Gaston De Serres

Summary

Country: Canada

Publications

  1. doi Bats in the bedroom, bats in the belfry: reanalysis of the rationale for rabies postexposure prophylaxis
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Laval University, Quebec, Canada
    Clin Infect Dis 48:1493-9. 2009
  2. pmc Contagious period for pandemic (H1N1) 2009
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 16:783-8. 2010
  3. pmc School absenteeism as an adjunct surveillance indicator: experience during the second wave of the 2009 H1N1 pandemic in Quebec, Canada
    Christelle Aïcha Kom Mogto
    Department of Social and Preventive Medicine, Universite Laval, Quebec City, Quebec, Canada
    PLoS ONE 7:e34084. 2012
  4. doi Higher risk of measles when the first dose of a 2-dose schedule of measles vaccine is given at 12-14 months versus 15 months of age
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec City, Canada
    Clin Infect Dis 55:394-402. 2012
  5. pmc Short and long-term safety of the 2009 AS03-adjuvanted pandemic vaccine
    Gaston De Serres
    Centre de Recherche du CHUQ CHUL, Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e38563. 2012
  6. pmc Seroprevalence of hepatitis A infection in a low endemicity country: a systematic review
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Ontario, Canada
    BMC Infect Dis 5:56. 2005
  7. pmc A review of interventions triggered by hepatitis A infected food-handlers in Canada
    Andrea C Tricco
    Epidemiology and Biostatistics, GlaxoSmithKline Canada, Mississauga, Ontario, Canada
    BMC Health Serv Res 6:157. 2006
  8. ncbi Population-based survey of travel patterns among Canadians visiting hepatitis A-endemic countries
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec, PQ, Canada
    J Travel Med 14:269-73. 2007
  9. ncbi Oculo-respiratory syndrome after influenza vaccination: trends over four influenza seasons
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Canada
    Vaccine 23:3726-32. 2005
  10. ncbi Pertussis vaccination beyond childhood
    Gaston De Serres
    Quebec National Institute of Public Health, Quebec City, Quebec, Canada G1E 7G9
    Lancet 365:1015-6. 2005

Collaborators

Detail Information

Publications91

  1. doi Bats in the bedroom, bats in the belfry: reanalysis of the rationale for rabies postexposure prophylaxis
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Laval University, Quebec, Canada
    Clin Infect Dis 48:1493-9. 2009
    ....
  2. pmc Contagious period for pandemic (H1N1) 2009
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 16:783-8. 2010
    ..Self-isolation only until fever abates appears insufficient to limit transmission. Self-isolation for a week may be more effective, although some case-patients still would shed infectious virus...
  3. pmc School absenteeism as an adjunct surveillance indicator: experience during the second wave of the 2009 H1N1 pandemic in Quebec, Canada
    Christelle Aïcha Kom Mogto
    Department of Social and Preventive Medicine, Universite Laval, Quebec City, Quebec, Canada
    PLoS ONE 7:e34084. 2012
    ..A school absenteeism surveillance system was implemented in the province of Quebec, Canada during the second wave of the 2009 H1N1 pandemic. This paper compares this surveillance approach with other available indicators...
  4. doi Higher risk of measles when the first dose of a 2-dose schedule of measles vaccine is given at 12-14 months versus 15 months of age
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec City, Canada
    Clin Infect Dis 55:394-402. 2012
    ..Effectiveness of this schedule was assessed during a high school outbreak...
  5. pmc Short and long-term safety of the 2009 AS03-adjuvanted pandemic vaccine
    Gaston De Serres
    Centre de Recherche du CHUQ CHUL, Laval University, Quebec City, Quebec, Canada
    PLoS ONE 7:e38563. 2012
    ..We compared its safety profile to that of the seasonal trivalent inactivated influenza vaccine (TIV) for 2010-2011...
  6. pmc Seroprevalence of hepatitis A infection in a low endemicity country: a systematic review
    Ba Pham
    Biomedical Data Sciences, GlaxoSmithKline, Ontario, Canada
    BMC Infect Dis 5:56. 2005
    ..This systematic review aimed to 1) estimate age-specific prevalence of HAV antibody in Canada and 2) evaluate infection-associated risk factors...
  7. pmc A review of interventions triggered by hepatitis A infected food-handlers in Canada
    Andrea C Tricco
    Epidemiology and Biostatistics, GlaxoSmithKline Canada, Mississauga, Ontario, Canada
    BMC Health Serv Res 6:157. 2006
    ..We undertook a systematic review of such incidents to evaluate the extent of viral transmission through food contamination and the scope of post-exposure prophylaxis (PEP) interventions...
