Laurent Descarries

Summary

Country: Canada

Publications

  1. ncbi Agonist-induced internalization of serotonin-1a receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors)
    M Riad
    Départements de pathologie et biologie cellulaire et de physiologie, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 21:8378-86. 2001
  2. pmc Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT
    Laurent Descarries
    Departments of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Philos Trans R Soc Lond B Biol Sci 367:2416-25. 2012
  3. ncbi Structural determinants of the roles of acetylcholine in cerebral cortex
    Laurent Descarries
    Departments of Pathology and Cell Biology and of Physiology, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Prog Brain Res 145:45-58. 2004
  4. ncbi The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease
    L Descarries
    Departement de pathologie et biologie cellulaire, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    J Neural Transm 112:149-62. 2005
  5. ncbi Glutamate in dopamine neurons: synaptic versus diffuse transmission
    Laurent Descarries
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, QC, Canada
    Brain Res Rev 58:290-302. 2008
  6. doi Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus
    Baptiste Lacoste
    Department of Pathology and Cell Biology, Universite de Montreal, 2900 Blvd Edouard Montpetit, Montreal, Quebec, Canada
    Eur J Neurosci 29:2303-14. 2009
  7. doi The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
    Noémie Bérubé-Carrière
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 517:873-91. 2009
  8. doi Acetylcholine innervation of the adult rat thalamus: distribution and ultrastructural features in dorsolateral geniculate, parafascicular, and reticular thalamic nuclei
    Martin Parent
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 511:678-91. 2008
  9. ncbi Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat
    Mustapha Riad
    Department of Pathology, and Centre de Recherche en Sciences Neurologiques, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 24:5420-6. 2004
  10. doi MicroPET imaging of 5-HT 1A receptors in rat brain: a test-retest [18F]MPPF study
    Nicolas Aznavour
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Eur J Nucl Med Mol Imaging 36:53-62. 2009

