Michel Desjardins

Summary

Country: Canada

Publications

  1. ncbi Phagocytosis: at the crossroads of innate and adaptive immunity
    Isabelle Jutras
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Annu Rev Cell Dev Biol 21:511-27. 2005
  2. pmc Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection
    Luc English
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Nat Immunol 10:480-7. 2009
  3. pmc The phagosome proteome: insight into phagosome functions
    J Garin
    Laboratoire de Chimie des Proteines, Commissariat a l Energie Atomique, 38054 Grenoble, France
    J Cell Biol 152:165-80. 2001
  4. ncbi ER-mediated phagocytosis: a new membrane for new functions
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Université de Montréal and Caprion Pharmaceuticals, Montreal, Canada
    Nat Rev Immunol 3:280-91. 2003
  5. ncbi Phagocytosis: latex leads the way
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Universite de Montreal, CP 6128, Succ Centre Ville, H3C 3J7, Montreal, Canada
    Curr Opin Cell Biol 15:498-503. 2003
  6. doi The good fat: a link between lipid bodies and antigen cross-presentation
    Michel Desjardins
    Département de pathologie et biologie cellulaire et Département de microbiologie et immunologie, Universite de Montreal, Montreal, Canada
    Immunity 31:176-8. 2009
  7. ncbi Phagocytosis: the convoluted way from nutrition to adaptive immunity
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    Immunol Rev 207:158-65. 2005
  8. pmc Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome
    François Xavier Campbell-Valois
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    Mol Cell Proteomics 11:M111.016378. 2012
  9. pmc Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages
    Christina Bell
    Institute for Research in Immunology and Cancer, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Mol Cell Proteomics 12:2394-407. 2013
  10. doi The endosomal proteome of macrophage and dendritic cells
    Sophie Duclos
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC, Canada
    Proteomics 11:854-64. 2011

