Caroline D Hoemann

Summary

Affiliation: Ecole Polytechnique
Country: Canada

Publications

  1. doi Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism and lactate-based media acidification
    Caroline D Hoemann
    Department of Chemical Engineering, Institute of Biomedical Engineering, FRQS Groupe de Recherche en Sciences et Technologies Biomédicales GRSTB, Ecole Polytechnique, 2900 Blvd Edouard Montpetit, Montreal, Quebec, H3T 1J4, Canada
    Molecules 18:1015-35. 2013
  2. ncbi The cartilage-bone interface
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    J Knee Surg 25:85-97. 2012
  3. pmc Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair
    Pascale Simard
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ CHUL, Laurier, Quebec G1V 4G2, Canada
    Arthritis Res Ther 11:R74. 2009
  4. doi In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7, Canada
    Pathol Biol (Paris) 57:318-23. 2009
  5. doi Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7 Canada
    Am J Sports Med 38:1845-56. 2010
  6. ncbi Cytocompatible gel formation of chitosan-glycerol phosphate solutions supplemented with hydroxyl ethyl cellulose is due to the presence of glyoxal
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    J Biomed Mater Res A 83:521-9. 2007
  7. ncbi Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 15:78-89. 2007
  8. ncbi Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects
    Caroline D Hoemann
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec H3C 3A7, Canada
    J Bone Joint Surg Am 87:2671-86. 2005
  9. ncbi Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    C D Hoemann
    Biomedical and Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 13:318-29. 2005
  10. pmc Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix depositio
    Charles Hubert Lafantaisie-Favreau
    Institute of Biomedical Engineering, Ecole Polytechnique, C, P, 6079 succ, Centre Ville, Montreal, QC, H3C 3A7, Canada
    BMC Musculoskelet Disord 14:27. 2013

