A Gupta

Summary

Affiliation: Division of Dermatology
Country: Canada

Publications

  1. ncbi Ciclopirox (Loprox) gel for superficial fungal infections
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens College Health Sciences Centre Sunnybrook site, University of Toronto, Toronto, ON, Canada
    Skin Therapy Lett 9:4-5, 9. 2004
  2. ncbi In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species
    A K Gupta
    Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Canada
    Med Mycol 43:179-85. 2005
  3. ncbi Rosacea and its management: an overview
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook Site, Toronto, Canada
    J Eur Acad Dermatol Venereol 19:273-85. 2005
  4. doi Investigational drugs for onychomycosis
    Aditya K Gupta
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada 1 519 657 4222 ext 277 1 519 657 4233
    Expert Opin Investig Drugs 23:97-106. 2014
  5. doi Improved efficacy in onychomycosis therapy
    Aditya K Gupta
    Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada Mediprobe Research, Inc, London, Ontario, Canada Electronic address
    Clin Dermatol 31:555-63. 2013
  6. doi Meta-analysis of randomized, controlled trials comparing particular doses of griseofulvin and terbinafine for the treatment of tinea capitis
    Aditya K Gupta
    University of Toronto, Toronto, Ontario, Canada
    Pediatr Dermatol 30:1-6. 2013
  7. doi Evidence-based optimal fluconazole dosing regimen for onychomycosis treatment
    Aditya K Gupta
    Department of Medicine, Division of Dermatology, University of Toronto, Toronto, Canada
    J Dermatolog Treat 24:75-80. 2013
  8. ncbi Newly approved laser systems for onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada
    J Am Podiatr Med Assoc 102:428-30. 2012
  9. ncbi A review of the use of infliximab to manage cutaneous dermatoses
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Cutan Med Surg 8:77-89. 2004
  10. ncbi Prevalence of Malassezia species on various body sites in clinically healthy subjects representing different age groups
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 42:35-42. 2004

Detail Information

Publications126 found, 100 shown here

  1. ncbi Ciclopirox (Loprox) gel for superficial fungal infections
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens College Health Sciences Centre Sunnybrook site, University of Toronto, Toronto, ON, Canada
    Skin Therapy Lett 9:4-5, 9. 2004
    ..Ciclopirox is indicated in the US for the treatment of tinea pedis, tinea corporis, pityriasis versicolor, seborrheic dermatitis, and cutaneous candidiasis...
  2. ncbi In vitro activities of posaconazole, ravuconazole, terbinafine, itraconazole and fluconazole against dermatophyte, yeast and non-dermatophyte species
    A K Gupta
    Sunnybrook and Women s College Health Sciences Center, University of Toronto, Toronto, Canada
    Med Mycol 43:179-85. 2005
    ....
  3. ncbi Rosacea and its management: an overview
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook Site, Toronto, Canada
    J Eur Acad Dermatol Venereol 19:273-85. 2005
    ..Since a cure for rosacea does not yet exist, management and treatment regimens are designed to suppress the inflammatory lesions, erythema, and to a lesser extent, the telangiectasia involved with rosacea...
  4. doi Investigational drugs for onychomycosis
    Aditya K Gupta
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada 1 519 657 4222 ext 277 1 519 657 4233
    Expert Opin Investig Drugs 23:97-106. 2014
    ..Oral therapy is limited by adverse events and drug-drug interactions, whereas topical therapy has limited penetrance through the nail plate...
  5. doi Improved efficacy in onychomycosis therapy
    Aditya K Gupta
    Department of Medicine, University of Toronto School of Medicine, Toronto, Ontario, Canada Mediprobe Research, Inc, London, Ontario, Canada Electronic address
    Clin Dermatol 31:555-63. 2013
    ..An improved efficacy was demonstrated for some of these strategies, such as combined oral and topical antifungal therapies, whereas most of them lack clear and direct evidence of an increase in therapeutic success. ..
  6. doi Meta-analysis of randomized, controlled trials comparing particular doses of griseofulvin and terbinafine for the treatment of tinea capitis
    Aditya K Gupta
    University of Toronto, Toronto, Ontario, Canada
    Pediatr Dermatol 30:1-6. 2013
    ..infection (p = 0.04). Our results support species-specific differences in treatment efficacy between griseofulvin and terbinafine and provide a clinical context in which this knowledge may be applied...
