Pollen Yeung

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. doi request reprint Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats
    Pollen K F Yeung
    College of Pharmacy, Dalhousie University, Halifax, NS, Canada B3H 1X7
    Ther Adv Cardiovasc Dis 7:63-74. 2013
  2. doi request reprint Comparing pharmacokinetics and metabolism of diltiazem in normotensive Sprague Dawley and Wistar Kyoto rats vs. spontaneously hypertensive rats in vivo
    Pollen K F Yeung
    Department of Medicine, Dalhousie University Halifax, Nova Scotia, Canada
    Drug Metabol Drug Interact 26:119-25. 2011
  3. doi request reprint Exercise improves hemodynamic profiles and increases red blood cell concentrations of purine nucleotides in a rodent model
    Pollen K F Yeung
    5968 College Street, Burbidge Building Dalhousie University, Halifax, NS, Canada B3H 3J5
    Ther Adv Cardiovasc Dis 4:341-7. 2010
  4. ncbi request reprint Pharmacokinetics and metabolism of diltiazem following multiple doses: comparing normotensive rat vs. hypertensive rat models in vivo
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, 5968 College Street, Dalhousie University, Halifax, Nova Scotia, Canada
    Drug Metab Lett 2:146-50. 2008
  5. ncbi request reprint Pharmacokinetics of cladribine in a rat model following subcutaneous and intra-arterial injections
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculty of Health Professions, Dalhousie University, Halifax, Nova Scotia, Canada
    Drug Metabol Drug Interact 23:291-8. 2008
  6. doi request reprint HPLC assay with UV detection for determination of RBC purine nucleotide concentrations and application for biomarker study in vivo
    Pollen Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, NS, Canada
    J Pharm Biomed Anal 47:377-82. 2008
  7. ncbi request reprint Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculty of Health Professions, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharm Sci 10:231-6. 2007
  8. ncbi request reprint Pharmacokinetics and metabolism of diltiazem in rats: comparing single vs repeated subcutaneous injections in vivo
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Biopharm Drug Dispos 28:403-7. 2007
  9. ncbi request reprint Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharm Sci 9:245-51. 2006
  10. ncbi request reprint Biomarker World Congress 2005
    Pollen K F Yeung
    Dalhousie University, Pharmacokinetics and Metabolism Laboratory, School of Pharmacy, Burbridge Building, Halifax, NS, Canada
    IDrugs 8:625-8. 2005