Collaborators

Detail Information

Publications42

  1. ncbi Agonist-induced internalization of serotonin-1a receptors in the dorsal raphe nucleus (autoreceptors) but not hippocampus (heteroreceptors)
    M Riad
    Départements de pathologie et biologie cellulaire et de physiologie, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 21:8378-86. 2001
    ..They suggest that this desensitization is the result of autoreceptor internalization...
  2. pmc Effects of the antidepressant fluoxetine on the subcellular localization of 5-HT1A receptors and SERT
    Laurent Descarries
    Departments of Pathology and Cell Biology, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Philos Trans R Soc Lond B Biol Sci 367:2416-25. 2012
    ..Ongoing and future investigations prompted by these finding are briefly outlined by way of conclusion...
  3. ncbi Structural determinants of the roles of acetylcholine in cerebral cortex
    Laurent Descarries
    Departments of Pathology and Cell Biology and of Physiology, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Prog Brain Res 145:45-58. 2004
  4. ncbi The acetylcholine innervation of cerebral cortex: new data on its normal development and its fate in the hAPP(SW,IND) mouse model of Alzheimer's disease
    L Descarries
    Departement de pathologie et biologie cellulaire, Faculte de Medecine, Universite de Montreal, Montreal, QC, Canada
    J Neural Transm 112:149-62. 2005
    ....
  5. ncbi Glutamate in dopamine neurons: synaptic versus diffuse transmission
    Laurent Descarries
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, QC, Canada
    Brain Res Rev 58:290-302. 2008
    ....
  6. doi Trafficking of neurokinin-1 receptors in serotonin neurons is controlled by substance P within the rat dorsal raphe nucleus
    Baptiste Lacoste
    Department of Pathology and Cell Biology, Universite de Montreal, 2900 Blvd Edouard Montpetit, Montreal, Quebec, Canada
    Eur J Neurosci 29:2303-14. 2009
    ..These results suggest that the trafficking of NK1rs represents a cellular mechanism in control of the modulation of serotonin neuron activity by SP in DRN...
  7. doi The dual dopamine-glutamate phenotype of growing mesencephalic neurons regresses in mature rat brain
    Noémie Bérubé-Carrière
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 517:873-91. 2009
    ..These results suggest a regression of the VGLUT2 phenotype of dopamine neurons with age, following normal development, lesion, or sprouting after injury, and a role for glutamate in the establishment of synapses by these neurons...
  8. doi Acetylcholine innervation of the adult rat thalamus: distribution and ultrastructural features in dorsolateral geniculate, parafascicular, and reticular thalamic nuclei
    Martin Parent
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 511:678-91. 2008
    ..In contrast, the entirely synaptic ACh input to PF should allow for a direct relaying of the information from brainstem, affecting basal ganglia function as well as perceptual awareness, including attention and pain perception...
  9. ncbi Acute treatment with the antidepressant fluoxetine internalizes 5-HT1A autoreceptors and reduces the in vivo binding of the PET radioligand [18F]MPPF in the nucleus raphe dorsalis of rat
    Mustapha Riad
    Department of Pathology, and Centre de Recherche en Sciences Neurologiques, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 24:5420-6. 2004
    ....
  10. doi MicroPET imaging of 5-HT 1A receptors in rat brain: a test-retest [18F]MPPF study
    Nicolas Aznavour
    Department of Psychiatry, McGill University, Montreal, QC, Canada
    Eur J Nucl Med Mol Imaging 36:53-62. 2009
    ..In the present study, we sought to determine if such data could be obtained in rat, with a microPET (R4, Concorde Microsystems)...
  11. ncbi Selective cholinergic denervation, independent from oxidative stress, in a mouse model of Alzheimer's disease
    J S Aucoin
    Complex Neural Systems, Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Room 748, Montreal, QC, Canada H3A 2B4
    Neuroscience 132:73-86. 2005
    ....
  12. doi Decreased [18F]MPPF binding potential in the dorsal raphe nucleus after a single oral dose of fluoxetine: a positron-emission tomography study in healthy volunteers
    Igor Sibon
    Department of Psychiatry, McGill University, Montreal, Quebec, Canada
    Biol Psychiatry 63:1135-40. 2008
    ....
  13. ncbi Postnatal development of the cholinergic innervation in the dorsal hippocampus of rat: Quantitative light and electron microscopic immunocytochemical study
    Nicolas Aznavour
    Departement de pathologie et biologie cellulaire, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Comp Neurol 486:61-75. 2005
    ..They emphasize the remarkable growth capacities of individual ACh neurons and substantiate a role for diffuse transmission by ACh during hippocampal development...
  14. ncbi Localization of EphA4 in axon terminals and dendritic spines of adult rat hippocampus
    Marie Eve Tremblay
    Département de pathologie et biologie cellulaire and Groupe de recherche sur le système nerveux central, Universite de Montreal, Montreal, Quebec, Canada
    J Comp Neurol 501:691-702. 2007
    ..The dual preferential labeling of EphA4 on pre- or postsynaptic specializations of excitatory synapses in adult rat hippocampus is consistent with roles for this receptor in synaptic plasticity and LTP...
  15. ncbi Pentylenetetrazol-induced seizures in immature rats provoke long-term changes in adult hippocampal cholinergic excitability
    Sebastien Meilleur
    Department of Pediatrics, Ste Justine Hospital Research Center, Montreal, Quebec, Canada
