Kenneth J Rockwood

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi request reprint Societal costs of vascular cognitive impairment in older adults
    Kenneth Rockwood
    Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 33:1605-9. 2002
  2. ncbi request reprint Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study
    Kenneth Rockwood
    Dalhousie University, Canada
    J Neurol Sci 252:106-12. 2007
  3. ncbi request reprint A comparison of two approaches to measuring frailty in elderly people
    Kenneth Rockwood
    Department of Medicine, Dalhousie University and Capital District Health Authority, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:738-43. 2007
  4. doi request reprint Frailty defined by deficit accumulation and geriatric medicine defined by frailty
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Room 1421, 5955 Veterans Memorial Lane, Nova Scotia B3H 2E1, Canada
    Clin Geriatr Med 27:17-26. 2011
  5. doi request reprint Accumulation of non-traditional risk factors for coronary heart disease is associated with incident coronary heart disease hospitalization and death
    Lindsay M K Wallace
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 9:e90475. 2014
  6. pmc Changes in cognition and mortality in relation to exercise in late life: a population based study
    Laura E Middleton
    Geriatric Medicine Research Unit, Centre for Health Care of the Elderly, Halifax, Nova Scotia, Canada
    PLoS ONE 3:e3124. 2008
  7. pmc Social vulnerability, frailty and mortality in elderly people
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 3:e2232. 2008
  8. pmc Biomarkers to measure treatment effects in Alzheimer's disease: what should we look for?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University and Centre for Health Care of the Elderly, Capital District Health Authority, 1421 5955 Veterans Memorial Lane, Halifax, NS, Canada B3H 2E1
    Int J Alzheimers Dis 2011:598175. 2011
  9. pmc A meta-ethnography of paid dementia care workers' perspectives on their jobs
    Cheryl Cook
    Department of Medicine, Division of Geriatric Medicine, Dalhousie University Capital District Health Authority, Halifax, NS
    Can Geriatr J 15:127-36. 2012
  10. pmc FRAILTY: A Report from the 3(rd) Joint Workshop of IAGG/WHO/SFGG, Athens, January 2012
    Kenneth Rockwood
    Department of Medicine Geriatric Medicine and Neurology, Dalhousie University and Capital District Health Authority, Halifax, NS
    Can Geriatr J 15:31-6. 2012

Collaborators

Detail Information

Publications90

  1. ncbi request reprint Societal costs of vascular cognitive impairment in older adults
    Kenneth Rockwood
    Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 33:1605-9. 2002
    ..The construct of vascular cognitive impairment (VCI) includes many whose care is or will be costly. Nevertheless, estimates of these costs are not well described. We therefore set out to estimate the societal costs of VCI in elderly people...
  2. ncbi request reprint Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study
    Kenneth Rockwood
    Dalhousie University, Canada
    J Neurol Sci 252:106-12. 2007
    ..We compared cognitive, functional, and behavioural outcomes in patients with VCI to patients with no cognitive impairment (NCI), and Alzheimer's disease (AD)...
  3. ncbi request reprint A comparison of two approaches to measuring frailty in elderly people
    Kenneth Rockwood
    Department of Medicine, Dalhousie University and Capital District Health Authority, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:738-43. 2007
    ..Many definitions of frailty exist, but few have been directly compared. We compared the relationship between a definition of frailty based on a specific phenotype with one based on an index of deficit accumulation...
  4. doi request reprint Frailty defined by deficit accumulation and geriatric medicine defined by frailty
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Room 1421, 5955 Veterans Memorial Lane, Nova Scotia B3H 2E1, Canada
    Clin Geriatr Med 27:17-26. 2011
    ..Understanding people and their needs as deficits accumulate is an exciting challenge for clinical research on frailty and its management by geriatricians...
  5. doi request reprint Accumulation of non-traditional risk factors for coronary heart disease is associated with incident coronary heart disease hospitalization and death
    Lindsay M K Wallace
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 9:e90475. 2014
    ..It appears that non-traditional risk factors can also predict risk. The objective was to investigate contributions of non-traditional risk factors to coronary heart disease risk using a deficit accumulation approach...
