Research Topics
| Jian WangSummaryAffiliation: Dalhousie University Country: Canada Publications
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Detail Information
Publications
Role of mitochondrial dysfunction in cellular responses to S-(1,2-dichlorovinyl)-L-cysteine in primary cultures of human proximal tubular cellsFeng Xu
Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA
Biochem Pharmacol 76:552-67. 2008..These results support the conclusion that mitochondrial dysfunction is an early and obligatory step in DCVC-induced cytotoxicity in hPT cells...
Carboplatin-induced early cochlear lesion in chinchillasJian Wang
School of Human Communication Disorders, Dalhousie University, 5599 Fenwick Street, B3H 1R2 Halifax, NS, Canada
Hear Res 181:65-72. 2003..The large fluctuations in SDR and DDR that occur several hours after carboplatin treatment are most likely due to the neurotoxic effects of carboplatin...
Over-expression of X-linked inhibitor of apoptosis protein slows presbycusis in C57BL/6J miceJian Wang
The Affiliated Sixth People s Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, Shanghai, China
Neurobiol Aging 31:1238-49. 2010..These results suggest that XIAP over-expression reduces age-related hearing loss and hair cell death in the cochlea...- The effect of gap-marker spectrum on gap-evoked auditory response from the inferior colliculus and auditory cortex of guinea pigsJian Wang
School of Human Communication Disorders, Dalhousie University, Halifax, NS, Canada
Int J Audiol 45:521-7. 2006..These results suggest that the total bandwidth of all auditory channels that are recruited determine the temporal resolution measured in gap-evoked potentials... - Is duration tuning a transient process in the inferior colliculus of guinea pigs?Jian Wang
School of Human Communication Disorders, Dalhousie University, 5599 Fenwick Street, Halifax, Canada NS B3H 1R2
Brain Res 1114:63-74. 2006..Therefore, duration tuning appears to be a transient neural coding process in the IC of guinea pigs. Duration tuning for these types of neurons may have been blurred by the use of a relatively unselective, long window... - Important factors for the hearing loss caused by the triple semicircular canal occlusion in guinea pigsShankai Yin
Department of Otolaryngology, Affiliated Sixth People s Hospital, Shanghai Jiao Tong University, Shanghai, China
Otol Neurotol 28:513-9. 2007..The damage to the membranous semicircular labyrinth is the single major contributor to hearing loss caused by TSCO... - [The experimental study of the anti-damage effect of iminoethyl-lysine on noise-induced cochlea damage in guinea pig]Min Xiong
Department of Otolaryngology, General Hospital of PLA Guangzhou Command, Guangzhou 510010, China
Zhonghua Lao Dong Wei Sheng Zhi Ye Bing Za Zhi 20:356-8. 2002..Iminoethyl-lysine could inhibit the activity of NOS II and has the anti-damage effect on noise-induced cochlea damage. It is indicated that nitric oxide plays an important role in the pathogenesis of noise-induced hearing loss... - The effect of noise-induced sloping high-frequency hearing loss on the gap-response in the inferior colliculus and auditory cortex of guinea pigsShan Kai Yin
The Affiliated Sixth People s Hospital, Otorhinolaryngology Institute, Shanghai Jiao Tong University, Shanghai 200233, China
Hear Res 239:126-40. 2008..These results strongly indicate that a high-frequency hearing loss exerted an off-channel impact on temporal processing in the low-frequency region of the auditory system... - General anesthesia changes gap-evoked auditory responses in guinea pigsYanmei Feng
Department of Otolaryngology, No 6 People s Hospital, Shanghai JiaoTong University Shanghai, China
Acta Otolaryngol 127:143-8. 2007..General anesthesia induced by sodium pentobarbital reduces temporal resolution as represented by an increase in the threshold of gap-evoked auditory responses in guinea pigs... - Gamma-aminobutyric acid circuits shape response properties of auditory cortex neuronsJian Wang
Center for Hearing and Deafness, State University of New York at Buffalo, Buffalo, NY 14214, USA
