J P Despres

Summary

Country: Canada

Publications

  1. ncbi HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Sainte Foy, Canada
    Atherosclerosis 153:263-72. 2000
  2. ncbi Increasing high-density lipoprotein cholesterol: an update on fenofibrate
    J P Despres
    Institute de Cardiologie de l Hôpital Laval, Sainte Foy, Quebec, Canada
    Am J Cardiol 88:30N-36N. 2001
  3. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
  4. ncbi [Fat distribution and metabolism]
    J P Despres
    L Institut de cardiologie de Québec, Centre de Recherche de l Hopital Laval, Sainte Foy Québec, Canada
    Diabetes Metab 27:209-14. 2001
  5. ncbi Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. HEalth, RIsk factors, exercise Training and GEnetics
    J P Despres
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Clin Biochem 32:157-65. 1999
  6. ncbi Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
  7. ncbi Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study
    J Bergeron
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, 2705, boulevard Laurier, RC 412, Quebec, G1V 4G2, Sainte Foy, Canada
    Atherosclerosis 159:399-406. 2001
  8. ncbi Is the gender difference in LDL size explained by the metabolic complications of visceral obesity?
    I Lemieux
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy, Quebec, Canada
    Eur J Clin Invest 32:909-17. 2002
  9. ncbi Is the relationship between adipose tissue and waist girth altered by weight loss in obese men?
    A Pare
    Lipid Research Center, CHUL Research Center, CHUQ, Sainte Foy, Quebec, Canada
    Obes Res 9:526-34. 2001
  10. ncbi Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Quebec, Canada
    Circulation 97:871-7. 1998

Collaborators

Detail Information

Publications71

  1. ncbi HDL-cholesterol as a marker of coronary heart disease risk: the Québec cardiovascular study
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Sainte Foy, Canada
    Atherosclerosis 153:263-72. 2000
    ..The objective of the present review article is to use data from the Quebec cardiovascular study to demonstrate that in men, a low HDL-cholesterol may be even more of a risk factor and a target for therapy than a high LDL-cholesterol...
  2. ncbi Increasing high-density lipoprotein cholesterol: an update on fenofibrate
    J P Despres
    Institute de Cardiologie de l Hôpital Laval, Sainte Foy, Quebec, Canada
    Am J Cardiol 88:30N-36N. 2001
    ....
  3. ncbi Race, visceral adipose tissue, plasma lipids, and lipoprotein lipase activity in men and women: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) family study
    J P Despres
    Lipid Research Center, CHUQ Research Center, CHUL Pavilion, Sainte Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 20:1932-8. 2000
    ....
  4. ncbi [Fat distribution and metabolism]
    J P Despres
    L Institut de cardiologie de Québec, Centre de Recherche de l Hopital Laval, Sainte Foy Québec, Canada
    Diabetes Metab 27:209-14. 2001
    ..Furthermore, the amount of abdominal adipose tissue should also be considered as an important therapeutic target for the optimal management of cardiovascular disease risk...
  5. ncbi Plasma post-heparin lipase activities in the HERITAGE Family Study: the reproducibility, gender differences, and associations with lipoprotein levels. HEalth, RIsk factors, exercise Training and GEnetics
    J P Despres
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Clin Biochem 32:157-65. 1999
    ..Examine the reproducibility of plasma lipid and lipoprotein measurements in the HERITAGE Family Study...
  6. ncbi Familial resemblance of plasma lipids, lipoproteins and postheparin lipoprotein and hepatic lipases in the HERITAGE Family Study
    L Perusse
    Division of Kinesiology, Laval University Medical School, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3263-9. 1997
    ....
  7. ncbi Race differences in the response of postheparin plasma lipoprotein lipase and hepatic lipase activities to endurance exercise training in men: results from the HERITAGE Family Study
    J Bergeron
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, 2705, boulevard Laurier, RC 412, Quebec, G1V 4G2, Sainte Foy, Canada
    Atherosclerosis 159:399-406. 2001
    ..However, the generally better metabolic profile of Black individuals may minimize further improvement of lipoprotein-lipid concentrations by exercise training...