  6. pmc Changes in cognition and mortality in relation to exercise in late life: a population based study
    Laura E Middleton
    Geriatric Medicine Research Unit, Centre for Health Care of the Elderly, Halifax, Nova Scotia, Canada
    PLoS ONE 3:e3124. 2008
    ..Here, we investigate how exercise is associated with cognitive change and mortality in older people and, particularly, whether exercise might paradoxically increase the risk of dementia by allowing people to live longer...
  7. pmc Social vulnerability, frailty and mortality in elderly people
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 3:e2232. 2008
    ..The aims of the present study were to operationalize social vulnerability according to a deficit accumulation approach, to compare social vulnerability and frailty, and to study social vulnerability in relation to mortality...
  8. pmc Biomarkers to measure treatment effects in Alzheimer's disease: what should we look for?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University and Centre for Health Care of the Elderly, Capital District Health Authority, 1421 5955 Veterans Memorial Lane, Halifax, NS, Canada B3H 2E1
    Int J Alzheimers Dis 2011:598175. 2011
    ..If not, their usefulness may be in supplementing, but not supplanting, clinical profiles of treatment effects...
  9. pmc A meta-ethnography of paid dementia care workers' perspectives on their jobs
    Cheryl Cook
    Department of Medicine, Division of Geriatric Medicine, Dalhousie University Capital District Health Authority, Halifax, NS
    Can Geriatr J 15:127-36. 2012
    ..While much work has been to evaluate paid workers' perspectives on the care they provide dementia patients, there is no evidence of any systematic review of this topic...
  10. pmc FRAILTY: A Report from the 3(rd) Joint Workshop of IAGG/WHO/SFGG, Athens, January 2012
    Kenneth Rockwood
    Department of Medicine Geriatric Medicine and Neurology, Dalhousie University and Capital District Health Authority, Halifax, NS
    Can Geriatr J 15:31-6. 2012
    ..Several approaches to frailty and its operationalization (including biomarkers) and to social vulnerability were discussed. The search programs that incorporate multiple measures and allows them to be tested were encouraged...
  11. ncbi request reprint Comparison of alternate scoring of variables on the performance of the frailty index
    Fernando G Peña
    Geriatric Medicine Research, Dalhousie University, Halifax, NS, Canada
    BMC Geriatr 14:25. 2014
    ..The purpose of this study was to systematically assess whether dichotomizing deficits included in an FI affects the information value of the whole index...
  12. ncbi request reprint Sleep disturbance is associated with incident dementia and mortality
    Roxanne Sterniczuk
    Department of Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Abbie J Lane Bldg, QEII Health Sciences Centre, Halifax, Nova Scotia, B3H 2E2, Canada
    Curr Alzheimer Res 10:767-75. 2013
    ..g., memory loss). Sleep-related questions may be useful for screening individuals at risk for dementia and may allow for the earlier detection of AD at the preclinical stage. ..
  13. doi request reprint Frailty in older adults: implications for end-of-life care
    Katalin Koller
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Cleve Clin J Med 80:168-74. 2013
    ..By recognizing frailty and measuring it objectively, clinicians can better engage patients and their loved ones in difficult discussions about treatment plans and prognosis, and ultimately deliver better palliative care...
  14. doi request reprint Gender differences in the relationship between smoking and frailty: results from the Beijing Longitudinal Study of Aging
    Chunxiu Wang
    Department of Evidence Based Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
    J Gerontol A Biol Sci Med Sci 68:338-46. 2013
    ..Smoking is common in China, where the population is aging rapidly. This study evaluated the relationship between smoking and frailty and their joint association with health and survival in older Chinese men and women...
  15. doi request reprint Frailty and its quantitative clinical evaluation
    P Moorhouse
    Queen Elizabeth II Health Sciences Centre, Department of Medicine, Dalhousie University, Halifax, Canada
    J R Coll Physicians Edinb 42:333-40. 2012
    ..Clinical research into outcomes associated with frailty in specific settings is ongoing and will be instrumental to the provision of appropriate care of older adults in the future...
