R J Letcher

Summary

Affiliation: Environment Canada
Country: Canada

Publications

  1. ncbi request reprint Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus)
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Department of Chemistry, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Environ Pollut 152:621-9. 2008
  2. ncbi request reprint Comparative fate of organohalogen contaminants in two top carnivores in Greenland: captive sledge dogs and wild polar bears
    Jonathan Verreault
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol C Toxicol Pharmacol 147:306-15. 2008
  3. ncbi request reprint Comparative hepatic in vitro depletion and metabolite formation of major perfluorooctane sulfonate precursors in arctic polar bear, beluga whale, and ringed seal
    Robert J Letcher
    Ecotoxicology and Wildlife Health Division, Wildlife and Landscape Science Directorate, Science and Technology Branch, National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada Electronic address
    Chemosphere 112:225-31. 2014
  4. doi request reprint Dietary exposure of American kestrels (Falco sparverius) to decabromodiphenyl ether (BDE-209) flame retardant: uptake, distribution, debromination and cytochrome P450 enzyme induction
    Robert J Letcher
    Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, Ottawa, Ontario K1A 0H3, Canada Electronic address
    Environ Int 63:182-90. 2014
  5. doi request reprint Flame retardants in eggs of American kestrels and European starlings from southern Lake Ontario region (North America)
    Da Chen
    Ecotoxicology and Wildlife Health Division, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON K1A 0H3, Canada
    J Environ Monit 14:2870-6. 2012
  6. doi request reprint Bioaccumulation and biotransformation of brominated and chlorinated contaminants and their metabolites in ringed seals (Pusa hispida) and polar bears (Ursus maritimus) from East Greenland
    Robert J Letcher
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada
    Environ Int 35:1118-24. 2009
  7. doi request reprint Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish
    Robert J Letcher
    Wildlife and Landscape Science Directorate, Science and Technology, Branch, Environment Canada, Carleton University, Ottawa, ON, Canada
    Sci Total Environ 408:2995-3043. 2010
  8. ncbi request reprint Determination of hydroxylated polychlorinated biphenyls (HO-PCBs) in blood plasma by high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry
    R J Letcher
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario, Canada N9B 3P4
    J Anal Toxicol 29:209-16. 2005
  9. doi request reprint Twenty years of temporal change in perfluoroalkyl sulfonate and carboxylate contaminants in herring gull eggs from the Laurentian Great Lakes
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada
    J Environ Monit 13:3365-72. 2011
  10. ncbi request reprint Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells
    Robert J Letcher
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Appl Pharmacol 209:95-104. 2005

Detail Information

Publications98

  1. ncbi request reprint Tissue-specific congener composition of organohalogen and metabolite contaminants in East Greenland polar bears (Ursus maritimus)
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Department of Chemistry, Carleton University, Ottawa, Ontario K1S 5B6, Canada
    Environ Pollut 152:621-9. 2008
    ..Our findings suggest that different congener pattern exposures to these classes of contaminants should be considered with respect to potential target tissue-specific effects in East Greenland polar bears...
  2. ncbi request reprint Comparative fate of organohalogen contaminants in two top carnivores in Greenland: captive sledge dogs and wild polar bears
    Jonathan Verreault
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Comp Biochem Physiol C Toxicol Pharmacol 147:306-15. 2008
    ....
  3. ncbi request reprint Comparative hepatic in vitro depletion and metabolite formation of major perfluorooctane sulfonate precursors in arctic polar bear, beluga whale, and ringed seal
    Robert J Letcher
    Ecotoxicology and Wildlife Health Division, Wildlife and Landscape Science Directorate, Science and Technology Branch, National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada Electronic address
    Chemosphere 112:225-31. 2014
    ..01) and with no concomitant formation of PFOS metabolite. This suggests that, in part, a source of FOSA is the biotransformation of accumulated N-EtFOSA in free-ranging Arctic ringed seal and polar bear. ..
  4. doi request reprint Dietary exposure of American kestrels (Falco sparverius) to decabromodiphenyl ether (BDE-209) flame retardant: uptake, distribution, debromination and cytochrome P450 enzyme induction
    Robert J Letcher
    Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, Ottawa, Ontario K1A 0H3, Canada Electronic address
    Environ Int 63:182-90. 2014
    ..3pmol/min/mg protein). Overall, the results demonstrated that following diet exposure of kestrels to high purity BDE-209, uptake occurred as well as BDE-209 degradation via debromination to lower brominated PBDE congeners. ..
  5. doi request reprint Flame retardants in eggs of American kestrels and European starlings from southern Lake Ontario region (North America)
    Da Chen
    Ecotoxicology and Wildlife Health Division, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON K1A 0H3, Canada
    J Environ Monit 14:2870-6. 2012
    ..AMKE and EUST have also been used as model species for laboratory evaluation of FR toxic effects in birds. Therefore, AMKE and EUST are deemed valuable bio-monitoring species for investigating FR contamination in terrestrial ecosystems...
  6. doi request reprint Bioaccumulation and biotransformation of brominated and chlorinated contaminants and their metabolites in ringed seals (Pusa hispida) and polar bears (Ursus maritimus) from East Greenland
    Robert J Letcher
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada
    Environ Int 35:1118-24. 2009
    ....
  7. doi request reprint Exposure and effects assessment of persistent organohalogen contaminants in arctic wildlife and fish
    Robert J Letcher
    Wildlife and Landscape Science Directorate, Science and Technology, Branch, Environment Canada, Carleton University, Ottawa, ON, Canada
    Sci Total Environ 408:2995-3043. 2010
    ....