  8. ncbi Population-based survey of travel patterns among Canadians visiting hepatitis A-endemic countries
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec, PQ, Canada
    J Travel Med 14:269-73. 2007
  9. ncbi Oculo-respiratory syndrome after influenza vaccination: trends over four influenza seasons
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Canada
    Vaccine 23:3726-32. 2005
    ..Oculo-respiratory syndrome (ORS) following influenza vaccination was identified in Canada in 2000. This report describes trends of ORS reported during four consecutive seasons 2000, 2001, 2002 and 2003 in the province of Quebec, Canada...
  10. ncbi Pertussis vaccination beyond childhood
    Gaston De Serres
    Quebec National Institute of Public Health, Quebec City, Quebec, Canada G1E 7G9
    Lancet 365:1015-6. 2005
  11. doi Bat rabies in the United States and Canada from 1950 through 2007: human cases with and without bat contact
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Canada
    Clin Infect Dis 46:1329-37. 2008
    ..Since the 1980s, rare cases of rabies in humans in Canada and the United States have been almost exclusively caused by the bat-variant virus...
  12. doi Importance of viral and bacterial infections in chronic obstructive pulmonary disease exacerbations
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Québec Québec, Canada
    J Clin Virol 46:129-33. 2009
    ..Few studies have evaluated the contribution of both viruses and bacteria in acute exacerbation of chronic obstructive pulmonary disease (AECOPD)...
  13. ncbi The clinical spectrum of the oculo-respiratory syndrome after influenza vaccination
    Gaston De Serres
    Quebec National Institute of Public Health, Quebec, Que, Canada
    Vaccine 21:2354-61. 2003
    ....
  14. ncbi Oculo-respiratory syndrome following influenza vaccination: evidence for occurrence with more than one influenza vaccine
    Gaston De Serres
    Direction de la santé publique de Québec, Que, Quebec, Canada G1E 7G9
    Vaccine 21:2346-53. 2003
    ..001) whereas that comparing Fluviral and Vaxigrip varied between 1.5 and 1.9 (P=0.02-0.05). ORS is an adverse event that is present with more than one vaccine and may be present with any influenza vaccines to a greater or lesser degree...
  15. ncbi Effectiveness of a single dose of acellular pertussis vaccine to prevent pertussis in children primed with pertussis whole cell vaccine
    G De Serres
    Institut National de Sante Publique du Quebec, Quebec, Canada G1E 7G9
    Vaccine 19:3004-8. 2001
    ..4 and 2.1 times higher respectively than in those who received 4 wP + 1 aP. A single dose of aP increased the protection against pertussis and this protection was greater than that obtained with a wP booster...
  16. ncbi Impact of vaccine cost and information about complications of varicella on parental decision regarding varicella vaccine
    Gaston De Serres
    Institut National de Santé Publique, Public Health Research Unit, CHUL Research Centre, Laval University, Quebec, Quebec
    Can J Public Health 93:114-6. 2002
    ..The influence of providing information about complications of disease and vaccine cost on parental decision to vaccinate against varicella was assessed...
  17. doi Comparison of risk factors for human metapneumovirus and respiratory syncytial virus disease severity in young children
    Jesse Papenburg
    Centre de recherche en infectiologie de l Université Laval, Centre de recherche du CHUQ, Quebec, Canada
    J Infect Dis 206:178-89. 2012
    ..However, risk factors for severe hMPV disease remain unknown. We comparatively assessed environmental, host, and viral determinants for severe hMPV and RSV infections...
  18. ncbi Comparative long term immunogenicity of two recombinant hepatitis B vaccines and the effect of a booster dose given after five years in a low endemicity country
    Bernard Duval
    Institut National de Sante Publique du Quebec, Quebec, Canada
    Pediatr Infect Dis J 24:213-8. 2005
    ..The long term effect of the booster dose in teenagers is unknown. We evaluated the immunogenicity of 2 pediatric hepatitis vaccines after primary vaccination and after a booster dose...
  19. doi Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children
    Rodica Gilca
    Institut National de Sante Publique du Quebec, Quebec City, Quebec, Canada
    Pediatrics 128:e1084-91. 2011
    ....
  20. ncbi Infections by human coronavirus-NL in hospitalized children
    Guy Boivin
    Centre Hospitalier Universitaire de Quebec and Laval University, Quebec City, Canada
    Pediatr Infect Dis J 24:1045-8. 2005
    ..Little information is available on the incidence, clinical manifestations and epidemiologic features of HCoV-NL infections...