Collaborators

Detail Information

Publications38

  1. ncbi Phagocytosis: at the crossroads of innate and adaptive immunity
    Isabelle Jutras
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    Annu Rev Cell Dev Biol 21:511-27. 2005
    ..Thus, phagocytosis has evolved from a nutritional function in unicellular organisms to play key roles in both innate and adaptive immunity in vertebrates...
  2. pmc Autophagy enhances the presentation of endogenous viral antigens on MHC class I molecules during HSV-1 infection
    Luc English
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Nat Immunol 10:480-7. 2009
    ..Viral peptides in autophagosomes were further processed by the proteasome, which suggests a complex interaction between the vacuolar and MHC class I presentation pathways...
  3. pmc The phagosome proteome: insight into phagosome functions
    J Garin
    Laboratoire de Chimie des Proteines, Commissariat a l Energie Atomique, 38054 Grenoble, France
    J Cell Biol 152:165-80. 2001
    ..The systematic characterization of phagosome proteins provided new insights into phagosome functions and the protein or groups of proteins involved in and regulating these functions...
  4. ncbi ER-mediated phagocytosis: a new membrane for new functions
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Université de Montréal and Caprion Pharmaceuticals, Montreal, Canada
    Nat Rev Immunol 3:280-91. 2003
    ....
  5. ncbi Phagocytosis: latex leads the way
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Universite de Montreal, CP 6128, Succ Centre Ville, H3C 3J7, Montreal, Canada
    Curr Opin Cell Biol 15:498-503. 2003
    ..These approaches have led to unique insights directly relevant for the understanding of the biology of intracellular pathogens and the ways by which they subvert their hosts...
  6. doi The good fat: a link between lipid bodies and antigen cross-presentation
    Michel Desjardins
    Département de pathologie et biologie cellulaire et Département de microbiologie et immunologie, Universite de Montreal, Montreal, Canada
    Immunity 31:176-8. 2009
    ..In this issue of Immunity, Bougnères et al. (2009) identify lipid bodies as an unexpected new player involved in this complex cellular pathway...
  7. ncbi Phagocytosis: the convoluted way from nutrition to adaptive immunity
    Michel Desjardins
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    Immunol Rev 207:158-65. 2005
    ....
  8. pmc Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome
    François Xavier Campbell-Valois
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, H3C 3J7, Canada
    Mol Cell Proteomics 11:M111.016378. 2012
    ..These results highlight promising new avenues for the description of the pathogenic mechanisms used by Leishmania, Brucella, and Legionella spp., which thrive in ER-rich phagosomes...
  9. pmc Quantitative proteomics reveals the induction of mitophagy in tumor necrosis factor-α-activated (TNFα) macrophages
    Christina Bell
    Institute for Research in Immunology and Cancer, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Mol Cell Proteomics 12:2394-407. 2013
    ..These findings highlight an unsuspected role of TNF-α in mitophagy and expanded our understanding of the mechanisms responsible for MHC presentation of self-antigens. ..
  10. doi The endosomal proteome of macrophage and dendritic cells
    Sophie Duclos
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC, Canada
    Proteomics 11:854-64. 2011
    ....
  11. ncbi Modulation of the phagosome proteome by interferon-gamma
    Isabelle Jutras
    Departement de pathologie et biologie cellulaire, Universite de Montreal, 2900 Edouard Montpetit, Montreal, Quebec H3T 1J4, Canada
    Mol Cell Proteomics 7:697-715. 2008
    ..These phagosomal conditions may favor antigen presentation by MHC class I molecules on IFN-gamma-activated macrophages...
  12. pmc Proteomic characterization of phagosomal membrane microdomains during phagolysosome biogenesis and evolution
    Guillaume Goyette
    Departement de pathologie et biologie cellulaire, Universite de Montreal, and Département de Pédiatrie, Centre de Recherche de l Hôpital Sainte Justine, C P 6128, Succ Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    Mol Cell Proteomics 11:1365-77. 2012
    ....
  13. ncbi Gamma-secretase is a functional component of phagosomes
    Isabelle Jutras
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Biol Chem 280:36310-7. 2005
    ..Finally, our results indicate that interferon-gamma stimulates gamma-secretase-dependent cleavages on phagosomes and that gamma-secretase activity may be involved in the phagocytic response of macrophages to inflammatory cytokines...
  14. pmc Inhibition of the host translation shutoff response by herpes simplex virus 1 triggers nuclear envelope-derived autophagy
    Kerstin Radtke
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    J Virol 87:3990-7. 2013
    ..We argue that NEDA is a cellular stress response triggered late during HSV-1 infection and might compensate for the viral alteration of the macroautophagic response...