  8. ncbi Is the gender difference in LDL size explained by the metabolic complications of visceral obesity?
    I Lemieux
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy, Quebec, Canada
    Eur J Clin Invest 32:909-17. 2002
    ....
  9. ncbi Is the relationship between adipose tissue and waist girth altered by weight loss in obese men?
    A Pare
    Lipid Research Center, CHUL Research Center, CHUQ, Sainte Foy, Quebec, Canada
    Obes Res 9:526-34. 2001
    ..The aim of the present study was to examine whether the association of waist girth to visceral adipose tissue (AT) accumulation was altered by weight loss in abdominally obese men...
  10. ncbi Relationships of abdominal obesity and hyperinsulinemia to angiographically assessed coronary artery disease in men with known mutations in the LDL receptor gene
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Quebec, Canada
    Circulation 97:871-7. 1998
    ..Whether the hyperinsulinemic-insulin-resistant state of abdominal obesity affects coronary atherosclerosis among FH patients has not been determined...
  11. ncbi Haplotypes in the phospholipid transfer protein gene are associated with obesity-related phenotypes: the Québec Family Study
    Y Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec, Canada
    Int J Obes (Lond) 29:1338-45. 2005
    ..The phospholipid transfer protein (PLTP) may play a role in body fat regulation...
  12. ncbi Impaired fasting glucose vs. glucose intolerance in pre-menopausal women: distinct metabolic entities and cardiovascular disease risk?
    M E Piché
    Department of Food Science and Nutrition, Laval University, Ste Foy Quebec G1K 7P4, Canada
    Diabet Med 21:730-7. 2004
    ..Impaired glucose tolerance (IGT) is associated with an increased cardiovascular disease risk. Less is known about cardiovascular disease risk among subjects with impaired fasting glucose (IFG) or with combined IFG and IGT...
  13. ncbi Hyperinsulinemia and abdominal obesity affect the expression of hypertriglyceridemia in heterozygous familial lipoprotein lipase deficiency
    P Julien
    Lipid Research Centre, CHUL Research Centre and Laval University, Ste Foy, Quebec, Canada
    Diabetes 46:2063-8. 1997
    ..It is suggested that heterozygotes with moderate obesity and/or insulin resistance may be at higher risk of coronary artery disease because of the expression of an atherogenic lipoprotein phenotype among these patients...
  14. ncbi Cross-trait familial resemblance for body fat and blood lipids: familial correlations in the Quebec Family Study
    L Perusse
    Division of Kinesiology, Laval University School of Medicine, Ste Foy, Quebec, Canada
    Arterioscler Thromb Vasc Biol 17:3270-7. 1997
    ....
  15. ncbi Metabolic fitness in active reduced-obese individuals
    A Tremblay
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Obes Res 7:556-63. 1999
    ..To verify whether a physical activity-low-fat diet follow-up could normalize the metabolic risk profile of reduced-obese men and women having undergone considerable weight loss through energy restriction and drug therapy...
  16. ncbi Genome-wide linkage scan reveals multiple susceptibility loci influencing lipid and lipoprotein levels in the Quebec Family Study
    Y Bosse
    Lipid Research Center, Laval University Medical Research Center, and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    J Lipid Res 45:419-26. 2004
    ..In conclusion, this genome scan provides evidence for several QTLs influencing lipid and lipoprotein levels. Promising candidate genes were located in the vicinity of the genomic regions showing evidence of linkage...
  17. ncbi Association between circulating oxidised low-density lipoprotein and fibrocalcific remodelling of the aortic valve in aortic stenosis
    C Cote
    Laboratoire d Études Moléculaires des Valvulopathies LEMV, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec, Canada
    Heart 94:1175-80. 2008
    ..In patients with moderate/severe AS, we sought to determine whether the remodelling process would be in relationship with transvalvular gradients and circulating oxidised low-density lipoprotein (ox-LDL) levels...
