Affiliation: Dalhousie University
Sawynok J, Reid A. Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats. Pain. 2003;102:179-86 pubmed
..Combinations of these particular agents could represent a method for augmented analgesia and minimization of local adverse reactions. ..
Sawynok J. Topical analgesics for neuropathic pain in the elderly: current and future prospects. Drugs Aging. 2014;31:853-62 pubmed publisher
..Nevertheless, case reports and acceptable response rates in larger cohorts are intriguing, and this area merits further investigation in controlled settings as well as continued documentation of clinical experiences. ..
Sawynok J. Adenosine receptor targets for pain. Neuroscience. 2016;338:1-18 pubmed publisher
Sawynok J, Reid A, Fredholm B. Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A1 receptors. Neurosci Lett. 2008;440:181-4 pubmed publisher
..When A1Rs are present, actions of amitriptyline may, however, partly depend on A1Rs. ..
Sawynok J, Reid A, Fredholm B. Caffeine reverses antinociception by oxcarbazepine by inhibition of adenosine A1 receptors: insights using knockout mice. Neurosci Lett. 2010;473:178-81 pubmed publisher
..Our results indicate that, while adenosine A(1) receptors are not required for oxcarbazepine to produce antinociception in knockout mice, such receptors are essential in order to see caffeine reversal of this antinociceptive effect. ..
Sawynok J, Lynch M. Qigong and Fibromyalgia circa 2017. Medicines (Basel). 2017;4: pubmed publisher
..Qigong merits further study as a complementary practice for those with fibromyalgia. Current treatment guidelines do not consider amount of practice, and usually make indeterminate recommendations. ..
Sawynok J, Reid A, Liu X, Parkinson F. Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake. Eur J Pharmacol. 2005;518:116-22 pubmed
..Therefore, increased extracellular adenosine levels in vivo appear to result partially from extracellular conversion of nucleotide and partially from inhibition of uptake. ..
Sawynok J, Reid A, Liu J. Spinal and peripheral adenosine A? receptors contribute to antinociception by tramadol in the formalin test in mice. Eur J Pharmacol. 2013;714:373-8 pubmed publisher
..5HT? receptors in the spinal cord do not appear to be involved in the recruitment of A? receptor mechanisms when tramadol is given systemically in this model...