J P Despres

Summary

Country: Canada

Publications

  1. ncbi Effect of rimonabant on the high-triglyceride/ low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, Universite Laval, Quebec, Canada
    Arterioscler Thromb Vasc Biol 29:416-23. 2009
  2. ncbi Pleiotropic effects of rimonabant: clinical implications
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite D Youville, Quebec City, QC, Canada
    Curr Pharm Des 15:553-70. 2009
  3. ncbi The concept of cardiometabolic risk: Bridging the fields of diabetology and cardiology
    Jean Pierre Despres
    Hôpital Laval Research Centre, Quebec, Canada
    Ann Med 40:514-23. 2008
  4. ncbi Abdominal obesity and metabolic syndrome
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, 2725 Chemin Sainte Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada
    Nature 444:881-7. 2006
  5. ncbi Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy Québec, Canada
    J Endocrinol Invest 29:77-82. 2006
  6. ncbi Contribution of CB1 blockade to the management of high-risk abdominal obesity
    J P Despres
    Quebec Heart Institute, Hôpital Laval Research Center, Quebec, Quebec, Canada
    Int J Obes (Lond) 30:S44-52. 2006
  7. ncbi Is visceral obesity the cause of the metabolic syndrome?
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy, Quebec, Canada
    Ann Med 38:52-63. 2006
  8. ncbi Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, and the Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    N Engl J Med 353:2121-34. 2005
  9. ncbi Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
    Jean Pierre Despres
    Hôpital Laval Research Centre, 2725 Chemin Ste Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V4G5, Canada
    Arterioscler Thromb Vasc Biol 28:1039-49. 2008
  10. ncbi Role of fibric acid derivatives in the management of risk factors for coronary heart disease
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, Quebec, Canada
    Drugs 64:2177-98. 2004

Collaborators

Detail Information

Publications148 found, 100 shown here

  1. ncbi Effect of rimonabant on the high-triglyceride/ low-HDL-cholesterol dyslipidemia, intraabdominal adiposity, and liver fat: the ADAGIO-Lipids trial
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, Universite Laval, Quebec, Canada
    Arterioscler Thromb Vasc Biol 29:416-23. 2009
    ..ADAGIO-Lipids assessed the effect of rimonabant on cardiometabolic risk factors and intraabdominal and liver fat...
  2. ncbi Pleiotropic effects of rimonabant: clinical implications
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, Pavilion Marguerite D Youville, Quebec City, QC, Canada
    Curr Pharm Des 15:553-70. 2009
    ..Rimonabant is a useful option for patients with abdominal obesity and with related cardiometabolic risk abnormalities such as an atherogenic dyslipidemia and/or type 2 diabetes...
  3. ncbi The concept of cardiometabolic risk: Bridging the fields of diabetology and cardiology
    Jean Pierre Despres
    Hôpital Laval Research Centre, Quebec, Canada
    Ann Med 40:514-23. 2008
    ....
  4. ncbi Abdominal obesity and metabolic syndrome
    Jean Pierre Despres
    Quebec Heart Institute, Hôpital Laval Research Centre, 2725 Chemin Sainte Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V 4G5, Canada
    Nature 444:881-7. 2006
    ..Better risk assessment algorithms are needed to quantify diabetes and cardiovascular disease risk on a global scale...
  5. ncbi Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy Québec, Canada
    J Endocrinol Invest 29:77-82. 2006
    ....
  6. ncbi Contribution of CB1 blockade to the management of high-risk abdominal obesity
    J P Despres
    Quebec Heart Institute, Hôpital Laval Research Center, Quebec, Quebec, Canada
    Int J Obes (Lond) 30:S44-52. 2006
    ....
  7. ncbi Is visceral obesity the cause of the metabolic syndrome?
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy, Quebec, Canada
    Ann Med 38:52-63. 2006
    ....
  8. ncbi Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, and the Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste Foy, Que, Canada
    N Engl J Med 353:2121-34. 2005
    ..The Rimonabant in Obesity-Lipids (RIO-Lipids) study examined the effects of rimonabant on metabolic risk factors, including adiponectin levels, in high-risk patients who are overweight or obese and have dyslipidemia...
  9. ncbi Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk
    Jean Pierre Despres
    Hôpital Laval Research Centre, 2725 Chemin Ste Foy, Pavilion Marguerite D Youville, 4th Floor, Quebec City, QC G1V4G5, Canada
    Arterioscler Thromb Vasc Biol 28:1039-49. 2008
    ....