  7. doi Evidence-based optimal fluconazole dosing regimen for onychomycosis treatment
    Aditya K Gupta
    Department of Medicine, Division of Dermatology, University of Toronto, Toronto, Canada
    J Dermatolog Treat 24:75-80. 2013
    ..By restricting the data to dermatophyte onychomycosis, we aimed to identify an optimal fluconazole dosing regimen...
  8. ncbi Newly approved laser systems for onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Canada
    J Am Podiatr Med Assoc 102:428-30. 2012
    ....
  9. ncbi A review of the use of infliximab to manage cutaneous dermatoses
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Cutan Med Surg 8:77-89. 2004
    ..Infliximab is a chimeric monoclonal antibody that binds specifically to human tumor necrosis factor-alpha (TNF-alpha), decreasing the effect of the cytokine in inflammatory diseases...
  10. ncbi Prevalence of Malassezia species on various body sites in clinically healthy subjects representing different age groups
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 42:35-42. 2004
    ..The amount and kind of Malassezia species that can be recovered from human skin varies with age and body site...
  11. ncbi Viral and nonviral uses of imiquimod: a review
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    J Cutan Med Surg 8:338-52. 2004
    ..This drug has been recently approved for the treatment of actinic keratoses and superficial basal cell carcinoma. There is a growing body of evidence for its effectiveness in treating a variety of other skin conditions...
  12. ncbi Evaluation of the efficacy of ciclopirox 0.77% gel in the treatment of tinea pedis interdigitalis (dermatophytosis complex) in a randomized, double-blind, placebo-controlled trial
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Canada
    Int J Dermatol 44:590-3. 2005
    ..These properties may give ciclopirox an advantage over other antifungal agents in the treatment of interdigital tinea pedis with secondary bacterial infection (dermatophytosis complex)...
  13. pmc Molecular differentiation of seven Malassezia species
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center and University of Toronto, Toronto, Ontario, Canada
    J Clin Microbiol 38:1869-75. 2000
    ..pachydermatis. This specific amplification may facilitate the rapid identification of this organism...
  14. ncbi Management of diaper dermatitis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, London, Ontario, Canada
    Int J Dermatol 43:830-4. 2004
  15. ncbi Cumulative meta-analysis of systemic antifungal agents for the treatment of onychomycosis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Br J Dermatol 150:537-44. 2004
    ..Onychomycosis is a common nail disease that is often chronic, difficult to eradicate, and has a tendency to recur. The most common oral therapies for dermatophyte toenail onychomycosis include terbinafine, itraconazole and fluconazole...
  16. ncbi The efficacy and safety of terbinafine in children
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Eur Acad Dermatol Venereol 17:627-40. 2003
    ..The adverse events profile for children is similar to that in adults with few adverse effects associated with its use. The evidence favours the use of terbinafine in the treatment of superficial infections in children...
  17. ncbi Evaluation of in vitro resistance in patients with onychomycosis who fail antifungal therapy
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Dermatology 207:375-80. 2003
    ..However, relatively little research has been published concerning the resistance of dermatophyte species...
  18. ncbi Onychomycosis: quality of studies
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Cutan Med Surg 7:312-6. 2003
    ..The quality of original clinical trial publications pertaining to the use of oral antifungal agents to treat onychomycosis was evaluated using predetermined criteria...
  19. ncbi Efficacy and safety of itraconazole use in children
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:521-35. 2003
    ....
  20. ncbi Hepatic safety of itraconazole
    Aditya K Gupta
    University of Toronto, Toronto, Canada
    J Cutan Med Surg 6:210-3. 2002
    ..The most common adverse events are gastrointestinal upset, headache, and transient skin reaction. There have also been rare reports of hepatitis...
  21. ncbi Fungicidal activities of commonly used disinfectants and antifungal pharmaceutical spray preparations against clinical strains of Aspergillus and Candida species
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    Med Mycol 40:201-8. 2002
    ..ochraceus conidia and an onset of fungicidal effect on C. parapsilosis yeast cells. Terbinafine was only moderately effective against C. albicans and was completely ineffective against C. krusei...