  8. ncbi request reprint Determination of hydroxylated polychlorinated biphenyls (HO-PCBs) in blood plasma by high-performance liquid chromatography-electrospray ionization-tandem quadrupole mass spectrometry
    R J Letcher
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario, Canada N9B 3P4
    J Anal Toxicol 29:209-16. 2005
    ....
  9. doi request reprint Twenty years of temporal change in perfluoroalkyl sulfonate and carboxylate contaminants in herring gull eggs from the Laurentian Great Lakes
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada
    J Environ Monit 13:3365-72. 2011
    ..Dietary changes as measured by carbon and nitrogen stable isotopes, showed minimal relationships to PFC levels in gull eggs, which indicates the complexity of aquatic and terrestrial food of gulls and sources of PFCs...
  10. ncbi request reprint Effects of bisphenol A-related diphenylalkanes on vitellogenin production in male carp (Cyprinus carpio) hepatocytes and aromatase (CYP19) activity in human H295R adrenocortical carcinoma cells
    Robert J Letcher
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Appl Pharmacol 209:95-104. 2005
    ..Environmental exposure of fish to BPA and related diphenylalkanes, depending on the structure, may pose anti-estrogenic, and to a lesser extent estrogenic, risks to development and reproduction...
  11. ncbi request reprint High-sensitivity method for determination of tetrabromobisphenol-S and tetrabromobisphenol-A derivative flame retardants in great lakes herring gull eggs by liquid chromatography-atmospheric pressure photoionization-tandem mass spectrometry
    Robert J Letcher
    Ecotoxicology and Wildlife Health Division, Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, K1A 0H3, Canada
    Environ Sci Technol 44:8615-21. 2010
    ..56 ng/g wet weight. Thus, TBBP-A-ae and TBBP-A-dbpe are present in herring gull eggs from these populations, bioaccumulate in the herring gull food chain, and are transferred from gull to egg...
  12. ncbi request reprint Plasma-associated halogenated phenolic contaminants in benthic and pelagic fish species from the Detroit River
    Hongxia Li
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ontario N9B 3P4, Canada
    Environ Sci Technol 37:832-9. 2003
    ..Target tissue exposure to circulating OH-PCBs was variable, and thus potential OH-PCB-mediated toxicological activity and effects (e.g., endocrine-related) and health risks are different among the fish species...
  13. doi request reprint The role of diet on long-term concentration and pattern trends of brominated and chlorinated contaminants in western Hudson Bay polar bears, 1991-2007
    Melissa A McKinney
    Ecotoxicology and Wildlife Health Division, Science and Technology Branch, Environment Canada, Carleton University Raven Road, Ottawa, Ontario K1A 0H3, Canada
    Sci Total Environ 408:6210-22. 2010
    ..Contaminant pattern trends may be useful in distinguishing the possible role of ecological/diet changes on contaminant burdens from expected dynamics due to atmospheric sources and weathering...
  14. ncbi request reprint Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland
    Wouter A Gebbink
    Science and Technology Branch, National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa, Ontario K1A OH3, Canada
    Environ Sci Technol 42:752-9. 2008
    ..MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific...
  15. ncbi request reprint Chlorinated hydrocarbon contaminants and metabolites in polar bears (Ursus maritimus) from Alaska, Canada, East Greenland, and Svalbard: 1996-2002
    Jonathan Verreault
    University of Windsor, Great Lakes Institute for Environmental Research, Windsor, Canada, ON N9B 3P4
    Sci Total Environ 351:369-90. 2005
    ..In addition to continued biomonitoring, further research on health and population status is needed to evaluate the impact from chronic exposure of polar bear populations to CHCs and their metabolites...
  16. ncbi request reprint Sea ice-associated diet change increases the levels of chlorinated and brominated contaminants in polar bears
    Melissa A McKinney
    Wildlife Toxicology and Disease Program, Science and Technology Branch, Environment Canada, Ottawa, Ontario KJA 0H3, Canada
    Environ Sci Technol 43:4334-9. 2009
    ....
  17. ncbi request reprint Persistent organic pollutants and mercury in marine biota of the Canadian Arctic: an overview of spatial and temporal trends
    B M Braune
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Carleton University Raven Road, Ottawa, ON, Canada K1A 0H3
    Sci Total Environ 351:4-56. 2005
    ..Continuing temporal monitoring of POPs and Hg in a variety of marine biota must be a priority...
  18. ncbi request reprint Composition of chlorinated hydrocarbon contaminants among major adipose tissue depots of polar bears (Ursus maritimus) from the Canadian high Arctic
    Jonathan Verreault
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, Ontario, Canada K1A 0H3
    Sci Total Environ 370:580-7. 2006
    ....
  19. ncbi request reprint Polybrominated diphenyl ethers and hydroxylated and methoxylated brominated and chlorinated analogues in the plasma of fish from the Detroit River
    Karlis Valters
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario, N9B 3P4 Canada
    Environ Sci Technol 39:5612-9. 2005
    ..In addition to emerging classes of brominated contaminant such as PBDEs, whether of metabolic or anthropogenic origin, fish collected from the Detroit River are exposed to a complex profile of PBDE-like organohalogens...
  20. ncbi request reprint Snapping turtles (Chelydra serpentina) as bioindicators in Canadian areas of concern in the Great Lakes Basin. 1. Polybrominated diphenyl ethers, polychlorinated biphenyls, and organochlorine pesticides in eggs
    S R de Solla
    Canadian Wildlife Service, Environment Canada, 867 Lakeshore Road, Box 5050, Burlington, ON, L7R 4A6, Canada
    Environ Sci Technol 41:7252-9. 2007
    ..In contrast, PBDE congener patterns in turtle eggs resembled PentaBDE technical formulations regardless of absolute concentrations or location, and were largely associated with urban environments...