  10. ncbi Role of fibric acid derivatives in the management of risk factors for coronary heart disease
    Jean Pierre Despres
    Quebec Heart Institute, Laval Hospital Research Center, Quebec, Canada
    Drugs 64:2177-98. 2004
    ....
  11. ncbi The endocannabinoid system: a new target for the regulation of energy balance and metabolism
    Jean Pierre Despres
    Quebec Heart Institute, Quebec QC, Canada
    Crit Pathw Cardiol 6:46-50. 2007
    ....
  12. ncbi Abdominal obesity: the cholesterol of the 21st century?
    Jean Pierre Despres
    Quebec Heart Institute, Quebec City, Quebec
    Can J Cardiol 24:7D-12D. 2008
    ....
  13. ncbi Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Québec Lipid Research Center, CHUL Research Center CHUQ, and Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Diabetes Metab 29:6S53-61. 2003
    ..Thus, metformin treatment may represent a relevant element of an integrated lifestyle modification-pharmacotherapy to prevent not only type 2 diabetes but also cardiovascular disease...
  14. ncbi Inflammation and cardiovascular disease: is abdominal obesity the missing link?
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, and Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 27:S22-4. 2003
  15. ncbi Cardiovascular disease under the influence of excess visceral fat
    Jean Pierre Despres
    Quebec Heart Institute, Quebec, QC, Canada
    Crit Pathw Cardiol 6:51-9. 2007
    ....
  16. ncbi Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
    ....
  17. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
    ....
  18. ncbi Is the relationship between adipose tissue and waist girth altered by weight loss in obese men?
    A Pare
    Lipid Research Center, CHUL Research Center, CHUQ, Sainte Foy, Quebec, Canada
    Obes Res 9:526-34. 2001
    ..The aim of the present study was to examine whether the association of waist girth to visceral adipose tissue (AT) accumulation was altered by weight loss in abdominally obese men...
  19. ncbi Is the gender difference in LDL size explained by the metabolic complications of visceral obesity?
    I Lemieux
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy, Quebec, Canada
    Eur J Clin Invest 32:909-17. 2002
    ....
  20. ncbi Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Quebec, Canada
    Circulation 97:871-7. 1998
    ..Whether the hyperinsulinemic-insulin-resistant state of abdominal obesity affects coronary atherosclerosis among FH patients has not been determined...
  21. ncbi Haplotypes in the phospholipid transfer protein gene are associated with obesity-related phenotypes: the Québec Family Study
    Y Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec, Canada
    Int J Obes (Lond) 29:1338-45. 2005
    ..The phospholipid transfer protein (PLTP) may play a role in body fat regulation...
  22. ncbi Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. HEalth, RIsk factors, exercise Training and GEnetics
    J P Despres
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Clin Biochem 32:157-65. 1999
    ..Examine the reproducibility of plasma lipid and lipoprotein measurements in the HERITAGE Family Study...
  23. ncbi Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk?
    M E Piché
    Department of Food Science and Nutrition, Laval University, Ste Foy Quebec G1K 7P4, Canada
    Diabet Med 21:730-7. 2004
    ..Impaired glucose tolerance (IGT) is associated with an increased cardiovascular disease risk. Less is known about cardiovascular disease risk among subjects with impaired fasting glucose (IFG) or with combined IFG and IGT...
  24. ncbi Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency
    P Julien
    Lipid Research Centre, CHUL Research Centre and Laval University, Ste Foy, Quebec, Canada
    Diabetes 46:2063-8. 1997
    ..It is suggested that heterozygotes with moderate obesity and/or insulin resistance may be at higher risk of coronary artery disease because of the expression of an atherogenic lipoprotein phenotype among these patients...
  25. ncbi Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men
    M Cote
    Hôpital Laval Research Centre, Quebec, Canada
    Int J Obes (Lond) 31:692-9. 2007
    ..7 to 35.2 kg/m(2)...
  26. ncbi Effects of the FABP2 A54T mutation on triglyceride metabolism of viscerally obese men
    M T Berthier
    Lipid Research Center, Laval University Medical Research Center, Sainte Foy, Quebec, Canada
    Obes Res 9:668-75. 2001
    ..This study examined the effect of this mutation on lipoprotein levels in viscerally obese hyperinsulinemic condition...