  22. ncbi Analysis of factors associated with increased prescription illegibility: results from the National Ambulatory Medical Care Survey, 1990-1998
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre Sunnybrook campus, Toronto, Ontario, Canada
    Am J Manag Care 9:548-52. 2003
    ..To estimate the incidence of, and the variables affecting, illegible drug prescriptions in the United States...
  23. ncbi Interdigital tinea pedis (dermatophytosis simplex and complex) and treatment with ciclopirox 0.77% gel
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    Int J Dermatol 42:23-7. 2003
    ....
  24. ncbi Open-label study to evaluate the healing rate and safety of the Profore Extra Four-Layer Bandage System in patients with venous leg ulceration
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens Health Sciences Centre Sunnybrook Site and the University of Toronto Medical School, Toronto, Ontario, Canada
    J Cutan Med Surg 4:8-11. 2000
    ..Venous ulcers are increasing in prevalence, especially since these are observed more frequently in the elderly, and the number of individuals in this age group is becoming a larger portion of the population...
  25. ncbi Therapies for onychomycosis: a review
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Sunnybrook Site, University of Toronto, 2075 Bayview Avenue Toronto, ON M4N 3M5, Canada
    Dermatol Clin 24:375-9. 2006
    ..Surgical, chemical, topical, and oral methods are reviewed in this article, with an emphasis on the three systemic treatments approved by the US Food and Drug Administration: terbinafine, itraconazole, and griseofulvin...
  26. ncbi The use of itraconazole to treat cutaneous fungal infections in children
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, and the University of Toronto, Toronto, Canada
    Dermatology 199:248-52. 1999
    ..There is relatively limited data regarding the use of the newer oral antifungal agents, e.g. itraconazole, in the treatment of these mycoses in children...
  27. ncbi Meta-analysis: griseofulvin efficacy in the treatment of tinea capitis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada
    J Drugs Dermatol 7:369-72. 2008
    ..Both genera showed good efficacy with griseofulvin therapy given from 6 to 8 weeks. Griseofulvin remains an effective therapy for tinea capitis...
  28. ncbi Evaluating the quality of rosacea studies: implications for the patient and physician
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ont, Canada
    Dermatology 207:173-7. 2003
    ..Patients suffering from rosacea may experience frequent blushing and flushing, erythema, telangiectasia, and/or rhinophyma. In an attempt to find effective treatments, many studies have been performed...
  29. doi Systematic review of nondermatophyte mold onychomycosis: diagnosis, clinical types, epidemiology, and treatment
    Aditya K Gupta
    University of Toronto, Toronto, Ontario, Canada
    J Am Acad Dermatol 66:494-502. 2012
    ..When evaluating different treatments, we suggest that authors clearly define their efficacy outcomes...
  30. ncbi Seborrheic dermatitis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario, M4N 3M5, Canada
    Dermatol Clin 21:401-12. 2003
    ..The wide range of antifungal formulations available (creams, shampoos, or oral) provides safe, effective, and flexible treatment options for seborrheic dermatitis...
  31. ncbi Pityriasis versicolor
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:413-29, v-vi. 2003
    ..Antifungal preparations have been used to treat the initial presentation effectively, although in a proportion of patients the disease tends to reoccur. They are available in a wide range of formulations and have been shown to be safe...
  32. ncbi Treatments of tinea pedis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:431-62. 2003
    ..In such instances, systemic antifungal therapy is required to ensure that adequate concentrations of the therapeutic agent are present at the site of infection...
  33. ncbi Naftifine: a review
    Aditya K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, ON
    J Cutan Med Surg 12:51-8. 2008
    ..Naftifine is fungicidal in vitro against a broad spectrum of dermatophyte fungi and provides good activity against Candida and Aspergillus species. It is also effective against gram-negative and gram-positive bacteria...
  34. ncbi Position statement for isotretinoin
    Aditya K Gupta
    J Cutan Med Surg 11:123-4. 2007
  35. ncbi Tinea corporis, tinea cruris, tinea nigra, and piedra
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada
    Dermatol Clin 21:395-400, v. 2003
    ..Preventative measures of tinea infections include practicing good personal hygiene; keeping the skin dry and cool at all times; and avoiding sharing towels, clothing, or hair accessories with infected individuals...
  36. ncbi Arthroconidial formation in Trichophyton raubitschekii
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, and the University of Toronto, Toronto, Ontario, Canada N6K 1L6
    Mycoses 46:322-8. 2003
    ..The availability of arthroconidia in T. raubitschekii cultures appears to offer a practical means of characterizing infective cells in T. rubrum...