Collaborators

Detail Information

Publications32

  1. doi Chitosan rate of uptake in HEK293 cells is influenced by soluble versus microparticle state and enhanced by serum-induced cell metabolism and lactate-based media acidification
    Caroline D Hoemann
    Department of Chemical Engineering, Institute of Biomedical Engineering, FRQS Groupe de Recherche en Sciences et Technologies Biomédicales GRSTB, Ecole Polytechnique, 2900 Blvd Edouard Montpetit, Montreal, Quebec, H3T 1J4, Canada
    Molecules 18:1015-35. 2013
    ....
  2. ncbi The cartilage-bone interface
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    J Knee Surg 25:85-97. 2012
    ..The tidemark can be regenerated through a bone marrow-driven growth process of EO near the articular surface...
  3. pmc Neutrophils exhibit distinct phenotypes toward chitosans with different degrees of deacetylation: implications for cartilage repair
    Pascale Simard
    Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du CHUQ CHUL, Laurier, Quebec G1V 4G2, Canada
    Arthritis Res Ther 11:R74. 2009
    ..The effect of 95% deacetylated chitosan on the function of neutrophils was therefore also investigated and compared with that of 80% deacetylated chitosan...
  4. doi In vitro osteogenesis assays: influence of the primary cell source on alkaline phosphatase activity and mineralization
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7, Canada
    Pathol Biol (Paris) 57:318-23. 2009
    ....
  5. doi Scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, H3C 3A7 Canada
    Am J Sports Med 38:1845-56. 2010
    ..Alternatively activated (AA) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular bone repair...
  6. ncbi Cytocompatible gel formation of chitosan-glycerol phosphate solutions supplemented with hydroxyl ethyl cellulose is due to the presence of glyoxal
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    J Biomed Mater Res A 83:521-9. 2007
    ..These data indicate that chitosan-GP/HEC is suitable as an adhesive and injectable delivery vehicle for clinical orthopedic applications involving single use treatments that guide acute cartilage repair processes...
  7. ncbi Chitosan-glycerol phosphate/blood implants elicit hyaline cartilage repair integrated with porous subchondral bone in microdrilled rabbit defects
    C D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 15:78-89. 2007
    ....
  8. ncbi Chitosan-glycerol phosphate/blood implants improve hyaline cartilage repair in ovine microfracture defects
    Caroline D Hoemann
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique, P O Box 6079, Station Centre Ville, Montreal, Quebec H3C 3A7, Canada
    J Bone Joint Surg Am 87:2671-86. 2005
    ....
  9. ncbi Tissue engineering of cartilage using an injectable and adhesive chitosan-based cell-delivery vehicle
    C D Hoemann
    Biomedical and Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 13:318-29. 2005
    ..To regenerate damaged cartilage, cell-assisted repair is thus viewed as a promising therapy, despite being limited by the lack of a suitable technique to deliver and retain chondrogenic cells at the defect site...
  10. pmc Subchondral pre-solidified chitosan/blood implants elicit reproducible early osteochondral wound-repair responses including neutrophil and stromal cell chemotaxis, bone resorption and repair, enhanced repair tissue integration and delayed matrix depositio
    Charles Hubert Lafantaisie-Favreau
    Institute of Biomedical Engineering, Ecole Polytechnique, C, P, 6079 succ, Centre Ville, Montreal, QC, H3C 3A7, Canada
    BMC Musculoskelet Disord 14:27. 2013
    ....
  11. doi Young adult chondrocytes proliferate rapidly and produce a cartilaginous tissue at the gel-media interface in agarose cultures
    Nicolas Tran-Khanh
    Institute of Biomedical Engineering and Department of Chemical Engineering, Ecole Polytechnique, Quebec, Canada
    Connect Tissue Res 51:216-23. 2010
    ..It also provides an in vitro model system to study neocartilage appositional growth...
  12. doi Depth of subchondral perforation influences the outcome of bone marrow stimulation cartilage repair
    Hongmei Chen
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique of Montreal, PO 6079 Station Centre ville, Montreal, Quebec, Canada H3C 3A7
    J Orthop Res 29:1178-84. 2011
    ..120) according to the aggregate indicator described above. We conclude that the depth of bone marrow stimulation can exert important influences on cartilage repair outcomes...
  13. doi Effect of chitosan particles and dexamethasone on human bone marrow stromal cell osteogenesis and angiogenic factor secretion
    Jessica Guzmán-Morales
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Bone 45:617-26. 2009
    ....
  14. doi Microdrilled cartilage defects treated with thrombin-solidified chitosan/blood implant regenerate a more hyaline, stable, and structurally integrated osteochondral unit compared to drilled controls
    Catherine Marchand
    Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, Montreal, Quebec, Canada
    Tissue Eng Part A 18:508-19. 2012
    ..Compared with drilled controls, chitosan implants solidified with thrombin elicited a more hyaline and structurally integrated osteochondral unit, features needed for long-term durability...
  15. ncbi Drilling and microfracture lead to different bone structure and necrosis during bone-marrow stimulation for cartilage repair
    Hongmei Chen
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, P O 6079 Station Centre ville, Montreal, QC, Canada
    J Orthop Res 27:1432-8. 2009
    ..Additional ongoing studies suggest these differences significantly affect long-term cartilage repair outcome...
  16. doi Bone marrow stimulation of the medial femoral condyle produces inferior cartilage and bone repair compared to the trochlea in a rabbit surgical model
    Hongmei Chen
    Department of Chemical Engineering and Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada H3C 3A7
    J Orthop Res 31:1757-64. 2013
    ..We conclude that the location of cartilage lesions influences cartilage repair, with better outcome in TR versus MFC defects in rabbits. Meniscal degeneration is associated with cartilage damage...
