Richard A Singer

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi request reprint The FACT chromatin modulator: genetic and structure/function relationships
    Richard A Singer
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
    Biochem Cell Biol 82:419-27. 2004
  2. pmc FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation
    Jennifer R Stevens
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 6:e25644. 2011
  3. pmc The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport
    Jeremy J R Benjamin
    Department of Microbiology and Immunology, DalhousieUniversity, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 286:5187-96. 2011
  4. doi request reprint New mutant versions of yeast FACT subunit Spt16 affect cell integrity
    Allyson F O'Donnell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, NS, B3H 1X5, Canada
    Mol Genet Genomics 282:487-502. 2009
  5. pmc Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast
    Jeremy J R Benjamin
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 22:2337-47. 2011
  6. pmc Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi
    Tania A Wong
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 102:12777-82. 2005
  7. pmc Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress
    Allyson F O'Donnell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Nucleic Acids Res 32:5894-906. 2004
  8. pmc The ArfGAP Glo3 is required for the generation of COPI vesicles
    Stephen M Lewis
    Departments of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 15:4064-72. 2004
  9. pmc Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast
    Lora L Yanagisawa
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Mol Biol Cell 13:2193-206. 2002

Collaborators

  • Anne Spang
  • Gerald C Johnston
  • Jeremy J R Benjamin
  • Allyson F O'Donnell
  • Pak P Poon
  • Jennifer R Stevens
  • Tania A Wong
  • Stephen M Lewis
  • Christine A Barnes
  • Lora L Yanagisawa
  • Troy E Perry
  • John D Drysdale
  • Xiangmin Wang
  • AndrĂ©anne Auger
  • Rosemarie Kepkay
  • Christopher R McMaster
  • Gregory D Fairn
  • Maya Shmulevitz
  • Joelius Kurniawan
  • Neil K Brewster
  • Laura V Minard
  • Pak Phi Poon
  • Zhigang Xie
  • Vytas A Bankaitis
  • Jennifer Marchena
  • Xinmin Li
  • Paul A Randazzo

Detail Information

Publications9

  1. ncbi request reprint The FACT chromatin modulator: genetic and structure/function relationships
    Richard A Singer
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
    Biochem Cell Biol 82:419-27. 2004
    ..Genetic studies suggest that FACT mediates nucleosome reorganization along several pathways, and reinforce the notion that protein unfolding and (or) refolding is involved in FACT activity for transcription...
  2. pmc FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation
    Jennifer R Stevens
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 6:e25644. 2011
    ....
  3. pmc The yeast Arf GTPase-activating protein Age1 is regulated by phospholipase D for post-Golgi vesicular transport
    Jeremy J R Benjamin
    Department of Microbiology and Immunology, DalhousieUniversity, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 286:5187-96. 2011
    ..We show by direct assessment of Age1 ArfGAP activity that Age1 is regulated by lipid composition and can provide ArfGAP function for post-Golgi transport...
  4. doi request reprint New mutant versions of yeast FACT subunit Spt16 affect cell integrity
    Allyson F O'Donnell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, NS, B3H 1X5, Canada
    Mol Genet Genomics 282:487-502. 2009
    ..Thus, the FACT subunit Spt16 and Pkc1 signaling have an overlapping essential function, with an unexpected role for FACT in the maintenance of cell integrity...
  5. pmc Dysregulated Arl1, a regulator of post-Golgi vesicle tethering, can inhibit endosomal transport and cell proliferation in yeast
    Jeremy J R Benjamin
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 22:2337-47. 2011
    ..Protein sequestration at the trans-Golgi membrane by dysregulated, active Arl1 may therefore be the mechanism of inhibition...
  6. pmc Membrane metabolism mediated by Sec14 family members influences Arf GTPase activating protein activity for transport from the trans-Golgi
    Tania A Wong
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 102:12777-82. 2005
    ..Thus, ArfGAPs are subject to both temporal and spatial regulation that is facilitated by Sfh2-mediated modulation of the lipid environment...
  7. pmc Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress
    Allyson F O'Donnell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Nucleic Acids Res 32:5894-906. 2004
    ..Genetic interactions suggest that some functions carried out by the Spt16 NTD may be partially redundant within FACT...
  8. pmc The ArfGAP Glo3 is required for the generation of COPI vesicles
    Stephen M Lewis
    Departments of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 15:4064-72. 2004
    ..Finally, we present evidence supporting a role for ArfGAP protein in the generation of COPI retrograde transport vesicles...
  9. pmc Activity of specific lipid-regulated ADP ribosylation factor-GTPase-activating proteins is required for Sec14p-dependent Golgi secretory function in yeast
    Lora L Yanagisawa
    Department of Cell Biology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0005, USA
    Mol Biol Cell 13:2193-206. 2002
    ....