  37. ncbi A phase I/II randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy, safety and pharmacokinetics of ravuconazole in the treatment of onychomycosis
    A K Gupta
    Division of Dermatology, Sunnybrook and Women s College Health Science Centre, University of Toronto, Ontario, Canada
    J Eur Acad Dermatol Venereol 19:437-43. 2005
    ..To determine the effectiveness and safety of ravuconazole in the treatment of toenail onychomycosis...
  38. ncbi Psoriatic nail disease: quality of life and treatment
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Centre and University of Toronto, Toronto, ON
    J Cutan Med Surg 13:S102-6. 2009
    ..Large-scale, long-term trials using standardized outcome measures are needed to further evaluate biologic therapies for the treatment of nail psoriasis...
  39. ncbi Onychomycosis therapy: past, present, future
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center, University of Toronto, Toronto, Canada
    J Drugs Dermatol 9:1109-13. 2010
    ..Research in these fields is preliminary, and the impact these methods may have on the future of onychomycosis remains to be seen...
  40. ncbi Intermittent short duration therapy with fluconazole is effective for tinea capitis
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto N6K 1L6, Canada
    Br J Dermatol 141:304-6. 1999
    ..This regimen appears to be effective and safe, and is associated with high compliance. The preliminary results of the investigation need to be evaluated in a larger sample of patients, and in tinea capitis caused by zoophilic species...
  41. ncbi Ciclopirox for the treatment of superficial fungal infections: a review
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    Int J Dermatol 42:3-9. 2003
    ..The new ciclopirox gel 0.77% formulation is also indicated for the treatment of seborrheic dermatitis of the scalp, interdigital tinea pedis and tinea corporis...
  42. ncbi Ciclopirox gel: an update
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site and the University of Toronto, Toronto, Canada
    Int J Dermatol 42:1-2. 2003
  43. ncbi Efalizumab in the treatment of psoriasis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre Sunnybrook Site and the University of Toronto, ON
    J Cutan Med Surg 10:57-68. 2006
    ..Efalizumab has recently been approved in Canada for this indication...
  44. ncbi Seborrheic dermatitis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Eur Acad Dermatol Venereol 18:13-26; quiz 19-20. 2004
    ..Moreover, the success of antifungal medications in treating seborrheic dermatitis provides new evidence for this view...
  45. ncbi Pityriasis versicolor: quality of studies
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Ontario, Canada
    J Dermatolog Treat 15:40-5. 2004
    ..To evaluate the quality of the published literature on the treatment of pityriasis versicolor and to compare this evaluation with the number of times the work has been cited...
  46. ncbi Ciclopirox topical solution, 8% combined with oral terbinafine to treat onychomycosis: a randomized, evaluator-blinded study
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, Canada
    J Drugs Dermatol 4:481-5. 2005
    ..The data suggest that combination therapy (PL8) may be an alternative regimen to continuous terbinafine (L12) in the treatment of moderate to severe dermatophyte toenail onychomycosis...
  47. ncbi Prednicarbate (Dermatop): profile of a corticosteroid
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook site and the University of Toronto, Toronto, Canada
    J Cutan Med Surg 8:244-7. 2004
    ....
  48. ncbi Dermatophytosis: the management of fungal infections
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Windermere Road, Toronto, Ontario, Canada NSX 2P1
    Skinmed 4:305-10. 2005
    ..Terbinafine, itraconazole, and fluconazole are oral antimycotics that are effective in the treatment of superficial mycoses, although, depending on the severity of the infection, a topical antifungal may be sufficient...
  49. ncbi Dermatophytes: diagnosis and treatment
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Canada
    J Am Acad Dermatol 54:1050-5. 2006
  50. ncbi Diagnosing onychomycosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre Sunnybrook Site, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Dermatol Clin 24:365-9. 2006
    ..This article discusses the efficacy of the various methods used for the diagnosis of onychomycosis...
  51. ncbi Optimal management of fungal infections of the skin, hair, and nails
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    Am J Clin Dermatol 5:225-37. 2004
    ..Terbinafine, itraconazole, and fluconazole are oral antifungals that are effective in the treatment of superficial mycoses...
