K Rockwood

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc Medical management of frailty: confessions of a gnostic
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 157:1081-4. 1997
  2. ncbi request reprint Prevalence of diabetes mellitus in elderly people in Canada: report from the Canadian Study of Health and Aging
    K Rockwood
    Department of Community Health and Epidemiology, 3 Dalhousie University, Halifax, 5955 Jubilee Road, Halifax, NS B3H 2EI, Canada
    Age Ageing 27:573-7. 1998
  3. ncbi request reprint Vascular cognitive impairment and vascular dementia
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, 5955 Jubilee Road, Halifax, NS, Canada B3H 2E1
    J Neurol Sci 203:23-7. 2002
  4. ncbi request reprint Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, 5955 Veterans Memorial Ln, Room 1421, Halifax, Nova Scotia, Canada B3H 2E1
    Arch Neurol 59:223-7. 2002
  5. pmc Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial
    K Rockwood
    Centre for Health Care of the Elderly, QEII Health Sciences Centre, 1421 5955 Veterans Memorial Lane, Halifax, Canada B3H 2E1
    J Neurol Neurosurg Psychiatry 71:589-95. 2001
  6. ncbi request reprint Assessing the clinical importance of statistically significant improvement in anti-dementia drug trials
    K Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 20:51-6. 2001
  7. ncbi request reprint Conceptualisation and measurement of frailty in elderly people
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
    Drugs Aging 17:295-302. 2000
  8. ncbi request reprint The diagnosis of "mixed" dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC)
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Ann N Y Acad Sci 903:522-8. 2000
  9. pmc Incidence and outcomes of diabetes mellitus in elderly people: report from the Canadian Study of Health and Aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 162:769-72. 2000
  10. ncbi request reprint Feasibility and measurement properties of the functional reach and the timed up and go tests in the Canadian study of health and aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Canada
    J Gerontol A Biol Sci Med Sci 55:M70-3. 2000

Detail Information

Publications107 found, 100 shown here

  1. pmc Medical management of frailty: confessions of a gnostic
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, NS
    CMAJ 157:1081-4. 1997
    ..More must be done to encourage all physicians to use these techniques in caring for frail elderly people who are ill...
  2. ncbi request reprint Prevalence of diabetes mellitus in elderly people in Canada: report from the Canadian Study of Health and Aging
    K Rockwood
    Department of Community Health and Epidemiology, 3 Dalhousie University, Halifax, 5955 Jubilee Road, Halifax, NS B3H 2EI, Canada
    Age Ageing 27:573-7. 1998
    ..to estimate the age-specific prevalence of diabetes mellitus in elderly people in Canada, and to examine the effect of method of ascertainment on the estimation of prevalence...
  3. ncbi request reprint Vascular cognitive impairment and vascular dementia
    Kenneth Rockwood
    Department of Medicine, Dalhousie University, 5955 Jubilee Road, Halifax, NS, Canada B3H 2E1
    J Neurol Sci 203:23-7. 2002
    ..The purpose of defining the new concept of VCI is to identify preventable risk factors. Importantly, not only physical health but also mental health should be monitored and treated...
  4. ncbi request reprint Use of lipid-lowering agents, indication bias, and the risk of dementia in community-dwelling elderly people
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Centre, 5955 Veterans Memorial Ln, Room 1421, Halifax, Nova Scotia, Canada B3H 2E1
    Arch Neurol 59:223-7. 2002
    ..This association could be due to indication bias, i.e., people who elect to take lipid-lowering agents (LLAs) may be healthier than those who do not, so that it may be these other health factors that explain their lower risk of dementia...
  5. pmc Effects of a flexible galantamine dose in Alzheimer's disease: a randomised, controlled trial
    K Rockwood
    Centre for Health Care of the Elderly, QEII Health Sciences Centre, 1421 5955 Veterans Memorial Lane, Halifax, Canada B3H 2E1
    J Neurol Neurosurg Psychiatry 71:589-95. 2001
    ..To assess the efficacy and safety of galantamine in Alzheimer's disease at 3 months using flexible dose escalation...
  6. ncbi request reprint Assessing the clinical importance of statistically significant improvement in anti-dementia drug trials
    K Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 20:51-6. 2001
    ..Large, systematic clinical studies of treated patients remain necessary to define reliable guides to successful treatment...
  7. ncbi request reprint Conceptualisation and measurement of frailty in elderly people
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, QEII Health Sciences Centre, Halifax, Nova Scotia, Canada
    Drugs Aging 17:295-302. 2000
    ..Future models of frailty should incorporate more precise operationalisation of the probability of frailty and better explain the relationship between disease, disability and frailty...