  18. ncbi Effects of the FABP2 A54T mutation on triglyceride metabolism of viscerally obese men
    M T Berthier
    Lipid Research Center, Laval University Medical Research Center, Sainte Foy, Quebec, Canada
    Obes Res 9:668-75. 2001
    ..This study examined the effect of this mutation on lipoprotein levels in viscerally obese hyperinsulinemic condition...
  19. ncbi Investigation of LRP8 gene in 1p31 QTL linked to LDL peak particle diameter in the Quebec family study
    G Dolley
    Department of Food Science and Nutrition, Laval University, Quebec City, Canada
    Mol Genet Metab 102:448-52. 2011
    ..005, p=0.004 and p=0.01, respectively) but not with LDL size-related variables. These results suggest that LRP8 gene polymorphisms influence plasma cholesterol levels as well as size and composition of LDL particles...
  20. ncbi Association of sleep duration with type 2 diabetes and impaired glucose tolerance
    J P Chaput
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Quebec City, Quebec, Canada
    Diabetologia 50:2298-304. 2007
    ..The aim of this study was to assess the relationship between sleep duration and type 2 diabetes or impaired glucose tolerance (IGT)...
  21. ncbi Fat balance and ageing: results from the Québec Family Study
    A Tremblay
    Physical Activity Sciences Laboratory, Laval University, Ste Foy, Quebec, Canada
    Br J Nutr 79:413-8. 1998
    ..This observation suggests that there is a strong effect of age-related factors on fat balance...
  22. ncbi Subcutaneous adipose tissue metabolism at menopause: importance of body fatness and regional fat distribution
    P Mauriege
    CHUQ Medical Research Center, Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    J Clin Endocrinol Metab 85:2446-54. 2000
    ..Taken together, these results suggest that menopause per se does not influence sc AT metabolism once the variation related to adipose cell size and total body fatness is taken into account...
  23. ncbi Health consequences of visceral obesity
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Sainte Foy, Canada
    Ann Med 33:534-41. 2001
    ....
  24. ncbi Contribution of receptor negative versus receptor defective mutations in the LDL-receptor gene to angiographically assessed coronary artery disease among young (25-49 years) versus middle-aged (50-64 years) men
    D Gaudet
    Chicoutimi Hospital Lipid Clinic, Quebec, Canada
    Atherosclerosis 143:153-61. 1999
    ..It also suggest that the selective screening for mutations in the LDL-R gene may allow a better assessment of the individual risk and facilitate the development of family-based preventive strategies or intervention programs in FH...
  25. ncbi Deterioration of the metabolic risk profile in women. Respective contributions of impaired glucose tolerance and visceral fat accumulation
    A Pascot
    Lipid Research Center, CHUQ Research Center, Laval University, Ste-Foy, , Canada
    Diabetes Care 24:902-8. 2001
    ....
  26. ncbi Elevated C-reactive protein: another component of the atherothrombotic profile of abdominal obesity
    I Lemieux
    , Laval Hospital Research Center, Sainte-Foy, , Canada
    Arterioscler Thromb Vasc Biol 21:961-7. 2001
    ..These results suggest that obesity and abdominal AT accumulation are the critical correlates of elevated plasma CRP levels found in men with atherogenic dyslipidemia of the insulin resistance syndrome...
  27. ncbi Insulin resistance and abdominal adiposity in young men with documented malnutrition during the first year of life
    N G Boulé
    Division of Kinesiology, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 27:598-604. 2003
    ..It was hypothesised that participants with early life malnutrition would display a more pronounced deterioration of insulin sensitivity in association with a gain in abdominal fat...
  28. ncbi Chronic effects of dehydroepiandrosterone on rat adipose tissue metabolism
    P Mauriege
    Department of Social and Preventive Medicine, and the Department of Anatomy and Physiology, Laval University, Ste Foy, Quebec, Canada
    Metabolism 52:264-72. 2003
    ..0001). These findings suggest that the antiobesity action of DHEA may be related in part to changes in lipase activities and in beta3-AR density, and that it is dependent on the ovarian status of the animal...