  52. ncbi Ciclopirox: a broad-spectrum antifungal with antibacterial and anti-inflammatory properties
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Canada
    Int J Dermatol 43:3-8. 2004
  53. ncbi Seborrhoeic dermatitis: current treatment practices
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Canada
    Expert Opin Pharmacother 5:1755-65. 2004
    ..Since the discovery of ketoconazole, a considerable amount of research has been focused on determining the efficacy of various antifungal agents. This article reviews clinical trial data on treatment options available for SD...
  54. ncbi Onychomycosis therapies: strategies to improve efficacy
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Centre, Sunnybrook Site, University of Toronto, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada
    Dermatol Clin 24:381-6. 2006
    ..These involve the combination of available therapies and/or a modification of treatment regimens...
  55. ncbi Pityriasis versicolor: a review of pharmacological treatment options
    Aditya K Gupta
    University of Toronto, and the Sunnybrook and Womens College Health Sciences Center Sunnybrook site, Toronto, Ontario, Canada
    Expert Opin Pharmacother 6:165-78. 2005
    ..A number of treatment options, both topical and systemic, have been shown to be effective. A critical evaluation of treatment options is presented...
  56. ncbi Onychomycosis: classification and diagnosis
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, and the University of Toronto, Toronto, Canada
    J Drugs Dermatol 3:51-6. 2004
    ..Prior to treatment an accurate diagnosis can provide guidance about the choice of antifungal agent, especially since the causative organism may vary in its response to the antifungal therapies available...
  57. ncbi Onychomycosis in children: a brief overview with treatment strategies
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center and University of Toronto, Toronto, Ontario, Canada
    Pediatr Dermatol 21:74-9. 2004
    ..More data are needed on the use of these antifungal agents for the treatment of onychomycosis in children...
  58. ncbi Pulse itraconazole vs. continuous terbinafine for the treatment of dermatophyte toenail onychomycosis in patients with diabetes mellitus
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, University of Toronto and Toronto General Hospital, Canada
    J Eur Acad Dermatol Venereol 20:1188-93. 2006
    ....
  59. ncbi Photodynamic therapy and topical aminolevulinic acid: an overview
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center and the University of Toronto, Toronto, Ontario, Canada
    Am J Clin Dermatol 4:699-708. 2003
    ..Further experience in the use of photodynamic therapy will help define its utility in the management of actinic keratosis and other dermatoses...
  60. ncbi Onychomycosis in children: an overview
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, University of Toronto, Toronto, Canada
    J Drugs Dermatol 2:31-4. 2003
    ..However, these agents appear to be effective and safe in this indication...
  61. ncbi Itraconazole pulse therapy is effective in the treatment of Majocchi's granuloma: a clinical and pharmacokinetic evaluation and implications for possible effectiveness in tinea capitis
    A K Gupta
    Department of Dermatology, Sunnybrook Health Science Center, Toronto, Ontario, Canada
    Clin Exp Dermatol 23:103-8. 1998
    ..These data suggest that itraconazole pulse therapy should be effective in the treatment of tinea capitis...
  62. pmc Utility of inoculum counting (Walshe and English criteria) in clinical diagnosis of onychomycosis caused by nondermatophytic filamentous fungi
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens College Health Sciences Center, Sunnybrook, Ontario, Canada
    J Clin Microbiol 39:2115-21. 2001
    ..It may, nonetheless, provide useful information both to the physician and to the laboratory, and it may be especially valuable when the patient does not present for follow-up sampling...
  63. ncbi Single-blind, randomized, prospective study of sequential itraconazole and terbinafine pulse compared with terbinafine pulse for the treatment of toenail onychomycosis
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    J Am Acad Dermatol 44:485-91. 2001
    ..Efficacy and safety of sequential pulse therapy with itraconazole and terbinafine were compared with pulse terbinafine alone in the treatment of toenail onychomycosis...
  64. ncbi Ciclopirox nail lacquer and podiatric practice
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, Toronto, Ontario, Canada
    J Am Podiatr Med Assoc 90:502-7. 2000
    ....
  65. ncbi Ciclopirox 8% nail lacquer in the treatment of onychomycosis of the toenails in the United States
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center Sunnybrook site, Toronto, Ontario, Canada
    J Am Podiatr Med Assoc 90:495-501. 2000
    ..Ciclopirox nail lacquer may also have potential for use in combination or adjunctive therapy. Further studies will help to better position this agent for the treatment of this widespread podiatric condition...