  8. ncbi request reprint The diagnosis of "mixed" dementia in the Consortium for the Investigation of Vascular Impairment of Cognition (CIVIC)
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Ann N Y Acad Sci 903:522-8. 2000
    ..The concept of mixed dementia should be extended to include vascular dementia in combination with dementias, other than Alzheimer's disease...
  9. pmc Incidence and outcomes of diabetes mellitus in elderly people: report from the Canadian Study of Health and Aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS
    CMAJ 162:769-72. 2000
    ..The purpose of this study was to estimate the incidence of diabetes mellitus among elderly people in Canada and the relative risks of death and admission to an institution among elderly diabetic patients...
  10. ncbi request reprint Feasibility and measurement properties of the functional reach and the timed up and go tests in the Canadian study of health and aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Canada
    J Gerontol A Biol Sci Med Sci 55:M70-3. 2000
    ..Estimates of the feasibility, reliability, and construct validity of these measures in large, heterogeneous samples are necessary to establish their importance relative to traditional measures of function...
  11. ncbi request reprint Comprehensive geriatric assessment. Helping your elderly patients maintain functional well-being
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University Faculty of Medicine, Halifax, Nova Scotia, Canada
    Postgrad Med 103:247-9, 254-8, 264. 1998
    ..With a 45- to 90-minute time investment, physicians can obtain an inventory of the factors that threaten an elderly patient's independence and gain a fuller understanding of the patient's complex needs...
  12. ncbi request reprint Retrospective diagnosis of dementia using an informant interview based on the Brief Cognitive Rating Scale
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, Canada
    Int Psychogeriatr 10:53-60. 1998
    ..The RetroBCRS used by an expert physician with a reliable informant is a valid method of detecting dementia and determining whether AD was present...
  13. ncbi request reprint Responsiveness of goal attainment scaling in a randomized controlled trial of comprehensive geriatric assessment
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Clin Epidemiol 56:736-43. 2003
    ..Goal Attainment Scaling (GAS) measures multiple, individualized goals, but its responsiveness in comparative clinical trials has not been established...
  14. ncbi request reprint Spectrum of disease in vascular cognitive impairment
    K Rockwood
    Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 18:248-54. 1999
    ..To better understand and treat ischaemic causes of cognitive impairment, the concept of VaD should be expanded to include patients who do not meet traditional dementia criteria...
  15. ncbi request reprint Educational interventions in delirium
    K Rockwood
    Geriatric Medicine, Dalhousie University, Halifax, Canada
    Dement Geriatr Cogn Disord 10:426-9. 1999
    ..The strength of educational interventions needs to be assessed carefully. Interventions which are time-sensitive, less complex, directed to observable, patient-focused endpoints are more likely to be successful...
  16. ncbi request reprint Prevalence and outcomes of vascular cognitive impairment. Vascular Cognitive Impairment Investigators of the Canadian Study of Health and Aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurology 54:447-51. 2000
    ....
  17. ncbi request reprint The risk of dementia and death after delirium
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax NS, Canada
    Age Ageing 28:551-6. 1999
    ..delirium is common and is associated with many adverse short-term consequences...
  18. ncbi request reprint Sleep disturbances and mortality: results from the Canadian Study of Health and Aging
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 49:639-41. 2001
    ..CONCLUSION: Daytime sleepiness itself is not associated with an increased risk of death when other factors are taken into account. Daytime sleepiness may be a proxy for other morbid conditions and therefore for overall tiredness...
  19. ncbi request reprint Transitions in cognitive status in relation to frailty in older adults: a comparison of three frailty measures
    A Mitnitski
    Department of the Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada
    J Nutr Health Aging 15:863-7. 2011
    ..Here, we compared 3 frailty measures in relation to cognitive changes and mortality in the Canadian Study of Health and Aging (CSHA)...
  20. ncbi request reprint Reliability and validity of questions about exercise in the Canadian Study of Health and Aging
    H S Davis
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:177-82. 2001
    ....
  21. ncbi request reprint Progression of impairment in patients with vascular cognitive impairment without dementia
    C Wentzel
    Dalhousie University, Halifax, Nova Scotia, Canada
    Neurology 57:714-6. 2001
    ..1, 1.0 to 4.5). Of 32 participants alive without dementia, cognition had deteriorated in seven and improved in four. Half of those with vascular CIND developed dementia within 5 years, suggesting a target for preventive interventions...
  22. ncbi request reprint Effect of smoking on the accumulation of deficits, frailty and survival in older adults: a secondary analysis from the Canadian Study of Health and Aging
    R E Hubbard
    Dalhousie University, Queen Elizabeth II Health Sciences Centre, Halifax, Canada
    J Nutr Health Aging 13:468-72. 2009
    ..Smoking has adverse effects on a variety of organ systems but little is known about the relationship between smoking and frailty. We aimed to investigate differences in health status between smoking and non smoking older adults...
