Claire M Dubois

Summary

Country: Canada

Publications

  1. pmc Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
    Annie Lauzier
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universit de Sherbrooke, 3001 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    Arthritis Res Ther 14:R159. 2012
  2. pmc HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 8:e55529. 2013
  3. doi request reprint Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src
    Annie Lauzier
    Department of Pediatrics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Arthritis Rheum 63:1591-602. 2011
  4. doi request reprint Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 227:789-800. 2012
  5. doi request reprint Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation
    Kelly Harper
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Cancer Res 70:4634-43. 2010
  6. pmc Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)
    Fabrice Lucien
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada
    PLoS ONE 6:e28851. 2011
  7. ncbi request reprint The p38-MSK1 Signaling Cascade Influences Cytokine Production through CREB and C/EBP Factors in Human Neutrophils
    Thomas Z Mayer
    Service de Pneumologie, Facult de M decine, Universit de Sherbrooke, Sherbrooke, Qu bec J1H 5N4, Canada
    J Immunol . 2013
  8. ncbi request reprint Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, and Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
    J Immunol 182:563-71. 2009
  9. ncbi request reprint Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells
    Martine Charbonneau
    Immunology Division, Departments of Pediatrics, Universite de Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 282:33714-24. 2007

Collaborators

  • Pierre Larivee
  • Dominique Arsenault
  • Kelly Harper
  • Annie Lauzier
  • Martine Charbonneau
  • Fabrice Lucien
  • Alexandre Cloutier
  • Patrick P McDonald
  • Thomas Z Mayer
  • Karine Brochu-Gaudreau
  • Fran ois A Simard
  • Harsh Vardhan
  • Maril ne Paquette
  • Manuela Jilaveanu-Pelmus
  • Stephanie Boulay-Jean
  • Chantal Guindi
  • Abdelaziz Amrani
  • Francine Grondin
  • Manuela Pelmus

Detail Information

Publications9

  1. pmc Transglutaminase 2 cross-linking activity is linked to invadopodia formation and cartilage breakdown in arthritis
    Annie Lauzier
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universit de Sherbrooke, 3001 12th North Avenue, Sherbrooke, Quebec, J1H 5N4, Canada
    Arthritis Res Ther 14:R159. 2012
    ..CONCLUSIONS: TG2, through its TGase activity, is required for ECM degradation in arthritic FLS and CIA joints. Our findings provide a potential target to prevent cartilage degradation in RA...
  2. pmc HDAC6 deacetylase activity is required for hypoxia-induced invadopodia formation and cell invasion
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    PLoS ONE 8:e55529. 2013
    ..The identification of HDAC6 as a key participant of hypoxia-induced cell invasion may have important therapeutic implications for the treatment of metastasis in cancer patients...
  3. doi request reprint Formation of invadopodia-like structures by synovial cells promotes cartilage breakdown in collagen-induced arthritis: involvement of the protein tyrosine kinase Src
    Annie Lauzier
    Department of Pediatrics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Arthritis Rheum 63:1591-602. 2011
    ..This study was undertaken to investigate whether arthritic synovial cells use invadopodia to invade and degrade cartilage components...
  4. doi request reprint Hypoxia enhances cancer cell invasion through relocalization of the proprotein convertase furin from the trans-Golgi network to the cell surface
    Dominique Arsenault
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    J Cell Physiol 227:789-800. 2012
    ..Our observations support the notion that hypoxia promotes the formation of a peripheral processing compartment where furin translocates for enhanced processing of proproteins involved in tumorigenesis...
  5. doi request reprint Autotaxin promotes cancer invasion via the lysophosphatidic acid receptor 4: participation of the cyclic AMP/EPAC/Rac1 signaling pathway in invadopodia formation
    Kelly Harper
    Immunology Division, Faculty of Medicine, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Cancer Res 70:4634-43. 2010
    ....
  6. pmc Hypoxia-induced invadopodia formation involves activation of NHE-1 by the p90 ribosomal S6 kinase (p90RSK)
    Fabrice Lucien
    Immunology Division, Department of Pediatrics, Faculty of Medicine and Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada
    PLoS ONE 6:e28851. 2011
    ..This study reveals an unsuspected role of p90RSK in tumor cell invasion and establishes p90RS kinase as a link between hypoxia and the acidic microenvironment of tumors...
  7. ncbi request reprint The p38-MSK1 Signaling Cascade Influences Cytokine Production through CREB and C/EBP Factors in Human Neutrophils
    Thomas Z Mayer
    Service de Pneumologie, Facult de M decine, Universit de Sherbrooke, Sherbrooke, Qu bec J1H 5N4, Canada
    J Immunol . 2013
    ..These are all potential molecular targets that could be exploited in the context of several chronic inflammatory diseases that prominently feature neutrophils and their products...
  8. ncbi request reprint Inflammatory cytokine production by human neutrophils involves C/EBP transcription factors
    Alexandre Cloutier
    Pulmonary Division, Faculty of Medicine, Universite de Sherbrooke, and Centre de recherche du CHUS, Sherbrooke, Quebec, Canada
    J Immunol 182:563-71. 2009
    ..This is the first demonstration that C/EBP factors are important regulators of cytokine expression in human neutrophils...
  9. ncbi request reprint Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells
    Martine Charbonneau
    Immunology Division, Departments of Pediatrics, Universite de Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 282:33714-24. 2007
    ..These findings suggest a mechanism by which TACE is increased in RA-affected joints. They also provide novel mechanistic clues on the influence of the hypoxic and inflammatory microenvironment on joint diseases...