  21. ncbi request reprint Hydroxylated and methyl sulfone PCB metabolites in adipose and whole blood of polar bear (Ursus maritimus) from East Greenland
    G M Sandala
    University of Windsor, Great Lakes Institute for Environmental Research, 401 Sunset Avenue, Windsor, ON, N9B 3P4, Canada
    Sci Total Environ 331:125-41. 2004
    ..Given the known toxicities of PCB metabolites, this population of polar bear may be experiencing health risks due to exposure to a complex loading of organohalogen contaminants that include HO-PCB and MeSO2-PCB metabolites...
  22. ncbi request reprint Brominated flame retardants and halogenated phenolic compounds in North American west coast bald eaglet (Haliaeetus leucocephalus) plasma
    Melissa A McKinney
    National Wildlife Research Centre, Canadian Wildlife Service, Environment Canada, Carleton University, Ottawa, Ontario K1A 0H3, Canada
    Environ Sci Technol 40:6275-81. 2006
    ..This study demonstrates that west coast North American bald eagles contain previously unreported organohalogens, which have the potential to impact the health and survival of these raptors...
  23. ncbi request reprint Biotransformation of polybrominated diphenyl ethers and polychlorinated biphenyls in beluga whale (Delphinapterus leucas) and rat mammalian model using an in vitro hepatic microsomal assay
    Melissa A McKinney
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ont, Canada N9B 3P4
    Aquat Toxicol 77:87-97. 2006
    ..This may suggest that the formation of potentially toxic oxidative PCB and PBDE products (metabolites), in addition to the parent pollutants, may be contributing to contaminant-related stress effects on the health of beluga whale...
  24. ncbi request reprint Brominated flame retardants in polar bears (Ursus maritimus) from Alaska, the Canadian Arctic, East Greenland, and Svalbard
    Derek C G Muir
    National Water Research Institute, Environment Canada, Burlington, Ontario, Canada
    Environ Sci Technol 40:449-55. 2006
    ..Significantly lower sigmaPBDE concentrations were found in fat of bears from Canada and Alaska (means ranging from 7.6 to 22 ng/g lw)...
  25. ncbi request reprint Organohalogen contaminants and metabolites in beluga whale (Delphinapterus leucas) liver from two Canadian populations
    Melissa A McKinney
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 25:1246-57. 2006
    ..Canadian beluga whale liver contains previously unidentified organohalogen contaminants and metabolites and, thus, a complexity of contaminant exposure that may be impacting the health of Canadian beluga whale populations...
  26. ncbi request reprint PCBs and organochlorine pesticides in blubber biopsies from free-ranging St. Lawrence River Estuary beluga whales (Delphinapterus leucas), 1994-1998
    Karen E Hobbs
    National Water Research Institute, Environment Canada, ON, L7R 4A6, Burlington, Canada
    Environ Pollut 122:291-302. 2003
    ..It also appears that measuring contaminant concentrations only in stranded whales, may overestimate OC levels in the population as a whole, especially for highly chlorinated OCs...
  27. doi request reprint Isomers of Dechlorane Plus flame retardant in the eggs of herring gulls (Larus argentatus) from the Laurentian Great Lakes of North America: temporal changes and spatial distribution
    Lewis T Gauthier
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada K1A 0H3
    Chemosphere 75:115-20. 2009
    ..Over the past 25 years, it is clear that DP isomers have accumulated in the food web of female herring gulls with subsequent transfer during ovogenesis...
  28. doi request reprint Biochemical tracers reveal intra-specific differences in the food webs utilized by individual seabirds
    Craig E Hebert
    Environment Canada, Wildlife and Landscape Science Directorate, National Wildlife Research Centre, Ottawa, ON, Canada
    Oecologia 160:15-23. 2009
    ..g., herring gulls, are common in food webs. By characterizing ecological tracer profiles in such species we can better understand spatial, temporal, and individual differences in pathways of contaminant, energy, and nutrient flow...
  29. doi request reprint Linear and branched perfluorooctane sulfonate isomers in technical product and environmental samples by in-port derivatization-gas chromatography-mass spectrometry
    Shaogang Chu
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, K1A 0H3, Canada
    Anal Chem 81:4256-62. 2009
    ..46 ng/mL. For the biotic samples, the method detection limits (MDLs) were slightly higher than the LODs and ranged from 0.09 to 0.46 ng/g wet weight (w.w.) with exception of L-PFOS (MDL = 6.87 ng/g w.w.)...
  30. ncbi request reprint Environmentally relevant concentrations of DE-71 and HBCD alter eggshell thickness and reproductive success of American kestrels
    Kim J Fernie
    Canadian Wildlife Service, Environment Canada, 867 Lakeshore Road, Burlington, Ontario, Canada L7R 4A6
    Environ Sci Technol 43:2124-30. 2009
    ..The results of this study are consistent with the PBDE-associated brood reduction in wild European peregrines and may partially explain the decline of kestrels in North America...
  31. ncbi request reprint Levels and trends of organochlorines and brominated flame retardants in ivory gull eggs from the Canadian Arctic, 1976 to 2004
    Birgit M Braune
    Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada K1A 0H3
    Sci Total Environ 378:403-17. 2007
    ....
  32. ncbi request reprint Reconcilable differences: the use of reference material to reduce methodological artifacts in the reporting of organochlorine pesticides and polychlorinated biphenyls
    Shane R de Solla
    Canadian Wildlife Service, Environment Canada, 867 Lakeshore Road, Box 5050, Burlington, Ontario L7R4A6, Canada
    Environ Toxicol Chem 29:19-26. 2010
    ..Assessments of the compatibility of analytical methodologies should be made using an appropriate RM...
