P S Wells

Summary

Affiliation: Division of Anatomical Pathology
Country: Canada

Publications

  1. ncbi Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Thromb Haemost 83:416-20. 2000
  2. ncbi Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injection
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Arch Intern Med 158:1809-12. 1998
  3. doi Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 9:1126-32. 2011
  4. doi Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism
    M J Kovacs
    Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
    J Thromb Haemost 8:1926-32. 2010
  5. doi Prediction of the warfarin maintenance dose after completion of the 10 mg initiation nomogram: do we really need genotyping?
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 8:90-4. 2010
  6. doi Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE
    M A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
    Thromb Res 126:222-6. 2010
  7. ncbi A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)
    M J Kovacs
    Department of Medicine, Victoria Hospital, London, ON, Canada
    J Thromb Haemost 5:1650-3. 2007
  8. doi Validation of a diagnostic approach to exclude recurrent venous thromboembolism
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 7:752-9. 2009
  9. doi Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies
    M Carrier
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Thromb Haemost 8:1716-22. 2010
  10. ncbi Extended outpatient therapy with low molecular weight heparin for the treatment of recurrent venous thromboembolism despite warfarin therapy
    C Luk
    University of Western Ontario, London, Ontario, Canada
    Am J Med 111:270-3. 2001

Collaborators

Detail Information

Publications35

  1. ncbi Derivation of a simple clinical model to categorize patients probability of pulmonary embolism: increasing the models utility with the SimpliRED D-dimer
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Thromb Haemost 83:416-20. 2000
    ..The combination of a score < or =4.0 by our simple clinical prediction rule and a negative SimpliRED D-Dimer result may safely exclude PE in a large proportion of patients with suspected PE...
  2. ncbi Expanding eligibility for outpatient treatment of deep venous thrombosis and pulmonary embolism with low-molecular-weight heparin: a comparison of patient self-injection with homecare injection
    P S Wells
    Department of Medicine, University of Ottawa, Ontario, Canada
    Arch Intern Med 158:1809-12. 1998
    ....
  3. doi Residual vein obstruction as a predictor for recurrent thromboembolic events after a first unprovoked episode: data from the REVERSE cohort study
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 9:1126-32. 2011
    ..We sought to determine if RVO as determined by compression ultrasonography (CUS) after completion of 5-7 months of anticoagulation for unprovoked DVT is associated with an increased risk of recurrent venous thromboembolism (VTE)...
  4. doi Patients with a first symptomatic unprovoked deep vein thrombosis are at higher risk of recurrent venous thromboembolism than patients with a first unprovoked pulmonary embolism
    M J Kovacs
    Department of Hematology, London Health Sciences Centre, Victoria Hospital, London, Ontario, Canada
    J Thromb Haemost 8:1926-32. 2010
    ....
  5. doi Prediction of the warfarin maintenance dose after completion of the 10 mg initiation nomogram: do we really need genotyping?
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 8:90-4. 2010
    ..A '10-mg nomogram' warfarin initiation protocol permits safe therapeutic anticoagulation in outpatients started on warfarin. We aimed to develop a safe and effective warfarin maintenance dose prediction tool in these patients...
  6. doi Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE
    M A Rodger
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Clinical Epidemiology Unit, Ottawa Hospital Research Institute, The Ottawa Hospital, Ottawa, Ottawa, Ontario, Canada
    Thromb Res 126:222-6. 2010
    ..We sought to determine if serum Lp(a) levels in patients with unprovoked VTE who discontinue anticoagulants after 5 to 7 months of therapy predict VTE recurrence in a prospective cohort study...
  7. ncbi A pilot study of central venous catheter survival in cancer patients using low-molecular-weight heparin (dalteparin) and warfarin without catheter removal for the treatment of upper extremity deep vein thrombosis (The Catheter Study)
    M J Kovacs
    Department of Medicine, Victoria Hospital, London, ON, Canada
    J Thromb Haemost 5:1650-3. 2007
    ..Central venous catheters in patients with cancer are associated with development of deep vein thrombosis (DVT); however, there is no accepted standard treatment...
  8. doi Validation of a diagnostic approach to exclude recurrent venous thromboembolism
    G Le Gal
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 7:752-9. 2009
    ..Our objective was to evaluate the safety of a diagnostic strategy utilizing comparison of diagnostic test results with baseline imaging results to rule out suspected recurrent VTE...
  9. doi Subsegmental pulmonary embolism diagnosed by computed tomography: incidence and clinical implications. A systematic review and meta-analysis of the management outcome studies
    M Carrier
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Thromb Haemost 8:1716-22. 2010