  29. ncbi High apolipoprotein B with low high-density lipoprotein cholesterol and normal plasma triglycerides and cholesterol
    A D Sniderman
    Mike Rosenbloom Laboratory for Cardiovascular Research, McGill University Health Centre, Montreal, Quebec, Canada
    Am J Cardiol 87:792-3, A8. 2001
    ..Measurment of apolipoprotein B is the key to diagnosis and such patients should be considered for statin therapy...
  30. ncbi The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study
    J Robitaille
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec, Canada
    Clin Genet 63:109-16. 2003
    ..These results suggest that the PPAR-gamma P12A polymorphism can modulate the association between dietary fat intake and components of the metabolic syndrome...
  31. ncbi Potential contribution of metformin to the management of cardiovascular disease risk in patients with abdominal obesity, the metabolic syndrome and type 2 diabetes
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Québec Lipid Research Center, CHUL Research Center CHUQ, and Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Diabetes Metab 29:6S53-61. 2003
    ..Thus, metformin treatment may represent a relevant element of an integrated lifestyle modification-pharmacotherapy to prevent not only type 2 diabetes but also cardiovascular disease...
  32. ncbi Circulating endocannabinoid levels, abdominal adiposity and related cardiometabolic risk factors in obese men
    M Cote
    Hôpital Laval Research Centre, Quebec, Canada
    Int J Obes (Lond) 31:692-9. 2007
    ..7 to 35.2 kg/m(2)...
  33. ncbi A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men
    B Lamarche
    Department of Food Sciences and Nutrition, Laval University, Quebec City, Quebec, Canada
    Can J Cardiol 17:859-65. 2001
    ....
  34. ncbi Hypoadiponectinemia is associated with valvular inflammation and faster disease progression in patients with aortic stenosis
    D Mohty
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Laval University, Quebec City, Que, Canada
    Cardiology 118:140-6. 2011
    ....
  35. ncbi [Risk factors associated with obesity: a metabolic perspective]
    J P Despres
    Institut de Cardiologie de Quebec, Centre de Recherche de l Hopital Laval, Pavillon Mallet, 2e etage, 2725, Chemin Sainte Foy, Sainte Foy Québec, GIV 4G5
    Ann Endocrinol (Paris) 61:31-38. 2000
    ..It is proposed that a rather modest weight loss (approximately 10%) could contribute to substantially improve the risk profile of these patients...
  36. ncbi Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study
    S M Ruchat
    Department of Social and Preventive Medicine, Division of Kinesiology, Laval University, Quebec, Canada
    Diabet Med 25:400-6. 2008
    ....
  37. ncbi Reduced HDL particle size as an additional feature of the atherogenic dyslipidemia of abdominal obesity
    A Pascot
    Lipid Research Center, CHUL Research Center, Ste-Foy, , Canada
    J Lipid Res 42:2007-14. 2001
    ..In conclusion, small HDL particle size appears to represent another feature of the high TG- low HDL cholesterol dyslipidemia found in viscerally obese subjects characterized by hyperinsulinemia...
  38. ncbi Age and duration of follow-up as modulators of the risk for ischemic heart disease associated with high plasma C-reactive protein levels in men
    M Pirro
    Lipid Research Center, R-9600, CHUL Research Center, 2705 Laurier Blvd, Ste-Foy, , Canada G1V 4G2
    Arch Intern Med 161:2474-80. 2001
    ..CONCLUSION: Plasma CRP levels may provide independent information on IHD risk only in younger middle-aged men and in the case of IHD events that may occur relatively soon after the baseline evaluation...
  39. ncbi The small, dense LDL phenotype and the risk of coronary heart disease: epidemiology, patho-physiology and therapeutic aspects
    B Lamarche
    Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Diabetes Metab 25:199-211. 1999
    ....
  40. ncbi Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size
    G Dolley
    CRML, CHUL Research Centre, 2705 Boul Laurier, Ste Foy, Canada
    Atherosclerosis 195:297-302. 2007
    ..In the liver, phosphatidylcholine transfer protein binds specifically phosphatidylcholine suggesting a role for this protein in the formation of HDL and possibly VLDL phospholipid membranes...