  21. ncbi Antibody and immune memory persistence after vaccination of preadolescents with low doses of recombinant hepatitis B vaccine
    Vladimir Gilca
    Institut National de Sante Publique du Quebec, Laval University, Quebec, Canada
    Hum Vaccin 6:212-8. 2010
    ..70-0.90). Three doses of RB administered at the age of 8-10 years induce a 10 years long-lasting immunity in virtually all vaccinees. The booster does not appear necessary on a 10 years perspective...
  22. ncbi Genetic diversity and molecular evolution of the major human metapneumovirus surface glycoproteins over a decade
    Jesse Papenburg
    Centre de recherche en infectiologie de l Université Laval, Centre de recherche du CHUQ, Quebec City, Quebec, Canada Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    J Clin Virol 58:541-7. 2013
    ..Human metapneumovirus (HMPV) is a recently discovered paramyxovirus that is a major cause of respiratory infections worldwide...
  23. doi Human respiratory syncytial virus and other viral infections in infants receiving palivizumab
    Guy Boivin
    Research Center in Infectious Diseases, CHUQ CHUL, Quebec City, QC, Canada
    J Clin Virol 42:52-7. 2008
    ..Palivizumab is a humanized monoclonal antibody that prevents severe human respiratory syncytial virus (HRSV) infections...
  24. pmc Human bocavirus infections in hospitalized children and adults
    Jean Longtin
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 14:217-21. 2008
    ..Two clades of HBoV were identified. The pathogenic role of HBoV in RTIs is uncertain because it was frequently detected in symptomatic and asymptomatic children and was commonly found with other viruses in symptomatic children...
  25. ncbi Immunogenicity of two paediatric doses of monovalent hepatitis B or combined hepatitis A and B vaccine in 8-10-year-old children
    Bernard Duval
    Institut National de Sante Publique du Quebec, Quebec, Canada
    Vaccine 23:4082-7. 2005
    ..This schedule could facilitate a greater vaccine acceptance and the addition of hepatitis A vaccine to existing adolescent universal hepatitis B virus immunization programs...
  26. ncbi Increased risk of anaphylaxis following administration of 2009 AS03-adjuvanted monovalent pandemic A/H1N1 (H1N1pdm09) vaccine
    Isabelle Rouleau
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Vaccine 31:5989-96. 2013
    ..However, adequate estimation of the incidence of anaphylaxis is hindered by wide variations in definitions and diagnosis...
  27. ncbi An outbreak of severe respiratory tract infection due to human metapneumovirus in a long-term care facility
    Guy Boivin
    Research Center in Infectious Diseases of the Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Clin Infect Dis 44:1152-8. 2007
    ..We sought to describe the epidemiological, virological, and histopathological findings associated with a large outbreak of hMPV infection in a long-term care facility...
  28. doi Long-term immunogenicity of two pediatric doses of combined hepatitis A and B or monovalent hepatitis B vaccine in 8 to 10-year-old children and the effect of a challenge dose given seven years later
    Vladimir Gilca
    Quebec National Public Health Institute, Quebec, Canada
    Pediatr Infect Dis J 28:916-8. 2009
    ..All vaccinees in the TX and 98% in the RB group showed an anamnestic response. Vaccination at the age of 8 to 10 years with two-pediatric doses of TX or RB given with a 6 months interval induces a long-lasting immunity in most vaccinees...
  29. doi Antibody persistence and the effect of a booster dose given 5, 10 or 15 years after vaccinating preadolescents with a recombinant hepatitis B vaccine
    Vladimir Gilca
    Institut National de Sante Publique du Quebec, Universite Laval, Quebec, Canada
    Vaccine 31:448-51. 2013
    ..These results do not support the need of a booster for at least 15 years when vaccinating preadolescents with Engerix-B...
  30. ncbi Largest measles epidemic in North America in a decade--Quebec, Canada, 2011: contribution of susceptibility, serendipity, and superspreading events
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec City, QC G1E 7G9, Canada
    J Infect Dis 207:990-8. 2013
    ..The largest measles epidemic in North America in the last decade, occurred in 2011 in Quebec, Canada, where rates of 1- and 2-dose vaccine coverage among children 3 years of age were 95%-97% and 90%, respectively, with 3%-5% unvaccinated...
  31. doi Antibody kinetics among 8-10 years old respondents to hepatitis B vaccination in a low endemic country and the effect of a booster dose given 5 or 10 years later
    Vladimir Gilca
    Institut National de Sante Publique du Quebec, Laval University, Quebec, Canada
    Vaccine 27:6048-53. 2009
    ..The excellent anamnestic response observed after the booster dose demonstrates the persistence of immunity in virtually all young adults vaccinated at the age of 8-10 with three paediatric doses of Engerix-B...
