Martel M, Balleydier A, Sauriol A, Drolet M. Constitutive stable DNA replication in Escherichia coli cells lacking type 1A topoisomerase activity. DNA Repair (Amst). 2015;35:37-47 pubmed publisher
..Thus, either topo I or III can provide the type 1A topo activity that is specifically required during cSDR to allow chromosome segregation. ..
Usongo V, Martel M, Balleydier A, Drolet M. Mutations reducing replication from R-loops suppress the defects of growth, chromosome segregation and DNA supercoiling in cells lacking topoisomerase I and RNase HI activity. DNA Repair (Amst). 2016;40:1-17 pubmed publisher
..Furthermore, we show that topo III overproduction is unable to complement the growth defect of topA rnhA null mutants at low temperatures that stabilizes hyper-negatively supercoiled DNA. ..
Drolet M. Growth inhibition mediated by excess negative supercoiling: the interplay between transcription elongation, R-loop formation and DNA topology. Mol Microbiol. 2006;59:723-30 pubmed
..Growth inhibition mediated by excess negative supercoiling might be related to this interplay between transcription elongation and supercoiling. ..
Martel M, Balleydier A, Brochu J, Drolet M. Detection of oriC-Independent Replication in Escherichia coli Cells. Methods Mol Biol. 2018;1703:131-138 pubmed publisher
..The oriC-independent replication is detected in fixed cells by flow cytometry and can be visualized by fluorescence microscopy. ..