    Epilepsia 44:507-17. 2003
    ..In this study, we investigated several factors as the possible mechanism for this effect, including age at convulsions...
  16. doi Distribution and ultrastructural features of the serotonin innervation in rat and squirrel monkey subthalamic nucleus
    Martin Parent
    Department of Pathology and Cell Biology, Universite de Montreal, Montreal, QC, Canada H3C 3J7
    Eur J Neurosci 31:1233-42. 2010
    ..A better understanding of the factors governing the complex interplay between these signaling processes would greatly improve our knowledge of the physiopathology of the STN...
  17. doi Glutamate corelease promotes growth and survival of midbrain dopamine neurons
    Guillaume M Fortin
    Department of Pharmacology, and Groupe de recherche sur le système nerveux central, Faculty of Medicine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Neurosci 32:17477-91. 2012
    ....
  18. ncbi Immunocytochemical evidence for the existence of substance P receptor (NK1) in serotonin neurons of rat and mouse dorsal raphe nucleus
    Baptiste Lacoste
    Departement de pathologie et biologie cellulaire, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Eur J Neurosci 23:2947-58. 2006
    ..These 5-HT neurons represent a new element in the neuronal circuitry currently proposed to account for the role of SP in mood regulation...
  19. ncbi A pentylenetetrazole-induced generalized seizure in early life enhances the efficacy of muscarinic receptor coupling to G-protein in hippocampus and neocortex of adult rat
    Soizic Potier
    Ste Justine Hospital Research Centre and Department of Pediatrics, Montreal, Quebec, Canada
    Eur J Neurosci 21:1828-36. 2005
    ..By analogy, such a mechanism could account for the susceptibility to epilepsy of human adults having suffered from prolonged convulsions in early life...
  20. doi Hippocampal atrophy and abnormal brain development following a prolonged hyperthermic seizure in the immature rat with a focal neocortical lesion
    Steve A Gibbs
    Sainte Justine Hospital Research Centre, Universite de Montreal, Montreal, QC, Canada
    Neurobiol Dis 32:176-82. 2008
    ..Thus, a prolonged hyperthermic seizure in immature brain with a subtle neocortical lesion impairs normal brain development, and the duration of the seizure appears to be a key factor in generating hippocampal atrophy...
  21. ncbi Ultrastructural features of the acetylcholine innervation in the developing parietal cortex of rat
    Naguib Mechawar
    Département de pathologie et biologie cellulaire and Centre de recherche en sciences neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    J Comp Neurol 443:250-8. 2002
    ....
  22. ncbi Fine structural features of the acetylcholine innervation in the developing neostriatum of rat
    Nicolas Aznavour
    Departement de pathologie et biologie cellulaire, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec H3C 3J7, Canada
    J Comp Neurol 460:280-91. 2003
    ....
  23. ncbi Comparative analysis of cholinergic innervation in the dorsal hippocampus of adult mouse and rat: a quantitative immunocytochemical study
    Nicolas Aznavour
    Department de Pathologie et Biologie Cellulaire et de Physiologie, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Hippocampus 12:206-17. 2002
    ..These quantitative data will be of particular interest to evaluate changes in mutant mice, or mice and rats subjected to experimental conditions affecting the cholinergic phenotype...
  24. doi Ultrastructural characterization of the mesostriatal dopamine innervation in mice, including two mouse lines of conditional VGLUT2 knockout in dopamine neurons
    Noémie Bérubé-Carrière
    Department of Pathology and Cell Biology, Faculty of Medicine, C P 6128, Succursale Centre Ville, Universite de Montreal, Montreal, QC H3C 3J7, Canada
    Eur J Neurosci 35:527-38. 2012
    ..They also suggest that, in mouse even more than rat, the mesostriatal DA system operates mainly through non-targeted release of DA, diffuse transmission and the maintenance of an ambient DA level...
  25. ncbi Diffuse transmission by acetylcholine in the CNS
    L Descarries
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, QC, Canada
    Prog Neurobiol 53:603-25. 1997
    ..The notions of diffuse transmission and of an ambient level of ACh in the CNS could also be of clinical relevance, in accounting for the production and nature of certain cholinergic deficits and the efficacy of substitution therapies...
  26. ncbi Dual character, asynaptic and synaptic, of the dopamine innervation in adult rat neostriatum: a quantitative autoradiographic and immunocytochemical analysis
    L Descarries
    Department de Physiologie, Universite de Montreal, Quebec, Canada
    J Comp Neurol 375:167-86. 1996
    ....
  27. doi Cholinergic innervation and thalamic input in rat nucleus accumbens
    Michael Ligorio
    Centre de Recherche Fernand Seguin, Universite de Montreal, Montreal, Que, Canada
    J Chem Neuroanat 37:33-45. 2009
    ....
  28. ncbi Noradrenaline axon terminals in adult rat neocortex: an immunocytochemical analysis in serial thin sections
    P Seguela
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Neuroscience 35:249-64. 1990
    ....
  29. doi Unchanged density of 5-HT(1A) autoreceptors on the plasma membrane of nucleus raphe dorsalis neurons in rats chronically treated with fluoxetine
    M Riad
    Department of Pathology, and Groupe de recherche sur le système nerveux central, Faculty of Medicine, Universite de Montreal, CP 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    Neuroscience 151:692-700. 2008
