
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 19:575-8. 2005
    ..New treatments are required, possibly defined on the basis of their effectiveness in reducing the severity and extent of intestinal disease, rather than more conventional statistically driven reductions in disease activity indexes...
  44. ncbi request reprint Endoscopic excision of a prolapsing malignant polyp which caused intermittent gastric outlet obstruction
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, V6T 1W5 Canada
    World J Gastroenterol 11:5245-7. 2005
    ..While prolapsing gastric antral polyps are usually benign and hyperplastic, inflammatory or regenerative in type, excisional snare polypectomy here led to complete resolution of his symptoms, but showed a malignant polyp...
  45. ncbi request reprint Collagenous mucosal inflammatory diseases of the gastrointestinal tract
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    Gastroenterology 129:338-50. 2005
    ..Some recent reports have documented treatment success but histopathologic reversal has been more difficult to substantiate owing to the focal, sometimes extensive nature, of this pathologic process...
  46. ncbi request reprint Demyelination-like syndrome in Crohn's disease after infliximab therapy
    Hugh J Freeman
    Department of Medicine, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1W5
    Can J Gastroenterol 19:313-6. 2005
    ..Development of new neuropsychiatric changes in Crohn's disease should be thoroughly evaluated to exclude a concomitant demyelinating process. Infliximab infusions should be terminated if demyelination is suspected...
  47. ncbi request reprint Crohn's disease defined in three elderly sisters
    Hugh J Freeman
    Department of Medicine, Division of Gastroenterology, University of British Columbia, Vancouver
    Can J Gastroenterol 19:251-2. 2005
    ..The observations presented here reflect a possible gene-based predisposition to Crohn's disease or, alternatively, disease clustering related to a commonly shared environmental factor...
  48. ncbi request reprint Granulomatous bronchiolitis with necrobiotic pulmonary nodules in Crohn's disease
    Hugh J Freeman
    Department of Medicine, University of British Columbia Hospital, Vancouver, Canada
    Can J Gastroenterol 18:687-90. 2004
    ....
  49. ncbi request reprint Long-term prognosis of early-onset Crohn's disease diagnosed in childhood or adolescence
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 18:661-5. 2004
    ..Information on long-term follow-up of early-onset Crohn's disease is crucial to avoid the direct extrapolation of adult data to children and adolescents...
  50. ncbi request reprint Risk of gastrointestinal malignancies and mechanisms of cancer development with obesity and its treatment
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W5, Canada
    Best Pract Res Clin Gastroenterol 18:1167-75. 2004
    ..Finally, pharmacologic and surgical avenues available for treatment of obesity, including lipase inhibitors and gastric or jejuno-ileal bypass procedures may set the stage for subsequent gastric or intestinal tract cancer...
  51. ncbi request reprint Lymphoproliferative and intestinal malignancies in 214 patients with biopsy-defined celiac disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Gastroenterol 38:429-34. 2004
    ..Finally, except for a single hypopharyngeal carcinoma in a celiac disease patient with a malignant lymphoma, other malignant disorders of esophagus, stomach, and colon were not detected...
  52. pmc Evolution of collagenous colitis into severe and extensive ulcerative colitis
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 21:315-8. 2007
    ....
  53. pmc Application of the Montreal classification for Crohn's disease to a single clinician database of 1015 patients
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 21:363-6. 2007
    ..Using the Montreal classification for Crohn's disease, these results define the clinical features in a large, single clinician database and demonstrate age dependence in the phenotypic clinical expression of Crohn's disease...
  54. pmc Pearls and pitfalls in the diagnosis of adult celiac disease
    H J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 22:273-80. 2008
    ..Finally, some with 'sprue-like intestinal disease' cannot be classified because a diet response fails to occur. This may be a heterogeneous group, although some are eventually found to have a malignant lymphoma...
  55. pmc Colorectal cancer risk in Crohn's disease
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada V6T 1W5, Canada
    World J Gastroenterol 14:1810-1. 2008
    ..Future research should focus on development of molecular or other bio-markers that might predict future dysplasia or cancer development in Crohn's disease...
  56. pmc Complications of collagenous colitis
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:1643-5. 2008
    ..Similar changes may result from increased intraluminal pressure during barium enema contrast studies. Finally, malignant disorders have also been reported, including carcinoma and lymphoproliferative disease...
  57. doi request reprint Natural history and long-term clinical behavior of segmental colitis associated with diverticulosis (SCAD syndrome)
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC, Canada
    Dig Dis Sci 53:2452-7. 2008
    ....
  58. pmc Proton pump inhibitors and an emerging epidemic of gastric fundic gland polyposis
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, 2211 Wesbrook Mall, Vancouver V6T 1W5, Canada
    World J Gastroenterol 14:1318-20. 2008
    ..While temporarily reassuring, ongoing vigilance, particularly in those genetically predisposed to colon cancer, is still warranted...
  59. pmc Adult autoimmune enteropathy
    Hugh James Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 14:1156-8. 2008
    ..A widely available, reproducible and quantitative anti-enterocyte antibody assay is needed that could be applied in small bowel disorders that have the histological appearance of celiac disease, but fail to respond to a gluten-free diet...