  41. ncbi Interactions between dietary fat intake and FASN genetic variation influence LDL peak particle diameter
    G Dolley
    Institute of Nutraceuticals and Functional Foods INAF, Laval University, Quebec, Canada
    J Nutrigenet Nutrigenomics 4:137-45. 2011
    ..FASN may play a role in the regulation of feeding and may be a potential therapeutic target for obesity and insulin resistance...
  42. ncbi The Three-Factor Eating Questionnaire and BMI in adolescents: results from the Québec family study
    A R Gallant
    Division of Kinesiology, Department of Preventive Medicine, Universite Laval, Quebec, QC, Canada
    Br J Nutr 104:1074-9. 2010
    ..These results show that the eating behaviour traits of disinhibition and rigid control are independently related to BMI z-scores in this group of adolescents...
  43. ncbi Effect of a low-glycaemic index--low-fat--high protein diet on the atherogenic metabolic risk profile of abdominally obese men
    J G Dumesnil
    Quebec Heart Institute, Laval Hospital Research Center, Quebec, Canada
    Br J Nutr 86:557-68. 2001
    ..However, the present study was a short-term intervention and additional trials are clearly needed to document the long-term efficacy of this dietary approach with regard to compliance and effects on the metabolic risk profile...
  44. ncbi Is lipoprotein(a) an independent risk factor for ischemic heart disease in men? The Quebec Cardiovascular Study
    B Cantin
    Lipid Research Centre, Laval University Medical Centre and Faculty of Medicine, Laval University, Ste Foy, Quebec, Canada
    J Am Coll Cardiol 31:519-25. 1998
    ..This study was undertaken to determine whether lipoprotein(a) [Lp(a)] is an independent risk factor for ischemic heart disease (IHD) and to establish the relation of Lp(a) to the other lipid fractions...
  45. ncbi Age-related differences in messenger ribonucleic acid expression of key proteins involved in adipose cell differentiation and metabolism
    P Imbeault
    Physical Activity Sciences Laboratory, Department of Social and Preventive Medicine, Laval University, Ste-Foy, , Canada G1K 7P4
    J Clin Endocrinol Metab 86:828-33. 2001
    ..05). Taken together, these results suggest that aging has an effect on the up-regulation of HSL and C3 mRNA levels, whereas PPAR gamma expression seems to be related mainly to increased adiposity...
  46. ncbi Comparison of various electrophoretic characteristics of LDL particles and their relationship to the risk of ischemic heart disease
    A C St-Pierre
    Department of Food Sciences and Nutrition, Laval University, the Lipid Research Center, Quebec, Canada
    Circulation 104:2295-9. 2001
    ....
  47. ncbi Inflammation and cardiovascular disease: is abdominal obesity the missing link?
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, and Department of Food Sciences and Nutrition, Laval University, Ste Foy, Quebec, Canada
    Int J Obes Relat Metab Disord 27:S22-4. 2003
  48. ncbi Obesity, inflammation, and cardiovascular risk
    P Mathieu
    Quebec Heart and Lung Institute Research Center, Quebec, Quebec, Canada
    Clin Pharmacol Ther 87:407-16. 2010
    ..In this review, we provide, in the context of CVD risk, an up-to-date account of the complex interactions that occur between a dysfunctional adipose tissue phenotype and inflammation...
  49. ncbi Sex steroid hormones, sex hormone-binding globulin, and obesity in men and women
    A Tchernof
    Molecular Endocrinology Laboratory and Lipid Research Center, Laval University Medical Research Center, Ste Foy, Quebec, Canada
    Horm Metab Res 32:526-36. 2000
    ..SHBG concentration may, therefore, represent the most important and reliable marker of the sex hormone profile in the examination of the complex interrelation of sex steroid hormones, obesity, and cardiovascular disease risk...