  17. ncbi Chitosan-glycerol phosphate/blood implants increase cell recruitment, transient vascularization and subchondral bone remodeling in drilled cartilage defects
    A Chevrier
    Chemical Engineering, Ecole Polytechnique, PO Box 6079, Station Centre Ville, Montreal, Quebec, Canada
    Osteoarthritis Cartilage 15:316-27. 2007
    ....
  18. doi Meniscus structure in human, sheep, and rabbit for animal models of meniscus repair
    Anik Chevrier
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    J Orthop Res 27:1197-203. 2009
    ....
  19. doi Biodegradable chitosan particles induce chemokine release and negligible arginase-1 activity compared to IL-4 in murine bone marrow-derived macrophages
    Jessica Guzmán-Morales
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Biochem Biophys Res Commun 405:538-44. 2011
    ....
  20. doi Characterization of initial microfracture defects in human condyles
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    J Knee Surg 26:347-55. 2013
    ..This study revealed that subchondral bone sclerosis can reach a critical limit beyond which MFX creates bone compaction and fissures instead of marrow access. ..
  21. ncbi Aged bovine chondrocytes display a diminished capacity to produce a collagen-rich, mechanically functional cartilage extracellular matrix
    Nicolas Tran-Khanh
    Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    J Orthop Res 23:1354-62. 2005
    ..More specifically, primary chondrocytes from aged donors may not possess sufficient capacity to produce the extracellular matrix that is required for a mechanically resilient tissue...
  22. ncbi Fibronectin, vitronectin, and collagen I induce chemotaxis and haptotaxis of human and rabbit mesenchymal stem cells in a standardized transmembrane assay
    Marc M Thibault
    Department of Chemical Engineering, Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    Stem Cells Dev 16:489-502. 2007
    ..Finally, the similarity of motogenic behavior of both rabbit and human cells suggests the rabbit is a reliable model for assessing MSC recruitment in repair and regeneration strategies...
  23. doi Characterization of subchondral bone repair for marrow-stimulated chondral defects and its relationship to articular cartilage resurfacing
    Hongmei Chen
    Chemical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada
    Am J Sports Med 39:1731-40. 2011
    ..This study examined the effect of hole depth and of microfracture versus drilling on subchondral bone repair and cartilage repair in full-thickness chondral defects...
  24. doi Standardized three-dimensional volumes of interest with adapted surfaces for more precise subchondral bone analyses by micro-computed tomography
    Catherine Marchand
    Institute of Biomedical Engineering, Ecole Polytechnique de Montreal, Quebec, Canada
    Tissue Eng Part C Methods 17:475-84. 2011
    ..Structural differences between the bone plate and cancellous bone were best captured using the smaller, depth-dependent Curved-RAS model...
  25. ncbi A multivalent assay to detect glycosaminoglycan, protein, collagen, RNA, and DNA content in milligram samples of cartilage or hydrogel-based repair cartilage
    Caroline D Hoemann
    BioSynTech, 475 Armand Frappier, Laval, Quebec H7V 4B3, Canada
    Anal Biochem 300:1-10. 2002
    ..This multivalent assay could be applied to a variety of cells cultured in biopolymers and to tissues from which biochemical components may be otherwise difficult to extract...
  26. ncbi Ultrastructure of hybrid chitosan-glycerol phosphate blood clots by environmental scanning electron microscopy
    M Iliescu
    Department of Chemical Engineering, Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada H3C 3A7
    Microsc Res Tech 71:236-47. 2008
    ..e. 4% w/v) significantly disturb erythrocyte morphology in fixed whole blood clots...
  27. doi C3, C5, and factor B bind to chitosan without complement activation
    C Marchand
    Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, Quebec, Canada H3C 3A7
    J Biomed Mater Res A 93:1429-41. 2010
    ..These data demonstrate that chitosan is a nonreactive biomaterial that does not directly activate complement, and provide a novel basis for predicting anionic serum protein-chitosan interactions...
  28. doi Solidification mechanisms of chitosan-glycerol phosphate/blood implant for articular cartilage repair
    C Marchand
    Institute of Biomedical Engineering, Ecole Polytechnique, Montreal, QC, Canada
    Osteoarthritis Cartilage 17:953-60. 2009
    ..For clinical ease-of-use, a faster in situ solidification is preferred. Therefore, we investigated the mechanisms underlying chitosan-GP/blood implant solidification...
  29. doi Stress relaxation of swine growth plate in semi-confined compression: depth dependent tissue deformational behavior versus extracellular matrix composition and collagen fiber organization
    Samira Amini
    Department of Mechanical Engineering, Ecole Polytechnique de Montreal, Montreal, QC, Canada
    Biomech Model Mechanobiol 12:67-78. 2013
    ....
  30. ncbi Soluble recombinant neprilysin induces aggrecanase-mediated cleavage of aggrecan in cartilage explant cultures
    A Chevrier
    Biomedical and Chemical Engineering, Ecole Polytechnique, Station Centre-ville, Montreal, Quebec H3C 3A7, Canada
    Arch Biochem Biophys 396:178-86. 2001
    ..These results suggest that NEP is present as a transmembrane enzyme on articular chondrocytes where it can cleave regulatory peptides and lead to the induction of aggrecanase...
  31. doi At-line quantification of bioactive antibody in bioreactor by surface plasmon resonance using epitope detection
    Natalie Chavane
    Department of Chemical Engineering, Ecole Polytechnique de Montreal, Montreal, QC H3C3A7, Canada
    Anal Biochem 378:158-65. 2008
    ..Our experimental approach represents a novel and robust analytical strategy to be applied to the control and optimization of the production of bioactive secreted proteins...
  32. ncbi Molecular and biochemical assays of cartilage components
    Caroline D Hoemann
    Department of Chemical Engineering, Ecole Polytechnique de Montreal, Quebec, Canada
    Methods Mol Med 101:127-56. 2004
    ..Samples between 1 and 5 mg may be directly digested with a small volume of papain buffer for DMB, hydroxyproline, and Hoechst DNA assays...