  23. ncbi request reprint Measurement of the influence of the physical environment on adverse health outcomes: technical report from the Canadian Study of Health and Aging
    C Wentzel
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:215-21. 2001
    ..quot; Limitations of the six items used to assess the physical environment and ways in which to improve the sensitivity of the items, consequently avoiding measurement bias, are discussed...
  24. ncbi request reprint The Canadian Study of Health and Aging: organizational lessons from a national, multicenter, epidemiologic study
    K Rockwood
    Division of Geriatric Medicine, Dalhousie University, Canada
    Int Psychogeriatr 13:233-7. 2001
    ..In hindsight, several important features of the study would be repeated. Future studies might profitably consider a longer funding period for analysis, and a more strategic approach to in-depth, supplementary studies...
  25. ncbi request reprint Assessing hypertension in the Canadian Study of Health and Aging
    H S Davis
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:115-23. 2001
    ..The SARF questions incorporating high blood pressure and treatment appear preferable to assess the risks associated with hypertension...
  26. ncbi request reprint The effect of the living situation on the severity of dementia at diagnosis
    A Sibley
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Dement Geriatr Cogn Disord 13:40-5. 2002
    ..This study explores the relationship between a patient's living situation and the severity of dementia at diagnosis...
  27. doi request reprint Trajectories of changes over twelve years in the health status of Canadians from late middle age
    A Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Gerontol 47:893-9. 2012
    ..The model is valuable for estimating how changes in health can influence mortality across the life course from late middle age...
  28. ncbi request reprint Linkage of the Canadian Study of Health and Aging to provincial administrative health care databases in Nova Scotia
    A M Yip
    Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:147-58. 2001
    ....
  29. ncbi request reprint Use of the chronic disease score to measure comorbidity in the Canadian Study of Health and Aging
    C MacKnight
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:137-42. 2001
    ..The calculation of the CDS from data contained in the Canadian Study of Health and Aging (CSHA) is described. This measure can be used to estimate comorbidity within the CSHA database...
  30. pmc Office management of elderly hypertensive patients. Focusing on cognition and function
    K Rockwood
    Dalhousie University, Halifax, NS
    Can Fam Physician 47:2520-5. 2001
    ..There is insufficient evidence for carrying out routine recommendations for frail elderly people. Treatment of comorbid illnesses dictates choice of therapeutic agent...
  31. pmc Outcomes of incident mild cognitive impairment in relation to case definition
    J D Fisk
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, NS, Canada
    J Neurol Neurosurg Psychiatry 76:1175-7. 2005
    ..Factors associated with recovery and non-progression in MCI require elucidation...
  32. doi request reprint Misplacing objects in mild to moderate Alzheimer's disease: a descriptive analysis from the VISTA clinical trial
    L Hamilton
    Geriatric Medicine Research Unit, Capital District Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurol Neurosurg Psychiatry 80:960-5. 2009
    ..Patient and carer descriptions of misplacing in clinical interviews are reported here...
  33. ncbi request reprint Gait and posture impairment, parkinsonism and cognitive decline in older people
    R Camicioli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Neural Transm 114:1355-61. 2007
    ..In conclusion, motor impairment and frailty are common in older people and are associated with an increased risk of cognitive decline and dementia. GPI is common in CIND, while GPI and parkinsonism are both common in dementia...
  34. pmc Goal setting and attainment in Alzheimer's disease patients treated with donepezil
    K Rockwood
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurol Neurosurg Psychiatry 73:500-7. 2002
    ....
  35. ncbi request reprint Comparison of the prognostic importance of diagnosed diabetes, co-morbidity and frailty in older people
    R E Hubbard
    Geriatric Medicine Research Unit, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Canada
    Diabet Med 27:603-6. 2010
    ..To compare the relative prognostic importance in older people of diagnosed diabetes, the number and severity of co-morbidities and frailty...
  36. doi request reprint Frailty and its quantitative clinical evaluation
    P Moorhouse
    Queen Elizabeth II Health Sciences Centre, Department of Medicine, Dalhousie University, Halifax, Canada
    J R Coll Physicians Edinb 42:333-40. 2012
    ..Clinical research into outcomes associated with frailty in specific settings is ongoing and will be instrumental to the provision of appropriate care of older adults in the future...
  37. pmc Size of the treatment effect on cognition of cholinesterase inhibition in Alzheimer's disease
    K Rockwood
    Centre for Health Care for Elderly, Halifax, Nova Scotia, Canada
    J Neurol Neurosurg Psychiatry 75:677-85. 2004
    ..Six cholinesterase inhibitors (ChEIs) have been tested in people with Alzheimer's disease, using methods currently required for regulatory approval. The clinical importance of their treatment effects is controversial...
