Rudolf Uher

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. doi A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness
    Rudolf Uher
    Capital District Health Authority, Halifax, Nova Scotia, Canada
    BMC Psychiatry 14:344. 2014
  2. pmc Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies
    Daniel Rasic
    To whom correspondence should be addressed Department of Psychiatry, Canada Research Chair in Early Intervention in Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Room 3089, Abbie J Lane Memorial Building, Halifax, Nova Scotia B3H 2E2, Canada fax 902 473 4877, E mail
    Schizophr Bull 40:28-38. 2014
  3. doi Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search
    Rudolf Uher
    Department of Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Halifax, B3H 2E2, NS, Canada
    Soc Psychiatry Psychiatr Epidemiol 49:3-14. 2014
  4. pmc The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases
    Mirko Manchia
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 8:e76295. 2013
  5. doi Why negative meta-analyses may be false?
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic Electronic address
    Eur Neuropsychopharmacol 23:1307-9. 2013
  6. pmc Insulin resistance, diabetes mellitus, and brain structure in bipolar disorders
    Tomas Hajek
    1 Department of Psychiatry, Dalhousie University, Halifax, NS, Canada 2 Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3rd School of Medicine, Charles University, Prague, Czech Republic
    Neuropsychopharmacology 39:2910-8. 2014
  7. doi Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Biol Psychiatry 73:144-52. 2013
  8. doi Insulin resistance and outcome in bipolar disorder
    Cynthia V Calkin
    Cynthia V Calkin, MD, CCFP, FRCPC, Martina Ruzickova, MD, PhD, FRCPC, Department of Psychiatry, Dalhousie University, Halifax, Canada Rudolf Uher, MD, PhD, Department of Psychiatry, Dalhousie University, Halifax, Canada and Institute of Psychiatry, MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, UK Tomas Hajek, MD, PhD, Department of Psychiatry, Dalhousie University, Halifax, Canada and Department of Psychiatry, 3rd School of Medicine, Prague, Charles University, Czech Republic Claire M Slaney, RN, Julie S Garnham, RNBN, Capital District Health Authority, Halifax, Canada M Claire O Donovan, MB, FRCPC, Department of Psychiatry, Dalhousie University, Halifax,
    Br J Psychiatry 206:52-7. 2015
  9. doi Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV
    Rudolf Uher
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Institute of Psychiatry, King s College London, London, UK
    Depress Anxiety 31:459-71. 2014

Collaborators

Detail Information

Publications9

  1. doi A familial risk enriched cohort as a platform for testing early interventions to prevent severe mental illness
    Rudolf Uher
    Capital District Health Authority, Halifax, Nova Scotia, Canada
    BMC Psychiatry 14:344. 2014
    ..It is based on the rationale that early developmental antecedents to SMI are likely to be more malleable than fully developed mood or psychotic disorders and that low-risk interventions targeting antecedents may reduce the risk of SMI...
  2. pmc Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies
    Daniel Rasic
    To whom correspondence should be addressed Department of Psychiatry, Canada Research Chair in Early Intervention in Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Room 3089, Abbie J Lane Memorial Building, Halifax, Nova Scotia B3H 2E2, Canada fax 902 473 4877, E mail
    Schizophr Bull 40:28-38. 2014
    ..We aimed to quantify the risk of mental disorders in offspring and determine whether increased risk extends beyond the disorder present in the parent...
  3. doi Gene-environment interactions in common mental disorders: an update and strategy for a genome-wide search
    Rudolf Uher
    Department of Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Halifax, B3H 2E2, NS, Canada
    Soc Psychiatry Psychiatr Epidemiol 49:3-14. 2014
    ..Statistical and biological prioritization strategies are proposed to facilitate a systematic discovery of novel gene-environment interactions in genome-wide analyses. ..
  4. pmc The impact of phenotypic and genetic heterogeneity on results of genome wide association studies of complex diseases
    Mirko Manchia
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 8:e76295. 2013
    ..These results suggest that accurate phenotype delineation may be more important for detecting true genetic associations than increase in sample size. ..
  5. doi Why negative meta-analyses may be false?
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic Electronic address
    Eur Neuropsychopharmacol 23:1307-9. 2013
    ..Over reliance on such meta-analyses may falsely identify certain potentially fruitful research avenues as blind alleys. ..
  6. pmc Insulin resistance, diabetes mellitus, and brain structure in bipolar disorders
    Tomas Hajek
    1 Department of Psychiatry, Dalhousie University, Halifax, NS, Canada 2 Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3rd School of Medicine, Charles University, Prague, Czech Republic
    Neuropsychopharmacology 39:2910-8. 2014
    ..These findings raise the possibility that improving diabetes care among BD subjects and intervening already at the level of prediabetes could slow brain aging in BD. ..
  7. doi Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Biol Psychiatry 73:144-52. 2013
    ..Thus, we examined the associations among genetic risk, illness burden, lithium treatment, and brain structure in BD...
  8. doi Insulin resistance and outcome in bipolar disorder
    Cynthia V Calkin
    Cynthia V Calkin, MD, CCFP, FRCPC, Martina Ruzickova, MD, PhD, FRCPC, Department of Psychiatry, Dalhousie University, Halifax, Canada Rudolf Uher, MD, PhD, Department of Psychiatry, Dalhousie University, Halifax, Canada and Institute of Psychiatry, MRC Social, Genetic and Developmental Psychiatry Centre, King s College London, UK Tomas Hajek, MD, PhD, Department of Psychiatry, Dalhousie University, Halifax, Canada and Department of Psychiatry, 3rd School of Medicine, Prague, Charles University, Czech Republic Claire M Slaney, RN, Julie S Garnham, RNBN, Capital District Health Authority, Halifax, Canada M Claire O Donovan, MB, FRCPC, Department of Psychiatry, Dalhousie University, Halifax,
    Br J Psychiatry 206:52-7. 2015
    ..Little is known about the impact of insulin resistance on bipolar disorder...
  9. doi Major depressive disorder in DSM-5: implications for clinical practice and research of changes from DSM-IV
    Rudolf Uher
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Institute of Psychiatry, King s College London, London, UK
    Depress Anxiety 31:459-71. 2014
    ..We review the changes in MDD definition, provide guidance on their implementation and discuss their implications for clinical practice and research. ..