  32. ncbi Ineffectiveness of the current strategy to prevent hepatitis A in travelers
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec, Canada
    J Travel Med 9:10-6. 2002
    ..All of the costs associated with such a visit are assumed by the traveler. We estimated the effectiveness of this strategy...
  33. ncbi Impact of the quebec school-based hepatitis B immunization program and potential benefit of the addition of an infant immunization program
    Vladimir Gilca
    Institut National de Sante Publique du Quebec, Canada
    Pediatr Infect Dis J 25:372-4. 2006
    ..The preteen vaccination program is highly effective. An infant immunization program would bring additional benefits...
  34. doi The need for validation of statistical methods for estimating respiratory virus-attributable hospitalization
    Rodica Gilca
    Institut National de Sante Publique du Quebec, Quebec, PQ, Canada
    Am J Epidemiol 170:925-36. 2009
    ..Until these methods are validated, their methodological limitations should be made explicit and proxy estimates used cautiously in guiding public policy...
  35. doi Measles in children vaccinated with 2 doses of MMR
    Fannie Defay
    Institut National de Santé Publique du Québec 2400 d Estimauville, Quebec City, Quebec, Canada, G1E 7G9
    Pediatrics 132:e1126-33. 2013
    ..Generalizability of this association was also assessed in the expanded provincial data set of notified cases...
  36. doi The cost of preventing rabies at any cost: post-exposure prophylaxis for occult bat contact
    Caroline Huot
    Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    Vaccine 26:4446-50. 2008
    ..Household bat exposure has become the most frequent reason for RPEP administration. Given the rarity of rabies, RPEP recommendations related to household bat exposure may warrant review...
  37. doi Risk of Guillain-Barré syndrome following H1N1 influenza vaccination in Quebec
    Philippe De Wals
    Department of Social and Preventive Medicine, Laval University, Quebec City, Quebec, Canada
    JAMA 308:175-81. 2012
    ..In fall 2009 in Quebec, Canada, an immunization campaign was launched against the 2009 influenza A(H1N1) pandemic strain, mostly using an AS03 adjuvant vaccine. By the end of the year, 57% of the 7.8 million residents had been vaccinated...
  38. pmc Molecular evolution of respiratory syncytial virus fusion gene, Canada, 2006-2010
    Jesse Papenburg
    McGill University Health Centre, Montreal, Quebec, Canada
    Emerg Infect Dis 18:120-4. 2012
    ..Resistance-conferring mutations within the palivizumab binding site occurred in 8.7% of palivizumab recipients and none of the nonrecipients...
  39. pmc Evaluation of serological diagnostic methods for the 2009 pandemic influenza A (H1N1) virus
    Jesse Papenburg
    Infectious Disease Research Center of the CHUQ CHUL and Laval University, Quebec City, Quebec, Canada
    Clin Vaccine Immunol 18:520-2. 2011
    ..Compared to hemagglutination inhibition, microneutralization demonstrated a higher level of concordance with RT-PCR (kappa = 0.69 versus kappa = 0.60) and greater sensitivity (83% versus 71%; P = 0.016)...
  40. ncbi Effectiveness of serogroup C meningococcal polysaccharide vaccine: results from a case-control study in Quebec
    Philippe De Wals
    Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    Clin Infect Dis 40:1116-22. 2005
    ....
  41. ncbi Distribution and clinical impact of human respiratory syncytial virus genotypes in hospitalized children over 2 winter seasons
    Rodica Gilca
    Laval University, Quebec, Canada
    J Infect Dis 193:54-8. 2006
    ..Group A and genotype GA2 strains were associated with greater severity of hRSV disease than were group B strains...
  42. doi Antibody persistence and response to 2010-2011 trivalent influenza vaccine one year after a single dose of 2009 AS03-adjuvanted pandemic H1N1 vaccine in children
    Vladimir Gilca
    Quebec Public Health Institute, Canada
    Vaccine 30:35-41. 2011
    ..In 2009, several countries used the ASO3-adjuvanted pandemic A/H1N1 vaccine. We assessed the persistence of antibody and the priming induced by a single paediatric dose of this vaccine in children...
  43. ncbi Antibiotic use in children is not influenced by the result of rapid antigen detection test for the respiratory syncytial virus
    Roseline Thibeault
    Universite Laval, Quebec G1K 7P4, Canada
    J Clin Virol 39:169-74. 2007
    ..Rapid antigen detection test (RADT) for respiratory syncytial virus (RSV) is widely used in children hospitalized with acute respiratory tract infection (ARTI), but its influence on antibiotic (AB) use is uncertain...