Brain Res 944:219-31. 2002..The inhibitory circuits that generate nonmonotonic rate-level functions are separate from those that influence other response properties of AI neurons... - Functional reorganization in chinchilla inferior colliculus associated with chronic and acute cochlear damageJian Wang
Hearing Research Lab, 215 Parker Hall, University of Buffalo, Buffalo, NY 14210, USA
Hear Res 168:238-49. 2002..The results suggest that lesioned-induced central auditory plasticity could contribute to several symptoms associated with sensorineural hearing loss such as loudness recruitment, tinnitus and poor speech discrimination in noise... - Coordination of presynaptic and postsynaptic maturation in a zebra finch forebrain motor control nucleus during song learningJian Wang
Laboratory for Vocal Behaviour Mechanisms, Brain Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan
Eur J Neurosci 24:2859-69. 2006..These results suggest that regulation of learning capacity may occur in part by coordination of presynaptic and postsynaptic function... - Human glioblastoma biopsy spheroids xenografted into the nude rat brain show growth inhibition after stereotactic radiosurgeryFrits Thorsen
Department of Oncology and Medical Physics, Haukeland University Hospital, Jonas Lies vei 65, 5021, Bergen, Norway
J Neurooncol 82:1-10. 2007..In this work, the growth and invasiveness of human glioblastoma spheroids xenografted into nude rat brains were assessed after radiosurgery. Temporary in vitro as well as long-term in vivo radiation effects were studied... - Triple semicircular canal occlusion in guinea pigs with endolymphatic hydropsShankai Yin
Department of Otolaryngology, Affiliated Sixth People's Hospital, Shanghai Jiao Tong University, Shanghai, China
Otol Neurotol 27:78-85. 2006..Also, the static compensation to the disequilibrium is quick and complete. These results suggest that triple semicircular canal occlusion should be an option for controlling rotatory vertigo in Ménière's disease... - Design and synthesis of 5-aryl-pyridone-carboxamides as inhibitors of anaplastic lymphoma kinaseRongshi Li
ChemBridge Research Laboratories and ChemBridge Corporation, 16981 Via Tazon, Suites K and G, San Diego, CA 92127, USA
J Med Chem 49:1006-15. 2006..Herein the details of the design process and synthesis of these novel pyridones, along with their enzymatic and cell-based activity, are discussed... - Delayed transplantation of adult neural precursor cells promotes remyelination and functional neurological recovery after spinal cord injurySoheila Karimi-Abdolrezaee
Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, M5T 2S8, Canada
J Neurosci 26:3377-89. 2006..Our data provide strong evidence in support of the feasibility of adult NPCs for cell-based remyelination after SCI... - Heme oxygenase 2 is neuroprotective against intracerebral hemorrhageJian Wang
Department of Anesthesiology Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross Bldg 364 365, Baltimore, MD 21205, USA
Neurobiol Dis 22:473-6. 2006.... - Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brainJian Wang
Department of Entomology, University of Maryland, College Park, 20742, USA
Development 133:1231-40. 2006..Taken together, Drosophila Ph is essential for governing neuronal diversity, especially during steroid hormone signaling... - 4-HPR modulates gene expression in ovarian cellsMolly Brewer
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Arizona Cancer Center, Tucson, 85724, USA
Int J Cancer 119:1005-13. 2006..These findings suggest that 4-HPR acts through different mechanisms in premalignant ovarian surface cells and cancer cells, with a preventive effect in premalignant cells and a treatment effect in cancer cells... - Myelination of congenitally dysmyelinated spinal cord axons by adult neural precursor cells results in formation of nodes of Ranvier and improved axonal conductionEftekhar Eftekharpour
Division of Cell and Molecular Biology, Toronto Western Research Institute, Krembil Neuroscience Center, Toronto, Ontario, Canada M5T 2S8