  50. ncbi Lipid-mediated inflammation and degeneration of bioprosthetic heart valves
    R Shetty
    Laval University, Quebec, QC, Canada
    Eur J Clin Invest 39:471-80. 2009
    ..The durability of bioprosthetic valves is limited by structural valve degeneration (SVD) leading to bioprostheses (BPs) stenosis or regurgitation. We hypothesized that a lipid-mediated inflammatory mechanism is involved in the SVD of BPs...
  51. ncbi A genome-wide scan for abdominal fat assessed by computed tomography in the Québec Family Study
    L Perusse
    Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Diabetes 50:614-21. 2001
    ....
  52. ncbi Effect of a six month gemfibrozil treatment and dietary recommendations on the metabolic risk profile of visceral obese men
    M Dumont
    Physical Activity Sciences Laboratory, Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, , Canada
    Int J Obes Relat Metab Disord 25:1136-43. 2001
    ..Furthermore, improvements in the plasma lipoprotein profile produced by gemfibrozil therapy appear to be independent from changes in indices of plasma glucose-insulin homeostasis...
  53. ncbi Difference in leptin response to a high-fat meal between lean and obese men
    P Imbeault
    Division of Kinesiology, Department of Social and Preventive Medicine, Laval University, Ste-Foy, , Canada G1K 7P4
    Clin Sci (Lond) 101:359-65. 2001
    ....
  54. ncbi A new method for HDL particle sizing by polyacrylamide gradient gel electrophoresis using whole plasma
    M Perusse
    Department of Food Sciences and Nutrition, Laval University, Quebec, Canada G1K 7P4
    J Lipid Res 42:1331-4. 2001
    ..5%. These lipid-stainable HDL calibrators simplify the assessment of HDL particle size by PAGGE using whole plasma, without the need for costly, time-consuming ultracentrifugation procedures...
  55. ncbi Physical inactivity, abdominal obesity and risk of coronary heart disease in apparently healthy men and women
    B J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Quebec, Canada
    Int J Obes (Lond) 34:340-7. 2010
    ..Our second objective was to examine the respective contribution of waist circumference and physical inactivity on coronary heart disease (CHD) risk...
  56. ncbi Obesity, coffee consumption and CRP levels in postmenopausal overweight/obese women: importance of hormone replacement therapy use
    B J Arsenault
    Centre de Recherche de l Institut Universitaire de Cardiologie et de Pneumologie de Quebec, Department of Cardiology, Quebec, Canada
    Eur J Clin Nutr 63:1419-24. 2009
    ..The objective of this study was to assess the relationship between obesity, coffee consumption and variation in CRP in postmenopausal, overweight/obese women with or without hormone replacement therapy (HRT) use...
  57. ncbi A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians
    J St-Pierre
    Dyslipidemia, Diabetes and Atherosclerosis Research Group, Chicoutimi Hospital, Quebec, Canada
    Mol Genet Metab 72:209-17. 2001
    ....
  58. ncbi Contribution of CB1 blockade to the management of high-risk abdominal obesity
    J P Despres
    Quebec Heart Institute, Hôpital Laval Research Center, Quebec, Quebec, Canada
    Int J Obes (Lond) 30:S44-52. 2006
    ....
  59. ncbi Effects of endurance exercise training on plasma HDL cholesterol levels depend on levels of triglycerides: evidence from men of the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
    C Couillard
    Lipid Research Center, Laval University Medical Research Center, CHUL Pavilion, Sainte-Foy, , Canada
    Arterioscler Thromb Vasc Biol 21:1226-32. 2001
    ..Results of the present study suggest that regular endurance exercise training may be particularly helpful in men with low HDL cholesterol, elevated TGs, and abdominal obesity...
  60. ncbi Do 6-y changes in eating behaviors predict changes in body weight? Results from the Québec Family Study
    V Drapeau
    Division of Kinesiology, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 27:808-14. 2003
    ....
  61. ncbi Effects of micronized fenofibrate versus atorvastatin in the treatment of dyslipidaemic patients with low plasma HDL-cholesterol levels: a 12-week randomized trial
    J P Despres
    Lipid Reseach Center, CHUL Research Center, Canada
    J Intern Med 251:490-9. 2002
    ..Studies have suggested that raising low levels of high-density lipoprotein cholesterol (HDL-C) may be an important target for the prevention of coronary heart disease...