  44. pmc Human metapneumovirus infections in hospitalized children
    Guy Boivin
    Centre Hospitalier Universitaire de Quebec, Quebec City, Canada
    Emerg Infect Dis 9:634-40. 2003
    ..HMPV is an important cause of illness in young children with a similar, although less severe, clinical presentation to that of HRSV...
  45. doi Effectiveness of serogroup C meningococcal conjugate vaccine: a 7-year follow-up in Quebec, Canada
    Philippe De Wals
    Department of Social and Preventive Medicine, Laval University, Quebec City, Canada
    Pediatr Infect Dis J 30:566-9. 2011
    ..In 2002, 1 C-MCV dose was routinely offered to children 12 months of age...
  46. doi Host and viral factors affecting clinical performance of a rapid diagnostic test for respiratory syncytial virus in hospitalized children
    Jesse Papenburg
    Department of Epidemiology, McGill University, Montreal, Quebec, Canada
    J Pediatr 163:911-3. 2013
    ..Older age, prolonged symptoms, and respiratory syncytial virus genotype-B infection were significantly associated with false-negative results of RADT. ..
  47. ncbi Recurrence risk of oculorespiratory syndrome after influenza vaccination: randomized controlled trial of previously affected persons
    Gaston De Serres
    Institut National de Sante Publique du Quebec, Quebec, Canada
    Arch Intern Med 164:2266-72. 2004
    ..Oculorespiratory syndrome (ORS) after influenza vaccination has many features of an allergic reaction...
  48. doi Risk factors for hospitalization and severe outcomes of 2009 pandemic H1N1 influenza in Quebec, Canada
    Rodica Gilca
    Quebec National Institute of Public Health, Quebec City, QC, Canada
    Influenza Other Respir Viruses 5:247-55. 2011
    ..Risk factors associated with hospitalization were assessed by comparing hospitalized to community cases and for ICU admission or death through comparison with hospitalized cases...
  49. doi Modeling the impact of one- and two-dose varicella vaccination on the epidemiology of varicella and zoster
    Marc Brisson
    Departement de Medecine sociale et preventive, Universite Laval, Quebec, Canada
    Vaccine 28:3385-97. 2010
    ..Adding a 2-dose program may help guarantee high population-level effectiveness against varicella. However, the incremental benefit of a second dose is highly dependant on the effectiveness of the first dose and its impact on zoster...
  50. pmc Seroconversion to seasonal influenza viruses after A(H1N1)pdm09 virus infection, Quebec, Canada
    Mariana Baz
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Emerg Infect Dis 18:1132-4. 2012
    ..05)...
  51. pmc Trends of hepatitis A hospitalization and risk factors in Quebec, Canada, between 1990 and 2003
    Magalie Canuel
    Department of Social and Preventive Medicine, Laval University, Quebec, Canada
    BMC Infect Dis 7:31. 2007
    ..This study estimated the year and age specific hospitalization rates and distribution of risk factors for HA in Quebec, Canada, between 1990 and 2003...
  52. ncbi Comparison of trip characteristics of children and adults with travel-acquired hepatitis A infection
    Cathy Gosselin
    Public Health Research Unit, CHUL Research Centre, Laval University, Quebec, Canada
    Pediatr Infect Dis J 25:1184-6. 2006
    ..Specific public health interventions should be undertaken to prevent HA in traveling children...
  53. ncbi Risk factors associated with anaphylaxis and other allergic-like events following receipt of 2009 monovalent AS03-adjuvanted pandemic influenza vaccine in Quebec, Canada
    Isabelle Rouleau
    Centre Hospitalier Universitaire de Quebec, Quebec City, Quebec, Canada
    Vaccine 32:3480-7. 2014
    ..In response to this safety signal, a case-control study was conducted to identify potential risk factors...
  54. ncbi Varicella vaccine: factors influencing uptake
    François P de Courval
    Departement de Medecine sociale et preventive, Faculte de Medecine, Universite Laval, Quebec
    Can J Public Health 94:268-71. 2003
    ..In Canada, varicella vaccine is recommended but its uptake has been low. In contrast to most other recommended paediatric vaccines, this one is not currently provided free of charge in all provinces and territories in Canada...
  55. pmc Multiplex real-time PCR assay for detection of influenza and human respiratory syncytial viruses
    Guy Boivin
    Research Center in Infectious Diseases of the CHUQ CHUL, Department of Pediatrics, Laval University, Quebec City, Canada
    J Clin Microbiol 42:45-51. 2004
    ..5 and 98.9% compared to 81.6 and 94.7% for the antigenic test. In conclusion, our multiplex real-time PCR assay combines both rapidity and sensitivity for detecting the most important respiratory viral pathogens in children...
