Sylvain Martel

Summary

Affiliation: Ecole Polytechnique
Country: Canada

Publications

  1. ncbi Preliminary investigation of the feasibility of magnetic propulsion for future microdevices in blood vessels
    Jean Baptiste Mathieu
    NanoRobotics Laboratory, Ecole Polytechnique de Montreal, Canada
    Biomed Mater Eng 15:367-74. 2005
  2. ncbi Magnetic resonance imaging of Fe3O4 nanoparticles embedded in living magnetotactic bacteria for potential use as carriers for in vivo applications
    Ouajdi Felfoul
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus of the Université de Montréal, Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:1463-6. 2007
  3. ncbi Magnetic field mapping by selective equipotential excitation
    Ouajdi Felfoul
    Dept of Comput Eng, Ecole Polytech de Montreal, Que
    Conf Proc IEEE Eng Med Biol Soc 1:3775-8. 2006
  4. ncbi Preliminary investigation of bio-carriers using magnetotactic bacteria
    Zhao Lu
    Dept of Comput Eng, Univ de Montréal, Que, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:3415-8. 2006
  5. ncbi Magnetic resonance propulsion, control and tracking at 24 Hz of an untethered device in the carotid artery of a living animal: an important step in the development of medical micro- and nanorobots
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus of the Université de Montréal, Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:1475-8. 2007
  6. doi Magnetic therapeutic delivery using navigable agents
    S Martel
    Departement of Computer and Software Engineering and Institute of Biomedical Engineering, Polytechnique Montréal Campus de l université de Montréal, PO Box 6079, Station Centre Ville, Montreal, Quebec, H3C 3A7, Canada
    Ther Deliv 5:189-204. 2014
  7. doi Bacterial microsystems and microrobots
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer and Software Engineering, and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Montreal, QC, Canada
    Biomed Microdevices 14:1033-45. 2012
  8. ncbi Towards MRI-controlled ferromagnetic and MC-1 magnetotactic bacterial carriers for targeted therapies in arteriolocapillar networks stimulated by tumoral angiogenesis
    Sylvain Martel
    Dept of Comput Eng, Ecole Polytech de Montreal, Que, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:3399-402. 2006
  9. doi Microrobotic navigable entities for Magnetic Resonance Targeting
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer and Software Engineering, and the Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Quebec, P O Box 6079 Station Centre Ville, H3C 3A7 Canada
    Conf Proc IEEE Eng Med Biol Soc 2010:1942-5. 2010
  10. ncbi Medical and technical protocol for automatic navigation of a wireless device in the carotid artery of a living swine using a standard clinical MRI system
    Sylvain Martel
    Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus de l Université de Montréal, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Med Image Comput Comput Assist Interv 10:144-52. 2007