  15. doi The phagosomal proteome in interferon-gamma-activated macrophages
    Matthias Trost
    Department of Pathology and Cell Biology, Universite de Montreal, Succ Centre Ville, Montreal, Quebec, Canada
    Immunity 30:143-54. 2009
    ....
  16. ncbi Trafficking of Leishmania donovani promastigotes in non-lytic compartments in neutrophils enables the subsequent transfer of parasites to macrophages
    Pascale Gueirard
    Departement de pathologie et biologie cellulaire, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Canada
    Cell Microbiol 10:100-11. 2008
    ..Thus, the ability of L. donovani to avoid trafficking into lysosomes-derived compartments in short-lived neutrophils constitutes a key process for the subsequent establishment of long-term parasitism...
  17. ncbi Phagosomes are competent organelles for antigen cross-presentation
    Mathieu Houde
    Departement de pathologie et biologie cellulaire, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, Quebec, H3C 3J7, Canada
    Nature 425:402-6. 2003
    ..Here we show that phagosomes display the elements and properties needed to be self-sufficient for the cross-presentation of exogenous antigens, a newly ascribed function linked to phagocytosis mediated by the endoplasmic reticulum...
  18. pmc Molecular characterization of the evolution of phagosomes
    Jonathan Boulais
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    Mol Syst Biol 6:423. 2010
    ..Our work thus provides the first thorough analysis of the changes that enabled the transformation of the phagosome from a phagotrophic compartment into an organelle fully competent for antigen presentation...
  19. ncbi Nuclear membrane-derived autophagy, a novel process that participates in the presentation of endogenous viral antigens during HSV-1 infection
    Luc English
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC, Canada
    Autophagy 5:1026-9. 2009
    ..The ability to enhance the contribution of autophagy to antigen presentation in various conditions suggests that this pathway could be used to boost the immune response against viral infection and develop new vaccines...
  20. doi Alternative pathways for MHC class I presentation: a new function for autophagy
    Magali Chemali
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Canada
    Cell Mol Life Sci 68:1533-41. 2011
    ..This review focuses on how various forms of autophagy participate to presentation of these antigens on MHC class I...
  21. ncbi Organelle proteomics: looking at less to see more
    Sylvain Brunet
    Departement de pathologie et biologie cellulaire, Universite de Montreal, C P 6128, Succ Centre Ville, H3C 3J7, Montreal, Canada
    Trends Cell Biol 13:629-38. 2003
    ..Current and expected advances in mass spectrometry and bioinformatics might help the realization of these goals in a shorter time than is currently predicted...
  22. ncbi Leishmania donovani lipophosphoglycan disrupts phagosome microdomains in J774 macrophages
    Jean François Dermine
    Departement de pathologie et biologie cellulaire, Universite de Montreal, C P 6128, Succ Centre Ville, Montreal, H3C 3J7, Canada
    Cell Microbiol 7:1263-70. 2005
    ..Targeting and disruption of functional foci, where proteins involved in key aspects of phagolysosome biogenesis assemble, is likely to confer a survival advantage to the parasite...
  23. ncbi Endoplasmic reticulum-mediated phagocytosis is a mechanism of entry into macrophages
    Etienne Gagnon
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, Quebec, Canada
    Cell 110:119-31. 2002
    ..We propose that intracellular pathogens have evolved to adapt and exploit ER-mediated phagocytosis to avoid destruction in host cells...
  24. doi A comprehensive characterization of membrane vesicles released by autophagic human endothelial cells
    Nicolas Pallet
    Research Centre, Centre hospitalier de l Université de Montréal CRCHUM, Montreal, Canada
    Proteomics 13:1108-20. 2013
    ..Instead, they are enriched with autophagosomes and mitochondria and convey various danger signals, including ATP, suggesting that they could be involved in the modulation of innate immunity...
  25. doi Human invariant chain isoform p35 restores thymic selection and antigen presentation in CD74-deficient mice
    Laetitia Genève
    Laboratoire d Immunologie Moléculaire, Departement de Microbiologie et Immunologie, Universite de Montreal, Montreal, Quebec, Canada
    Immunol Cell Biol 90:896-902. 2012
    ..Altogether, our results suggest that Iip35 is functional and does not require co-expression of other isoforms for antigen presentation...
  26. doi Organelle proteomics
    Sophie Duclos
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC, Canada H3T 1J4
    Methods Mol Biol 753:117-28. 2011
    ..The success of this approach relies on the isolation of highly enriched cell fractions enabling the separation of organelles with minimal contamination by other cellular structures...