  56. ncbi Pertussis resurgence in Canada largely caused by a cohort effect
    Benoît Ntezayabo
    Department of Social and Community Medicine, Faculty of Medicine, Levalle University, Quebec, Canada
    Pediatr Infect Dis J 22:22-7. 2003
    ..Changes in incidence and hospitalization according to age in the province of Quebec between 1983 and 1998 were examined to assess the presence of a cohort effect resulting from a poorly protective vaccine...
  57. doi Long-lasting measles outbreak affecting several unrelated networks of unvaccinated persons
    Frederic Dallaire
    Department of Preventive and Social Medicine, Faculty of Medicine, Laval University, Quebec, PQ, Canada
    J Infect Dis 200:1602-5. 2009
    ..Mathematical work is needed regarding the level of aggregation of unvaccinated individuals that would jeopardize elimination...
  58. pmc Comparison of automated microarray detection with real-time PCR assays for detection of respiratory viruses in specimens obtained from children
    Frederic Raymond
    Infectious Disease Research Center of the CHUQ CHUL and Laval University, Sainte Foy, Quebec, Canada
    J Clin Microbiol 47:743-50. 2009
    ..The two methods yielded concordant results for 94.1% of specimens. These tests allowed a thorough etiological assessment of respiratory viruses infecting children in hospital settings and would assist public health interventions...
  59. doi Analysis of mortality following a mass immunization campaign with serogroup C meningococcal conjugate vaccine: methodological difficulties and imperfect solutions
    Philippe De Wals
    Department of Preventive and Social Medicine, Laval University, Quebec City, Canada
    Vaccine 27:3223-7. 2009
    ..In 2001, a mass immunization campaign was implemented in the province of Quebec, Canada, using a new serogroup C meningococcal conjugate vaccine (C-MCV)...
  60. ncbi Effectiveness of pneumococcal conjugate vaccine using a 2+1 infant schedule in Quebec, Canada
    Genevieve Deceuninck
    Public Health Research Unit, Quebec University Hospital Research Centre, Quebec City, Canada
    Pediatr Infect Dis J 29:546-9. 2010
    ....
  61. ncbi Human metapneumovirus viral load is an important risk factor for disease severity in young children
    Jean Francois Roussy
    Research Center in Infectious Diseases of the CHU of Québec and Laval University, Quebec City, QC, Canada
    J Clin Virol 60:133-40. 2014
    ..The role of viral load in human metapneumovirus (HMPV) disease severity has not yet been clearly determined...
  62. ncbi [Public health: the control of meningococcal disease in Quebec]
    Philippe De Wals
    Departement de Medecine sociale et preventive, Universite Laval, Pavillon de l Est, 2180, Chemin Sainte Foy, local 1110, Quebec, G1K 7P4 Canada
    Med Sci (Paris) 19:1011-5. 2003
    ..Clinical, epidemiological, economic and social studies were instrumental in the decision making for implementing these control programs...
  63. pmc Field performance of a rapid diagnostic test for influenza in an ambulatory setting
    Isabelle Rouleau
    Unite de Recherche en Sante publique, Centre de Recherche du CHUL, Universite Laval, Quebec, Canada
    J Clin Microbiol 47:2699-703. 2009
    ..Negative results cannot rule out the diagnosis of influenza, and in that context, this test is of questionable utility for routine application in the clinical setting...
  64. ncbi Effectiveness of a mass immunization campaign using serogroup C meningococcal conjugate vaccine
    Philippe De Wals
    Quebec National Public Health Institute and Department of Preventive and Social Medicine, Laval University, Quebec City, Quebec
    JAMA 292:2491-4. 2004
    ..Meningococcal polysaccharide vaccines are of limited effectiveness. New protein-polysaccharide conjugate vaccines have yet to be evaluated in field conditions...
  65. doi Safe vaccination of patients with egg allergy with an adjuvanted pandemic H1N1 vaccine
    Remi Gagnon
    Centre Hospitalier Universitaire de Quebec, Laval University, Quebec City, Quebec, Canada
    J Allergy Clin Immunol 126:317-23. 2010
    ....
  66. doi Comparison of pandemic and seasonal influenza in the pediatric emergency department
    Emilio Aguirre
    Centre de Recherche en Pédiatrie du CHUL CHUQ, Quebec, Canada
    Pediatr Infect Dis J 30:633-9. 2011
    ..Our objective was to describe the clinical manifestations of pH1N1 in the pediatric ED. We also compared these characteristics to seasonal influenza A, and explored risk factors for pH1N1 hospitalization...