  16. pmc Making mobility-related disability better: a complex response to a complex problem
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Dalhousie University and Queen Elizabeth Health Sciences Centre, 5955 Veterans Memorial Lane, Halifax, NS B3H 2E1, Canada
    BMC Med 10:121. 2012
    ..Unless we understand the complexity of the needs of frail older adults, we will neither be able to treat them effectively nor evaluate our efforts sensibly.Please see related article http://www.biomedcentral.com/1741-7015/10/120...
  17. doi request reprint Frailty in relation to the risk of falls, fractures, and mortality in older Chinese adults: results from the Beijing Longitudinal Study of Aging
    X Fang
    Department of Epidemiology and Social Medicine, Xuanwu Hospital, The Capital Medical University, Beijing, China
    J Nutr Health Aging 16:903-7. 2012
    ..Less is known about the relationship between falls and frailty defined as deficit accumulation. Our objective was to investigate the relationship between falls, fractures, and frailty based on deficit accumulation...
  18. pmc Frailty in primary care: a review of its conceptualization and implications for practice
    Alethea Lacas
    Department of Medicine Division of Geriatric Medicine Dalhousie University, Halifax, NS, Canada
    BMC Med 10:4. 2012
    ..This review seeks to address how frailty is recognised and managed, especially in the realm of primary care...
  19. pmc Prevalence and outcomes of delirium in community and non-acute care settings in people without dementia: a report from the Canadian Study of Health and Aging
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    BMC Med 4:15. 2006
    ..We examined delirium prevalence and outcomes in a large cohort of older Canadians living outside of acute care...
  20. pmc Analysis of frailty and survival from late middle age in the Beijing Longitudinal Study of Aging
    Jing Shi
    Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing, China
    BMC Geriatr 11:17. 2011
    ..Less is known about deficit accumulation in China, the country with the world's largest number of older adults...
  21. pmc Incomplete functional recovery after delirium in elderly people: a prospective cohort study
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Geriatr 5:5. 2005
    ..Our objective was to identify factors associated with short-term (by discharge) and long-term (by 6 month) incomplete recovery of function following delirium...
  22. pmc Transitions in cognitive test scores over 5 and 10 years in elderly people: evidence for a model of age-related deficit accumulation
    Arnold Mitnitski
    Department of Medicine and Geriatric Medicine Research Unit, Dalhousie University and QEII Health Sciences Centre, Capital District Health Authority, Halifax, Nova Scotia, Canada
    BMC Geriatr 8:3. 2008
    ..Given that cognition also changes with age, we wondered whether the same model might also describe the accumulation of errors in cognitive test scores in community-dwelling older adults...
  23. pmc A standard procedure for creating a frailty index
    Samuel D Searle
    Geriatric Medicine Research Unit, Dalhousie University and Capital District Health Authority, Halifax, Canada
    BMC Geriatr 8:24. 2008
    ..A frailty index can be developed from most ageing databases. Our objective is to systematically describe a standard procedure for constructing a frailty index...
  24. doi request reprint Physiological redundancy in older adults in relation to the change with age in the slope of a frailty index
    Kenneth Rockwood
    Division of Geriatric Medicine, Centre for Health Care of the Elderly, Capital District Health Authority, Dalhousie University, 1421 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada
    J Am Geriatr Soc 58:318-23. 2010
    ..In keeping with the reliability theory of aging, this would be quantitated by attenuation in the slope of a Frailty Index (FI) with age. The more deficits, the less steep the slope and the less redundancy...
  25. pmc The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial
    Kenneth Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Canada
    BMC Neurol 7:26. 2007
    ..We examined how this change compared with measures of clinical meaningfulness...
  26. ncbi request reprint Frailty in relation to the accumulation of deficits
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada, B3H 2E1
    J Gerontol A Biol Sci Med Sci 62:722-7. 2007
    ..Future studies include the application of network analyses and stochastic analytical techniques to the evaluation of the frailty index and the description of other state variables in relation to frailty...
