- Molecular cloning and characterization of hNP22: a gene up-regulated in human alcoholic brainL Fan
Department of Biochemistry, The University of Queensland, Brisbane, Australia
J Neurochem 76:1275-81. 2001..The results suggest that hNP22 may have a role in alcohol-related adaptations and may mediate regulatory signal transduction pathways in neurones...
- Genetic study of alcoholism and novel gene expression in the alcoholic brainLi Fan
Department of Biochemistry and Molecular Biology, The University of Queensland, Brisbane, Australia
Addict Biol 9:11-8. 2004..This review discusses the current information on the genetic basis of alcoholism and the induction and characterization of these alcohol-responsive genes...
- Cortactin activation by FVIIa/tissue factor and PAR2 promotes endothelial cell migrationTang Zhu
Department of Pediatrics, Maisonneuve Rosemont Hospital Research Centre, University of Montreal, Quebec, Canada
Am J Physiol Regul Integr Comp Physiol 300:R577-85. 2011..Overall, we demonstrate a novel regulation and role for cortactin in FVIIa/TF-mediated endothelial cell migration that occurs through a PAR2 and RhoA dependent mechanism...
- MALAT-1, a non protein-coding RNA is upregulated in the cerebellum, hippocampus and brain stem of human alcoholicsRosemarie Kryger
Department of Biochemistry, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Australia
Alcohol 46:629-34. 2012..As MALAT-1 regulates RNA processing, this suggests that alcohol-induced upregulation of MALAT-1 represents an important novel mechanism for alcohol actions in the CNS...
- Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptorA Marilise Marrache
Department of Pharmacology and Therapeutics, McGill University, Montreal, Quebec, Canada
J Immunol 169:6474-81. 2002..This study describes for the first time the nucleus as a putative organelle capable of generating PAF and expresses its receptor, which upon stimulation induces the expression of the proinflammatory gene COX-2...
- Intracellular-specific colocalization of prostaglandin E2 synthases and cyclooxygenases in the brainAlejandro Vazquez-Tello
Deptartment of Pediatrics, Research Center of Hôpital Sainte Justine, 3175, Cote Sainte Catherine, Montreal, Quebec, Canada H3T 1C5
Am J Physiol Regul Integr Comp Physiol 287:R1155-63. 2004..Hence, contrary to a previously proposed model of exclusive COX-2/mPGES-1 coordination, COX-2 can coordinate with mPGES-1 and/or cPGES in the brain, depending on the cell compartment and the age group...
- Smooth muscle-specific expression of SV40 large TAg induces SMC proliferation causing adaptive arterial remodelingJurgen R Sindermann
Krannert Institute of Cardiology and Indiana Center for Vascular Biology and Medicine, Indiana University Medical Center, Indianapolis 46202, USA
Am J Physiol Heart Circ Physiol 283:H2714-24. 2002..This establishes a new model of adaptive vessel remodeling occurring in response to a proliferative input in the absence of mechanical injury or primary flow perturbation...
- Identification of a novel gentisate 1,2-dioxygenase from Silicibacter pomeroyiDongqi Liu
College of Environmental Sciences, Peking University, Beijing, 100871, P R China
Biotechnol Lett 29:1529-35. 2007..The K (m) and K (cat)/K (m) for gentisate were 12 muM and 653 x 10(4) M(-1 )s(-1); the pI was 4.6-4.8. It was optimally active at 40 degrees C and pH 8.0...
- Sarcoplasmic reticulum Ca2+ release channel ryanodine receptor (RyR2) plays a crucial role in aconitine-induced arrhythmiasMin Fu
School of Medicine and Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, People s Republic of China
Biochem Pharmacol 75:2147-56. 2008..The present study demonstrates a potential method for preventing aconitine-induced arrhythmias by inhibiting Ca(2+) leakage through the sarcoplasmic reticulum RyR(2) channel...
- XPD helicase structures and activities: insights into the cancer and aging phenotypes from XPD mutationsLi Fan
Department of Molecular Biology, Skaggs Institute of Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
Cell 133:789-800. 2008..These results provide a foundation for understanding disease consequences of mutations in XPD and related 4Fe-4S helicases including FancJ...
- Physiological and biochemical defects in carboxyl-terminal mutants of mitochondrial DNA helicaseYuichi Matsushima
Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824 1319, USA
J Biol Chem 283:23964-71. 2008..Our findings may be applicable to understand the role of the carboxyl-terminal region in superfamily 4 DNA helicases in general...
- Survival motor neuron (SMN) protein: role in neurite outgrowth and neuromuscular maturation during neuronal differentiation and developmentLi Fan
Centre de Recherche, Hopital Sainte Justine, Montreal, Quebec, Canada H3T 1C5
Hum Mol Genet 11:1605-14. 2002..The primary SMA pathology most likely initiates in the peripheral axon--the result of deficient neurite outgrowth and/or neuromuscular maturation...
- Conserved XPB core structure and motifs for DNA unwinding: implications for pathway selection of transcription or excision repairLi Fan
Life Sciences Division, Department of Molecular Biology, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
Mol Cell 22:27-37. 2006..Together, these results provide an unexpected mechanism of DNA unwinding with implications for XPB damage verification in nucleotide excision repair...