  60. pmc Venous thromboembolism with inflammatory bowel disease
    Hugh James Freeman
    Department of Medicine, Gastroenterology, University of British Columbia Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T 1W5, Canada
    World J Gastroenterol 14:991-3. 2008
    ..Particular consideration should be given if there has been a prior thrombotic event, if hospitalization will require surgery, or if an underlying coagulation disorder is present...
  61. pmc Refractory celiac disease and sprue-like intestinal disease
    Hugh James Freeman
    Department of Gastroenterology, University of British Columbia, Hospital, 2211 Wesbrook Mall, Vancouver, BC V6T1W5, Canada
    World J Gastroenterol 14:828-30. 2008
    ..Precise definition will be critical in the future as an array of new treatments, including biological agents, may emerge...
  62. pmc Granuloma-positive Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 21:583-7. 2007
    ..In some pathological classification schemes, the criteria for a definite, probable or possible diagnosis have been listed, with the epithelioid granuloma indicating definite Crohn's disease...
  63. ncbi request reprint Crohn's disease initially diagnosed after age 60 years
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada V6T 1W5
    Age Ageing 36:587-9. 2007
  64. ncbi request reprint Pancreatic endocrine and exocrine changes in celiac disease
    Hugh J Freeman
    Gastroenterology, UBC Hospital, 2211 Wesbrook Mall, Vancouver, BC, V6T 1W8, Canada
    World J Gastroenterol 13:6344-6. 2007
    ..Pancreatic exocrine alterations may also occur, and if severe, marked malnutrition with pancreatic failure and ductal calcification have been observed. Finally, other pancreatic disorders have been recorded with celiac disease...
  65. pmc The spirit of Henry Norman Bethune and gastroenterology
    Hugh J Freeman
    Department of Medicine, University of British Columbia, UBC Hospital, Vancouver, British Columbia, Canada
    World J Gastroenterol 14:174-5. 2008
    ..It is hoped that this series will gather expert commentaries on a range of issues critical to the subspecialty from fundamental science to clinical care so that future directions can be defined...
  66. ncbi request reprint Age-dependent phenotypic clinical expression of Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia, Canada
    J Clin Gastroenterol 39:774-7. 2005
    ..These results demonstrate the phenomenon of age dependence in the phenotypic clinical expression of Crohn's disease...
  67. doi request reprint Adult celiac disease followed by onset of systemic lupus erythematosus
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC
    J Clin Gastroenterol 42:252-5. 2008
    ..Conversely, tissue transglutaminase antibodies have been detected in autoimmune disorders, including systemic lupus erythematosus (SLE), but cases of celiac disease with SLE have been only rarely recorded...
  68. ncbi request reprint Comparison of longstanding pediatric-onset and adult-onset Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC, Canada
    J Pediatr Gastroenterol Nutr 39:183-6. 2004
    ..Limited information is available on the characteristics of longstanding Crohn's disease with onset in childhood or adolescence...
  69. ncbi request reprint Tabulation of myeloid, lymphoid and intestinal malignancies in Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, British Columbia
    Can J Gastroenterol 16:779-84. 2002
    ....
  70. ncbi request reprint Free perforation due to intestinal lymphoma in biopsy-defined or suspected celiac disease
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver, British Columbia
    J Clin Gastroenterol 37:299-302. 2003
    ..This report documents a high mortality for this serious complication in celiac disease, its lack of predictability and the potential for development even with strict compliance to a gluten-free diet...
  71. ncbi request reprint Collagenous sprue associated with an extensive T-cell lymphoma
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, Canada
    J Clin Gastroenterol 36:144-6. 2003
    ..With improved treatment measures, including modern nutritional support, it is likely that there will be an increased opportunity in future for improved appreciation of the complications of collagenous sprue, specifically, lymphoma...
  72. ncbi request reprint Spontaneous free perforation of the small intestine in Crohn's disease
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver
    Can J Gastroenterol 16:23-7. 2002
    ..There have been no mortalities, and the subsequent clinical course of these patients has been limited to a minority requiring corticosteroid or immunosuppressive medications, or further surgical resections...
  73. ncbi request reprint Appendiceal carcinoids in Crohn's disease
    Hugh J Freeman
    Department of Medicine, University of British Columbia, Vancouver
    Can J Gastroenterol 17:43-6. 2003
    ..This percentage would be higher if only those having an intestinal resection were considered (0.68%). Additional studies are needed to further define this risk of appendiceal carcinoids in Crohn's disease...
  74. ncbi request reprint Familial Crohn's disease in single or multiple first-degree relatives
    Hugh J Freeman
    Department of Medicine Gastroenterology, University of British Columbia, Vancouver, BC
    J Clin Gastroenterol 35:9-13. 2002
    ..Future studies are needed to further explore the role of both genetic and environmental factors in the pathogenesis and phenotypic expression of familial CD...
  75. ncbi request reprint Abdominal pain as the initial and sole clinical presenting feature of systemic lupus erythematosus
    Henry V Chung
    Department of Medicine, University of British Columbia, Vancouver, Canada
    Can J Gastroenterol 17:111-3. 2003
    ..The authors' experiences, and a review of the literature suggest that a diagnosis of SLE should be considered in young Asian women who present with significant but clinically enigmatic gastrointestinal illness...