  62. ncbi Total cholesterol/HDL cholesterol ratio vs LDL cholesterol/HDL cholesterol ratio as indices of ischemic heart disease risk in men: the Quebec Cardiovascular Study
    I Lemieux
    Quebec Heart Institute, Laval Hospital Research Center, 2725, chemin Sainte-Foy, Sainte-Foy, Quebec G1V 4G5, Canada
    Arch Intern Med 161:2685-92. 2001
    ....
  63. ncbi Evidence for the existence of adaptive thermogenesis during weight loss
    E Doucet
    Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Br J Nutr 85:715-23. 2001
    ....
  64. ncbi Impact of high-intensity exercise on energy expenditure, lipid oxidation and body fatness
    M Yoshioka
    Division of Kinesiology, Laval University, Ste-Foy, , Canada
    Int J Obes Relat Metab Disord 25:332-9. 2001
    ..CONCLUSION: These results suggest that high-intensity exercise favors a lesser body fat deposition which might be related to an increase in post-exercise energy metabolism that is mediated by beta-adrenergic stimulation...
  65. ncbi Exercise in weight management of obesity
    P Poirier
    Department of Pharmacy, Laval University School of Pharmacy, Sainte-Foy, , Canada
    Cardiol Clin 19:459-70. 2001
    ..This notion is critical, as it has been shown that less than half of obese adults have reported being advised to lose weight under the guidance of health care professionals...
  66. ncbi Skeletal muscle low attenuation area and maximal fat oxidation rate during submaximal exercise in male obese individuals
    O Deriaz
    CRML, CHUL, Research Center and Department of Food Science and Nutrition, Laval University, Quebec, Canada
    Int J Obes Relat Metab Disord 25:1579-84. 2001
    ..Muscle triacylglycerols (TG) are known to be a source of energy during submaximal exercise...
  67. ncbi The 'valvulo-metabolic' risk in calcific aortic valve disease
    Patrick Mathieu
    Laboratoire d Etudes Moléculaires des Valvulopathies, Groupe de Recherche en Valvulopathies, Laval Hospital Research Center Quebec Heart Institute, Department of Surgery, Quebec, Quebec
    Can J Cardiol 23:32B-39B. 2007
    ....
  68. ncbi Intra-abdominal obesity: an untreated risk factor for Type 2 diabetes and cardiovascular disease
    J P Despres
    Quebec Heart Institute, Laval Hospital Research Center, Ste Foy Québec, Canada
    J Endocrinol Invest 29:77-82. 2006
    ....
  69. ncbi Increase in plasma pollutant levels in response to weight loss in humans is related to in vitro subcutaneous adipocyte basal lipolysis
    P Imbeault
    Department of Social and Preventive Medicine, Laval University, Ste-Foy, , Canada
    Int J Obes Relat Metab Disord 25:1585-91. 2001
    ..CONCLUSION: The weight loss-induced increase in plasma pollutant levels is related to the rise in subcutaneous abdominal and femoral adipocyte basal lipolysis, especially in men...
  70. ncbi Glycerol as a correlate of impaired glucose tolerance: dissection of a complex system by use of a simple genetic trait
    D Gaudet
    Lipid Research Group, Chicoutimi Hospital, Chicoutimi, and Lipid Research Center, Laval University, Quebec, Canada ca
    Am J Hum Genet 66:1558-68. 2000
    ....
  71. ncbi Expression of the androgen metabolizing enzyme UGT2B15 in adipose tissue and relative expression measurement using a competitive RT-PCR method
    A Tchernof
    Molecular Endocrinology Laboratory, CHUQ Research Center, Ste Foy, Quebec, Canada
    Clin Endocrinol (Oxf) 50:637-42. 1999
    ..The objective of the present study was to investigate whether adipose tissue was a site of expression of the androgen metabolizing enzymes UDP-glucuronosyltransferases (UGT) 2B15 and 2B17...