  38. ncbi request reprint Prediction of delirium in fractured neck of femur as part of routine preoperative nursing care
    S H Freter
    Division of Geriatric Medicine and Surgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2EI
    Age Ageing 34:387-8. 2005
  39. ncbi request reprint Rasch analysis of the hierarchical assessment of balance and mobility (HABAM)
    C MacKnight
    Division of Geriatric Medicine, Camp Hill Veterans Memorial Building, Room 2650, 5955 Jubilee Road, Dalhousie University, B3H 2E1, Halifax, Nova Scotia, Canada
    J Clin Epidemiol 53:1242-7. 2000
    ..On this basis, an improved version of the HABAM was developed, suitable in its graphical form for everyday clinical use and for research, using the interval numbers that were generated...
  40. ncbi request reprint Butyrylcholinesterase and cognitive function
    S Darvesh
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 13:461-4. 2001
    ..We suggest that, because neurons expressing BuChE may be involved in cognition, there is merit to further evaluation of selective BuChE inhibitors in treating cognitive dysfunction...
  41. ncbi request reprint Epidemiological and clinical trials evidence about a preventive role for statins in Alzheimer's disease
    K Rockwood
    Alzheimer Research, Dalhousie University, Halifax, Canada
    Acta Neurol Scand Suppl 185:71-7. 2006
    ..Still, the first reports appear to have overestimated the extent of protection, so that unless there are important effects achievable with specific statins, a more than a modest role for statins in preventing AD seems unlikely...
  42. ncbi request reprint Epilepsy and antiepileptic drug use in elderly people as risk factors for dementia
    M D Carter
    Department of Chemistry, Dalhousie University, Canada
    J Neurol Sci 252:169-72. 2007
    ..A secondary objective was to isolate the effect of the AED phenytoin on the development of dementia and AD...
  43. doi request reprint Role of the fractalkine receptor CX3CR1 polymorphisms V249I and T280M as risk factors for early-onset coronary artery disease in patients with no classic risk factors
    B A Nassar
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Scand J Clin Lab Invest 68:286-91. 2008
    ..Two CX3CR1 mutations, V249I and T280M, reportedly decrease coronary artery disease (CAD) risk independent of established risk factors. An I249 protective effect is attributed to reducing CX3CR1 binding to fractalkine, its ligand...
  44. doi request reprint An individualized approach to tracking and treating Alzheimer's disease
    K Rockwood
    Division of Geriatric Medicine, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Pharmacol Ther 88:446-9. 2010
    ..This variability further complicates the difficulty of dementia's high dimensionality--Alzheimer's disease affects many aspects of cognition, function, and behavior...
  45. doi request reprint Frailty in relation to the risk of falls, fractures, and mortality in older Chinese adults: results from the Beijing Longitudinal Study of Aging
    X Fang
    Department of Epidemiology and Social Medicine, Xuanwu Hospital, The Capital Medical University, Beijing, China
    J Nutr Health Aging 16:903-7. 2012
    ..Less is known about the relationship between falls and frailty defined as deficit accumulation. Our objective was to investigate the relationship between falls, fractures, and frailty based on deficit accumulation...
  46. ncbi request reprint A vascular risk factor index in relation to mortality and incident dementia
    A Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Canada
    Eur J Neurol 13:514-21. 2006
    ..This may be because of death being a competing risk for incident late-onset dementia...
  47. doi request reprint Evaluation of common structural brain changes in aging and Alzheimer disease with the use of an MRI-based brain atrophy and lesion index: a comparison between T1WI and T2WI at 1.5T and 3T
    H Guo
    From the Neuroimaging Research Laboratory, Biomedical Translational Imaging Center H G, X S, W C, N Z, QEII and IWK Health Centre former National Research Council Canada Institute for Biodiagnostics Atlantic, Halifax, Nova Scotia, Canada
    AJNR Am J Neuroradiol 35:504-12. 2014
    ..In this study, we evaluated measurement properties of the Brain Atrophy and Lesion Index by use of T1WI and T2WI at 1.5T and 3T MR imaging to comprehensively assess the usefulness of the lower field-strength testing...
  48. ncbi request reprint Screening for PS1 mutations in a referral-based series of AD cases: 21 novel mutations
    E A Rogaeva
    Centre for Research in Neurodegenerative Diseases and Division of Neurology, Department of Medicine, The University Health Network, Toronto, Ontario, Canada
    Neurology 57:621-5. 2001
    ..Mutations in the presenilin-1 gene (PS1) account for a majority of patients with early-onset familial AD. However, the clinical indications and algorithms for genetic testing in dementia are still evolving...
  49. ncbi request reprint Clinical and radiographic subtypes of vascular cognitive impairment in a clinic-based cohort study
    Kenneth Rockwood
    Dalhousie University, Canada
    J Neurol Sci 240:7-14. 2006
    ..There is a need for empirical studies to define criteria for vascular cognitive impairment (VCI) subtypes. In this paper, we report the predictive validity of a subtype classification scheme based on clinical and radiographic features...