  33. ncbi request reprint Evidence of immunomodulation in nestling American kestrels (Falco sparverius) exposed to environmentally relevant PBDEs
    Kim J Fernie
    Canadian Wildlife Service, PO Box 5050, 867 Lakeshore Rd, Burlington, Ontario, Canada, L7R 4A6
    Environ Pollut 138:485-93. 2005
    ..Immunomodulation from PBDE exposure may be exacerbated in wild birds experiencing greater environmental stresses...
  34. ncbi request reprint Changes in reproductive courtship behaviors of adult American kestrels (Falco sparverius) exposed to environmentally relevant levels of the polybrominated diphenyl ether mixture, DE-71
    Kim J Fernie
    Canadian Wildlife Service, Environment Canada, Burlington, Ontario, Canada, L7R 4A6
    Toxicol Sci 102:171-8. 2008
    ..In addition, these behavioral effects are consistent with the observed reproductive changes in these birds...
  35. ncbi request reprint Pipping success, isomer-specific accumulation, and hepatic mRNA expression in chicken embryos exposed to HBCD
    Doug Crump
    Environment Canada, National Wildlife Research Centre, Ottawa, Ontario, Canada K1A 0H3
    Toxicol Sci 115:492-500. 2010
    ..Research on the effects of HBCD in wild avian species is warranted...
  36. ncbi request reprint Exposure to polybrominated diphenyl ethers (PBDEs): changes in thyroid, vitamin A, glutathione homeostasis, and oxidative stress in American kestrels (Falco sparverius)
    Kim J Fernie
    Canadian Wildlife Service, Burlington, Ontario
    Toxicol Sci 88:375-83. 2005
    ..Subsequently, concentrations of PBDE congeners in wild birds may alter thyroid hormone and vitamin A concentrations, glutathione metabolism and oxidative stress...
  37. doi request reprint Historical contaminants, flame retardants, and halogenated phenolic compounds in peregrine Falcon (Falco peregrinus) nestlings in the Canadian Great Lakes Basin
    Kim J Fernie
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, Burlington, Ontario L7R 4A6, Canada
    Environ Sci Technol 44:3520-6. 2010
    ..Low ppb levels of putative OH-PBDE metabolites, dominated by 6'-OH-BDE47, were also detected in the peregrine nestlings...
  38. ncbi request reprint Current-use flame retardants in the eggs of herring gulls (Larus argentatus) from the Laurentian Great Lakes
    Lewis T Gauthier
    Science and Technology Branch, National Wildlife Research Centre, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada
    Environ Sci Technol 41:4561-7. 2007
    ..Given the aquatic diet of herring gull, this suggests that there are non-PBDE BFRs present in the gull-associated aquatic food web of the Great Lakes...
  39. ncbi request reprint Hydroxylated and methylsulfone-containing metabolites of polychlorinated biphenyls in the plasma and blubber of bowhead whales (Balaena mysticetus)
    Paul F Hoekstra
    University of Guelph, Department of Environmental Biology, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 22:2650-8. 2003
    ..Further research is required to elucidate the toxicokinetics and distribution of OH-PCBs in this cetacean...
  40. ncbi request reprint Changes in the growth, but not the survival, of American kestrels (Falco sparverius) exposed to environmentally relevant polybrominated diphenyl ethers
    Kim J Fernie
    Canadian Wildlife Service, Burlington, Ontario, Canada
    J Toxicol Environ Health A 69:1541-54. 2006
    ..The repeated relationships with BDE-100 and growth may be important for wild Falconidae, since this is the predominant penta-BDE congener in these raptors...
  41. ncbi request reprint Fate, partitioning, and mass loading of polybrominated diphenyl ethers (PBDEs) during the treatment processing of municipal sewage
    Min Song
    Department of Civil and Environmental Engineering, University of Windsor, 401 Sunset Avenue, Windsor, Ontario, N9B 3P4 Canada
    Environ Sci Technol 40:6241-6. 2006
    ..7 kg/year. The total mass loading of sigma5PBDE to the Detroit River is expected to be much larger as effluent from this facility accounts for <10% of the total STP discharges to the river...
  42. doi request reprint Dietary, age and trans-generational effects on the fate of organohalogen contaminants in captive sledge dogs in Greenland
    Jonathan Verreault
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario, Canada K1S 5B6
    Environ Int 35:56-62. 2009
    ....
  43. doi request reprint In vitro metabolism of polychlorinated biphenyls and cytochrome P450 monooxygenase activities in dietary-exposed Greenland sledge dogs
    Jonathan Verreault
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 150:91-100. 2009
    ....
  44. doi request reprint Recombinant transthyretin purification and competitive binding with organohalogen compounds in two gull species (Larus argentatus and Larus hyperboreus)
    Francisco Ucán-Marin
    National Wildlife Research Centre, Carleton University, Ottawa, Ontario, K1A 0H3, Canada
    Toxicol Sci 107:440-50. 2009
    ....
  45. ncbi request reprint Simultaneous determination of tetrabromobisphenol A, tetrachlorobisphenol A, bisphenol A and other halogenated analogues in sediment and sludge by high performance liquid chromatography-electrospray tandem mass spectrometry
    Shaogang Chu
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ont, Canada N9B 3P4
    J Chromatogr A 1097:25-32. 2005
    ..Mean recovery of the analytes from spiked samples ranged from 70 to 105%, and the relative standard deviation ranged from 4.9 to 13.1%. The method was successfully applied to sediment and sludge samples analysis...