  27. ncbi Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study
    L Perusse
    Division of Kinesiology, Laval University School of Medicine, Ste Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3270-7. 1997
    ....
  28. ncbi Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study
    J Bergeron
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, 2705, boulevard Laurier, RC 412, Quebec, G1V 4G2, Sainte Foy, Canada
    Atherosclerosis 159:399-406. 2001
    ..However, the generally better metabolic profile of Black individuals may minimize further improvement of lipoprotein-lipid concentrations by exercise training...
  29. ncbi Metabolic fitness in active reduced-obese individuals
    A Tremblay
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Obes Res 7:556-63. 1999
    ..To verify whether a physical activity-low-fat diet follow-up could normalize the metabolic risk profile of reduced-obese men and women having undergone considerable weight loss through energy restriction and drug therapy...
  30. ncbi Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  31. ncbi Investigation of LRP8 gene in 1p31 QTL linked to LDL peak particle diameter in the Quebec family study
    G Dolley
    Department of Food Science and Nutrition, Laval University, Quebec City, Canada
    Mol Genet Metab 102:448-52. 2011
    ..005, p=0.004 and p=0.01, respectively) but not with LDL size-related variables. These results suggest that LRP8 gene polymorphisms influence plasma cholesterol levels as well as size and composition of LDL particles...
  32. ncbi Insulin resistance and abdominal adiposity in young men with documented malnutrition during the first year of life
    N G Boulé
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 27:598-604. 2003
    ..It was hypothesised that participants with early life malnutrition would display a more pronounced deterioration of insulin sensitivity in association with a gain in abdominal fat...
  33. ncbi Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis
    C Cote
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec, Canada
    Heart 94:1175-80. 2008
    ..In patients with moderate/severe AS, we sought to determine whether the remodelling process would be in relationship with transvalvular gradients and circulating oxidised low-density lipoprotein (ox-LDL) levels...
  34. ncbi Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men
    D Gaudet
    Chicoutimi Hospital Lipid Clinic, Quebec, Canada
    Atherosclerosis 143:153-61. 1999
    ..It also suggest that the selective screening for mutations in the LDL-R gene may allow a better assessment of the individual risk and facilitate the development of family-based preventive strategies or intervention programs in FH...
  35. ncbi Association of sleep duration with type 2 diabetes and impaired glucose tolerance
    J P Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Diabetologia 50:2298-304. 2007
    ..The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT)...
  36. ncbi Health consequences of visceral obesity
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Sainte Foy, Canada
    Ann Med 33:534-41. 2001
    ....
  37. ncbi Fat balance and ageing: results from the Québec Family Study
    A Tremblay
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Br J Nutr 79:413-8. 1998
    ..This observation suggests that there is a strong effect of age-related factors on fat balance...
  38. ncbi Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism
    P Mauriege
    Department of Social and Preventive Medicine, and the Department of Anatomy and Physiology, Laval University, Ste Foy, Quebec, Canada
    Metabolism 52:264-72. 2003
    ..0001). These findings suggest that the antiobesity action of DHEA may be related in part to changes in lipase activities and in beta3-AR density, and that it is dependent on the ovarian status of the animal...
  39. ncbi Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis
    D Mohty
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec City, Que, Canada
    Cardiology 118:140-6. 2011
    ....
  40. ncbi Subcutaneous adipose tissue metabolism at menopause: importance of body fatness and regional fat distribution
    P Mauriege
    CHUQ Medical Research Center, Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 85:2446-54. 2000
    ..Taken together, these results suggest that menopause per se does not influence sc AT metabolism once the variation related to adipose cell size and total body fatness is taken into account...
  41. ncbi The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study
    J Robitaille
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    Clin Genet 63:109-16. 2003
    ..These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome...
  42. ncbi High apolipoprotein B with low high-density lipoprotein cholesterol and normal plasma triglycerides and cholesterol
    A D Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Cardiol 87:792-3, A8. 2001
    ..Measurment of apolipoprotein B is the key to diagnosis and such patients should be considered for statin therapy...
  43. ncbi Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada
    Diabet Med 25:400-6. 2008
    ....