  50. ncbi request reprint Relative fitness and frailty of elderly men and women in developed countries and their relationship with mortality
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 53:2184-9. 2005
    ..To investigate the relationship between accumulated health-related problems (deficits), which define a frailty index in older adults, and mortality in population-based and clinical/institutional-based samples...
  51. ncbi request reprint Evaluation of a frailty index based on a comprehensive geriatric assessment in a population based study of elderly Canadians
    David Jones
    Faculty of Medicine, Memorial University, St John s, Canada
    Aging Clin Exp Res 17:465-71. 2005
    ..Objectives were to develop a frailty index (FI) based on a standard comprehensive geriatric assessment (CGA) derived from a clinical examination; to assess the validity of the FI-CGA and to compare its precision with other frailty measures...
  52. ncbi request reprint Lipid-lowering agents and the risk of cognitive impairment that does not meet criteria for dementia, in relation to apolipoprotein E status
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Neuroepidemiology 29:201-7. 2007
    ..Adjusting for apolipoprotein E4 status did not change the point estimates of the ORs. The greatest impact of LLAs was seen in the CIND subtype circumscribed memory impairment...
  53. ncbi request reprint The Consortium to Investigate Vascular Impairment of Cognition: methods and first findings
    Kenneth Rockwood
    Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 30:237-43. 2003
    ..We report its organization and the impact of diagnostic criteria on the study of VCI...
  54. ncbi request reprint How should we grade frailty in nursing home patients?
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    J Am Med Dir Assoc 8:595-603. 2007
    ..To compare 3 methods of describing the frailty of older adults in nursing homes...
  55. ncbi request reprint Validity and reliability of the Edmonton Frail Scale
    Darryl B Rolfson
    Division of Geriatric Medicine, University of Alberta, B139C Clin Sci Building, 8440 112 Street, Edmonton, Alberta, Canada, T6G 2B7
    Age Ageing 35:526-9. 2006
  56. ncbi request reprint Neuropsychiatric symptom clusters and functional disability in cognitively-impaired-not-demented individuals
    Kevin R Peters
    Department of Psychology, Trent University, Peterborough, Ontario, Canada
    Am J Geriatr Psychiatry 16:136-44. 2008
    ....
  57. ncbi request reprint Outcomes of cognitively impaired not demented at 2 years in the Canadian Cohort Study of Cognitive Impairment and Related Dementias
    Ging Yuek R Hsiung
    Division of Neurology, Department of Medicine University of British Columbia, Vancouver, Canada
    Dement Geriatr Cogn Disord 22:413-20. 2006
    ..People who are cognitively impaired not demented (CIND) can be at an increased risk for developing dementia, but little is known about the natural history of CIND in clinical settings...
  58. ncbi request reprint Emerging therapies for vascular dementia and vascular cognitive impairment
    Timo Erkinjuntti
    Helsinki University Central Hospital, Helsinki, Finland
    Stroke 35:1010-7. 2004
    ..Cerebrovascular disease (CVD) and ischemic brain injury secondary to cardiovascular disease are common causes of dementia and cognitive decline in the elderly. CVD also contributes to cognitive loss in Alzheimer disease (AD)...
  59. ncbi request reprint Neuropsychological predictors of incident dementia in patients with vascular cognitive impairment, without dementia
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 33:1999-2002. 2002
    ..Follow-up cognitive diagnoses were available for 102 individuals. After 5 years, 45 patients (44%) developed dementia. Low baseline scores on tests of memory and category fluency were associated with incident dementia...
  60. pmc Transitions in cognitive test scores over 5 and 10 years in elderly people: evidence for a model of age-related deficit accumulation
    Arnold Mitnitski
    Department of Medicine and Geriatric Medicine Research Unit, Dalhousie University and QEII Health Sciences Centre, Capital District Health Authority, Halifax, Nova Scotia, Canada
    BMC Geriatr 8:3. 2008
    ..Given that cognition also changes with age, we wondered whether the same model might also describe the accumulation of errors in cognitive test scores in community-dwelling older adults...
  61. ncbi request reprint Does vascular MCI progress at a different rate than does amnestic MCI?
    Serge Gauthier
    McGill Centre for Studies in Aging, McGill University, Montreal, Canada
    Int Psychogeriatr 15:257-9. 2003
    ..The issues to be resolved prior to the use of a survival design for conversion from vascular MCI to dementia will be discussed...
  62. ncbi request reprint Disease progression in vascular cognitive impairment: cognitive, functional and behavioural outcomes in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) cohort study
    Kenneth Rockwood
    Dalhousie University, Canada
    J Neurol Sci 252:106-12. 2007
    ..We compared cognitive, functional, and behavioural outcomes in patients with VCI to patients with no cognitive impairment (NCI), and Alzheimer's disease (AD)...