  46. ncbi request reprint Linear and branched perfluorooctane sulfonate isomer patterns in herring gull eggs from colonial sites across the Laurentian Great Lakes
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, ON, K1A 0H3, Canada
    Environ Sci Technol 44:3739-45. 2010
    ....
  47. doi request reprint Pipping success and liver mRNA expression in chicken embryos exposed in ovo to C8 and C11 perfluorinated carboxylic acids and C10 perfluorinated sulfonate
    Jason M O'Brien
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, 20 Marie Curie Street, Ottawa, Ontario K1N 6N5, Canada
    Toxicol Lett 190:134-9. 2009
    ..Based on the present results for white leghorn chickens, current environmental concentrations of PFOA, PFUdA and PFDS are unlikely to affect the hatching success of wild birds...
  48. ncbi request reprint Characterization and profiling of hepatic cytochromes P450 and phase II xenobiotic-metabolizing enzymes in beluga whales (Delphinapterus leucas) from the St. Lawrence River Estuary and the Canadian Arctic
    Melissa A McKinney
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ont, Canada N9B 3P4
    Aquat Toxicol 69:35-49. 2004
    ..and CA animals demonstrated similar, immunologically cross-reactive phase I and II hepatic enzyme profiles, which is suggestive of the importance of metabolism in the toxicokinetics and fate of xenobiotics in animals from both populations..
  49. ncbi request reprint Determination of carotenoids and all-trans-retinol in fish eggs by liquid chromatography-electrospray ionization-tandem mass spectrometry
    Hongxia Li
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, Windsor, Ont, Canada N9B 3P4
    J Chromatogr B Analyt Technol Biomed Life Sci 816:49-56. 2005
    ..To our knowledge, this is the first report on a method for LC-MS determination of carotenoids and retinoids in a fish egg matrix, and the first carotenoid-specific determination in any fish egg sample...
  50. doi request reprint Highly elevated levels of perfluorooctane sulfonate and other perfluorinated acids found in biota and surface water downstream of an international airport, Hamilton, Ontario, Canada
    S R de Solla
    Wildlife and Landscape Science Directorate, Environment Canada, 867 Lakeshore Road, Burlington, ON, Canada
    Environ Int 39:19-26. 2012
    ..Although there was no known spill event or publicly reported use of AFFF associated with a fire event at the Hamilton airport, the airport is a likely major source of PFC contamination in the Welland River...
  51. ncbi request reprint Triclosan in waste and surface waters from the upper Detroit River by liquid chromatography-electrospray-tandem quadrupole mass spectrometry
    Wenyi Hua
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario, Canada N9B 3P4
    Environ Int 31:621-30. 2005
    ..Two hydroxylated tribrominated diphenyl ethers, which are structurally similar to triclosan, were also detected in WSTP effluent and surface water samples...
  52. ncbi request reprint Bioaccumulation and biotransformation of 61 polychlorinated biphenyl and four polybrominated diphenyl ether congeners in juvenile American kestrels (Falco sparverius)
    Ken G Drouillard
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 26:313-24. 2007
    ..6 to 44.7 d. Assuming differences in PBDE toxicokinetics between juveniles and adults similar to those measured for PCBs, adult American kestrel PBDE half-lives are expected to range from 72 to 572 d...
  53. ncbi request reprint Hepatic microsomal cytochrome P450 enzyme activity in relation to in vitro metabolism/inhibition of polychlorinated biphenyls and testosterone in Baltic grey seal (Halichoerus grypus)
    Hongxia Li
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 22:636-44. 2003
    ..Defining the profiles of CYP enzymes that are responsible for PCB biotransformation is necessary to fully understand the bioaccumulation, toxicokinetics, and risk of PCB exposure in seals and other free-ranging marine mammals...
  54. ncbi request reprint Biological monitoring of polyfluoroalkyl substances: A review
    Magali Houde
    Department of Environmental Biology, University of Guelph, Guelph, Ontario, N1G 2W1, Canada
    Environ Sci Technol 40:3463-73. 2006
    ..Continuous monitoring with key sentinel species and standardization of analytical methods are recommended...
  55. ncbi request reprint Perfluorinated carboxylates and sulfonates and precursor compounds in herring gull eggs from colonies spanning the Laurentian Great Lakes of North America
    Wouter A Gebbink
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, ON K1A 0H3, Canada
    Environ Sci Technol 43:7443-9. 2009
    ....
  56. ncbi request reprint Polychlorinated biphenyls and hydroxylated polychlorinated biphenyls in plasma of bottlenose dolphins (Tursiops truncatus) from the Western Atlantic and the Gulf of Mexico
    Magali Houde
    Department of Environmental Biology, University of Guelph, Ontario, Canada
    Environ Sci Technol 40:5860-6. 2006
    ..Results from this study show that OH-PCB are important environmental contaminants in dolphins and suggest that PCBs, decades after their ban, may still constitute a threat to wildlife...
  57. ncbi request reprint Temporal trends and spatial distribution of non-polybrominated diphenyl ether flame retardants in the eggs of colonial populations of Great Lakes herring gulls
    Lewis T Gauthier
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, Canada
    Environ Sci Technol 43:312-7. 2009
    ....
  58. ncbi request reprint Seasonality effects on pharmaceuticals and s-triazine herbicides in wastewater effluent and surface water from the Canadian side of the upper Detroit River
    Wen Yi Hua
    Great Lakes Institute for Environmental Research, University of Windsor, 2990 Riverside Drive West, Windsor, Ontario N9B 3P4, Canada
    Environ Toxicol Chem 25:2356-65. 2006
    ..Detroit River surface water concentrations of carbamazepine, cotinine, and atrazine may present a health concern to aquatic wildlife and to humans via the consumption of drinking water...
