Claire M Dubois

Summary

Country: Canada

Publications

  1. pmc HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 8:e55529. 2013
  2. pmc Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)
    Fabrice Lucien
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada
    PLoS ONE 6:e28851. 2011
  3. pmc Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
    Annie Lauzier
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universit de Sherbrooke, 3001 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    Arthritis Res Ther 14:R159. 2012
  4. ncbi request reprint Sox9-dependent transcriptional regulation of the proprotein convertase furin
    Philippe Guimont
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, QC, Canada J1H 5N4
    Am J Physiol Cell Physiol 293:C172-83. 2007
  5. doi request reprint Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 227:789-800. 2012
  6. ncbi request reprint Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    Stephanie McMahon
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Biol Chem 281:24171-81. 2006
  7. ncbi request reprint Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, and Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
    J Immunol 182:563-71. 2009
  8. doi request reprint Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src
    Annie Lauzier
    Department of Pediatrics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Arthritis Rheum 63:1591-602. 2011
  9. doi request reprint The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils
    Thomas Z Mayer
    Service de Pneumologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Immunol 191:4299-307. 2013
  10. ncbi request reprint Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins
    Stephanie McMahon
    Immunology Division, Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec
    J Biol Chem 280:6561-9. 2005

Collaborators

Detail Information

Publications18

  1. pmc HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 8:e55529. 2013
    ..The identification of HDAC6 as a key participant of hypoxia-induced cell invasion may have important therapeutic implications for the treatment of metastasis in cancer patients...
  2. pmc Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)
    Fabrice Lucien
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada
    PLoS ONE 6:e28851. 2011
    ..This study reveals an unsuspected role of p90RSK in tumor cell invasion and establishes p90RS kinase as a link between hypoxia and the acidic microenvironment of tumors...
  3. pmc Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
    Annie Lauzier
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universit de Sherbrooke, 3001 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    Arthritis Res Ther 14:R159. 2012
    ..CONCLUSIONS: TG2, through its TGase activity, is required for ECM degradation in arthritic FLS and CIA joints. Our findings provide a potential target to prevent cartilage degradation in RA...
  4. ncbi request reprint Sox9-dependent transcriptional regulation of the proprotein convertase furin
    Philippe Guimont
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, QC, Canada J1H 5N4
    Am J Physiol Cell Physiol 293:C172-83. 2007
    ..Our work suggests a mechanism by which furin is regulated during chondrogenesis. It also adds to the complexity of Sox molecule interaction during gene regulation...
  5. doi request reprint Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 227:789-800. 2012
    ..Our observations support the notion that hypoxia promotes the formation of a peripheral processing compartment where furin translocates for enhanced processing of proproteins involved in tumorigenesis...
  6. ncbi request reprint Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression
    Stephanie McMahon
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Biol Chem 281:24171-81. 2006
    ..This study reveals a novel mechanism by which a growth factor controls HIF-1 stability, and thereby drives the expression of specific genes, through the regulation of PHD2 levels...
  7. ncbi request reprint Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, and Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
    J Immunol 182:563-71. 2009
    ..This is the first demonstration that C/EBP factors are important regulators of cytokine expression in human neutrophils...
  8. doi request reprint Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src
    Annie Lauzier
    Department of Pediatrics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Arthritis Rheum 63:1591-602. 2011
    ..This study was undertaken to investigate whether arthritic synovial cells use invadopodia to invade and degrade cartilage components...
  9. doi request reprint The p38-MSK1 signaling cascade influences cytokine production through CREB and C/EBP factors in human neutrophils
    Thomas Z Mayer
    Service de Pneumologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Immunol 191:4299-307. 2013
    ..These are all potential molecular targets that could be exploited in the context of several chronic inflammatory diseases that prominently feature neutrophils and their products. ..
  10. ncbi request reprint Hypoxia-enhanced expression of the proprotein convertase furin is mediated by hypoxia-inducible factor-1: impact on the bioactivation of proproteins
    Stephanie McMahon
    Immunology Division, Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec
    J Biol Chem 280:6561-9. 2005
    ..Our findings unveil a new facet of the physiological consequences of hypoxia/HIF-1, through enhanced furin-induced proteolytic processing/activation of proproteins known to be involved in tumorigenesis...
  11. ncbi request reprint Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells
    Martine Charbonneau
    Immunology Division, Departments of Pediatrics, Universite de Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 282:33714-24. 2007
    ..These findings suggest a mechanism by which TACE is increased in RA-affected joints. They also provide novel mechanistic clues on the influence of the hypoxic and inflammatory microenvironment on joint diseases...
  12. doi request reprint Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation
    Kelly Harper
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Cancer Res 70:4634-43. 2010
    ....
  13. doi request reprint Leukotriene D4 up-regulates furin expression through CysLT1 receptor signaling
    Charles Thompson
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Am J Respir Cell Mol Biol 39:227-34. 2008
    ..These findings suggest that CysLT1 is involved in remodeling processes through modulation of furin transcription...
  14. ncbi request reprint Lipopolysaccharide mediated regulation of neuroendocrine associated proprotein convertases and neuropeptide precursor processing in the rat spleen
    Guillaume Lansac
    Departement de Pharmacologie, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada, J1H 5N4
    J Neuroimmunol 171:57-71. 2006
    ..Collectively, these data clearly implicate PCs in immune responses, both innate and acquired...
  15. ncbi request reprint The CDX2 transcription factor regulates furin expression during intestinal epithelial cell differentiation
    Fernand Pierre Gendron
    Département d Anatomie et de Biologie Cellulaire, Faculte de Medecine, Universite de Sherbrooke, Sherbrooke, QC, Canada J1H5N4
    Am J Physiol Gastrointest Liver Physiol 290:G310-8. 2006
    ..These results suggest that CDX2 regulates furin expression in intestinal epithelial cells. Furin may be important in modulating the maturation and/or activation of key factors involved in enterocyte differentiation...
  16. ncbi request reprint Differential involvement of NF-kappaB and MAP kinase pathways in the generation of inflammatory cytokines by human neutrophils
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, 3001, 12e Avenue Nord, pièce 4849, Sherbrooke, Quebec, Canada
    J Leukoc Biol 81:567-77. 2007
    ..Our data also raise the possibility that NF-kappaB or MAPK inhibitors could be useful in the treatment of inflammatory disorders in which neutrophils predominate...
  17. ncbi request reprint The serpin proteinase inhibitor 8: an endogenous furin inhibitor released from human platelets
    Julie Leblond
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada J1H 5N4
    Thromb Haemost 95:243-52. 2006
    ..The finding that PI8 is released by platelets and controls functional responses suggests a role for this serpin in platelet-regulated pathophysiological responses...
  18. ncbi request reprint Alternative pathway for the role of furin in tumor cell invasion process. Enhanced MMP-2 levels through bioactive TGFbeta
    Stephanie McMahon
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke QC, Canada J1H 5N4
    Exp Cell Res 291:326-39. 2003
    ..Taken together, our findings established the existence of a novel alternative/complementary pathway by which furin increases tumor cell invasion through an amplification/activation loop between MMP-2 and TGFbeta...