  44. ncbi Effect of apoC-III gene polymorphisms on the lipoprotein-lipid profile of viscerally obese men
    Charles Couillard
    Department of Food Sciences and Nutrition, Laval University, Sainte Foy, Quebec, Canada, G1K 7P4
    J Lipid Res 44:986-93. 2003
    ..Results of the present study support the notion of a hypertriglyceridemic effect associated with the apoC-III SstI polymorphism that could modulate the magnitude of the dyslipidemic state in abdominally obese patients...
  45. ncbi A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men
    B Lamarche
    Department of Food Sciences and Nutrition, Laval University, Quebec City, Quebec, Canada
    Can J Cardiol 17:859-65. 2001
    ....
  46. ncbi Is lipoprotein(a) an independent risk factor for ischemic heart disease in men? The Quebec Cardiovascular Study
    B Cantin
    Lipid Research Centre, Laval University Medical Centre and Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    J Am Coll Cardiol 31:519-25. 1998
    ..This study was undertaken to determine whether lipoprotein(a) [Lp(a)] is an independent risk factor for ischemic heart disease (IHD) and to establish the relation of Lp(a) to the other lipid fractions...
  47. ncbi Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter
    G Dolley
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:137-45. 2011
    ..FASN may play a role in the regulation of feeding and may be a potential therapeutic target for obesity and insulin resistance...
  48. ncbi The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects
    B Lamarche
    Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Diabetes Metab 25:199-211. 1999
    ....
  49. ncbi Visceral adipose tissue accumulation, cardiorespiratory fitness, and features of the metabolic syndrome
    Benoit J Arsenault
    Hôpital Laval Research Centre, Hopital Laval, Quebec, Canada
    Arch Intern Med 167:1518-25. 2007
    ..It has been suggested that overweight and obese individuals with an adequate level of cardiorespiratory fitness (CRF), the so-called fat and fit, are at reduced risk of coronary heart disease and type 2 diabetes mellitus...
  50. ncbi Postprandial variations of plasma inflammatory markers in abdominally obese men
    Patricia Blackburn
    Department of Physical Activity and Health Sciences, , Chicoutimi, Quebec, Canada
    Obesity (Silver Spring) 14:1747-54. 2006
    ..Our results suggest a possible role of insulin resistance in the modulation of the postprandial inflammatory response, which could, in turn, contribute to worsen the state of insulin resistance...
  51. ncbi [Treatment of obesity: the need to target attention on high-risk patients characterized by abdominal obesity]
    Carla Scarsella
    Quebec Heart Institute, Saint-Foy, Quebec, Canada
    Cad Saude Publica 19:S7-19. 2003
    ..Stabilization of the atherosclerotic plaque would become a legitimate therapeutic objective, and more feasible for prevention of CAD, in AO patients...
  52. ncbi Effect of a low-glycaemic index--low-fat--high protein diet on the atherogenic metabolic risk profile of abdominally obese men
    J G Dumesnil
    Quebec Heart Institute, Laval Hospital Research Center, Quebec, Canada
    Br J Nutr 86:557-68. 2001
    ..However, the present study was a short-term intervention and additional trials are clearly needed to document the long-term efficacy of this dietary approach with regard to compliance and effects on the metabolic risk profile...
  53. ncbi Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size
    G Dolley
    CRML, CHUL Research Centre, 2705 Boul Laurier, Ste Foy, Canada
    Atherosclerosis 195:297-302. 2007
    ..In the liver, phosphatidylcholine transfer protein binds specifically phosphatidylcholine suggesting a role for this protein in the formation of HDL and possibly VLDL phospholipid membranes...
  54. ncbi The Three-Factor Eating Questionnaire and BMI in adolescents: results from the Québec family study
    A R Gallant
    Division of Kinesiology, Department of Preventive Medicine, Universite Laval, Quebec, QC, Canada
    Br J Nutr 104:1074-9. 2010
    ..These results show that the eating behaviour traits of disinhibition and rigid control are independently related to BMI z-scores in this group of adolescents...
  55. ncbi Effect of exercise training on cardiometabolic risk markers among sedentary, but metabolically healthy overweight or obese post-menopausal women with elevated blood pressure
    Benoit J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Atherosclerosis 207:530-3. 2009
    ..To investigate the effect of exercise training on markers of the lipoprotein-lipid profile and inflammatory markers in post-menopausal overweight/obese women with a moderately elevated systolic blood pressure...