  27. pmc Changes in relative fitness and frailty across the adult lifespan: evidence from the Canadian National Population Health Survey
    Kenneth Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 183:E487-94. 2011
    ..Furthermore, less is known about how frailty changes over time among younger adults. We estimated the prevalence and outcomes of frailty, in relation to accumulation of deficits, across the adult lifespan...
  28. pmc Goal setting and attainment in Alzheimer's disease patients treated with donepezil
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurol Neurosurg Psychiatry 73:500-7. 2002
    ....
  29. ncbi request reprint How should we grade frailty in nursing home patients?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    J Am Med Dir Assoc 8:595-603. 2007
    ..To compare 3 methods of describing the frailty of older adults in nursing homes...
  30. ncbi request reprint Lipid-lowering agents and the risk of cognitive impairment that does not meet criteria for dementia, in relation to apolipoprotein E status
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Neuroepidemiology 29:201-7. 2007
    ..Adjusting for apolipoprotein E4 status did not change the point estimates of the ORs. The greatest impact of LLAs was seen in the CIND subtype circumscribed memory impairment...
  31. doi request reprint Apolipoprotein E-polymorphism, frailty and mortality in older adults
    Kenneth Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Cell Mol Med 12:2754-61. 2008
    ..07; 95% confidence interval: 0.90-1.29, frailty HR 35.3; 95% confidence interval: 20.4-61.1). The data do not support an association between ApoE polymorphism and frailty. This result did not depend on how frailty was defined...
  32. pmc The inclusion of cognition in vascular risk factor clinical practice guidelines
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, Halifax, NS, Canada
    Clin Interv Aging 4:425-33. 2009
    ..The objective of this study was to evaluate whether vascular risk factor clinical practice guidelines consider cognition as an outcome or in connection with treatment compliance...
  33. doi request reprint The ADAS-cog and clinically meaningful change in the VISTA clinical trial of galantamine for Alzheimer's disease
    Kenneth Rockwood
    Division of Geriatric Medicine, Capital District Health Authority, Dalhousie University, Halifax, NS, Canada
    Int J Geriatr Psychiatry 25:191-201. 2010
    ..In an investigator-initiated, clinical trial of galantamine, we investigated the extent to which a 4-point change classifies goal attainment by individual patients...
  34. pmc Con: Can biomarkers be gold standards in Alzheimer's disease?
    Kenneth Rockwood
    Centre for Health Care of the Elderly, Capital District Health Authority, 1421 5955 Veterans Memorial Lane, Halifax, Nova Scotia, Canada, B3H 2E1
    Alzheimers Res Ther 2:16. 2010
    ..These roles will best be executed by hearing what patients and caregivers tell us about dementia, and its response to treatment...
  35. doi request reprint An individualized approach to tracking and treating Alzheimer's disease
    K Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Pharmacol Ther 88:446-9. 2010
    ..This variability further complicates the difficulty of dementia's high dimensionality--Alzheimer's disease affects many aspects of cognition, function, and behavior...
  36. doi request reprint Reliability of the hierarchical assessment of balance and mobility in frail older adults
    Kenneth Rockwood
    Department of Medicine, Division of Geriatric Medicine, Geriatric Medicine Research Unit, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 56:1213-7. 2008
    ..To study the test-retest and interrater reliability of the Hierarchical Assessment of Balance and Mobility (HABAM) in frail older adults...
  37. pmc Out of the furrow and into the fire: where do we go with delirium?
    Kenneth J Rockwood
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 167:763-4. 2002
  38. ncbi request reprint Improving clinical descriptions to understand the effects of dementia treatment: consensus recommendations
    Kenneth Rockwood
    Dalhousie University, Halifax, Nova Scotia
    Int J Geriatr Psychiatry 17:1006-11. 2002
    ..To recommend how the description of clinically detectable treatment effects might be improved for antidementia drug trials...
  39. ncbi request reprint Effect of galantamine on verbal repetition in AD: a secondary analysis of the VISTA trial
    Kenneth Rockwood
    Division of Geriatric Medicine, QEII Health Sciences, Dalhousie University, Halifax, NS, Canada
    Neurology 68:1116-21. 2007
    ....