  67. doi Household transmission of the 2009 pandemic A/H1N1 influenza virus: elevated laboratory‐confirmed secondary attack rates and evidence of asymptomatic infections
    Jesse Papenburg
    Infectious Disease Research Center of the Centre Hospitalier Universitaire de Québec CHUL and Laval University, Quebec City, Canada
    Clin Infect Dis 51:1033-41. 2010
    ....
  68. ncbi Preadolescent non- and hyporesponders following three doses of hepatitis B vaccine need only one more dose
    Bernard Duval
    Institut National de Sante Publique du Quebec, 2400 rue d Estimauville, Que, G1E 7G9, Beauport, Canada
    Vaccine 20:3632-4. 2002
    ..Most healthy children, particularly if they are hyporesponders, will have reached the seroprotective level after one dose and will not need further injections...
  69. ncbi Nationwide canadian study of hepatitis a antibody prevalence among children eight to thirteen years old
    Bernard Duval
    Institut National de Sante Publique du Quebec, Canada
    Pediatr Infect Dis J 24:514-9. 2005
    ..Consequently we do not know the incidence of infection in children and what would be the most appropriate age for hepatitis A vaccination...
  70. ncbi [Why are some children incompletely vaccinated at the age of 2?]
    Nicole Boulianne
    Institut National de Sante Publique du Quebec, Beauport
    Can J Public Health 94:218-23. 2003
    ..A survey was conducted in the Province of Quebec to document the factors associated with an incomplete immunization status among 2-year-old children...
  71. ncbi Ophthalmological and biological features of the oculorespiratory syndrome after influenza vaccination
    Marie Josée Fredette
    Centre Hospitalier Universitaire de Laval Research Center, Laval University, Ste Foy, Quebec, Canada
    Clin Infect Dis 37:1136-8. 2003
    ..Patients had lymphopenia and decreased levels of the total hemolytic complement and the third and fourth component of the complement. We conclude that ORS causes conjunctivitis and seems to involve the complement...
  72. doi Use of surveillance data to estimate the effectiveness of the 7-valent conjugate pneumococcal vaccine in children less than 5 years of age over a 9 year period
    Gaston De Serres
    Institut National de Santé Publique du Québec and Laval University, Quebec, Canada
    Vaccine 30:4067-72. 2012
    ....
  73. ncbi Oculo-respiratory syndrome: a new influenza vaccine-associated adverse event?
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, University of British Columbia, Vancouver, Canada
    Clin Infect Dis 36:705-13. 2003
    ..The surveillance case definition for ORS for 2001-2002 was revised to include onset <or=24 h after vaccination, with no restriction on duration. ORS should be incorporated into annual influenza vaccine safety monitoring...
  74. ncbi Does antigen-specific cytokine response correlate with the experience of oculorespiratory syndrome after influenza vaccine?
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Epidemiology Services, Vancouver, British Columbia, Canada
    J Infect Dis 187:495-9. 2003
    ..Although vaccinated ORS-affected individuals had less of a type 1 basis than did vaccinated unaffected individuals, this difference was not statistically significant...
  75. pmc Low risk of recurrence of oculorespiratory syndrome following influenza revaccination
    Danuta M Skowronski
    UBC Centre for Disease Control, Vancouver, BC
    CMAJ 167:853-8. 2002
    ..We examined the risk of recurrence of ORS for individuals affected in 2000-2001 who were revaccinated in the community setting in 2001-2002...
  76. ncbi Skin testing to evaluate oculo-respiratory syndrome (ORS) associated with influenza vaccination during the 2000-2001 season
    Danuta M Skowronski
    UBC Centre for Disease Control, 655 West 12th Avenue, Vancouver, British Columbia, Canada V5Z 4R4
    Vaccine 20:2713-9. 2002
    ..Skin test reaction size or quality could not identify persons at risk of ORS. Skin testing could not identify a specific strain or the stage in the manufacturing process during which the trigger may have been introduced...
  77. pmc Strain variation among Bordetella pertussis isolates from Québec and Alberta provinces of Canada from 1985 to 1994
    Mark S Peppler
    Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta, Canada
    J Clin Microbiol 41:3344-7. 2003
    ..This study provides a baseline for continued surveillance of prevalent and emerging strains of B. pertussis in Canada...
  78. ncbi The changing age and seasonal profile of pertussis in Canada
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Epidemiology Services, Vancouver, British Columbia, Canada V5Z 4R4
    J Infect Dis 185:1448-53. 2002
    ....