  56. ncbi Prevalence of 'hypertriglyceridemic waist' in men who participated in the Quebec Health Survey: association with atherogenic and diabetogenic metabolic risk factors
    Isabelle Lemieux
    Quebec Heart Institute, Laval Hospital Research Center, Laval University, Sainte-Foy,
    Can J Cardiol 18:725-32. 2002
    ..Furthermore, this high risk clinical phenotype is highly prevalent (about 20%) among adult men...
  57. ncbi A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  58. ncbi Lipid-mediated inflammation and degeneration of bioprosthetic heart valves
    R Shetty
    Laval University, Quebec, QC, Canada
    Eur J Clin Invest 39:471-80. 2009
    ..The durability of bioprosthetic valves is limited by structural valve degeneration (SVD) leading to bioprostheses (BPs) stenosis or regurgitation. We hypothesized that a lipid-mediated inflammatory mechanism is involved in the SVD of BPs...
  59. ncbi Obesity, coffee consumption and CRP levels in postmenopausal overweight/obese women: importance of hormone replacement therapy use
    B J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Department of Cardiology, Quebec, Canada
    Eur J Clin Nutr 63:1419-24. 2009
    ..The objective of this study was to assess the relationship between obesity, coffee consumption and variation in CRP in postmenopausal, overweight/obese women with or without hormone replacement therapy (HRT) use...
  60. ncbi Obesity, inflammation, and cardiovascular risk
    P Mathieu
    Quebec Heart and Lung Institute Research Center, Quebec, Quebec, Canada
    Clin Pharmacol Ther 87:407-16. 2010
    ..In this review, we provide, in the context of CVD risk, an up-to-date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation...
  61. ncbi HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Sainte Foy, Canada
    Atherosclerosis 153:263-72. 2000
    ..The objective of the present review article is to use data from the Quebec cardiovascular study to demonstrate that in men, a low HDL-cholesterol may be even more of a risk factor and a target for therapy than a high LDL-cholesterol...
  62. ncbi Sex differences in inflammatory markers: what is the contribution of visceral adiposity?
    Amélie Cartier
    Quebec Heart Institute, Hôpital Laval Research Centre, Hopital Laval, Quebec, Canada
    Am J Clin Nutr 89:1307-14. 2009
    ....
  63. ncbi Prevalence of metabolic alterations predictive of cardiovascular disease risk in the Québec population
    Carla Scarsella
    , Laval Hospital Research Centre, Sainte-Foy, Canada
    Can J Cardiol 19:51-7. 2003
    ..Such a high prevalence should be a source of concern justifying the development of simple screening tools for early identification of the asymptomatic carriers of this cluster of metabolic abnormalities...
  64. ncbi Contribution of abdominal obesity and hypertriglyceridemia to impaired fasting glucose and coronary artery disease
    Julie St-Pierre
    Dyslipidemia, Diabetes and Atherosclerosis Research Group and the Community Genetics Research Center, Chicoutimi Hospital, Chicoutimi, , Canada
    Am J Cardiol 90:15-8. 2002
    ....
  65. ncbi A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians
    J St-Pierre
    Dyslipidemia, Diabetes and Atherosclerosis Research Group, Chicoutimi Hospital, Quebec, Canada
    Mol Genet Metab 72:209-17. 2001
    ....
  66. ncbi Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women
    B J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Int J Obes (Lond) 34:340-7. 2010
    ..Our second objective was to examine the respective contribution of waist circumference and physical inactivity on coronary heart disease (CHD) risk...
  67. ncbi Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women
    A Tchernof
    Molecular Endocrinology Laboratory and Lipid Research Center, Laval University Medical Research Center, Ste Foy, Quebec, Canada
    Horm Metab Res 32:526-36. 2000
    ..SHBG concentration may, therefore, represent the most important and reliable marker of the sex hormone profile in the examination of the complex interrelation of sex steroid hormones, obesity, and cardiovascular disease risk...
  68. ncbi Middle-aged men with increased waist circumference and elevated C-reactive protein level are at higher risk for postoperative atrial fibrillation following coronary artery bypass grafting surgery
    Nicolas Girerd
    Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada G1V 4G5
    Eur Heart J 30:1270-8. 2009
    ..In the present work, we sought to determine which feature of the MetS is associated with POAF...
  69. ncbi The quest for the optimal assessment of global cardiovascular risk: are traditional risk factors and metabolic syndrome partners in crime?
    Benoit J Arsenault
    Department of Anatomy and Physiology, Universite Laval, Quebec, Que, Canada
    Cardiology 113:35-49. 2009
    ....