Collaborators

Detail Information

Publications41

  1. ncbi Preliminary investigation of the feasibility of magnetic propulsion for future microdevices in blood vessels
    Jean Baptiste Mathieu
    NanoRobotics Laboratory, Ecole Polytechnique de Montreal, Canada
    Biomed Mater Eng 15:367-74. 2005
    ..370 +/- 0.0064 l/min (19.5 cm/s) and 0.311 +/- 0.01209 l/min (16.4 cm/s) respectively when placed inside a 6.35 mm diameter PMMA tube and subjected to a 18 mT/m magnetic field gradient...
  2. ncbi Magnetic resonance imaging of Fe3O4 nanoparticles embedded in living magnetotactic bacteria for potential use as carriers for in vivo applications
    Ouajdi Felfoul
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus of the Université de Montréal, Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:1463-6. 2007
    ..These results show that a bacterial concentration of 2.2x10(7) cells/mL can be detected using a T2-weighted image, which is very encouraging to further investigate the application of MTB for in vivo applications...
  3. ncbi Magnetic field mapping by selective equipotential excitation
    Ouajdi Felfoul
    Dept of Comput Eng, Ecole Polytech de Montreal, Que
    Conf Proc IEEE Eng Med Biol Soc 1:3775-8. 2006
    ..This method can help in the correction of susceptibility artifacts by providing an accurate map of the perturbing field generated by magnetic markers on medical instruments...
  4. ncbi Preliminary investigation of bio-carriers using magnetotactic bacteria
    Zhao Lu
    Dept of Comput Eng, Univ de Montréal, Que, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:3415-8. 2006
    ..The effects on the MTB's swimming speed under the control of micro-electromagnets and influenced by the wall effects when each MTB is attached to a microbead are investigated...
  5. ncbi Magnetic resonance propulsion, control and tracking at 24 Hz of an untethered device in the carotid artery of a living animal: an important step in the development of medical micro- and nanorobots
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus of the Université de Montréal, Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:1475-8. 2007
    ..Here, based on these initial experimental data obtained in vivo, such strategies and methods are briefly described with some initial design concepts of medical interventional micro- and nanorobots...
  6. doi Magnetic therapeutic delivery using navigable agents
    S Martel
    Departement of Computer and Software Engineering and Institute of Biomedical Engineering, Polytechnique Montréal Campus de l université de Montréal, PO Box 6079, Station Centre Ville, Montreal, Quebec, H3C 3A7, Canada
    Ther Deliv 5:189-204. 2014
    ..If the introduction of engineering and principles of robotics to provide complementary techniques in targeted cancer therapy prove to be beneficial, it could influence future delivery methods and the synthesis of therapeutic carriers. ..
  7. doi Bacterial microsystems and microrobots
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer and Software Engineering, and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Montreal, QC, Canada
    Biomed Microdevices 14:1033-45. 2012
    ....
  8. ncbi Towards MRI-controlled ferromagnetic and MC-1 magnetotactic bacterial carriers for targeted therapies in arteriolocapillar networks stimulated by tumoral angiogenesis
    Sylvain Martel
    Dept of Comput Eng, Ecole Polytech de Montreal, Que, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:3399-402. 2006
    ..Based on preliminary experimental results, carriers and a new method combining the induction of force in a ferromagnetic material with the thrust provided by MTB for direct targeting to the tumor mass are proposed...
  9. doi Microrobotic navigable entities for Magnetic Resonance Targeting
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer and Software Engineering, and the Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Quebec, P O Box 6079 Station Centre Ville, H3C 3A7 Canada
    Conf Proc IEEE Eng Med Biol Soc 2010:1942-5. 2010
    ....
  10. ncbi Medical and technical protocol for automatic navigation of a wireless device in the carotid artery of a living swine using a standard clinical MRI system
    Sylvain Martel
    Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus de l Université de Montréal, P O Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    Med Image Comput Comput Assist Interv 10:144-52. 2007
    ..In the context of this demonstration, many challenges which provide insights about concrete issues of future nanomedical interventions and interventional platforms have been identified and addressed...