  63. ncbi request reprint Preclinical vascular cognitive impairment and Alzheimer disease: neuropsychological test performance 5 years before diagnosis
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 38:1148-53. 2007
    ..We compared the neuropsychological performances of people with incident VCI, incident AD, and no cognitive impairment (NCI) 5 years before their clinical diagnoses...
  64. ncbi request reprint Psychiatric illness in relation to frailty in community-dwelling elderly people without dementia: a report from the Canadian Study of Health and Aging
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University
    Can J Aging 26:33-8. 2007
    ....
  65. ncbi request reprint Diabetes mellitus and the risk of dementia, Alzheimer's disease and vascular cognitive impairment in the Canadian Study of Health and Aging
    Chris MacKnight
    Division of Geriatric Medicine, Dalhousie University, Halifax, Canada
    Dement Geriatr Cogn Disord 14:77-83. 2002
    ..We investigated the relationship between diabetes and incident dementia (including Alzheimer's disease and vascular cognitive impairment) in a 5-year longitudinal study...
  66. ncbi request reprint Improving clinical descriptions to understand the effects of dementia treatment: consensus recommendations
    Kenneth Rockwood
    Dalhousie University, Halifax, Nova Scotia
    Int J Geriatr Psychiatry 17:1006-11. 2002
    ..To recommend how the description of clinically detectable treatment effects might be improved for antidementia drug trials...
  67. ncbi request reprint Verbal repetition in patients with Alzheimer's disease who receive donepezil
    Elissa Asp
    Geriatric Medicine Research Unit, Dalhousie University, Halifax, NS, Canada
    Int J Geriatr Psychiatry 21:426-31. 2006
    ..Current outcome measures for Alzheimer's disease (AD) drugs have been criticized as insufficiently patient-centred. One commonly unmeasured goal of patients and caregivers is verbal repetition...
  68. ncbi request reprint Exercise: a potential contributing factor to the relationship between folate and dementia
    Laura E Middleton
    Division of Geriatric Medicine, Dalhousie University, Halifax, Canada
    J Am Geriatr Soc 55:1095-8. 2007
    ..To investigate whether exercise confounds the relationship between folate and cerebrovascular events, all-cause dementia, and Alzheimer's disease...
  69. ncbi request reprint Improvement and decline in health status from late middle age: modeling age-related changes in deficit accumulation
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, NS, Canada
    Exp Gerontol 42:1109-15. 2007
    ..From late middle age, transitions in health states occur with a regularity that is easily modeled. Improvements in health can occur at any age. At all ages, there is a limit to deficit accumulation...
  70. ncbi request reprint Patterns of decline and evidence of subgroups in patients with Alzheimer's disease taking galantamine for up to 48 months
    Kenneth Rockwood
    Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Int J Geriatr Psychiatry 23:207-14. 2008
    ..We aimed to: 1) understand changes in cognition and function in people taking galantamine; (2) identify treatment subgroups...
  71. ncbi request reprint Decreased initiation of usual activities in people with mild-to-moderate Alzheimer's disease: a descriptive analysis from the VISTA clinical trial
    Cheryl Cook
    Geriatric Medicine Research Unit, Capital District Health Authority and Dalhousie University, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 20:952-63. 2008
    ..Decreased initiation of activities is a common symptom in Alzheimer's disease (AD) and creates significant burden for carers, yet little is known about how patients, carers and treating physicians describe this problem...
  72. doi request reprint Vascular cognitive impairment: current concepts and clinical developments
    Paige Moorhouse
    Division of Geriatric Medicine, Halifax, Nova Scotia, Canada
    Lancet Neurol 7:246-55. 2008
    ..VCI might be preventable, although the evidence for this is not as complete as it is for the prevention of stroke. Future studies into specific therapies for VCI will need to consider the clinical features and outcomes carefully...
  73. doi request reprint Reliability of the hierarchical assessment of balance and mobility in frail older adults
    Kenneth Rockwood
    Department of Medicine, Division of Geriatric Medicine, Geriatric Medicine Research Unit, Dalhousie University, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 56:1213-7. 2008
    ..To study the test-retest and interrater reliability of the Hierarchical Assessment of Balance and Mobility (HABAM) in frail older adults...
  74. pmc Social vulnerability, frailty and mortality in elderly people
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 3:e2232. 2008
    ..The aims of the present study were to operationalize social vulnerability according to a deficit accumulation approach, to compare social vulnerability and frailty, and to study social vulnerability in relation to mortality...