  66. ncbi Increased incidence of Trichophyton tonsurans tinea capitis in Ontario, Canada between 1985 and 1996
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center and the University of Toronto, Toronto, Ontario, Canada
    Med Mycol 36:55-60. 1998
    ..This should provide guidance regarding where to concentrate health resources and deliver patient/parent education to combat this epidemic of tinea capitis...
  67. ncbi Epidemiology and prevalence of onychomycosis in HIV-positive individuals
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    Int J Dermatol 39:746-53. 2000
    ....
  68. ncbi Tinea capitis
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, University of Toronto, Canada
    Med Mycol 38:255-87. 2000
    ..Both griseofulvin and the newer antimycotics have a favorable adverse-effect profile and are associated with high compliance...
  69. ncbi The prevalence and management of onychomycosis in diabetic patients
    A K Gupta
    University of Toronto, Toronto, Canada
    Eur J Dermatol 10:379-84. 2000
    ..An ideal antifungal agent should combine a broad spectrum of activity with good efficacy and a favorable safety profile...
  70. ncbi Once weekly fluconazole is effective in children in the treatment of tinea capitis: a prospective, multicentre study
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Womens College Health Sciences Center Sunnybrook site, University of Toronto, Toronto, Canada
    Br J Dermatol 142:965-8. 2000
    ..9%) of 17 patients; this was asymptomatic, and reversible. No patient discontinued therapy. The data suggest that once weekly fluconazole dosing is effective, safe and associated with high compliance when used to treat tinea capitis...
  71. ncbi Combined distal and lateral subungual and white superficial onychomycosis in the toenails
    A K Gupta
    Department of Medicine, Sunnybrook Health Sciences Center and the University of Toronto, and the Ontario Ministry of Health, Laboratory Services Branch and Department of Laboratory Medicine and Pathology, University of Toronto
    J Am Acad Dermatol 41:938-44. 1999
    ..In the literature there is infrequent discussion about 2 types of onychomycosis present in the toenails of the same individual...
  72. ncbi The new oral antifungal agents for onychomycosis of the toenails
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center and the University of Toronto, Canada
    J Eur Acad Dermatol Venereol 13:1-13. 1999
    ..To review the use of the new oral antifungal agents, itraconazole, terbinafine and fluconazole for the treatment of onychomycosis of the toenails...
  73. ncbi Management of onychomycosis in children
    A K Gupta
    Division of Dermatology, University of Toronto Faculty of Medicine, Ontario, Canada
    Postgrad Med . 1999
    ..Terbinafine (continuous) or fluconazole (intermittent) regimens are other treatment options. It is important to take steps to reduce the risk of reinfection and to treat tinea pedis at an early stage...
  74. ncbi Drug interactions with itraconazole, fluconazole, and terbinafine and their management
    A K Gupta
    Division of Dermatology, Department of Medicine, University of Toronto, London, Ontario, N6K 1L6, Canada
    J Am Acad Dermatol 41:237-49. 1999
    ..In the case of contraindicated drugs, it may be possible to use an alternative agent...
  75. ncbi Tinea capitis: an overview with emphasis on management
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada University of Toronto, Toronto, Ontario, Canada
    Pediatr Dermatol 16:171-89. 1999
    ..Adjunctive therapies may help decrease the risk of infection to other individuals. Appropriate measures should be taken to reduce the possibility of reinfection...
  76. ncbi Factors that may affect the response of onychomycosis to oral antifungal therapy
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Canada
    Australas J Dermatol 39:222-4. 1998
    ..Possible explanations for this may be grouped into categories, including: (i) patient characteristics; (ii) organisms causing or associated with the nail infection; (iii) nail characteristics; and (iv) local diseases involving the nail...
  77. ncbi Itraconazole oral solution for the treatment of onychomycosis
    A K Gupta
    Sunnybrook Health Science Center, Division of Dermatology, University of Toronto, Ontario, Canada
    Pediatr Dermatol 15:472-4. 1998
    ..Both patients were clinically and mycologically cured with no adverse effects. Itraconazole oral solution (3 mg/kg/day) given as pulse therapy may be a consideration in the treatment of onychomycosis in some children...