  11. ncbi A computer-assisted protocol for endovascular target interventions using a clinical MRI system for controlling untethered microdevices and future nanorobots
    Sylvain Martel
    NanoRobotics Laboratory, Department of Computer and Software Engineering, and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Montreal, Canada
    Comput Aided Surg 13:340-52. 2008
    ....
  12. doi Corrosion study of iron-cobalt alloys for MRI-based propulsion embedded in untethered microdevices operating in the vascular network
    Pierre Pouponneau
    NanoRobotics Laboratory, Ecole Polytechnique de Montreal EPM, Montreal, Canada
    J Biomed Mater Res B Appl Biomater 93:203-11. 2010
    ..This study concluded that Fe-Co alloys could be used preferably in medical microdevices if they were coated so as not to come in contact with physiological solutions...
  13. doi Interventional procedure based on nanorobots propelled and steered by flagellated magnetotactic bacteria for direct targeting of tumors in the human body
    Sylvain Martel
    Department of Computer and Software Engineering, NanoRobotics Laboratory, Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, Quebec, Station Centre Ville, Canada
    Conf Proc IEEE Eng Med Biol Soc 2008:2497-500. 2008
    ....
  14. doi Encapsulation of magnetotactic bacteria for targeted and controlled delivery of anticancer agents for tumor therapy
    Fatemeh Afkhami
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Institute ofBiomedical Engineering, Ecole Polytechnique de Montreal, Montreal, Canada
    Conf Proc IEEE Eng Med Biol Soc 2011:6668-71. 2011
    ..The survival of the encapsulated bacteria was monitored. The release of bacteria from giant vesicles was also studied in different time intervals and conditions...
  15. ncbi Magnetic steering of iron oxide microparticles using propulsion gradient coils in MRI
    Jean Baptiste Mathieu
    Dept of Computer Engineering, Ecole Polytechnique de Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:472-5. 2006
    ..The experimental results based on the percentage of particles retrieved at the targeted outlet during the experiments show that magnetic gradient steering in the human cardiovascular system within an MRI bore can be envisioned...
  16. ncbi Bidimensional MRI-based navigation system using a PID controller
    Samer Tamaz
    Dept of Comput Eng, Ecole Polytech de Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:4424-7. 2006
    ..Preliminary experimental results confirm that a simple PID controller can be suitable for several applications where targeting out-of-reach locations within the cardiovascular system is essential...
  17. doi Thermoresponsive hydrogel with embedded magnetic nanoparticles for the implementation of shrinkable medical microrobots and for targeting and drug delivery applications
    Jacinthe Lapointe
    NanoRobotics Laboratory, Ecole Polytechnique de Montreal, QC, H3T 1J4 Canada
    Conf Proc IEEE Eng Med Biol Soc 2009:4246-9. 2009
    ....
  18. ncbi Method of propulsion of a ferromagnetic core in the cardiovascular system through magnetic gradients generated by an MRI system
    Jean Baptiste Mathieu
    Ecole Polytechnique de Montreal, QC, Canada
    IEEE Trans Biomed Eng 53:292-9. 2006
    ....
  19. doi Corrosion study of single crystal Ni-Mn-Ga alloy and Tb0.27Dy0.73Fe1.95 alloy for the design of new medical microdevices
    Pierre Pouponneau
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, C P 6079, Succursale Centre Ville, Montreal, QC, H3C 3A7, Canada
    J Mater Sci Mater Med 22:237-45. 2011
    ..They could only be used for medical applications if they are coated with high strain biocompatible materials or embedded in composites to prevent direct contact with physiological fluids...
  20. doi Real-time MRI-based control of a ferromagnetic core for endovascular navigation
    Samer Tamaz
    Ecole Polytechnique de Montreal, Montreal, QC H3C 3A7, Canada
    IEEE Trans Biomed Eng 55:1854-63. 2008
    ..The experimental results suggest the likelihood of controlling untethered microdevices or robots equipped with a ferromagnetic core inside complex pathways in the human body...
  21. doi Magnetic nanoparticles encapsulated into biodegradable microparticles steered with an upgraded magnetic resonance imaging system for tumor chemoembolization
    Pierre Pouponneau
    NanoRobotics Laboratory, Canada Research Chair in Micro Nanosystem Development, Fabrication and Validation, Department of Computer and Software Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, C P 6079, Succursale Centre Ville, Montreal, Quebec H3C 3A7, Canada
    Biomaterials 30:6327-32. 2009
    ..The data presented in this paper confirms the feasibility of the steering of these TMMC...