  70. ncbi Body composition, cardiorespiratory fitness, and low-grade inflammation in middle-aged men and women
    Benoit J Arsenault
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec, Quebec, Canada
    Am J Cardiol 104:240-6. 2009
    ....
  71. ncbi What is a normal glucose value? Differences in indexes of plasma glucose homeostasis in subjects with normal fasting glucose
    Marie Eve Piché
    Nutraceuticals and Functional Foods Institute, Laval University, Quebec, Canada
    Diabetes Care 27:2470-7. 2004
    ..4 mmol/l but < 6.1 mmol/l have been shown to have an increased risk of developing type 2 diabetes over 5 years, little is known about glucose metabolism abnormalities in this population...
  72. ncbi Contribution of visceral adiposity to the exaggerated postprandial lipemia of men with impaired glucose tolerance
    Patricia Blackburn
    , Laval Hospital Research Center, Ste-Foy, , Canada
    Diabetes Care 26:3303-9. 2003
    ..CONCLUSIONS: These results provide evidence that visceral adipose tissue accumulation is an important factor involved in the deterioration of postprandial lipemia noted among men with IGT...
  73. ncbi Type 2 diabetes without the atherogenic metabolic triad does not predict angiographically assessed coronary artery disease in women
    Patricia Blackburn
    , , , , Canada
    Diabetes Care 31:170-2. 2008
  74. ncbi Effect of the factor VII R353Q missense mutation on plasma apolipoprotein B levels: impact of visceral obesity
    Marie Thérèse Berthier
    Lipid Research Center, CHUQ Pavilion CHUL, 2705 Laurier Blvd, TR93, Sainte Foy, Quebec, G1V 4G2, Canada
    J Hum Genet 48:367-73. 2003
    ..However, the presence of visceral obesity abolishes this effect. Further studies will be necessary to confirm this association and the mechanism involved...
  75. ncbi Associations between the fatty acid content of triglyceride, visceral adipose tissue accumulation, and components of the insulin resistance syndrome
    André J Tremblay
    Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Metabolism 53:310-7. 2004
    ..002) blood pressure. In summary, results of this study suggest that the fatty acid content of TG is associated with many metabolic variables of the insulin resistance syndrome independently of body fat mass or visceral AT accumulation...
  76. ncbi Skeletal muscle low attenuation area and maximal fat oxidation rate during submaximal exercise in male obese individuals
    O Deriaz
    CRML, CHUL, Research Center and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 25:1579-84. 2001
    ..Muscle triacylglycerols (TG) are known to be a source of energy during submaximal exercise...
  77. ncbi Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study
    V Drapeau
    Division of Kinesiology, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 27:808-14. 2003
    ....
  78. ncbi The 'valvulo-metabolic' risk in calcific aortic valve disease
    Patrick Mathieu
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Quebec, Quebec
    Can J Cardiol 23:32B-39B. 2007
    ....
  79. ncbi Increasing high-density lipoprotein cholesterol: an update on fenofibrate
    J P Despres
    Institute de Cardiologie de l Hôpital Laval, Sainte Foy, Quebec, Canada
    Am J Cardiol 88:30N-36N. 2001
    ....
  80. ncbi [Risk factors associated with obesity: a metabolic perspective]
    J P Despres
    Institut de Cardiologie de Quebec, Centre de Recherche de l Hopital Laval, Pavillon Mallet, 2e etage, 2725, Chemin Sainte Foy, Sainte Foy Québec, GIV 4G5
    Ann Endocrinol (Paris) 61:31-38. 2000
    ..It is proposed that a rather modest weight loss (approximately 10%) could contribute to substantially improve the risk profile of these patients...
  81. ncbi [Fat distribution and metabolism]
    J P Despres
    L Institut de cardiologie de Québec, Centre de Recherche de l Hopital Laval, Sainte Foy Québec, Canada
    Diabetes Metab 27:209-14. 2001
    ..Furthermore, the amount of abdominal adipose tissue should also be considered as an important therapeutic target for the optimal management of cardiovascular disease risk...
  82. ncbi Effects of micronized fenofibrate versus atorvastatin in the treatment of dyslipidaemic patients with low plasma HDL-cholesterol levels: a 12-week randomized trial
    J P Despres
    Lipid Reseach Center, CHUL Research Center, Canada
    J Intern Med 251:490-9. 2002
    ..Studies have suggested that raising low levels of high-density lipoprotein cholesterol (HDL-C) may be an important target for the prevention of coronary heart disease...