  75. doi request reprint A five-point change in Modified Mini-Mental State Examination was clinically meaningful in community-dwelling elderly people
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University and QEII Health Sciences Centre, Suite 1421, CHVMB, 5955 Veterans Memorial Lane, Halifax, Nova Scotia, B3H 2E1, Canada
    J Clin Epidemiol 61:827-31. 2008
    ..To determine what change in the Modified Mini-Mental State Examination (3MS), a validated and widely used cognitive screening tool for which meaningful change scores have not been clearly characterized, should be considered meaningful...
  76. doi request reprint Transition from cognitively impaired not demented to Alzheimer's disease: an analysis of changes in functional abilities in a dementia clinic cohort
    Ging Yuek R Hsiung
    Division of Neurology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada
    Dement Geriatr Cogn Disord 25:483-90. 2008
    ..We evaluated whether impairments on the Disability Assessment for Dementia (DAD) and Functional Rating Scale (FRS) can predict progression to AD...
  77. doi request reprint Prevention of CIND by physical activity: different impact on VCI-ND compared with MCI
    Laura Middleton
    Dalhousie University, Canada
    J Neurol Sci 269:80-4. 2008
    ..While greater physical activity is generally associated with a lower odds of both dementia and CIND, whether this effect applies across subgroups is not known...
  78. ncbi request reprint Geriatric syndromes
    Kenneth Rockwood
    J Am Geriatr Soc 55:2092; author reply 2092-3. 2007
  79. ncbi request reprint Is mild cognitive impairment a valid target of therapy
    Kenneth Rockwood
    Department of Medicine Geriatric Medicine and Neurology, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 34:S90-6. 2007
    ..The phenomenon of slowing or non-progression itself should be investigated, and such investigations likely should extend to people now classified as having mild dementia...
  80. ncbi request reprint Societal costs of vascular cognitive impairment in older adults
    Kenneth Rockwood
    Dalhousie University, Halifax, Nova Scotia, Canada
    Stroke 33:1605-9. 2002
    ..The construct of vascular cognitive impairment (VCI) includes many whose care is or will be costly. Nevertheless, estimates of these costs are not well described. We therefore set out to estimate the societal costs of VCI in elderly people...
  81. ncbi request reprint Global assessment measures for assessing efficacy in dementia drug trials
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    Can J Neurol Sci 34:S52-6. 2007
    ..Steps should be taken to improve the specificity of treatment effect description and to incorporate patient/caregiver preferences in global measures about disease treatment in dementia...
  82. ncbi request reprint Prevalence, attributes, and outcomes of fitness and frailty in community-dwelling older adults: report from the Canadian study of health and aging
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Gerontol A Biol Sci Med Sci 59:1310-7. 2004
    ..Frailty and fitness are important attributes of older persons, but population samples of their prevalence, attributes, and outcomes are limited...
  83. ncbi request reprint Operationalizing a frailty index from a standardized comprehensive geriatric assessment
    David M Jones
    Faculty of Medicine, Memorial University, St John s, Newfoundland, Canada
    J Am Geriatr Soc 52:1929-33. 2004
    ..To construct and validate a frailty index (FI) that is clinically sensible and practical for geriatricians by basing it on a routinely used comprehensive geriatric assessment (CGA) instrument...
  84. ncbi request reprint Frailty and the geriatrician
    Kenneth Rockwood
    Age Ageing 33:429-30. 2004
  85. ncbi request reprint The estimation of relative fitness and frailty in community-dwelling older adults using self-report data
    Arnold B Mitnitski
    Division of Geriatric Medicine, Dalhousie University, Suite 1421, 5955 Veterans Memorial Lane Rd, Halifax, NS, B3H 2E1, Canada
    J Gerontol A Biol Sci Med Sci 59:M627-32. 2004
    ..In our earlier investigations, personal biological age demonstrated a strong relationship with 6-year survival. Here we extend this approach to self-reported data...
  86. ncbi request reprint Assessment of individual risk of death using self-report data: an artificial neural network compared with a frailty index
    Xiaowei Song
    Geriatric Medicine Research Unit, Queen Elizabeth II Health Sciences Center, Halifax, Nova Scotia, Canada
    J Am Geriatr Soc 52:1180-4. 2004
    ..To evaluate the potential of an artificial neural network (ANN) in predicting survival in elderly Canadians, using self-report data...
  87. ncbi request reprint Five-year follow-up of cognitive impairment with no dementia
    Holly Tuokko
    Centre on Aging, University of Victoria, Victoria, British Columbia, Canada
    Arch Neurol 60:577-82. 2003
    ..To date, there is limited information from large-scale studies regarding outcomes of persons specifically identified with cognitive impairment but no dementia (CIND)...
  88. ncbi request reprint The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture
    Mark A Bach
    Merck Research Laboratories, Rahway, New Jersey, USA
    J Am Geriatr Soc 52:516-23. 2004
    ..To evaluate the effects of MK-0677, an orally active growth hormone (GH) secretagogue, on functional recovery from hip fracture in previously mobile older individuals...