    ..We sought to summarize the proportion of subsegmental PE diagnosed with single- and multiple-detectors CTPA and assess the safety of diagnostic strategies based on single- or multiple-detectors CTPA to exclude PE...
  10. ncbi Extended outpatient therapy with low molecular weight heparin for the treatment of recurrent venous thromboembolism despite warfarin therapy
    C Luk
    University of Western Ontario, London, Ontario, Canada
    Am J Med 111:270-3. 2001
    ....
  11. ncbi Clinical utility of a rapid whole-blood D-dimer assay in patients with cancer who present with suspected acute deep venous thrombosis
    A Y Lee
    McMaster University, Hamilton, Ontario, Canada
    Ann Intern Med 131:417-23. 1999
    ..Although D-dimer assays have high negative predictive values for the diagnosis of deep venous thrombosis, their accuracy in patients with cancer is uncertain...
  12. ncbi Outpatient treatment of patients with deep-vein thrombosis or pulmonary embolism
    P S Wells
    Department of Medicine, Ottawa Health Research Institute, 737 Parkdale Avenue, Ottawa, Ontario K1Y 1J8, Canada
    Curr Opin Pulm Med 7:360-4. 2001
    ..Low-molecular-weight heparin followed by oral anticoagulant therapy provides adequate therapy in most patients with deep-vein thrombosis or pulmonary embolism, and many patients can be treated as outpatients...
  13. ncbi Combined use of clinical assessment and d-dimer to improve the management of patients presenting to the emergency department with suspected deep vein thrombosis (the EDITED Study)
    D R Anderson
    Department of Medicine, QEII Health Sciences Center, Dalhousie University, Halifax, Nova Scotia, Canada
    J Thromb Haemost 1:645-51. 2003
    ..5%) developed pulmonary embolism in the follow-up period. A diagnostic strategy for the evaluation of patients with suspected DVT based on pretest probability and d-dimer is safe and feasible in the emergency department setting...
  14. ncbi Assessment of deep vein thrombosis or pulmonary embolism by the combined use of clinical model and noninvasive diagnostic tests
    P S Wells
    Department of Medicine, Ottawa Hospital and the University of Ottawa, Ontario, Canada
    Semin Thromb Hemost 26:643-56. 2000
    ..In addition, a negative result with less-sentive D-dimer testing and a low clinical probability excludes DVT or PE...
  15. ncbi Diagnostic value of arterial blood gas measurement in suspected pulmonary embolism
    M A Rodger
    Department of Medicine, University of Ottawa, Ontario, Canada
    Am J Respir Crit Care Med 162:2105-8. 2000
    ..We conclude that ABG data alone or in combination with other clinical data are not useful in the assessment of suspected PE...
  16. doi Residual vein obstruction to predict the risk of recurrent venous thromboembolism in patients with deep vein thrombosis: a systematic review and meta-analysis
    M Carrier
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON, Canada
    J Thromb Haemost 9:1119-25. 2011
    ....
  17. ncbi The safety of dosing dalteparin based on actual body weight for the treatment of acute venous thromboembolism in obese patients
    E Al-Yaseen
    London Health Sciences Center, London, Ontario, Canada
    J Thromb Haemost 3:100-2. 2005
    ..0-3.0. All patients were followed for 12 weeks post diagnosis. Only two patients had a major hemorrhage, 4 and 8 weeks from diagnosis. This study supports the safety of dosing dalteparin based on actual body weight in obese patients...
  18. doi Baseline imaging after therapy for unprovoked venous thromboembolism: a randomized controlled comparison of baseline imaging for diagnosis of suspected recurrence
    A Hamadah
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, Ontario, Canada
    J Thromb Haemost 9:2406-10. 2011
    ..Whether baseline imaging, conducted after completion of anticoagulation, helps in interpreting diagnostic testing in patients who subsequently have suspected recurrent VTE is unknown...
  19. ncbi Outpatient treatment of patients with pulmonary embolism
    P S Wells
    Department of Medicine, Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada
    Semin Vasc Med 1:229-34. 2001
    ..Low-molecular-weight heparin or intravenous unfractionated heparin, followed by oral anticoagulant therapy, provide adequate therapy in most patients with PE, and many can be treated as outpatients...
  20. ncbi Improvements in the diagnostic approach for patients with suspected deep vein thrombosis or pulmonary embolism
    D R Anderson
    Department of Medicine, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
    Thromb Haemost 82:878-86. 1999
    ..There is still need to improve management strategies for the diagnosis of recurrent venous thrombosis and to determine whether diagnostic testing results may be correlated with long-term patient treatment needs...
  21. ncbi Steady-state end-tidal alveolar dead space fraction and D-dimer: bedside tests to exclude pulmonary embolism
    M A Rodger
    Department of Medicine, University of Ottawa, Ontario, Canada
    Chest 120:115-9. 2001
    ..15, (2) a negative D-dimer result, and (3) the combination of a steady-state end-tidal AVDSf of < 0.15 and a negative D-dimer result. Study design: Prospective cohort study...
  22. doi D-dimer testing is useful to exclude deep vein thrombosis in elderly outpatients
    M Carrier
    Thrombosis Program, Division of Hematology, Department of Medicine, University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 6:1072-6. 2008
