Research Topics
Species | P S WellsSummaryAffiliation: Division of Anatomical Pathology Country: Canada Publications
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Detail Information
Publications
Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimerP S Wells
Department of Medicine, University of Ottawa, Ontario, Canada
Thromb Haemost 83:416-20. 2000..The combination of a score < or =4.0 by our simple clinical prediction rule and a negative SimpliRED D-Dimer result may safely exclude PE in a large proportion of patients with suspected PE...- Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injectionP S Wells
Department of Medicine, University of Ottawa, Ontario, Canada
Arch Intern Med 158:1809-12. 1998.... 
Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort studyG Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 9:1126-32. 2011..We sought to determine if RVO as determined by compression ultrasonography (CUS) after completion of 5-7 months of anticoagulation for unprovoked DVT is associated with an increased risk of recurrent venous thromboembolism (VTE)...- Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolismM J Kovacs
Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
J Thromb Haemost 8:1926-32. 2010.... - Prediction of the warfarin maintenance dose after completion of the 10 mg initiation nomogram: do we really need genotyping?G Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 8:90-4. 2010..A '10-mg nomogram' warfarin initiation protocol permits safe therapeutic anticoagulation in outpatients started on warfarin. We aimed to develop a safe and effective warfarin maintenance dose prediction tool in these patients... - Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTEM A Rodger
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
Thromb Res 126:222-6. 2010..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study... - A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)M J Kovacs
Department of Medicine, Victoria Hospital, London, ON, Canada
J Thromb Haemost 5:1650-3. 2007..Central venous catheters in patients with cancer are associated with development of deep vein thrombosis (DVT); however, there is no accepted standard treatment... - Validation of a diagnostic approach to exclude recurrent venous thromboembolismG Le Gal
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 7:752-9. 2009..Our objective was to evaluate the safety of a diagnostic strategy utilizing comparison of diagnostic test results with baseline imaging results to rule out suspected recurrent VTE... - Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studiesM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Thromb Haemost 8:1716-22. 2010..We sought to summarize the proportion of subsegmental PE diagnosed with single- and multiple-detectors CTPA and assess the safety of diagnostic strategies based on single- or multiple-detectors CTPA to exclude PE... - Extended outpatient therapy with low molecular weight heparin for the treatment of recurrent venous thromboembolism despite warfarin therapyC Luk
University of Western Ontario, London, Ontario, Canada
Am J Med 111:270-3. 2001.... - Clinical utility of a rapid whole-blood D-dimer assay in patients with cancer who present with suspected acute deep venous thrombosisA Y Lee
McMaster University, Hamilton, Ontario, Canada
Ann Intern Med 131:417-23. 1999..Although D-dimer assays have high negative predictive values for the diagnosis of deep venous thrombosis, their accuracy in patients with cancer is uncertain... - Outpatient treatment of patients with deep-vein thrombosis or pulmonary embolismP S Wells
Department of Medicine, Ottawa Health Research Institute, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
Curr Opin Pulm Med 7:360-4. 2001..Low-molecular-weight heparin followed by oral anticoagulant therapy provides adequate therapy in most patients with deep-vein thrombosis or pulmonary embolism, and many patients can be treated as outpatients... - Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)D R Anderson
Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
J Thromb Haemost 1:645-51. 2003..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting... - Assessment of deep vein thrombosis or pulmonary embolism by the combined use of clinical model and noninvasive diagnostic testsP S Wells
Department of Medicine, Ottawa Hospital and the University of Ottawa, Ontario, Canada
Semin Thromb Hemost 26:643-56. 2000..In addition, a negative result with less-sentive D-dimer testing and a low clinical probability excludes DVT or PE... - Diagnostic value of arterial blood gas measurement in suspected pulmonary embolismM A Rodger
Department of Medicine, University of Ottawa, Ontario, Canada
Am J Respir Crit Care Med 162:2105-8. 2000..We conclude that ABG data alone or in combination with other clinical data are not useful in the assessment of suspected PE... - Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysisM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
J Thromb Haemost 9:1119-25. 2011.... - The safety of dosing dalteparin based on actual body weight for the treatment of acute venous thromboembolism in obese patientsE Al-Yaseen
London Health Sciences Center, London, Ontario, Canada
J Thromb Haemost 3:100-2. 2005..0-3.0. All patients were followed for 12 weeks post diagnosis. Only two patients had a major hemorrhage, 4 and 8 weeks from diagnosis. This study supports the safety of dosing dalteparin based on actual body weight in obese patients... - Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrenceA Hamadah
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
J Thromb Haemost 9:2406-10. 2011..Whether baseline imaging, conducted after completion of anticoagulation, helps in interpreting diagnostic testing in patients who subsequently have suspected recurrent VTE is unknown... - Outpatient treatment of patients with pulmonary embolismP S Wells