  40. pmc Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease
    K Rockwood
    Centre for Health Care for Elderly, Halifax, Nova Scotia, Canada
    J Neurol Neurosurg Psychiatry 75:677-85. 2004
    ..Six cholinesterase inhibitors (ChEIs) have been tested in people with Alzheimer's disease, using methods currently required for regulatory approval. The clinical importance of their treatment effects is controversial...
  41. ncbi request reprint Limits to deficit accumulation in elderly people
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, Halifax, NS, Canada
    Mech Ageing Dev 127:494-6. 2006
    ..The data suggest a level of frailty beyond which, even in developed countries, further deficit accumulation is not sustainable...
  42. ncbi request reprint What would make a definition of frailty successful?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Age Ageing 34:432-4. 2005
    ..The need for progress on our understanding of frailty is evident, but for now, there is insufficient evidence to accept a single definition of frailty...
  43. ncbi request reprint Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Gerontol A Biol Sci Med Sci 59:1310-7. 2004
    ..Frailty and fitness are important attributes of older persons, but population samples of their prevalence, attributes, and outcomes are limited...
  44. ncbi request reprint Lending a helping eye: artists in residence at a memory clinic
    Kenneth Rockwood
    Dalhousie University, Halifax, Canada
    Lancet Neurol 3:119-23. 2004
    ..The artist programme has inspired a design initiative for the improvement of the physical environment for older patients, and has created a unique art collection that is becoming a resource for scholarship...
  45. pmc Attainment of treatment goals by people with Alzheimer's disease receiving galantamine: a randomized controlled trial
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 174:1099-105. 2006
    ..An important aspect of clinical meaningfulness is the extent to which an intervention meets the goals of treatment...
  46. ncbi request reprint The treatment of Alzheimer's disease: success short of cure
    Kenneth Rockwood
    Dalhousie University, Halifax, Canada
    Lancet Neurol 2:630-3. 2003
    ..To understand how there can be treatment success short of cure, without knowing at the outset what form that success may take, will require systematic observation and careful description of patients' experiences...
  47. ncbi request reprint Potential treatment effects of donepezil not detected in Alzheimer's disease clinical trials: a physician survey
    Kenneth Rockwood
    Divisions of Geriatric Medicine and Neurology, Dalhousie University, Halifax, Nova Scotia B3H 2E1, Canada
    Int J Geriatr Psychiatry 19:954-60. 2004
    ..We sought to identify and categorize clinically recognizable effects of donepezil treatment in Alzheimer's disease...
  48. ncbi request reprint Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Dalhousie University, 1431 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada
    J Am Geriatr Soc 54:975-9. 2006
    ..To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes...
  49. ncbi request reprint Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease
    K Rockwood
    Alzheimer Research, Dalhousie University, Halifax, Canada
    Acta Neurol Scand Suppl 185:71-7. 2006
    ..Still, the first reports appear to have overestimated the extent of protection, so that unless there are important effects achievable with specific statins, a more than a modest role for statins in preventing AD seems unlikely...
  50. ncbi request reprint Patterns of decline and evidence of subgroups in patients with Alzheimer's disease taking galantamine for up to 48 months
    Kenneth Rockwood
    Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Int J Geriatr Psychiatry 23:207-14. 2008
    ..We aimed to: 1) understand changes in cognition and function in people taking galantamine; (2) identify treatment subgroups...
  51. ncbi request reprint Changes with age in the distribution of a frailty index
    Kenneth Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, 1421 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 1C6, Canada
    Mech Ageing Dev 125:517-9. 2004
    ..Of note, the variation coefficient, initially high, decreased from middle age on. Being able to quantify frailty means that health risks can be summarised at both the individual and group levels...
  52. ncbi request reprint The risk of dementia in relation to statins and other lipid lowering agents
    Kenneth Rockwood
    Divisions of Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Neurol Res 25:601-4. 2003
    ..Dedicated clinical trials are now under way, and their results are awaited with great interest...