    ..Deep vein thrombosis (DVT) can be safely and reliably excluded in patients with a low clinical probability and a negative D-dimer result but the accuracy and utility of such a strategy is unclear in elderly patients...
  23. ncbi Diagnosis of deep-vein thrombosis in the year 2000
    P S Wells
    Department of Medicine and Epidemiology and Community Medicine, Ottawa Hospital and the University of Ottawa, Ontario, Canada
    Curr Opin Pulm Med 6:309-13. 2000
    ..The combination of the D-dimer with clinical model assessment will enable diagnostic testing strategies that are more safe, effective, and convenient for patients...
  24. ncbi Does this patient have deep vein thrombosis?
    S S Anand
    Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    JAMA 279:1094-9. 1998
    ..To review the validity of the clinical assessment and diagnostic tests in patients with suspected deep vein thrombosis (DVT)...
  25. ncbi Protein C and protein S levels can be accurately determined within 24 hours of diagnosis of acute venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, ON, Canada
    Clin Lab Haematol 28:9-13. 2006
    ..8% of initial protein C and protein S results were accurate. If protein C and protein S are measured at the time of diagnosis of acute venous thromboembolism, the majority of the results will be normal and false positives are uncommon...
  26. ncbi Prospective assessment of a nomogram for the initiation of oral anticoagulation therapy for outpatient treatment of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Pathophysiol Haemost Thromb 32:131-3. 2002
    ..There were no major bleeds and only 6 instances of INR >4.5. This outpatient warfarin nomogram appears to be safe and efficacious in obtaining timely therapeutic levels of warfarin and deserves further study...
  27. ncbi Diagnosis of pulmonary embolism
    M Rodger
    Department of Medicine, Ottawa Hospital and the University of Ottawa, Ottawa, Ontario, Canada
    Thromb Res 103:V225-38. 2001
    ..These algorithms permit safe diagnostic management of patients with suspected PE while limiting invasiveness, inaccessibility and expense...
  28. ncbi A regression model to predict warfarin dose from clinical variables and polymorphisms in CYP2C9, CYP4F2, and VKORC1: Derivation in a sample with predominantly a history of venous thromboembolism
    P S Wells
    University of Ottawa, Ottawa, Canada Ottawa Hospital Research Institute, Ottawa, Canada
    Thromb Res 125:e259-64. 2010
    ..We sought to develop a new algorithm to predict maintenance dose in a cohort of patients, using clinical variables and genetic polymorphism in CYP2C9, VKORC1, and CYP4F2...
  29. ncbi A comparison of three rapid D-dimer methods for the diagnosis of venous thromboembolism
    M J Kovacs
    Department of Medicine, London Health Sciences Centre, London, Ontario, Canada
    Br J Haematol 115:140-4. 2001
    ..The SimpliRED D-dimer was found to be less sensitive than the Accuclot or IL-Test. When combined with pre-test probability all three methods are probably acceptable for use in the diagnosis of venous thromboembolism...
  30. ncbi Thrombolysis in deep vein thrombosis: is there still an indication?
    P S Wells
    Department of Medicine, University of Ottawa, Canada
    Thromb Haemost 86:499-508. 2001
    ..We conclude that more work is needed to define the role of thrombolytic therapy but it is too early to abandon this therapeutic modality...
  31. ncbi Does the type of hormone replacement therapy influence the risk of deep vein thrombosis? A prospective case-control study
    J D Douketis
    Department of Medicine, McMaster University, Hamilton, Canada
    J Thromb Haemost 3:943-8. 2005
    ..Although hormone replacement therapy (HRT) is associated with an increased risk of deep vein thrombosis (DVT), it is not clear if the risk differs in users of combined estrogen-progestin HRT and estrogen-only HRT...
  32. ncbi Günther Tulip filter: preliminary clinical experience with retrieval
    S F Millward
    Department of Diagnostic Imaging, University of Ottawa, Ottawa Hospital, Ontario, Canada
    J Vasc Interv Radiol 11:75-82. 2000
    ..The Günther Tulip filter is a permanent filter that has a hook to permit retrieval. The authors report their preliminary clinical evaluation of the filter with regard to feasibility and safety of retrieval...
  33. ncbi Use of recombinant-hirudin in pulmonary thromboendarterectomy
    F D Rubens
    Department of Surgery, University of Ottawa, Ontario, Canada
    Ann Thorac Surg 69:1942-3. 2000
    ..Techniques for administration as well as monitoring of this drug's effects are discussed...
  34. ncbi Integrated strategies for the diagnosis of venous thromboembolism
    P S Wells
    Department of Medicine, Ottawa Hospital, Ottawa Health Research Institute, and the University of Ottawa, Ottawa, ON, Canada
    J Thromb Haemost 5:41-50. 2007
    ..These integration strategies result in safer, more convenient and cost-effective care for patients...
  35. doi Cognitive and behavioural effects of genetic testing for thrombophilia
    J Heshka
    University of Ottawa, Ottawa, Ontario, Canada
    J Genet Couns 17:288-96. 2008
    ..37.2% did not appreciate that thrombophilia increases risk. Behaviour changes were uncommon. There is a need for research on education and strategies to improve knowledge in thrombophilia carriers...