Department of Medicine, Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada
Semin Vasc Med 1:229-34. 2001..Low-molecular-weight heparin or intravenous unfractionated heparin, followed by oral anticoagulant therapy, provide adequate therapy in most patients with PE, and many can be treated as outpatients... - Improvements in the diagnostic approach for patients with suspected deep vein thrombosis or pulmonary embolismD R Anderson
Department of Medicine, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
Thromb Haemost 82:878-86. 1999..There is still need to improve management strategies for the diagnosis of recurrent venous thrombosis and to determine whether diagnostic testing results may be correlated with long-term patient treatment needs... - Steady-state end-tidal alveolar dead space fraction and D-dimer: bedside tests to exclude pulmonary embolismM A Rodger
Department of Medicine, University of Ottawa, Ontario, Canada
Chest 120:115-9. 2001..15, (2) a negative D-dimer result, and (3) the combination of a steady-state end-tidal AVDSf of < 0.15 and a negative D-dimer result. Study design: Prospective cohort study... - D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatientsM Carrier
Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 6:1072-6. 2008..Deep vein thrombosis (DVT) can be safely and reliably excluded in patients with a low clinical probability and a negative D-dimer result but the accuracy and utility of such a strategy is unclear in elderly patients... - Diagnosis of deep-vein thrombosis in the year 2000P S Wells
Department of Medicine and Epidemiology and Community Medicine, Ottawa Hospital and the University of Ottawa, Ontario, Canada
Curr Opin Pulm Med 6:309-13. 2000..The combination of the D-dimer with clinical model assessment will enable diagnostic testing strategies that are more safe, effective, and convenient for patients... - Does this patient have deep vein thrombosis?S S Anand
Department of Medicine, McMaster University, Hamilton, Ontario, Canada
JAMA 279:1094-9. 1998..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)... - Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, ON, Canada
Clin Lab Haematol 28:9-13. 2006..8% of initial protein C and protein S results were accurate. If protein C and protein S are measured at the time of diagnosis of acute venous thromboembolism, the majority of the results will be normal and false positives are uncommon... - Prospective assessment of a nomogram for the initiation of oral anticoagulation therapy for outpatient treatment of venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Pathophysiol Haemost Thromb 32:131-3. 2002..There were no major bleeds and only 6 instances of INR >4.5. This outpatient warfarin nomogram appears to be safe and efficacious in obtaining timely therapeutic levels of warfarin and deserves further study... - Diagnosis of pulmonary embolismM Rodger
Department of Medicine, Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada
Thromb Res 103:V225-38. 2001..These algorithms permit safe diagnostic management of patients with suspected PE while limiting invasiveness, inaccessibility and expense... - A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolismP S Wells
University of Ottawa, Ottawa, Canada Ottawa Hospital Research Institute, Ottawa, Canada
Thromb Res 125:e259-64. 2010..We sought to develop a new algorithm to predict maintenance dose in a cohort of patients, using clinical variables and genetic polymorphism in CYP2C9, VKORC1, and CYP4F2... - A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolismM J Kovacs
Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
Br J Haematol 115:140-4. 2001..The SimpliRED D-dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism... - Thrombolysis in deep vein thrombosis: is there still an indication?P S Wells
Department of Medicine, University of Ottawa, Canada
Thromb Haemost 86:499-508. 2001..We conclude that more work is needed to define the role of thrombolytic therapy but it is too early to abandon this therapeutic modality... - Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control studyJ D Douketis
Department of Medicine, McMaster University, Hamilton, Canada
J Thromb Haemost 3:943-8. 2005..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT... - Günther Tulip filter: preliminary clinical experience with retrievalS F Millward
Department of Diagnostic Imaging, University of Ottawa, Ottawa Hospital, Ontario, Canada
J Vasc Interv Radiol 11:75-82. 2000..The Günther Tulip filter is a permanent filter that has a hook to permit retrieval. The authors report their preliminary clinical evaluation of the filter with regard to feasibility and safety of retrieval... - Use of recombinant-hirudin in pulmonary thromboendarterectomyF D Rubens
Department of Surgery, University of Ottawa, Ontario, Canada
Ann Thorac Surg 69:1942-3. 2000..Techniques for administration as well as monitoring of this drug's effects are discussed... - Integrated strategies for the diagnosis of venous thromboembolismP S Wells
Department of Medicine, Ottawa Hospital, Ottawa Health Research Institute, and the University of Ottawa, Ottawa, ON, Canada
J Thromb Haemost 5:41-50. 2007..These integration strategies result in safer, more convenient and cost-effective care for patients... - Cognitive and behavioural effects of genetic testing for thrombophiliaJ Heshka
University of Ottawa, Ottawa, Ontario, Canada
J Genet Couns 17:288-96. 2008..37.2% did not appreciate that thrombophilia increases risk. Behaviour changes were uncommon. There is a need for research on education and strategies to improve knowledge in thrombophilia carriers...