Detail Information

Publications17

  1. doi request reprint Effect of acute exercise on cardiovascular hemodynamic and red blood cell concentrations of purine nucleotides in hypertensive compared with normotensives rats
    Pollen K F Yeung
    College of Pharmacy, Dalhousie University, Halifax, NS, Canada B3H 1X7
    Ther Adv Cardiovasc Dis 7:63-74. 2013
    ..This study investigated the effects of exercise and hypertension on cardiovascular hemodynamic responses and red blood cell (RBC) concentrations of purine nucleotides using normotensive and hypertensive rat models in vivo...
  2. doi request reprint Comparing pharmacokinetics and metabolism of diltiazem in normotensive Sprague Dawley and Wistar Kyoto rats vs. spontaneously hypertensive rats in vivo
    Pollen K F Yeung
    Department of Medicine, Dalhousie University Halifax, Nova Scotia, Canada
    Drug Metabol Drug Interact 26:119-25. 2011
    ....
  3. doi request reprint Exercise improves hemodynamic profiles and increases red blood cell concentrations of purine nucleotides in a rodent model
    Pollen K F Yeung
    5968 College Street, Burbidge Building Dalhousie University, Halifax, NS, Canada B3H 3J5
    Ther Adv Cardiovasc Dis 4:341-7. 2010
    ..To study the effect of exercise on hemodynamic profiles and red blood cell (RBC) concentrations of adenosine-5'-triphosphate (ATP)...
  4. ncbi request reprint Pharmacokinetics and metabolism of diltiazem following multiple doses: comparing normotensive rat vs. hypertensive rat models in vivo
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, 5968 College Street, Dalhousie University, Halifax, Nova Scotia, Canada
    Drug Metab Lett 2:146-50. 2008
    ..05). The preliminary results suggest metabolism profile of DTZ in the SHR may be closer to humans than the SD rats and may be more preferred in pre-clinical drug development studies for DTZ...
  5. ncbi request reprint Pharmacokinetics of cladribine in a rat model following subcutaneous and intra-arterial injections
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculty of Health Professions, Dalhousie University, Halifax, Nova Scotia, Canada
    Drug Metabol Drug Interact 23:291-8. 2008
    ..It is concluded that the rat is a reasonably good animal model to study the pharmacokinetics of CdA in plasma, and that sc injection may produce more favourable pharmacokinetic profiles than ia injection following a single dose...
  6. doi request reprint HPLC assay with UV detection for determination of RBC purine nucleotide concentrations and application for biomarker study in vivo
    Pollen Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, NS, Canada
    J Pharm Biomed Anal 47:377-82. 2008
    ....
  7. ncbi request reprint Development and validation of a sensitive and specific HPLC assay of cladribine for pharmacokinetics studies in rats
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculty of Health Professions, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharm Sci 10:231-6. 2007
    ..To develop and validate a sensitive and specific HPLC assay for cladribine (CdA) in plasma for pharmacokinetic studies in rats...
  8. ncbi request reprint Pharmacokinetics and metabolism of diltiazem in rats: comparing single vs repeated subcutaneous injections in vivo
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Biopharm Drug Dispos 28:403-7. 2007
    ..The results also suggest that possible binding of DTZ may occur at the site of injection when administered subcutaneously in the higher dose...
  9. ncbi request reprint Exercise hemodynamic and neurohormone responses as sensitive biomarkers for diltiazem in rats
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy and Department of Medicine, Faculties of Health Professions and Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharm Sci 9:245-51. 2006
    ..To investigate the potential of exercise hemodyanamic and neurohormone variables as sensitive biomarkers for pre-clinical evaluation of diltiazem (DTZ)...
  10. ncbi request reprint Biomarker World Congress 2005
    Pollen K F Yeung
    Dalhousie University, Pharmacokinetics and Metabolism Laboratory, School of Pharmacy, Burbridge Building, Halifax, NS, Canada
    IDrugs 8:625-8. 2005
    ..Although relatively small, the meeting provided a good opportunity for business networking, particularly for those involved in the development and regulation of medical diagnostics and biopharmaceuticals...
  11. ncbi request reprint DP-b99 (D-Pharm)
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Burbridge Building, Dalhousie University, Halifax, NS B3H 3J5, Canada
    Curr Opin Investig Drugs 5:90-4. 2004
    ..By March 2003, phase II clinical trials in acute stroke and traumatic brain injury were ongoing...
  12. ncbi request reprint Technology evaluation: GEM-231, Hybridon
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, NS B3H 3J5, Canada
    Curr Opin Mol Ther 5:315-20. 2003
    ..At this time, a phase I/II trial of GEM-231 in combination with irinotecan (CPT-11) was initiated in patients with solid tumors. As of February 2003, Hybridon planned to initiate phase II trials in 2003...
  13. ncbi request reprint American Association of Pharmaceutical Scientists 2002 Annual Meeting and Exposition, Drug development in a global marketplace: challenges and opportunities. 10-14 November 2002, Toronto, Canada
    Pollen K F Yeung
    Pharmacokinetics and Metabolism Laboratory, Dalhousie University, Burbridge Building, Halifax, Nova Scotia B3H 3J5, Canada
    IDrugs 6:12-5. 2003
  14. ncbi request reprint Effect of administration route and length of exposure on pharmacokinetics and metabolism of diltiazem in dogs
    P K Yeung
    College of Pharmacy and Department of Medicine, Faculty of Health Professions, Dalhousie University, Halifax, Nova Scotia, Canada
    Drug Metabol Drug Interact 18:251-62. 2001
    ..05). This study cautions the use of mongrel dogs for direct extrapolation to humans, particularly for chronic pharmacokinetics studies of DTZ...
  15. ncbi request reprint VEGF-2 (St Elizabeth's Medical Center)
    P K Yeung
    Dalhousie University, Pharmacokinetics and Metabolism Laboratory, School of Pharmacy, Halifax, Canada
    Curr Opin Investig Drugs 2:796-800. 2001
    ..Reduced angina was reported by 28 out of 30 patients and tolerance of exercise increased from 240 to 410 s up to 180 days post-therapy [348632]...
  16. ncbi request reprint Determination of plasma concentrations of losartan in patients by HPLC using solid phase extraction and UV detection
    P K Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Faculty of Health Professions, Dalhousie University, Halifax, NS, Canada
    Int J Pharm 204:17-22. 2000
    ..To establish a HPLC assay for plasma losartan and its active metabolite EXP3174 to facilitate clinical pharmacokinetic studies...
  17. ncbi request reprint Pharmacokinetics and haemodynamic effect of deacetyl diltiazem (M1) in rabbits after a single intravenous administration
    P K Yeung
    Pharmacokinetics and Metabolism Laboratory, College of Pharmacy, Dalhousie University, Halifax, Nova Scotia, Canada
    Biopharm Drug Dispos 19:109-13. 1998
    ..05), but had no significant effect on the heart rate (P > 0.05). The Emax and EC50 as estimated by the inhibitory sigmoidal Emax model were 20 +/- 18% 620 +/- 310 ng mL-1, respectively for SBP; 20 +/- 8.3% and 420 +/- 160 ng mL-1 for DBP...