  53. ncbi request reprint The measuring, meaning and importance of activities of daily living (ADLs) as an outcome
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, and Centre for Health Care of the Elderly, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 19:467-82. 2007
    ..How best to improve sensitivity to change of functional measurements is controversial, but it is necessary to do so in order to evaluate the full effects of treatment...
  54. ncbi request reprint Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study
    Kenneth Rockwood
    Dalhousie University, Canada
    J Neurol Sci 240:7-14. 2006
    ..There is a need for empirical studies to define criteria for vascular cognitive impairment (VCI) subtypes. In this paper, we report the predictive validity of a subtype classification scheme based on clinical and radiographic features...
  55. doi request reprint Prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation
    Xiaowei Song
    Department of Medicine, Dalhousie University, Halifax, Canada
    J Am Geriatr Soc 58:681-7. 2010
    ..To evaluate the prevalence and 10-year outcomes of frailty in older adults in relation to deficit accumulation...
  56. ncbi request reprint Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 33:1999-2002. 2002
    ..Follow-up cognitive diagnoses were available for 102 individuals. After 5 years, 45 patients (44%) developed dementia. Low baseline scores on tests of memory and category fluency were associated with incident dementia...
  57. doi request reprint Social vulnerability predicts cognitive decline in a prospective cohort of older Canadians
    Melissa K Andrew
    Division of Geriatric Medicine and Geriatric Medicine Research Unit, Dalhousie University, Halifax, NS, Canada
    Alzheimers Dement 6:319-325.e1. 2010
    ..We investigated whether social vulnerability, defined as an index comprising many social factors, is associated with cognitive decline...
  58. doi request reprint Executive dysfunction in vascular cognitive impairment in the consortium to investigate vascular impairment of cognition study
    Paige Moorhouse
    Dalhousie University, Canada
    J Neurol Sci 288:142-6. 2010
    ..The importance of executive dysfunction is increasingly recognized in the dementia syndrome. Although executive dysfunction has been associated with subcortical ischemic lesions, it may not be unique to VCI or to its clinical subtypes...
  59. ncbi request reprint Psychiatric illness in relation to frailty in community-dwelling elderly people without dementia: a report from the Canadian Study of Health and Aging
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University
    Can J Aging 26:33-8. 2007
    ....
  60. ncbi request reprint APOE genotype, vascular risk factors, memory test performance and the five-year risk of vascular cognitive impairment or Alzheimer's disease
    Jennifer D Klages
    Department of Psychology, Dalhousie University, Halifax, Canada
    Dement Geriatr Cogn Disord 20:292-7. 2005
    ..75; CI, 1.27-2.42) and AD (OR, 1.86; CI, 1.29-2.67) but attenuated the APOE epsilon4 effect in AD. VCI and AD have different risk profiles and outcomes, but subtle memory difficulties may be an early feature of both...
  61. ncbi request reprint Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 53:2184-9. 2005
    ..To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples...
  62. doi request reprint Transition from cognitively impaired not demented to Alzheimer's disease: an analysis of changes in functional abilities in a dementia clinic cohort
    Ging Yuek R Hsiung
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Dement Geriatr Cogn Disord 25:483-90. 2008
    ..We evaluated whether impairments on the Disability Assessment for Dementia (DAD) and Functional Rating Scale (FRS) can predict progression to AD...
  63. ncbi request reprint APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging
    Jennifer D Klages
    Department of Psychology, Dalhousie University, Halifax, Canada
    Dement Geriatr Cogn Disord 15:1-5. 2003
    ..This study examined the relation between two risks for Alzheimer's disease (AD): the apolipoprotein (APOE) epsilon4 allele and poor memory test performance...
  64. doi request reprint Decreased initiation of usual activities in people with mild-to-moderate Alzheimer's disease: a descriptive analysis from the VISTA clinical trial
    Cheryl Cook
    Geriatric Medicine Research Unit, Capital District Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 20:952-63. 2008
    ..Decreased initiation of activities is a common symptom in Alzheimer's disease (AD) and creates significant burden for carers, yet little is known about how patients, carers and treating physicians describe this problem...