  78. ncbi Onychomycosis in children: prevalence and management
    A K Gupta
    Sunnybrook Health Science Center, Division of Dermatology, University of Toronto, Ontario, Canada
    Pediatr Dermatol 15:464-71. 1998
    ..The data suggest that the new oral antifungal agents have a role in the treatment of onychomycosis in children. Further experience will help us better position these drugs when evaluating the management of onychomycosis in children...
  79. ncbi Efficacy of itraconazole, terbinafine, fluconazole, griseofulvin and ketoconazole in the treatment of Scopulariopsis brevicaulis causing onychomycosis of the toes
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, and University of Toronto, Ont, Canada
    Dermatology 202:235-8. 2001
    ..Scopulariopsis brevicaulis is a common non-dermatophyte mould that can cause onychomycosis...
  80. ncbi Itraconazole is effective in the treatment of tinea capitis caused by Microsporum canis
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site, University of Toronto, Toronto, Canada
    Pediatr Dermatol 18:519-22. 2001
    ..Compliance was very good in the patient group. Itraconazole 5 mg/kg/day given either as a capsule or an oral suspension for 4-8 weeks is effective and safe in the treatment of tinea capitis caused by M. canis...
  81. ncbi Pityriasis versicolor
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Science Center, Toronto, Ontario, Canada
    J Eur Acad Dermatol Venereol 16:19-33. 2002
    ..The taxonomy of Malassezia spp. has recently been modified to include six obligatorily lipophilic species, all of which can be found on human skin, plus one non-obligatorily lipophilic species, which only rarely colonizes human hosts...
  82. ncbi Comparative efficacies of commonly used disinfectants and antifungal pharmaceutical spray preparations against dermatophytic fungi
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Sciences Center, and the University of Toronto, Ontario, Canada
    Med Mycol 39:321-8. 2001
    ..mentagrophytes strains. Bifonazole (1%) was also fungistatic in its action against T. mentagrophytes. Sodium dodecyl sulphate (0.5%) was largely ineffective against Trichophyton arthroconidia...
  83. ncbi An overview of topical antifungal therapy in dermatomycoses. A North American perspective
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada
    Drugs 55:645-74. 1998
    ..For tinea pedis the most common treatment duration is 4 to 6 weeks...
  84. ncbi A questionnaire study on the management of onychomycosis: a Canadian perspective
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Canada
    Int J Dermatol 37:457-60. 1998
    ..Onychomycosis of the toenails is a condition that responds poorly to griseofulvin. The introduction of terbinafine in Canada in May 1993 resulted in a marked shift in the choice of treatment for pedal onychomycosis...
  85. ncbi Imiquimod: a review
    Aditya K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Science Center Sunnybrook site and the University of Toronto, Toronto, Canada
    J Cutan Med Surg 6:554-60. 2002
    ..Currently, imiquimod is approved for use in the treatment of external genital and perianal warts in adults...
  86. ncbi Management of toe onychomycosis: what is the potential for improving efficacy of treatment?
    Aditya K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Sciences Center, Toronto, Ontario, Canada
    Clin Dermatol 20:607-9. 2002
  87. pmc Variation in restriction fragment length polymorphisms among serial isolates from patients with Trichophyton rubrum infection
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center, Women s College Hospital, Sunnybrook Site, and University of Toronto, Toronto, Ontario, Canada
    J Clin Microbiol 39:3260-6. 2001
    ..The recovery of multiple strains during the course of sequential sampling of uncured patients further suggests that the typing system is not able to distinguish between relapse or reinfection, ongoing infection, and de novo infection...
  88. ncbi Onychomycosis: strategies to improve efficacy and reduce recurrence
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center Sunnybrook site and the University of Toronto, Toronto, Ontario, Canada
    J Eur Acad Dermatol Venereol 16:579-86. 2002
    ..Steps should be taken to reduce the possibility of recurrence once cure has been achieved...
  89. ncbi Tacrolimus: a review of its use for the management of dermatoses
    A K Gupta
    Department of Medicine, Sunnybrook and Women s College Health Science Center and University of Toronto, Canada
    J Eur Acad Dermatol Venereol 16:100-14. 2002
    ..This is generally transient and the patient is able to continue with therapy. The other dermatoses where tacrolimus has been used include contact dermatitis, psoriasis and pyoderma gangrenosum...
