Donald F Weaver

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi request reprint Exploring neurotherapeutic space: how many neurological drugs exist (or could exist)?
    Donald F Weaver
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharmacol 63:136-9. 2011
  2. doi request reprint Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s)
    Donald F Weaver
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:80-5. 2013
  3. doi request reprint Design of innovative therapeutics for pharmacoresistant epilepsy: challenges and needs
    Donald F Weaver
    Department of Medicine Neurology and Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:56-9. 2013
  4. ncbi request reprint Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model
    Valérie Campagna-Slater
    Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3
    Neurosci Lett 418:28-33. 2007
  5. doi request reprint The puzzle(s) of pharmacoresistant epilepsy
    Bernd Pohlmann-Eden
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:1-4. 2013
  6. ncbi request reprint Epileptogenesis, ictogenesis and the design of future antiepileptic drugs
    Donald F Weaver
    Department of Medicine Neurology, Dalhousie University Halifax, Nova Scotia, Canada
    Can J Neurol Sci 30:4-7. 2003
  7. ncbi request reprint Designing future drugs for the treatment of intractable epilepsy
    Donald F Weaver
    Department of Medicine Neurology and Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Adv Neurol 97:429-34. 2006
  8. pmc Improving the clinical assessment of consciousness with advances in electrophysiological and neuroimaging techniques
    Jodie R Gawryluk
    Department of Psychology, Dalhousie University, Halifax, Canada
    BMC Neurol 10:11. 2010
  9. doi request reprint The bioisosteric similarity of the tetrazole and carboxylate anions: clues from the topologies of the electrostatic potential and of the electron density
    Chérif F Matta
    Department of Chemistry and Physics, Mount Saint Vincent University, Halifax, Nova Scotia, Canada B3M 2J6 Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3
    Eur J Med Chem 45:1868-72. 2010
  10. ncbi request reprint "Organic" pseudoseizures as an unrecognized side-effect of anticonvulsant therapy
    Donald F Weaver
    Department of Medicine Neurology, School of Biomedical Engineering, 6274 Coburg Road, Chemistry Building, Dalhousie University, Halifax, NS, B3H 4J3, Canada
    Seizure 13:467-9. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Exploring neurotherapeutic space: how many neurological drugs exist (or could exist)?
    Donald F Weaver
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Pharm Pharmacol 63:136-9. 2011
    ..e. the total number of molecules that are or could be neuroactive)'. We present an approach to providing an estimate of the size of neurotherapeutic space...
  2. doi request reprint Pharmacoresistant epilepsy: unmet needs in solving the puzzle(s)
    Donald F Weaver
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:80-5. 2013
    ....
  3. doi request reprint Design of innovative therapeutics for pharmacoresistant epilepsy: challenges and needs
    Donald F Weaver
    Department of Medicine Neurology and Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:56-9. 2013
    ....
  4. ncbi request reprint Anaesthetic binding sites for etomidate and propofol on a GABAA receptor model
    Valérie Campagna-Slater
    Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3
    Neurosci Lett 418:28-33. 2007
    ..Potential interactions of etomidate and propofol with other side-chains were also identified...
  5. doi request reprint The puzzle(s) of pharmacoresistant epilepsy
    Bernd Pohlmann-Eden
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Epilepsia 54:1-4. 2013
    ..The participants were fully aware that their diverse contributions represent only still-fragmented pieces of this frustrating but clinically important puzzle...
  6. ncbi request reprint Epileptogenesis, ictogenesis and the design of future antiepileptic drugs
    Donald F Weaver
    Department of Medicine Neurology, Dalhousie University Halifax, Nova Scotia, Canada
    Can J Neurol Sci 30:4-7. 2003
    ..Just as aspirin is not the drug of choice for meningitis, an anticonvulsant is not the drug of choice for epilepsy. Drug design for epilepsy needs to discover a penicillin, not more aspirins...
  7. ncbi request reprint Designing future drugs for the treatment of intractable epilepsy
    Donald F Weaver
    Department of Medicine Neurology and Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Adv Neurol 97:429-34. 2006
  8. pmc Improving the clinical assessment of consciousness with advances in electrophysiological and neuroimaging techniques
    Jodie R Gawryluk
    Department of Psychology, Dalhousie University, Halifax, Canada
    BMC Neurol 10:11. 2010
    ....
  9. doi request reprint The bioisosteric similarity of the tetrazole and carboxylate anions: clues from the topologies of the electrostatic potential and of the electron density
    Chérif F Matta
    Department of Chemistry and Physics, Mount Saint Vincent University, Halifax, Nova Scotia, Canada B3M 2J6 Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3
    Eur J Med Chem 45:1868-72. 2010
    ..A model of the receptor region responsible for binding to either of these bioisosteres is proposed on the basis of an electrostatic "lock-and-key"...
  10. ncbi request reprint "Organic" pseudoseizures as an unrecognized side-effect of anticonvulsant therapy
    Donald F Weaver
    Department of Medicine Neurology, School of Biomedical Engineering, 6274 Coburg Road, Chemistry Building, Dalhousie University, Halifax, NS, B3H 4J3, Canada
    Seizure 13:467-9. 2004
    ..The term "organic pseudoseizures" is used to denote this group of medication related behavioural alterations...
  11. ncbi request reprint Deducing the bioactive face of hydantoin anticonvulsant drugs using NMR spectroscopy
    Kathryn E Tiedje
    Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Neurol Sci 35:232-6. 2008
    ..The general purpose of this study was to deduce the geometry of the bioactive face (pharmacophore) for the hydantoin class of anticonvulsants...
  12. ncbi request reprint Molecular modelling of the GABAA ion channel protein
    Valérie Campagna-Slater
    Department of Chemistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4J3
    J Mol Graph Model 25:721-30. 2007
    ..The final model of the alpha1beta2gamma2 GABAA protein agrees with available experimental data concerning general anaesthetics...
  13. ncbi request reprint Challenges in the clinical diagnosis of Alzheimer's disease: influence of "family coaching" on the mini-mental state examination
    Teneille Gofton
    Department of Medicine Neurology, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Alzheimers Dis Other Demen 21:109-12. 2006
    ..These results demonstrate that coaching of patients prior to administration of the MMSE is not uncommon, and that this needs to be taken into consideration when forming therapeutic decisions based on MMSE results...
  14. ncbi request reprint The "promiscuous drug concept" with applications to Alzheimer's disease
    Vanessa C Stephenson
    Department of Chemistry, Dalhousie University, Halifax, NS, Canada B3H 4J3
    FEBS Lett 579:1338-42. 2005
    ....
  15. doi request reprint Towards brain first-aid: a diagnostic device for conscious awareness
    Ryan C N D'Arcy
    Institute for Biodiagnostics Atlantic, National Research Council Canada, Halifax, NS B3H 3A7, Canada
    IEEE Trans Biomed Eng 58:750-4. 2011
    ..The technology is designed to be wireless-enabled for remote monitoring and assessment capabilities. In essence, the device is developed to scan for conscious awareness in order to optimize subsequent patient care...