  79. ncbi Randomized, double-blind, placebo-controlled trial to assess the rate of recurrence of oculorespiratory syndrome following influenza vaccination among persons previously affected
    Danuta M Skowronski
    Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
    Clin Infect Dis 37:1059-66. 2003
    ..Previously affected persons should be informed of the risk of ORS recurrence but also that episodes of such recurrence are mild and well tolerated...
  80. ncbi Aggregate content influences the Th1/Th2 immune response to influenza vaccine: evidence from a mouse model
    Shawn Babiuk
    Vaccine and Infectious Disease Organization, Saskatoon, SK, Canada
    J Med Virol 72:138-42. 2004
    ..We confirm that vaccine aggregates deviate the immune response to a greater Th2 cytokine pattern with potential implications for vaccine screening, safety, and efficacy...
  81. doi Rapid decline of influenza vaccine-induced antibody in the elderly: is it real, or is it relevant?
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    J Infect Dis 197:490-502. 2008
    ..The historic concern that the influenza vaccine-induced antibody response in the elderly declines more rapidly and below seroprotective levels within 4 months of immunization should be reconsidered...
  82. ncbi The effect of changing from whole-cell to acellular pertussis vaccine on the epidemiology of hospitalized children with pertussis in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 26:31-5. 2007
    ..To assess effects on pertussis epidemiology of this nationwide change, we analyzed hospitalizations during 1991-2004 using the Canadian Immunization Monitoring Program, Active (IMPACT) pertussis database...
  83. pmc Has the change to acellular pertussis vaccine improved or worsened pertussis control?
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, NS
    CMAJ 175:1227. 2006
  84. ncbi Solicited adverse events after influenza immunization among infants, toddlers, and their household contacts
    Danuta M Skowronski
    British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Pediatrics 117:1963-71. 2006
    ..We assessed adverse events, including oculorespiratory syndrome, following influenza immunization during the first year of a publicly-funded program for infants, toddlers and their household members in Canada...
  85. ncbi Economic evaluation of an extended acellular pertussis vaccine program for adolescents in Québec, Canada
    Michael Iskedjian
    PharmIdeas Research and Consulting Inc, Oakville, Ontario, Canada
    Paediatr Drugs 7:123-36. 2005
    ..The purpose of this analysis was to estimate the health and economic impact of an additional booster dose of the acellular vaccine in adolescents in Québec...
  86. ncbi Methodologic issues regarding the use of three observational study designs to assess influenza vaccine effectiveness
    Evan W Orenstein
    Yale University, New Haven, CT, USA
    Int J Epidemiol 36:623-31. 2007
    ....
  87. ncbi [Coverage of anti-tetanus vaccinations in adults in Canada-year 2002. ]
    Norbert Coulibaly
    Departement de Medecine sociale et preventive, Faculte de Medecine, Universite Laval, Quebec
    Can J Public Health 95:456-9. 2004
    ..The rare cases of tetanus that have occurred in Canada were in adults whose vaccination was not up-to-date. The objective of this study was to estimate the vaccine coverage in Canadian adults...
  88. ncbi Measles elimination in Canada
    Arlene King
    Immunization and Respiratory Infections Division, Centre for Infectious Disease Prevention and Control, Population and Public Health Branch, Health Canada, Ottawa, Ontario, Canada
    J Infect Dis 189:S236-42. 2004
    ..Epidemiological and virological evidence suggests that endemic transmission of measles has been mostly interrupted since 1998...
  89. ncbi Unique roles of a data and safety monitoring board in vaccine safety trials with compressed timelines and urgent implications
    David Scheifele
    Canadian Association for Immunization Research and Evaluation, Vancouver, British Columbia, Canada
    Control Clin Trials 24:99-104. 2003
    ..Providing a safety valve for inevitable tensions between investigators and sponsor was an understated but significant role. Lessons from our experience will be particularly pertinent to future studies of pandemic influenza vaccines...
  90. ncbi Assessment of the status of measles elimination from reported outbreaks: United States, 1997-1999
    Nigel J Gay
    Health Protection Agency, Modelling and Economics Unit, Communicable Disease Surveillance Centre, London, UK
    J Infect Dis 189:S36-42. 2004
    ..These results demonstrate that susceptibility to measles was beneath the epidemic threshold and that endemic transmission was eliminated...
  91. ncbi Comments on the paper "the effectiveness of serogroup C meningococcal vaccine estimated from routine surveillance data" [P Rivest, R Allard, Vaccine 20 (2002) 2533-2536]
    Philippe De Wals
    Vaccine 21:2260-1; author reply 2262. 2003