  22. doi Adapting the clinical MRI software environment for real-time navigation of an endovascular untethered ferromagnetic bead for future endovascular interventions
    Arnaud Chanu
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, Campus of the University of Montréal, Montreal, Canada
    Magn Reson Med 59:1287-97. 2008
    ..These preliminary feasibility experiments suggest that navigation of such devices can be achieved using a similar software architecture on other conventional clinical MRI systems at an operational closed-loop control frequency of 32 Hz...
  23. doi Preliminary design of a SIMO fuzzy controller for steering microparticles inside blood vessels by using a magnetic resonance imaging system
    Ke Peng
    NanoRobotics Laboratory, Department of Computer Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, QC H3T 1J4, Canada
    Conf Proc IEEE Eng Med Biol Soc 2011:920-3. 2011
    ..The validity of the fuzzy controller has been tested by preliminary simulation results...
  24. ncbi Ferromagnetic artifacts in MRI: minimization of motion effects in long TR acquisitions
    Eric Aboussouan
    Dept of Comput Eng, Ecole Polytech de Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:1750-3. 2006
    ..At approximately 6.4 cm, no distortion or signal loss is observed. These results suggest that slow breathing motion can be measured and/or gated using the undistorted parts of the images...
  25. doi Co-encapsulation of magnetic nanoparticles and doxorubicin into biodegradable microcarriers for deep tissue targeting by vascular MRI navigation
    Pierre Pouponneau
    Department of Computer and Software Engineering, Ecole Polytechnique de Montreal EPM, Montreal, Quebec, Canada
    Biomaterials 32:3481-6. 2011
    ..Parameters such as flow velocity, TMMC release site in the artery, magnetic gradient and TMMC properties, affected the steering efficiency. These data illustrate the potential of MRN to improve drug targeting in deep tissues...
  26. ncbi Initial design of a bacterial actuated microrobot for operations in an aqueous medium
    Walder Andre
    Dept of Comput Eng, Ecole Polytech de Montreal, Que, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:2824-7. 2006
    ..The work presented is an initial step towards the development of platforms capable of relatively complex tasks being executed by a swarm of such microrobots pre-programmed with various behaviors...
  27. ncbi Magnetic microparticle steering within the constraints of an MRI system: proof of concept of a novel targeting approach
    Jean Baptiste Mathieu
    Department of Computer Engineering and Institute of Biomedical Engineering, NanoRobotics Laboratory, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
    Biomed Microdevices 9:801-8. 2007
    ..Furthermore, these results establish a proof of concept of microparticle steering using magnetic gradients within an MRI bore for applications in the human cardiovascular system...
  28. doi Steering of aggregating magnetic microparticles using propulsion gradients coils in an MRI Scanner
    Jean Baptiste Mathieu
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
    Magn Reson Med 63:1336-45. 2010
    ..A simple analytical method based on magnetophoretic velocity predictions and geometric considerations is proposed for steering ratio calculation...
  29. doi Poly(N-isopropylacrylamide) beads synthesis with nanoparticles embedded for the implementation of shrinkable medical microrobots for biomedical applications
    Jacinthe Lapointe
    NanoRobotics Laboratory, Department of Computer Engineering, Ecole Polytechnique of Montreal, QC, Canada, H3J 1J4
    Conf Proc IEEE Eng Med Biol Soc 2010:3800-3. 2010
    ..Finally, transition temperature has been increase over the body temperature by copolymerization with acrylic acid...
  30. doi Magnetotactic bacteria penetration into multicellular tumor spheroids for targeted therapy
    Nisryn Mokrani
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Ecole Polytechnique de Montreal, Quebec Canada, H3C 3A7
    Conf Proc IEEE Eng Med Biol Soc 2010:4371-4. 2010
    ..The results show the ability of these MTB when submitted to a directional magnetic field to penetrate inside a 3D multicellular tumor spheroid through openings present in the tissue...
  31. ncbi Assessment of navigation control strategy for magnetotactic bacteria in microchannel: toward targeting solid tumors
    Ouajdi Felfoul
    Department of Computer and Software Engineering, NanoRobotics Laboratory, Polytechnique de Montréal, Montreal, Quebec, Canada, H3C 3A7
    Biomed Microdevices 15:1015-24. 2013
    ..Besides targeted drug delivery to tumor sites using bacterial carrier, aggregation of microorganisms is required for micromanipulation and microassembly. ..