  65. ncbi request reprint Specific symptomatic changes following donepezil treatment of Alzheimer's disease: a multi-centre, primary care, open-label study
    Kenneth Rockwood
    Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Int J Geriatr Psychiatry 22:312-9. 2007
    ..We studied a symptom checklist, completed separately by caregivers and by clinicians, to identify patterns of change associated with donepezil treatment...
  66. doi request reprint Verbal repetition in people with mild-to-moderate Alzheimer Disease: a descriptive analysis from the VISTA clinical trial
    Cheryl Cook
    Geriatric Medicine Research Unit, QEII Health Sciences, Dalhousie University, Halifax, NS B3H 2E1, Canada
    Alzheimer Dis Assoc Disord 23:146-51. 2009
    ..Verbal repetition is a common symptom and target for treatment in Alzheimer disease (AD), yet little is known of its manifestations in the daily lives of patients. Here we characterized the nature of verbal repetition and its correlates...
  67. ncbi request reprint Variations in case definition affect prevalence but not outcomes of mild cognitive impairment
    John D Fisk
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurology 61:1179-84. 2003
    ..To examine the prevalence estimates and 5-year outcomes of various case definitions of mild cognitive impairment (MCI)...
  68. ncbi request reprint A cross-national study of transitions in deficit counts in two birth cohorts: implications for modeling ageing
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Canada
    Exp Gerontol 42:241-6. 2007
    ..The model suggests that all health transitions, including health improvement, worsening, and death, can be summarized in a unified stochastic model with a few interpretable parameters...
  69. ncbi request reprint Going from bad to worse: a stochastic model of transitions in deficit accumulation, in relation to mortality
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, NS, Canada
    Mech Ageing Dev 127:490-3. 2006
    ..Age-related deficit accumulation is highly characteristic, and can be modeled as a stochastic process with readily interpretable parameters...
  70. pmc A global clinical measure of fitness and frailty in elderly people
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 173:489-95. 2005
    ..We aimed to develop a tool that would be both predictive and easy to use...
  71. ncbi request reprint Verbal repetition in patients with Alzheimer's disease who receive donepezil
    Elissa Asp
    Geriatric Medicine Research Unit, Dalhousie University, Halifax, NS, Canada
    Int J Geriatr Psychiatry 21:426-31. 2006
    ..Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition...
  72. ncbi request reprint Validity and reliability of the Edmonton Frail Scale
    Darryl B Rolfson
    Division of Geriatric Medicine, University of Alberta, B139C Clin Sci Building, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7
    Age Ageing 35:526-9. 2006
  73. ncbi request reprint Global assessment measures for assessing efficacy in dementia drug trials
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 34:S52-6. 2007
    ..Steps should be taken to improve the specificity of treatment effect description and to incorporate patient/caregiver preferences in global measures about disease treatment in dementia...
  74. doi request reprint Modeling the impact of sex on how exercise is associated with cognitive changes and death in older Canadians
    Nader Fallah
    Geriatric Medicine Research, Centre for Health Care of the Elderly, Halifax, NS, Canada
    Neuroepidemiology 33:47-54. 2009
    ..Cognition and mortality are each also affected by biological sex, which might modify the effect of exercise. We investigated how sex mediates the impact of exercise on mortality and 5-year changes in cognition...
  75. ncbi request reprint Assessment of individual risk of death using self-report data: an artificial neural network compared with a frailty index
    Xiaowei Song
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 52:1180-4. 2004
    ..To evaluate the potential of an artificial neural network (ANN) in predicting survival in elderly Canadians, using self-report data...
  76. ncbi request reprint Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, 5955 Veterans Memorial Ln, Room 1421, Halifax, Nova Scotia, Canada B3H 2E1
    Arch Neurol 59:223-7. 2002
    ..This association could be due to indication bias, i.e., people who elect to take lipid-lowering agents (LLAs) may be healthier than those who do not, so that it may be these other health factors that explain their lower risk of dementia...
  77. ncbi request reprint Patterns of clinically detectable treatment effects with galantamine: a qualitative analysis
    Christine Joffres
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, Halifax, Canada
    Dement Geriatr Cogn Disord 15:26-33. 2003
    ..Clinicians appear to be skeptical of cognitive changes not supported by like changes in function or behaviour...