  83. ncbi Metabolic syndrome: the danger signal in atherosclerosis
    Patrick Mathieu
    Department of Surgery, Centre de Recherche de l Hôpital Laval Institut de Cardiologie de Québec, Quebec, Canada
    Vasc Health Risk Manag 2:285-302. 2006
    ..Furthermore, therapeutic options that specifically target the metabolic syndrome components are reviewed in light of recent developments...
  84. ncbi Comparison of plaque sealing with paclitaxel-eluting stents versus medical therapy for the treatment of moderate nonsignificant saphenous vein graft lesions: the moderate vein graft lesion stenting with the taxus stent and intravascular ultrasound (VELETI
    Josep Rodes-Cabau
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, 2725, Chemin Sainte Foy, Quebec, Canada
    Circulation 120:1978-86. 2009
    ..We determined the effects of sealing moderate nonsignificant SVG lesions with paclitaxel-eluting stents (PES) on the prevention of SVG atherosclerosis progression...
  85. ncbi Visceral obesity and the heart
    Patrick Mathieu
    Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, 2725 Chemin Ste Foy, Quebec, Canada, G1V 4G5
    Int J Biochem Cell Biol 40:821-36. 2008
    ..Implications and failure of lipid partitioning and some of the potential pathways mediating development of heart diseases are also covered in view of recent development of therapeutic options...
  86. ncbi Obesity and metabolic syndrome are independent risk factors for atrial fibrillation after coronary artery bypass graft surgery
    Najmeddine Echahidi
    Department of Medicine, Laval University, Quebec, Canada
    Circulation 116:I213-9. 2007
    ..Previous studies have reported that obesity is a risk factor for POAF after cardiac surgery. However, it is unknown whether the metabolic syndrome (MS) also increases the risk of postoperative atrial fibrillation...
  87. ncbi Cardiometabolic effects of rosiglitazone in patients with type 2 diabetes and coronary artery bypass grafts: A randomized placebo-controlled clinical trial
    Olivier F Bertrand
    Quebec Heart Lung Institute, Quebec, Canada
    Atherosclerosis 211:565-73. 2010
    ..To assess the efficacy and safety of rosiglitazone on saphenous vein graft (SVG) atherosclerosis prevention and on modification of the global cardiometabolic risk profile...
  88. ncbi Comparison of prognosis for men with type 2 diabetes mellitus and men with cardiovascular disease
    Gilles R Dagenais
    Institut Universitaire de Cardiologie et Pneumologie, Montreal, Que
    CMAJ 180:40-7. 2009
    ..We compared cardiovascular mortality between incident cases of diabetes and cardiovascular disease...
  89. ncbi Improvement of metabolic risk profile under second-generation antipsychotics: a pilot intervention study
    Mélissa Blouin
    Centre de recherche de l Institut universitaire de cardiologie et de pneumologie de Québec Hôpital Laval, Quebec, Quebec, Canada
    Can J Psychiatry 54:275-9. 2009
    ..To assess the impact of a weight management program on metabolic health of second-generation antipsychotic (SGA)-treated patients...
  90. ncbi Intermittent claudication: From its risk factors to its long-term prognosis in men. The Quebec Cardiovascular Study
    A St-Pierre
    Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Universite Laval, Quebec City, Canada
    Can J Cardiol 26:17-21. 2010
    ..The natural history of intermittent claudication, from its risk factors to its cardiovascular prognosis, has been reported in few prospective studies...
  91. ncbi Low cardiorespiratory fitness levels and elevated blood pressure: what is the contribution of visceral adiposity?
    Caroline Rheaume
    Department of Family and Emergency Medicine, Universite Laval, Quebec, Canada
    Hypertension 54:91-7. 2009
    ..Individuals with high visceral adipose tissue levels have higher blood pressure, independent of their fitness. Visceral adipose tissue may represent an important clinical target in the management of elevated blood pressure...
  92. ncbi Relation of the "hypertriglyceridemic waist" phenotype to earlier manifestations of coronary artery disease in patients with glucose intolerance and type 2 diabetes mellitus
    Julie St Pierre
    Department of Medicine, Universite de Montreal, University of Montreal Community Genomic Medicine Center and Lipid Clinic, Chicoutimi Hospital, Chicoutimi, Quebec, Canada
    Am J Cardiol 99:369-73. 2007
    ....