  90. ncbi Alternate week and combination itraconazole and terbinafine therapy for chromoblastomycosis caused by Fonsecaea pedrosoi in Brazil
    A K Gupta
    Division of Dermatology, Sunnybrook and Women s College Health Science Center, University of Toronto, Toronto, Ontario, Canada
    Med Mycol 40:529-34. 2002
    ..Some success with alternative week therapy was also noted in one patient. The favorable response and lack of significant adverse effects suggests that these regimens may be an option for some patients with chromoblastomycosis...
  91. ncbi In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook Site, and the University of Toronto, Toronto, ON, Canada
    Br J Dermatol 149:296-305. 2003
    ....
  92. ncbi Fast and sensitive detection of Trichophyton rubrum DNA from the nail samples of patients with onychomycosis by a double-round polymerase chain reaction-based assay
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Sciences Center and the University of Toronto, Toronto, Ontario, Canada
    Br J Dermatol 157:698-703. 2007
    ..Trichophyton rubrum is one of the most frequently isolated pathogens in onychomycosis. Isolation of T. rubrum from nail samples by traditional methods is time-consuming and has a high false-negative rate of detection...
  93. ncbi Hypersensitivity syndrome reaction to oral terbinafine
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Canada
    Australas J Dermatol 39:171-2. 1998
    ..Prompt recognition and determination of the extent of systemic involvement is important for the proper management of the patient...
  94. ncbi The implications and management of drug interactions with itraconazole, fluconazole and terbinafine
    N Shear
    Departments of Medicine and Pharmacology, University of Toronto, Canada
    Dermatology 201:196-203. 2000
    ..An improved understanding of the drug interaction processes and appropriate control measures mean that the high benefit-to-risk ratio of these medications can be maintained...
  95. ncbi Update on the safety of itraconazole pulse therapy in onychomycosis and dermatomycoses
    A Gupta
    Department of Medicine, University of Toronto, Toronto, Canada
    Eur J Dermatol 11:6-10. 2001
    ..Adverse events are generally mild and transient. Furthermore, a dose increase to 400 mg in the pulse regimen has had no adverse impact on safety...
  96. ncbi Itraconazole oral solution for the treatment of tinea capitis using the pulse regimen
    A K Gupta
    Department of Dermatology, Sunnybrook Health Science Center, Toronto, Ontario, Canada
    Cutis 64:192-4. 1999
    ..The availability of the oral solution will enable more young children to be considered for treatment of tinea capitis with itraconazole than was possible when only tablets or capsules were available...
  97. ncbi Prescribing practices for seborrheic dermatitis vary with the physician's specialty: implications for clinical practice
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook and Women s College Health Science Center, Sunnybrook Site, University of Toronto, Canada
    J Dermatolog Treat 15:208-13. 2004
    ....
  98. ncbi A risk-benefit assessment of the newer oral antifungal agents used to treat onychomycosis
    A K Gupta
    Department of Medicine, Sunnybrook and Women s Health Sciences Center, University of Toronto Medical School, Canada
    Drug Saf 22:33-52. 2000
    ..The newer antifungal agents are generally well tolerated with drug interactions that are usually predictable...
  99. ncbi Prevalence and epidemiology of toenail onychomycosis in diabetic subjects: a multicentre survey
    A K Gupta
    Division of Dermatology, Department of Medicine, Sunnybrook Health Science Center and the University of Toronto, Toronto, Canada
    Br J Dermatol 139:665-71. 1998
    ..Predisposing factors include increasing age, male gender, family history of onychomycosis, concurrent intake of immunosuppressive agents and peripheral vascular disease...
  100. ncbi Onychomycosis: strategies to reduce failure and recurrence
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Ontario, Canada
    Cutis 62:189-91. 1998
    ..We review here some instances in which this is appropriate, as well as strategies to reduce recurrence of onychomycosis...
  101. ncbi Pharmacoeconomic analysis of oral antifungal therapies used to treat dermatophyte onychomycosis of the toenails. A US analysis
    A K Gupta
    Department of Medicine, Sunnybrook Health Science Center, Toronto, Ontario, Canada
    Pharmacoeconomics 13:243-56. 1998
    ..62. In conclusion, in this analysis, itraconazole (pulse) and terbinafine were the most cost-effective therapies for dermatophyte onychomycosis of the toenails, both being substantially more cost effective than griseofulvin...