    ..Thus, the regulatory function of these autoreceptors may depend on a dynamic balance among their production, activation, internalization and recycling to the plasma membrane in inactivated (desensitized) form...
  30. ncbi Decreased G-protein coupling of serotonin 5-HT(1A) receptors in the brain of 5-HT(1B) knockout mouse
    A R Ase
    Faculte de Medecine, Departement de Physiologie, Universite de Montreal, Succursale Centre Ville, Montreal, Quebec, Canada
    Neuropharmacology 42:941-9. 2002
    ..This could represent the first indication of a cross-talk between these two 5-HT receptor subtypes, at least in brain regions where they are co localized in the same neurons...
  31. ncbi Altered serotonin and dopamine metabolism in the CNS of serotonin 5-HT(1A) or 5-HT(1B) receptor knockout mice
    A R Ase
    Department de Physiologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 75:2415-26. 2000
    ..Thus, markedly different alterations in CNS monoamine metabolism may contribute to the opposite behavioral phenotypes of these two knockouts...
  32. ncbi Regional changes in density of serotonin transporter in the brain of 5-HT1A and 5-HT1B knockout mice, and of serotonin innervation in the 5-HT1B knockout
    A R Ase
    Departement de Physiologie, Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada
    J Neurochem 78:619-30. 2001
    ..v) These increases in density of 5-HT innervation provide the first evidence for a negative control of 5-HT neuron growth mediated by 5-HT1B receptors...
  33. doi Promotion of non-rapid eye movement sleep and activation of reticular thalamic neurons by a novel MT2 melatonin receptor ligand
    Rafael Ochoa-Sanchez
    Neurobiological Psychiatry Unit, Department of Psychiatry, McGill University and McGill University Health Center, Montreal, Quebec, Canada
    J Neurosci 31:18439-52. 2011
    ..Since developing hypnotics that increase NREMS without altering sleep architecture remains a medical challenge, MT(2) receptors may represent a novel target for the treatment of sleep disorders...
  34. ncbi Similar ultrastructural distribution of the 5-HT(2A) serotonin receptor and microtubule-associated protein MAP1A in cortical dendrites of adult rat
    V Cornea-Hébert
    Départements de pathologie et biologie cellulaire et de physiologie, Faculte de Medecine, Universite de Montreal, P O Box 6128, Succursale Centre Ville, Montreal, Quebec, Canada H3C 3J7
    Neuroscience 113:23-35. 2002
    ....
  35. ncbi The cholinergic innervation develops early and rapidly in the rat cerebral cortex: a quantitative immunocytochemical study
    N Mechawar
    , and Centre de Recherche en Sciences Neurologiques, , , P.O. Box 6128, Succursale Centre-Ville, H3C 3J7, Montreal, QC, Canada
    Neuroscience 108:555-67. 2001
    ....
  36. ncbi Cellular and subcellular distribution of the serotonin 5-HT2A receptor in the central nervous system of adult rat
    V Cornea-Hébert
    Départements de pathologie et biologie cellulaire et de physiologie, and Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    J Comp Neurol 409:187-209. 1999
    ....
  37. doi Enhanced glutamatergic phenotype of mesencephalic dopamine neurons after neonatal 6-hydroxydopamine lesion
    G Dal Bo
    Department of Pharmacology, Faculty of Medicine, Universite de Montreal, C P 6128, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    Neuroscience 156:59-70. 2008
    ..They also support the hypothesis of co-release of glutamate and DA by mesencephalic neurons in vivo, at least in the developing brain...
  38. ncbi Possible existence of a presynaptic positive feedback mechanism enhancing dopamine transmission in the anterior cingulate cortex of the rat
    M Beauregard
    Centre de Recherche en Sciences Neurologiques Département de Physiologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Experientia 45:888-92. 1989
    ....
  39. ncbi Severe neuronal losses with age in the parietal cortex and ventrobasal thalamus of mice transgenic for the human NF-L neurofilament protein
    D Ma
    Département de pathologie et biologie cellulaire and Centre de recherche en sciences neurologiques, Universite de Montreal, Quebec, Canada
    J Comp Neurol 406:433-48. 1999
    ..Furthermore, strong accumulation of lipofuscin in the neurons of aged transgenic mice suggested that oxidative stress partakes in the mechanisms through which NF-L overproduction compromises neuronal viability...
  40. ncbi Catecholaminergic activation of G-protein coupling in rat spinal cord: further evidence for the existence of dopamine and noradrenaline receptors in spinal grey and white matter
    V V Venugopalan
    Departement de Physiologie, Faculte de Medecine, Universite de Montreal, Montreal, Quebec, Canada H3C 3J7
    Brain Res 1070:90-100. 2006
    ..In white matter, they strongly suggested the presence of dopamine D1, and of alpha 1 and alpha 2 adrenergic receptors on glia and/or microvessels, that might be activated by diffuse transmission in vivo...
  41. ncbi Central serotonin system in Dystonia musculorum mutant mice: biochemical, autoradiographic and immunocytochemical data
    A R Ase
    Centre de Recherche en Sciences Neurologiques, Faculte de Medecine, Universite de Montreal, Montreal Qc H3C 3J7 Canada
    Synapse 37:179-93. 2000
    ....
  42. ncbi CNS distribution and overexpression of neurofilament light proteins (NF-L) in mice transgenic for the human NF-L: aberrant accumulation in thalamic perikarya
    J F Mathieu
    Departement de Pathologie, Faculte de Medecine, Universite de Montreal, Quebec, Canada
    Exp Neurol 132:134-46. 1995
    ..It was compatible with prolonged survival of the animal and could provide a new experimental model of neurodegenerative disease...