  78. ncbi request reprint Cognitive impairment of acute onset in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) study: occurrence, correlates, and outcomes
    Paige King
    Division of Geriatric Medicine, Dalhousie University, Canada
    Am J Geriatr Psychiatry 14:893-6. 2006
    ..Having demonstrated that dementia of acute onset represents a distinct syndrome with distinct outcomes, the authors investigated whether similar attributes describe cognitive impairment of acute onset (CIAO)...
  79. doi request reprint Effect of parental age at birth on the accumulation of deficits, frailty and survival in older adults
    Ruth E Hubbard
    Dalhousie University and QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
    Age Ageing 38:380-5. 2009
    ..The effect of parental age on fitness/frailty in late life is unknown. We aimed to investigate the relationships between parental age and frailty and longevity in older adults...
  80. doi request reprint A five-point change in Modified Mini-Mental State Examination was clinically meaningful in community-dwelling elderly people
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University and QEII Health Sciences Centre, Suite 1421, CHVMB, 5955 Veterans Memorial Lane, Halifax, Nova Scotia, B3H 2E1, Canada
    J Clin Epidemiol 61:827-31. 2008
    ..To determine what change in the Modified Mini-Mental State Examination (3MS), a validated and widely used cognitive screening tool for which meaningful change scores have not been clearly characterized, should be considered meaningful...
  81. ncbi request reprint Improvement and decline in health status from late middle age: modeling age-related changes in deficit accumulation
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, NS, Canada
    Exp Gerontol 42:1109-15. 2007
    ..From late middle age, transitions in health states occur with a regularity that is easily modeled. Improvements in health can occur at any age. At all ages, there is a limit to deficit accumulation...
  82. ncbi request reprint Exercise: a potential contributing factor to the relationship between folate and dementia
    Laura E Middleton
    Division of Geriatric Medicine, Dalhousie University, Halifax, Canada
    J Am Geriatr Soc 55:1095-8. 2007
    ..To investigate whether exercise confounds the relationship between folate and cerebrovascular events, all-cause dementia, and Alzheimer's disease...
  83. ncbi request reprint Is mild cognitive impairment a valid target of therapy
    Kenneth Rockwood
    Department of Medicine Geriatric Medicine and Neurology, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 34:S90-6. 2007
    ..The phenomenon of slowing or non-progression itself should be investigated, and such investigations likely should extend to people now classified as having mild dementia...
  84. ncbi request reprint Help available--phenomenological models for research on aging
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Sci Aging Knowledge Environ 2003:VP2. 2003
    ..This method consists of systematizing facts that cannot necessarily be explained by considering those facts in isolation...
  85. ncbi request reprint Five-year outcomes for dementia defined solely by neuropsychological test performance
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 22:172-8. 2003
    ..The case definition of NPDementia identified individuals with cognitive impairment that is unlikely to resolve and likely to progress to dementia...
  86. ncbi request reprint Techniques for knowledge discovery in existing biomedical databases: estimation of individual aging effects in cognition in relation to dementia
    Arnold B Mitnitski
    Geriatric Medicine Research, Unit Suite 1421, Dalhousie University, 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada
    J Clin Epidemiol 56:116-23. 2003
    ..At the individual level, KDD suggests that more precise diagnosis seems possible as well as individual life expectancy prediction. Biomedical databases appear to hold the potential for novel insights when explored by systematic modeling...
  87. ncbi request reprint Preclinical vascular cognitive impairment and Alzheimer disease: neuropsychological test performance 5 years before diagnosis
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 38:1148-53. 2007
    ..We compared the neuropsychological performances of people with incident VCI, incident AD, and no cognitive impairment (NCI) 5 years before their clinical diagnoses...
  88. pmc Nontraditional risk factors combine to predict Alzheimer disease and dementia
    Xiaowei Song
    Department of Medicine, Dalhousie University, Halifax, Canada
    Neurology 77:227-34. 2011
    ..To investigate whether dementia risk can be estimated using only health deficits not known to predict dementia...