  59. ncbi request reprint Ozone treatment and the depletion of detectable pharmaceuticals and atrazine herbicide in drinking water sourced from the upper Detroit River, Ontario, Canada
    Wenyi Hua
    Great Lakes Institute for Environmental Research, University of Windsor, Windsor, Ont, Canada N9B 3P4
    Water Res 40:2259-66. 2006
    ..Currently very few Canadian DWTPs incorporate ozonation into conventional treatment, which suggests that human exposure to these compounds via drinking water consumption may be an issue in affected communities...
  60. ncbi request reprint Dramatic changes in the temporal trends of polybrominated diphenyl ethers (PBDEs) in herring gull eggs from the Laurentian Great Lakes: 1982-2006
    Lewis T Gauthier
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, ON K1S 5B6, Canada
    Environ Sci Technol 42:1524-30. 2008
    ....
  61. ncbi request reprint Changes in prolactin in a highly organohalogen contaminated Arctic top predator seabird, the glaucous gull
    Jonathan Verreault
    National Wildlife Research Centre, Science and Technology Branch, Environment Canada, Carleton University, Ottawa, Ont, Canada K1A 0H3
    Gen Comp Endocrinol 156:569-76. 2008
    ....
  62. doi request reprint Comparative hepatic activity of xenobiotic-metabolizing enzymes and concentrations of organohalogens and their hydroxylated analogues in captive Greenland sledge dogs (Canis familiaris)
    Jonathan Verreault
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, Ontario K1A 0H3
    Environ Toxicol Chem 28:162-72. 2009
    ..These results also suggest that plasma OH-PBDEs likely are not products of cytochrome P450-mediated transformation but, rather, are accumulated via the diet...
  63. ncbi request reprint Elimination of 10 polybrominated diphenyl ether (PBDE) congeners and selected polychlorinated biphenyls (PCBs) from the freshwater mussel, Elliptio complanata
    Ken G Drouillard
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Ave, Windsor, ON, Canada N9B 3P4
    Chemosphere 69:362-70. 2007
    ..Given the long time periods required for steady state, mussel accumulated PBDE residues should be interpreted in the context of calibrated bioaccumulation models...
  64. ncbi request reprint Dacthal and chlorophenoxy herbicides and chlorothalonil fungicide in eggs of osprey (Pandion haliaetus) from the Duwamish-Lake Washington-Puget Sound area of Washington state, USA
    Shaogang Chu
    Great Lakes Institute for Environment Research, University of Windsor, 401 Sunset Avenue, Windsor, ON N9B 3P4, Canada
    Environ Pollut 145:374-81. 2007
    ....
  65. ncbi request reprint Analysis of fluorotelomer alcohols and perfluorinated sulfonamides in biotic samples by liquid chromatography-atmospheric pressure photoionization mass spectrometry
    Shaogang Chu
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON K1A 0H3, Canada
    J Chromatogr A 1215:92-9. 2008
    ....
  66. doi request reprint Perfluorooctane sulfonate (PFOS) toxicity in domestic chicken (Gallus gallus domesticus) embryos in the absence of effects on peroxisome proliferator activated receptor alpha (PPARalpha)-regulated genes
    Jason M O'Brien
    Centre for Advanced Research in Environmental Genomics, Department of Biology, University of Ottawa, Ottawa, Ontario, Canada
    Comp Biochem Physiol C Toxicol Pharmacol 149:524-30. 2009
    ..PFOS exposure via egg injection prior to incubation did not affect the transcriptional activity of any of the assayed PPARalpha-regulated genes at any of the doses examined in day 21 chicken embryos...
  67. doi request reprint Recombinant albumin and transthyretin transport proteins from two gull species and human: chlorinated and brominated contaminant binding and thyroid hormones
    Francisco Ucán-Marin
    Wildlife and Landscape Science Directorate, Science and Technology Branch, Environment Canada, National Wildlife Research Centre, Carleton University, Ottawa, ON, K1A 0H3, Canada
    Environ Sci Technol 44:497-504. 2010
    ..This suggests the possibility that OH-substituted organohalogen contaminants may be an exposure concern to the thyroid system in free-ranging gulls as well as for humans...
  68. ncbi request reprint Circumpolar study of perfluoroalkyl contaminants in polar bears (Ursus maritimus)
    Marla Smithwick
    Department of Environmental Biology, University of Guelph, Bovey Building, Guelph, Ontario N1G 2W1, Canada
    Environ Sci Technol 39:5517-23. 2005
    ....
  69. doi request reprint Maternally derived testosterone and 17beta-estradiol in the eggs of Arctic-breeding glaucous gulls in relation to persistent organic pollutants
    Nanette Verboven
    Division of Cell Sciences, Institute of Comparative Medicine, University of Glasgow Veterinary School, 464 Bearsden Road, Glasgow G61 1QH, Scotland, UK
    Comp Biochem Physiol C Toxicol Pharmacol 148:143-51. 2008
    ....
  70. doi request reprint Cytochrome P4501A1 expression, polychlorinated biphenyls and hydroxylated metabolites, and adipocyte size of bottlenose dolphins from the Southeast United States
    Eric W Montie
    Woods Hole Oceanographic Institution WHOI, Woods Hole, MA, United States
    Aquat Toxicol 86:397-412. 2008
    ..The OH-PCBs thus formed have the potential to interfere with thyroid hormone homeostasis...
  71. pmc Do organohalogen contaminants contribute to histopathology in liver from East Greenland polar bears (Ursus maritimus)?
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, Roskilde, Denmark
    Environ Health Perspect 113:1569-74. 2005
    ....
  72. ncbi request reprint Perfluorinated alkyl substances in plasma, liver, brain, and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian arctic
    Jonathan Verreault
    Norwegian Polar Institute, Tromsø, NO 9296, Norway
    Environ Sci Technol 39:7439-45. 2005
    ....