  27. ncbi Combined enzymatic and data mining approaches for comprehensive phosphoproteome analyses: application to cell signaling events of interferon-gamma-stimulated macrophages
    Maria Marcantonio
    Institute for Research in Immunology and Cancer, Departments of Biochemistry, Universite de Montreal, Station Centre Ville, Montreal H3C 3J7, Canada
    Mol Cell Proteomics 7:645-60. 2008
    ....
  28. ncbi Remodeling of endosomes during lysosome biogenesis involves 'kiss and run' fusion events regulated by rab5
    Sophie Duclos
    Departement de pathologie et biologie cellulaire, Universite de Montreal, CP 6128, Succ Centre Ville, Montreal, QC, H3C 3J7, Canada
    J Cell Sci 116:907-18. 2003
    ..Together, our results indicate that endosome maturation occurs during the early part of lysosome biogenesis. This process involves transient fusion events regulated, in part, by the small GTPase rab5...
  29. doi Subcellular phosphoproteomics
    Matthias Trost
    Institute for Research in Immunology and Cancer, Universite de Montreal, P O Box 6128, Station Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Mass Spectrom Rev 29:962-90. 2010
    ....
  30. doi Proteomics analysis of herpes simplex virus type 1-infected cells reveals dynamic changes of viral protein expression, ubiquitylation, and phosphorylation
    Christina Bell
    Departement de Chimie, Proteomics and Mass Spectrometry Research Unit, Institute for Research in Immunology and Cancer, and Département de Pathologie et Biologie Cellulaire, Universite de Montreal, C P 6128 Succursale Centre Ville, Montreal, Quebec H3C 3J7, Canada
    J Proteome Res 12:1820-9. 2013
    ..Given the importance of expression dynamics, ubiquitylation, and phosphorylation for protein function, these findings will serve as important tools for future studies on herpesvirus biology. ..
  31. doi Leishmania evades host immunity by inhibiting antigen cross-presentation through direct cleavage of the SNARE VAMP8
    Diana Matheoud
    Departement de pathologie et biologie cellulaire, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Cell Host Microbe 14:15-25. 2013
    ..These findings indicate that Leishmania subverts immune recognition by altering phagosome function and highlight the importance of VAMP8 in phagosome biogenesis and antigen cross-presentation. ..
  32. doi Cell biology through proteomics--ad astra per alia porci
    John J M Bergeron
    The Research Institute of the McGill University Health Centre, Department of Medicine, McGill University, 687 Pine Avenue West, Montreal, Quebec H3A 1A1, Canada
    Trends Cell Biol 20:337-45. 2010
    ....
  33. ncbi Proteomic analysis reveals a role for protein kinase C-alpha in phagosome maturation
    John Derek Ng Yan Hing
    INRS Institut Armand Frappier, Universite du Quebec, Laval, Que, Canada H7V 1B7
    Biochem Biophys Res Commun 319:810-6. 2004
    ..Collectively, these data provide evidence that PKC-alpha plays a role in phagolysosome biogenesis, a critical process of the innate immune response against infections...
  34. ncbi ER-mediated phagocytosis: myth or reality?
    Etienne Gagnon
    J Leukoc Biol 77:843-5. 2005
  35. ncbi Activation of Rho and Rab GTPases dissociates Brucella abortus internalization from intracellular trafficking
    Esteban Chaves-Olarte
    Programa de Investigación en Enfermedades Tropicales, Escuela de Medicina Veterinaria, Universidad Nacional, Aptdo 304 3000 Heredia, Costa Rica
    Cell Microbiol 4:663-76. 2002
    ..Besides, CNF-induced super-infection demonstrates that Brucella does not interfere with crucial cellular processes and has shown its potential as tool to characterize the intracellular compartments occupied by this bacterium...
  36. ncbi Alkylation potency and protein specificity of aromatic urea derivatives and bioisosteres as potential irreversible antagonists of the colchicine-binding site
    Jessica S Fortin
    Unité des Biotechnologies et de Bioingénierie, CHUQ, Hopital Saint Francois d Assise, Quebec, Que, Canada G1L 3L5
    Bioorg Med Chem 15:4456-69. 2007
    ..Our results suggest that increasing the potency of the electrophilic moiety of the aromatic ureas enhances their antiproliferative activity but decreases significantly their capacity to covalently bind to the colchicine-binding site...
  37. ncbi N-Phenyl-N'-(2-chloroethyl)ureas (CEU) as potential antineoplastic agents. Part 2: role of omega-hydroxyl group in the covalent binding to beta-tubulin
    Sebastien Fortin
    Unité des Biotechnologies et de Bioingénierie, Centre de Recherche, C H U Q, Hopital Saint Francois d Assise, Universite Laval, Quebec, QC, Canada G01L 3L5
    Bioorg Med Chem 15:1430-8. 2007
    ..We have confirmed that the pentyl substituted CEUs 1f, 2f, and 3e are still covalently binding to beta-tubulin and still arrest cell division in G(2)/M phase...
  38. ncbi Leishmania antigens are presented to CD8+ T cells by a transporter associated with antigen processing-independent pathway in vitro and in vivo
    Sylvie Bertholet
    Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 0425, USA
    J Immunol 177:3525-33. 2006
    ....