J Neurosci 27:3416-28. 2007..These data suggest the therapeutic potential of aNPCs to promote functionally significant myelination in CNS disorders characterized by longstanding myelin deficiency... - BRCA1 overexpression sensitizes cancer cells to lovastatin via regulation of cyclin D1-CDK4-p21WAF1/CIP1 pathway: analyses using a breast cancer cell line and tumoral xenograft modelXiaoping Yu
Department of Public Health, School of Preclinical Medicine, Chengdu Medical College, Chengdu, Sichuan 610081, P R China
Int J Oncol 33:555-63. 2008.... - Protein 600 is a microtubule/endoplasmic reticulum-associated protein in CNS neuronsSu Yeon Shim
Hotchkiss Brain Institute, Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta, Canada T2N 4N1
J Neurosci 28:3604-14. 2008..Thus, p600 constitutes the only known MAP to associate with the ER in neurons, and this interaction may impact on multiple cellular processes ranging from neuronal development to neuronal maturation and plasticity... - Local inhibition shapes duration tuning in the inferior colliculus of guinea pigsShankai Yin
The Affiliated Sixth People s Hospital, Otolaryngology Institute of Shanghai Jiao Tong University, 600 Yishan Road, 7th Building Rm220, Shanghai 200233, China
Hear Res 237:32-48. 2008..In conclusion, the inhibitory effect on the early responses appears to be the main contributor for the duration selectivity of the IC in guinea pigs; potential mechanisms for this duration selectivity are also discussed... - Generation of functional inhibitory neurons in the adult rat hippocampusShuHong Liu
Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada, T2N 4N1
J Neurosci 23:732-6. 2003..These data show for the first time that functional inhibitory neurons are recruited in the dentate gyrus of adult rats... - Multiple huge cutaneous horns overlying verrucae vulgaris induced by human papillomavirus type 2: a case reportChen Wang
Br J Dermatol 156:760-2. 2007 - Stability of lipids on peritoneal dialysis in a patient with familial LCAT deficiencyCatherine L Weber
Department of Medicine, Section of Nephrology, Laboratory Medicine, University of British Columbia/St Paul's Hospital, 1081 Burrard Street, Providence Building, Room 6010A, Vancouver, British Columbia, Canada V6Z 1Y6
Nephrol Dial Transplant 22:2084-8. 2007 - Preclinical pharmacokinetics and in vitro metabolism of dasatinib (BMS-354825): a potent oral multi-targeted kinase inhibitor against SRC and BCR-ABLAmrita V Kamath
Department of Pharmacokinetic and Pharmacodynamic Sciences, Genentech, 1 DNA Way, South San Francisco, CA 94080, USA
Cancer Chemother Pharmacol 61:365-76. 2008..Possible mechanisms contributing to the incomplete oral bioavailability of dasatinib in animals were investigated... - Overexpression of lentivirus-mediated glial cell line-derived neurotrophic factor in bone marrow stromal cells and its neuroprotection for the PC12 cells damaged by lactacystinYa Ru Su
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
Neurosci Bull 23:67-74. 2007.... - In vitro targeting of NG2 antigen by 213Bi-9.2.27 alpha-immunoconjugate induces cytotoxicity in human uveal melanoma cellsYong Li
Centre for Experimental Radiation Oncology, Cancer Care Centre, St. George Hospital, Kogarah, NSW, Australia
Invest Ophthalmol Vis Sci 46:4365-71. 2005..213Bi-9.2.27 AIC used directly or as adjunct therapy may be a promising new agent for treating NG2-positive uveal melanomas or metastases... - Reduced locomotion in the serum and glucocorticoid inducible kinase 3 knock out mouseUndine E Lang
Department of Physiology I, Gmelinstr 5, 72076 Tuebingen, Germany
Behav Brain Res 167:75-86. 2006..In conclusion, lack of SGK3 leads to subtle behavioral defects which may result from deranged neuronal regulation of transporters and ion channels... - Characterization and body distribution of beta-elemene solid lipid nanoparticles (SLN)Yanzhi Wang
School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China
Drug Dev Ind Pharm 31:769-78. 2005..Therefore, the SLN containing beta-elemene might be an attractive candidate for the treatment of liver cancer... - The chemopreventive agents 4-HPR and DFMO inhibit growth and induce apoptosis in uterine leiomyomasRussell R Broaddus
Department of Pathology, The University of Texas M D Anderson Cancer Center, Houston, Tex, USA