  32. ncbi MR imaging of therapeutic magnetic microcarriers guided by magnetic resonance navigation for targeted liver chemoembolization
    Pierre Pouponneau
    NanoRobotics Laboratory, Department of Computer and Software Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, C P 6079, Succursale Centre Ville, Montreal, QC, H3C 3A7, Canada
    Cardiovasc Intervent Radiol 37:784-90. 2014
    ....
  33. ncbi A microsensor for the detection of a single pathogenic bacterium using magnetotactic bacteria-based bio-carriers: simulations and preliminary experiments
    Ryan C Denomme
    NanoRobotics Laboratory, Department of Computer Engineering, Ecole Polytechnique de Montreal, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:99-102. 2007
    ..coli bacterium are considered to investigate their impedance variations. Furthermore, preliminary experimental data using a microfabricated microfluidic device connected to an impedance analyzer are presented...
  34. ncbi System for the validation of cell-tracking algorithms using on-demand simulated optical microscope images
    Béchara Moufarrej
    Dept of Comput Eng, Ecole Polytech de Montreal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:1960-3. 2006
    ..The system is designed to work well even in cases of three-dimensional, real-time or very fast moving cells, cases where other validation techniques fail. An evaluation of a popular particle tracker is also presented...
  35. doi Catheter steering using a Magnetic Resonance Imaging system
    Viviane Lalande
    NanoRobotics Laboratory, Ecole Polytechnique de Montreal EPM, Canada
    Conf Proc IEEE Eng Med Biol Soc 2010:1874-7. 2010
    ..Depending on the interactions between the spheres, progressive or discontinuous/jumping displacement was observed for increasing magnetic load. This phenomenon is accurately predicted by a simple theoretical dipole interaction model...
  36. ncbi High-precision absolute positioning of medical instruments in MRI systems
    Eric Aboussouan
    NanoRobotics Laboratory, Department of Computer Engineering, Ecole Polytechnique de Montreal, Campus of the Université de Montréal, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:743-6. 2006
    ..The validity of the method has been demonstrated and its precision was found sufficient to correctly register the device position with MRI images...
  37. doi Effect of the chain of magnetosomes embedded in magnetotactic bacteria and their motility on magnetic resonance imaging
    Ouajdi Felfoul
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Ecole Polytechnique de Montreal, Quebec Canada, H3C 3A7
    Conf Proc IEEE Eng Med Biol Soc 2010:4367-70. 2010
    ..It is found that nanoparticles synthesized by MC-1 MTB are the predominant source of contrast in MRI over motion and the cell body...
  38. ncbi Biocompatibility of candidate materials for the realization of medical microdevices
    Pierre Pouponneau
    Laboratory for the Innovation and Analysis of the Bioperformance, Ecole Polytechnique de Montreal, Department of Computer Engineering, Institute of Biomedical Engineering, Quebec, Canada
    Conf Proc IEEE Eng Med Biol Soc 1:2362-5. 2006
    ....
  39. ncbi Covalent binding of nanoliposomes to the surface of magnetotactic bacteria for the synthesis of self-propelled therapeutic agents
    Samira Taherkhani
    NanoRobotics Laboratory, Department of Computer and Software Engineering, Institute of Biomedical Engineering, Polytechnique Montréal, Montreal, Quebec, Canada H3C3A7
    ACS Nano 8:5049-60. 2014
    ..Cytotoxicity assays using three different cell types (J774, NIH/3T3, and Colo205) reveal that liposomal attachments to MTB formulation improve the biocompatibility of MTB, whereas attachment does not interfere with liposomal uptake. ..
  40. ncbi Therapeutic magnetic microcarriers guided by magnetic resonance navigation for enhanced liver chemoembilization: a design review
    Pierre Pouponneau
    NanoRobotics Laboratory, Department of Computer and Software Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal EPM, C P 6079, Succ Centre Ville, Montreal, QC, H3C 3A7, Canada
    Ann Biomed Eng 42:929-39. 2014
    ....
  41. ncbi An integrated biosensor for the detection of bio-entities using magnetotactic bacteria and CMOS technology
    Jaouad El Fouladi
    Electrical Engineering Department, Ecole Polytechnique de Montreal, Canada
    Conf Proc IEEE Eng Med Biol Soc 2007:119-22. 2007
    ....

Research Grants2

  1. MRI-BASED TUMOR TARGETING ENHANCEMENT WITH MAGNETOTACTIC BACTERIAL CARRIERS
    Sylvain Martel; Fiscal Year: 2007
    ..Navigation control of such bacterial carriers will be performed by changing the direction of the magnetic field under computer control to "migrate" such bacteria towards the tumoral region. ..