  89. ncbi request reprint Differential effects of lipid-lowering agents on human cholinesterases
    Sultan Darvesh
    Division of Neurology, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 2E1
    Clin Biochem 37:42-9. 2004
    ..Epidemiologic reports indicate that lipid-lowering agents (LLAs) protect against dementia. We hypothesized that LLAs might affect cholinergic systems. The effects of LLAs on the activity of cholinesterases were examined...
  90. ncbi request reprint The treatment of Alzheimer's disease: success short of cure
    Kenneth Rockwood
    Dalhousie University, Halifax, Canada
    Lancet Neurol 2:630-3. 2003
    ..To understand how there can be treatment success short of cure, without knowing at the outset what form that success may take, will require systematic observation and careful description of patients' experiences...
  91. ncbi request reprint The risk of dementia in relation to statins and other lipid lowering agents
    Kenneth Rockwood
    Divisions of Geriatric Medicine and Neurology, Dalhousie University, Halifax, Canada
    Neurol Res 25:601-4. 2003
    ..Dedicated clinical trials are now under way, and their results are awaited with great interest...
  92. ncbi request reprint Five-year outcomes for dementia defined solely by neuropsychological test performance
    Janet L Ingles
    School of Human Communication Disorders, Dalhousie University, Halifax, Nova Scotia, Canada
    Neuroepidemiology 22:172-8. 2003
    ..The case definition of NPDementia identified individuals with cognitive impairment that is unlikely to resolve and likely to progress to dementia...
  93. ncbi request reprint Frailty and its definition: a worthy challenge
    Kenneth Rockwood
    J Am Geriatr Soc 53:1069-70. 2005
  94. ncbi request reprint Vascular dementia
    Timo Erkinjuntti
    Department of Neurology, University of Helsinki, Helsinki, Finland
    Semin Clin Neuropsychiatry 8:37-45. 2003
    ..Attempts to treat VaD had varying degrees of success, but it now appears that many forms of VCI might be preventable, especially with good control of vascular risk factors in middle age...
  95. ncbi request reprint APOE genotype, memory test performance, and the risk of Alzheimer's disease in the Canadian Study of Health and Aging
    Jennifer D Klages
    Department of Psychology, Dalhousie University, Halifax, Canada
    Dement Geriatr Cogn Disord 15:1-5. 2003
    ..This study examined the relation between two risks for Alzheimer's disease (AD): the apolipoprotein (APOE) epsilon4 allele and poor memory test performance...
  96. ncbi request reprint The measuring, meaning and importance of activities of daily living (ADLs) as an outcome
    Kenneth Rockwood
    Division of Geriatric Medicine, Dalhousie University, and Centre for Health Care of the Elderly, Halifax, Nova Scotia, Canada
    Int Psychogeriatr 19:467-82. 2007
    ..How best to improve sensitivity to change of functional measurements is controversial, but it is necessary to do so in order to evaluate the full effects of treatment...
  97. ncbi request reprint A cross-national study of transitions in deficit counts in two birth cohorts: implications for modeling ageing
    Arnold Mitnitski
    Department of Medicine, Dalhousie University, Halifax, Canada
    Exp Gerontol 42:241-6. 2007
    ..The model suggests that all health transitions, including health improvement, worsening, and death, can be summarized in a unified stochastic model with a few interpretable parameters...
  98. ncbi request reprint Cognitive impairment of acute onset in the Consortium to Investigate Vascular Impairment of Cognition (CIVIC) study: occurrence, correlates, and outcomes
    Paige King
    Division of Geriatric Medicine, Dalhousie University, Canada
    Am J Geriatr Psychiatry 14:893-6. 2006
    ..Having demonstrated that dementia of acute onset represents a distinct syndrome with distinct outcomes, the authors investigated whether similar attributes describe cognitive impairment of acute onset (CIAO)...
  99. pmc Prevalence and outcomes of delirium in community and non-acute care settings in people without dementia: a report from the Canadian Study of Health and Aging
    Melissa K Andrew
    Division of Geriatric Medicine, Dalhousie University, Halifax, NS, Canada
    BMC Med 4:15. 2006
    ..We examined delirium prevalence and outcomes in a large cohort of older Canadians living outside of acute care...
  100. ncbi request reprint Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70
    Kenneth Rockwood
    Geriatric Medicine Research Unit, Dalhousie University, 1431 5955 Veterans Memorial Lane, Halifax, Nova Scotia B3H 2E1, Canada
    J Am Geriatr Soc 54:975-9. 2006
    ..To measure relative fitness and frailty in older people without specific frailty instruments and to relate that measurement to long-term health outcomes...
  101. pmc Capacity, population aging and professionalism
    Kenneth Rockwood
    CMAJ 174:1689, 1691. 2006