Am J Obstet Gynecol 190:686-92. 2004..This study examined the effects of the chemopreventive agents 4-(N-hydroxyphenyl)retinamide (4-HPR) and alpha-difluoromethylornithine (DFMO) on leiomyoma growth... - [Screening of the drug resistance-associated gene in HepG2 cell line transfected with aldose reductase like gene-1 (ARL-1)]Xiang Dong Yang
Centre of Molecular Biology, Nanhua University, Hengyang, Hunan, PR China
Ai Zheng 22:1289-95. 2003.... - Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptorsJian Wang
Department of Physiology and Biophysics, University of Calgary, Calgary T2N 4N1, Canada
Nat Neurosci 6:1039-47. 2003..Thus, we conclude that modulation of NMDA receptors by Cdk5 is the primary intracellular event underlying the ischemic injury of CA1 pyramidal neurons... - [Study on the origin and differentiation of gastrointestinal stromal tumors]Ying-yong Hou
Department of Pathology, Cancer Hospital, Medical College of Fudan University, Shanghai 200032, China
Zhonghua Bing Li Xue Za Zhi 32:106-10. 2003..CONCLUSIONS: Data from both immunophenotype and electron microscopy suggest that GIST might originate from the mesenchymal cells, differentiating to be ICC afterwards, and possessing myoid characteristics in various extent... - [Nerve tissue morphological study of tutin microinjection into pontine NPBM in two hours]Jian Wang
Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China
Hua Xi Yi Ke Da Xue Xue Bao 33:54-7. 2002..CONCLUSION: In our experiment condition, there was no morphological damage caused by Tutin microinjection into pontine NPBM respiratory area of the rabbit... - TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brainXiaoyan Zheng
Department of Cell and Structural Biology, University of Illinois, Urbana, IL 61801, USA
Cell 112:303-15. 2003..We conclude that the Drosophila Activin signaling pathway mediates neuronal remodeling in part by regulating EcR-B1 expression... - Interaction of calcineurin and type-A GABA receptor gamma 2 subunits produces long-term depression at CA1 inhibitory synapsesJian Wang
Neuroscience Research Group, Department of Physiology and Biophysics, Faculty of Medicine, University of Calgary, Calgary, Canada, T2N 4N1
J Neurosci 23:826-36. 2003..Thus, an activity-dependent physical and functional interaction between CaN and GABA(A) receptors is both necessary and sufficient for inducing LTD at CA1 individual inhibitory synapses... - Congenital and acquired long QT syndromesBruce D Walker
Division of Cardiology and the Blackburn Genetics Laboratory, Robarts Research Institute, University of Western Ontario, London
Can J Cardiol 19:76-87. 2003..This review summarizes the clinical, genetic and electrophysiological understanding of congenital and acquired LQTS... - [Establishment and identification of the gene cell line transfected aldose reductase like gene and its drug resistance to drugs containing carbonyl group]Jian Wang
Center of Molecular Biology of Nanhua University, Hengyang 421001, China
Zhonghua Gan Zang Bing Za Zhi 10:445-8. 2002.... - N-(4-hydroxyphenyl)retinamide (4-HPR) modulates GADD45 expression in radiosensitive bladder cancer cell linesChangping Zou
Department of Obstetrics and Gynecology, The University of Texas-Houston Medical School, Houston, TX 77030, USA
Cancer Lett 180:131-7. 2002..Once our results are verified and replicated by other investigators, 4-HPR may have a potential clinical implication in effectively treating bladder cancer in combination with low-gamma-irradiation therapy... - [Peri-uvulopalatopharyng oplasty otoacoustic emissions in patients with obstructive sleep apnea-hypopnea syndrome]Wan dong She
Department of Otorhinolaryngology, Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China
Zhonghua Er Bi Yan Hou Ke Za Zhi 39:48-51. 2004..To study the cochlear function of patients with obstructive sleep apnea-hypopnea syndrome (OSAHS)... - Cell-specific role for epsilon- and betaI-protein kinase C isozymes in protecting cortical neurons and astrocytes from ischemia-like injuryJian Wang
Department of Anesthesia, School of Medicine, Stanford University, Stanford, CA 94305-5117, USA