  93. ncbi A multicentre, randomized, double-blind placebo-controlled trial evaluating rosiglitazone for the prevention of atherosclerosis progression after coronary artery bypass graft surgery in patients with type 2 diabetes. Design and rationale of the VeIn-Coron
    Olivier F Bertrand
    Hopital Laval, Quebec Heart Lung Institute, Quebec, Quebec, Canada
    Can J Cardiol 25:509-15. 2009
    ..However, its role in the prevention of atherosclerosis progression is uncertain...
  94. ncbi Contributions of cardiorespiratory fitness and visceral adiposity to six-year changes in cardiometabolic risk markers in apparently healthy men and women
    Caroline Rheaume
    Department of Family and Emergency Medicine, Faculty of Medicine, Universite Laval, Quebec, Canada G1V 0A6
    J Clin Endocrinol Metab 96:1462-8. 2011
    ..Both excess visceral adipose tissue (VAT) and low cardiorespiratory fitness (CRF) levels are associated with a deteriorated cardiometabolic risk profile...
  95. ncbi The effect of topiramate on energy balance in obese men: a 6-month double-blind randomized placebo-controlled study with a 6-month open-label extension
    Angelo Tremblay
    Division of Kinesiology PEPS, Department of Social and Preventive Medicine, Laval University, G1K 7P4 Quebec, Canada
    Eur J Clin Pharmacol 63:123-34. 2007
    ..Thus, the aim of this study was to study the impact of TPM on food preferences, measures of satiety, food intake, resting metabolic rate (RMR), and 24-h energy expenditure...
  96. ncbi Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study
    Jean Philippe Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    Obesity (Silver Spring) 15:253-61. 2007
    ..To explore cross-sectional associations between short sleep duration and variations in body fat indices and leptin levels during adulthood in a sample of men and women involved in the Québec Family Study...
  97. ncbi Identifying which patients with diabetes should be tested for the presence of coronary artery disease--the importance of baseline electrocardiogram and exercise testing
    Paul Poirier
    Institut Universitaire de Cardiologie et de Pneumologie, Hopital Laval, Ste Foy, Quebec
    Can J Cardiol 22:9A-15A. 2006
    ..The present paper reviews some clinical markers that may be helpful to the clinician to increase the yield of finding significant occult CAD while screening patients with diabetes...
  98. ncbi Effect of plasma C-reactive protein levels in modulating the risk of coronary heart disease associated with small, dense, low-density lipoproteins in men (The Quebec Cardiovascular Study)
    Annie C St-Pierre
    Institute on Nutraceuticals and Fonctionnal Foods, Laval University, Ste-Foy, , Canada
    Am J Cardiol 91:555-8. 2003
    ..6 vs 3.0). Thus, increased plasma CRP levels further elevate the risk of CHD associated with having small, dense LDL particles...
  99. ncbi Development of an atherogenic metabolic risk factor profile associated with the use of atypical antipsychotics
    Natalie Almeras
    Laval Hospital Research Center, Department of Food Sciences and Nutrition, Laval University, Pavilion Marguerite D Youville, 4th Floor, 2725 Chemin Ste Foy, Ste Foy, Quebec, Canada G1V 4G5
    J Clin Psychiatry 65:557-64. 2004
    ..The objective of the present study was to evaluate whether 2 atypical antipsychotics differ regarding their impact on the cardiovascular disease risk profile compared with a reference group...
  100. ncbi [Impact of obesity in contemporary cardiology]
    Paul Poirier
    Institut Universitaire de Cardiologie et de Pneumologie, Centre de recherche de I Hôpital Laval, 2725, Chemin Sainte Foy, Sainte Foy Québec, G1V 4G5, Canada
    Med Sci (Paris) 21:3-9. 2005
    ....
  101. ncbi Impact of adiponectin gene polymorphisms on plasma lipoprotein and adiponectin concentrations of viscerally obese men
    Marie Thérèse Berthier
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    J Lipid Res 46:237-44. 2005
    ..These results suggest that some Apm1 gene polymorphisms influence plasma adiponectin concentrations and lipoprotein/lipid levels. In addition, the impact of these polymorphisms is modulated by the presence of visceral obesity...