  73. ncbi request reprint Inhibition and induction of aromatase (CYP19) activity by brominated flame retardants in H295R human adrenocortical carcinoma cells
    Rocío F Cantón
    Institute for Risk Assessment Sciences, IRAS Utrecht University, The Netherlands
    Toxicol Sci 88:447-55. 2005
    ..These in vitro results provide a basis for studies of more detailed structure-activity relationships between these brominated compounds and the modulation of aromatase activity...
  74. ncbi request reprint Flame retardants and methoxylated and hydroxylated polybrominated diphenyl ethers in two Norwegian Arctic top predators: glaucous gulls and polar bears
    Jonathan Verreault
    Norwegian Polar Institute, Tromsø, NO 9296, Norway
    Environ Sci Technol 39:6021-8. 2005
    ..Our findings suggest that there are dissimilar biochemical mechanisms involved in PCB and PBDE metabolism and accumulation/elimination and/or OH-PBDE accumulation and retention in glaucous gulls and polar bears...
  75. ncbi request reprint Perflouroalkyl contaminants in liver tissue from East Greenland polar bears (Ursus maritimus)
    Marla Smithwick
    Department of Environmental Biology, University of Guelph, Guelph, Ontario N1G 2W1, Canada
    Environ Toxicol Chem 24:981-6. 2005
    ..No significant correlations were found between concentrations of PFCAs in liver tissue and previously reported polychlorinated biphenyl (PCB) congeners analyzed in fat samples from the same bears...
  76. pmc Is bone mineral composition disrupted by organochlorines in east Greenland polar bears (Ursus maritimus)?
    Christian Sonne
    National Environmental Research Institute, Department of Arctic Environment, Roskilde, Denmark
    Environ Health Perspect 112:1711-6. 2004
    ..06). In conclusion, the strong correlative relationships suggest that disruption of the bone mineral composition in East Greenland polar bears may have been caused by organochlorine exposure...
  77. ncbi request reprint Dietary accumulation and metabolism of polybrominated diphenyl ethers by juvenile carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Toxicol Chem 23:1939-46. 2004
    ..This study suggests that BDEs have significantly different fate dynamics relative to PCBs in wild carp and likely other species of fish...
  78. pmc A reassessment of the nomenclature of polychlorinated biphenyl (PCB) metabolites
    Johan Maervoet
    Toxicological Center, University of Antwerp, Universiteitsplein 1, 2610 Wilrijk, Belgium
    Environ Health Perspect 112:291-4. 2004
    ....
  79. ncbi request reprint Debromination of polybrominated diphenyl ether congeners BDE 99 and BDE 183 in the intestinal tract of the common carp (Cyprinus carpio)
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland, Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Sci Technol 38:1054-61. 2004
    ..Reactions occurring within the gut transform BDE congeners to other products that may accumulate or be excreted. Further studies are needed to identify and determine the effects of these BDE metabolites...
  80. ncbi request reprint Debromination of the flame retardant decabromodiphenyl ether by juvenile carp (Cyprinus carpio) following dietary exposure
    Heather M Stapleton
    Chesapeake Biological Laboratory, University of Maryland Center for Environmental Science, Solomons, Maryland 20688, USA
    Environ Sci Technol 38:112-9. 2004
    ..Although exposure of carp to BDE 209 did not result in the accumulation of BDE 209 in carp tissues, our results indicate evidence of limited BDE 209 bioavailability from food in the form of lower brominated metabolites...
  81. ncbi request reprint Metabolism in the toxicokinetics and fate of brominated flame retardants--a review
    Heldur Hakk
    USDA ARS, Biosciences Research Laboratory, 1605 Albrecht Blvd, Fargo, ND 58105, USA
    Environ Int 29:801-28. 2003
    ....
  82. ncbi request reprint The state-of-the-science and trends of brominated flame retardants in the environment: present knowledge and future directions
    Robert J Letcher
    Environ Int 29:663-4. 2003
  83. ncbi request reprint New organochlorine contaminants and metabolites in plasma and eggs of glaucous gulls (Larus hyperboreus) from the Norwegian Arctic
    Jonathan Verreault
    Norwegian Polar Institute, Tromsø, NO 9296, Norway
    Environ Toxicol Chem 24:2486-99. 2005
    ..As part of a complex profile of contaminant exposure, these chemical classes and metabolites may be contributing factors to enhance physiological stress in breeding glaucous gulls...
  84. ncbi request reprint Maternal transfer of organohalogen contaminants and metabolites to eggs of Arctic-breeding glaucous gulls
    Jonathan Verreault
    Norwegian Polar Institute, Department of Ecotoxicology, The Polar Environment Centre, Tromsø, NO 9296, Norway
    Environ Pollut 144:1053-60. 2006
    ..In general, maternal transfer favored low K(ow) and/or less persistent compounds, whereas the recalcitrant and/or higher-halogenated compounds were less readily transferred, and consequently more selectively retained in the mother...
  85. ncbi request reprint Geographic distribution of selected elements in the livers of polar bears from Greenland, Canada and the United States
    Scott A Rush
    University of Georgia, Warnell School of Forestry and Natural Resources, Athens, GA 30602 2152, USA
    Environ Pollut 153:618-26. 2008
    ..Concentrations of most elements in the polar bears did not exceed toxicity thresholds, although Cd and Hg exceeded levels correlated with the formation of hepatic lesions in laboratory animals...
  86. ncbi request reprint Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail
    Christian Sonne
    Section for Contaminants, Effects and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, University of Aarhus, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
    Environ Res 106:72-80. 2008
    ..It is reasonable to infer that other apex predators such as polar bears (Ursus maritimus) and humans may suffer from similar impacts...