Neuropharmacology 47:136-45. 2004..Our data demonstrate protection of neurons by selective activation of epsilonPKC but enhanced astrocyte cell death with selective inhibition of betaIPKC. Thus PKC isozymes exhibit cell type-specific effects on ischemia-like injury... - A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transportRama Soundararajan
Division of Nephrology, Department of Medicine, University of California at San Francisco, San Francisco, California 94143 0532, USA
J Biol Chem 280:39970-81. 2005..These observations suggest a novel link between GILZ and regulation of epithelial sodium transport through modulation of ERK signaling and could represent an important pathway for mediating aldosterone actions in health and disease... - In vitro model of normal, immortalized ovarian surface epithelial and ovarian cancer cells for chemoprevention of ovarian cancerMolly Brewer
Department of Gynecologic Oncology, University of Texas, The M D Anderson Cancer Center, Houston, TX 77030, USA
Gynecol Oncol 98:182-92. 2005..However, the effectiveness of its application for different populations has been questioned because of the genetic differences among normal, high risk, and women with cancer... - Genotype-dependent expression of endothelial nitric oxide synthase (eNOS) and its regulatory proteins in cultured endothelial cellsDuraisamy Senthil
Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA
DNA Cell Biol 24:218-24. 2005..However, the cigarette smoking-genotype interaction may require such in vivo conditions to be manifested... - Neuroprotection by inhibition of matrix metalloproteinases in a mouse model of intracerebral haemorrhageJian Wang
Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA
Brain 128:1622-33. 2005..Blockade of MMP activity during this critical period may have efficacy as a therapeutic strategy for the treatment of acute brain injury after ICH... - Regulation of GluR1 abundance in murine hippocampal neurones by serum- and glucocorticoid-inducible kinase 3Nathalie Strutz-Seebohm
Department of Physiology I, University of Tuebingen, 72076 Tuebingen, Germany
J Physiol 565:381-90. 2005..The present observations disclose a novel mechanism in the regulation of GluR1... - Mitochondria play a central role in estrogen-induced neuroprotectionJames W Simpkins
Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX 76102, USA
Curr Drug Targets CNS Neurol Disord 4:69-83. 2005.... - Tuftsin fragment 1-3 is beneficial when delivered after the induction of intracerebral hemorrhageJian Wang
Department of Pharmacological Sciences, University Medical Center at Stony Brook, Stony Brook, NY 11794-8651, USA
Stroke 36:613-8. 2005..CONCLUSIONS: Activated microglia/macrophages are important contributors to brain injury after ICH. MIF could be a valuable neuroprotective agent for the treatment of ICH, if treatment is initiated soon after the onset of hemorrhage... - Effect of retinoic acid and interferon alpha-2a on transitional cell carcinoma of bladderChangping Zou
Department of Obstetrics/Gynecology and Urology, University of Arizona, Tucson, Arizona 85724, USA
J Urol 173:247-51. 2005.... - Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesisJian Wang
Department of Cell and Structural Biology, University of Illinois, Urbana 61801, USA
Neuron 43:663-72. 2004..2] affects MB axons. These results suggest that exon 17.1 is minimally involved in axonal morphogenesis and that morphogenesis of MB axons probably involves multiple distinct exon 17.2-containing Dscam isoforms... - Neuronal gene expression and function in the growth-stimulated R28 retinal precursor cell lineGail M Seigel
Department of Ophthalmology, University at Buffalo, SUNY, NY 14214, USA
Curr Eye Res 28:257-69. 2004..In this study, we tested the hypothesis that the proliferative R28 retinal cell line contains subpopulations of cells that express neuronal mRNAs and proteins characteristic of CNS neurons... - Beta blockers normalize QT hysteresis in long QT syndromeAndrew D Krahn
Division of Cardiology, University of Western Ontario, London, Ontario, Canada
Am Heart J 143:528-34. 2002..This study was performed to evaluate the impact of beta blockers on QT adaptation to heart rate during the exercise and recovery phases of exercise testing in long QT syndrome...