  87. ncbi request reprint Brominated flame retardants in glaucous gulls from the Norwegian Arctic: more than just an issue of polybrominated diphenyl ethers
    Jonathan Verreault
    Norwegian Polar Institute, Tromsø NO 9296, Norway
    Environ Sci Technol 41:4925-31. 2007
    ....
  88. ncbi request reprint Effects of organohalogen pollutants on haematological and urine clinical-chemical parameters in Greenland sledge dogs (Canis familiaris)
    Christian Sonne
    Section for Contaminants and Marine Mammals, Department of Arctic Environment, National Environmental Research Institute, University of Aarhus, Roskilde, Denmark
    Ecotoxicol Environ Saf 69:381-90. 2008
    ..We therefore suggest that the consumption of contaminated Arctic marine blubber impacted liver and kidney function in adult and pup sledge dogs...
  89. ncbi request reprint Organohalogen contaminants and reproductive hormones in incubating glaucous gulls (Larus hyperboreus) from the Norwegian Arctic
    Jonathan Verreault
    Norwegian Polar Institute, Tromsø NO 9296, Norway
    Environ Toxicol Chem 25:2990-6. 2006
    ..Because significant effects were found in males exclusively, it cannot be completely ruled out that male glaucous gulls are more sensitive than females to organohalogen-mediated alteration of P4 synthesis and breakdown...
  90. ncbi request reprint Age and seasonal variability of polybrominated diphenyl ethers in free-ranging East Greenland polar bears (Ursus maritimus)
    Rune Dietz
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
    Environ Pollut 146:166-73. 2007
    ..We suggest that future geographical PBDE data comparisons may not need corrections for sex or age, but such data sets should be corrected for seasonal variability, using the presented correctional trigonometric regression...
  91. ncbi request reprint Xenoendocrine pollutants may reduce size of sexual organs in East Greenland polar bears (Ursus maritimus)
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, Frederiksborgvej 399, P O Box 358, DK 4000 Roskilde, Denmark
    Environ Sci Technol 40:5668-74. 2006
    ..This may pose a riskto this polar bear subpopulation in the future because of reduced sperm and egg quality/quantity and uterus and penis size/robustness...
  92. ncbi request reprint In vitro effects of brominated flame retardants and metabolites on CYP17 catalytic activity: a novel mechanism of action?
    Rocío F Cantón
    Institute for Risk Assessment Sciences IRAS, University of Utrecht, Yalelaan 2, 3508 TD, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 216:274-81. 2006
    ..These in vitro results indicate that OH and CH(3)O-PBDEs have potential to interfere with CYP17 activity for which the in vivo relevance still has to be adequately determined...
  93. ncbi request reprint Organohalogen contamination in breeding glaucous gulls from the Norwegian Arctic: associations with basal metabolism and circulating thyroid hormones
    Jonathan Verreault
    Norwegian Polar Institute, Polar Environmental Centre, NO 9296 Tromsø, Norway
    Environ Pollut 145:138-45. 2007
    ..The present study suggests that BMR may be altered in glaucous gulls exposed to high loadings of persistent contaminants in the Norwegian Arctic environment...
  94. ncbi request reprint Impairment of cellular immunity in west Greenland sledge dogs (Canis familiaris) dietary exposed to polluted minke whale (Balaenoptera acutorostrata) blubber
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, DK 4000 Roskilde, Denmark
    Environ Sci Technol 40:2056-62. 2006
    ..Additionally, our study suggests that the fatty acid composition may be of importance when investigating combined immunotoxic effects of contaminated food resources in future Inuit and polar bear studies...
  95. ncbi request reprint In vitro antiestrogenic effects of aryl methyl sulfone metabolites of polychlorinated biphenyls and 2,2-bis(4-chlorophenyl)-1,1-dichloroethene on 17beta-estradiol-induced gene expression in several bioassay systems
    Robert J Letcher
    Institute for Risk Assessment Sciences IRAS, Utrecht University, NL 3508 TD Utrecht, The Netherlands
    Toxicol Sci 69:362-72. 2002
    ..MeSO(2)-PCB metabolites are persistent and bioaccumulative contaminants, and therefore, could be potentially active as environmental antiestrogens in wildlife and humans...
  96. ncbi request reprint A high-performance-liquid-chromatography-based method for the determination of hydroxylated testosterone metabolites formed in vitro in liver microsomes from gray seal (Halichoerus grypus)
    Hongxia Li
    Great Lakes Institute for Environmental Research, University of Windsor, ON, Canada
    J Chromatogr Sci 40:397-402. 2002
    ..The within-day precision (relative standard deviation) is less than 3% for testosterone metabolites. Five relatively substantial peaks are detected but not identified...
  97. ncbi request reprint Debromination of polybrominated diphenyl ether-99 (BDE-99) in carp (Cyprinus carpio) microflora and microsomes
    Rae T Benedict
    University of Maryland Center for Environmental Science, Chesapeake Biological Laboratory, P O Box 38, Solomons, MD 20688, USA
    Chemosphere 69:987-93. 2007
    ....
  98. ncbi request reprint Are organohalogen contaminants a cofactor in the development of renal lesions in east Greenland polar bears (Ursus maritimus)?
    Christian Sonne
    Department of Arctic Environment, National Environmental Research Institute, P O Box 358, Frederiksborgvej 399, DK 4000 Roskilde, Denmark
    Environ Toxicol Chem 25:1551-7. 2006
    ..This is new and important knowledge in the assessment of health status among wildlife populations and humans relying on food resources that are contaminated with OHCs...