Hyo Sung Ro

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi request reprint Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis
    Hyo Sung Ro
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Obesity (Silver Spring) 15:288-302. 2007
  2. pmc Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 103:2346-51. 2006
  3. pmc Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 18:930-42. 2007
  4. pmc Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling
    Ryan W Holloway
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Biol Chem 287:39171-81. 2012
  5. pmc Adipocyte enhancer-binding protein 1 (AEBP1) (a novel macrophage proinflammatory mediator) overexpression promotes and ablation attenuates atherosclerosis in ApoE (-/-) and LDLR (-/-) mice
    Oleg Bogachev
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Med 17:1056-64. 2011
  6. ncbi request reprint MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1
    Peter J Lyons
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Biochemistry 44:926-31. 2005
  7. ncbi request reprint Modeling and functional analysis of AEBP1, a transcriptional repressor
    Peter J Lyons
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Proteins 63:1069-83. 2006
  8. pmc The role of AEBP1 in sex-specific diet-induced obesity
    Lei Zhang
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Mol Med 11:39-47. 2005
  9. pmc Lactation defect with impaired secretory activation in AEBP1-null mice
    Lei Zhang
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 6:e27795. 2011
  10. ncbi request reprint The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms
    Jessica R Miller
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    J Lipid Res 49:550-62. 2008

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Adipocyte enhancer-binding protein 1 modulates adiposity and energy homeostasis
    Hyo Sung Ro
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Obesity (Silver Spring) 15:288-302. 2007
    ....
  2. pmc Adipocyte enhancer-binding protein 1 is a potential novel atherogenic factor involved in macrophage cholesterol homeostasis and inflammation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, Halifax, NS, Canada B3H 1X5
    Proc Natl Acad Sci U S A 103:2346-51. 2006
    ..Thereby, we speculate that AEBP1 may be critically implicated in the development of atherosclerosis, and it may serve as a molecular target toward developing antiinflammatory, antiatherogenic therapeutic approaches...
  3. pmc Adipocyte enhancer-binding protein-1 promotes macrophage inflammatory responsiveness by up-regulating NF-kappaB via IkappaBalpha negative regulation
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Biol Cell 18:930-42. 2007
    ..We speculate that AEBP1 may serve as a potential therapeutic target for the treatment of various chronic inflammatory diseases and cancer...
  4. pmc Stromal adipocyte enhancer-binding protein (AEBP1) promotes mammary epithelial cell hyperplasia via proinflammatory and hedgehog signaling
    Ryan W Holloway
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    J Biol Chem 287:39171-81. 2012
    ..Our findings highlight the role of AEBP1 in the signaling pathways regulating the cross-talk between mammary epithelium and stroma that could predispose the mammary tissue to tumorigenesis...
  5. pmc Adipocyte enhancer-binding protein 1 (AEBP1) (a novel macrophage proinflammatory mediator) overexpression promotes and ablation attenuates atherosclerosis in ApoE (-/-) and LDLR (-/-) mice
    Oleg Bogachev
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Med 17:1056-64. 2011
    ..Our in vivo experimental data strongly suggest that macrophage AEBP1 plays critical regulatory roles in atherogenesis, and it may serve as a potential therapeutic target for the prevention or treatment of atherosclerosis...
  6. ncbi request reprint MAPK modulates the DNA binding of adipocyte enhancer-binding protein 1
    Peter J Lyons
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Biochemistry 44:926-31. 2005
    ..These results suggest that MAPK regulates the transcriptional activity of AEBP1 by a novel dual mechanism, in which MAPK interaction enhances and subsequent phosphorylation decreases the DNA-binding ability of AEBP1...
  7. ncbi request reprint Modeling and functional analysis of AEBP1, a transcriptional repressor
    Peter J Lyons
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Proteins 63:1069-83. 2006
    ..AEBP1 was also found to interact with Ca2+/calmodulin through this basic region, suggesting another mechanism of functional regulation...
  8. pmc The role of AEBP1 in sex-specific diet-induced obesity
    Lei Zhang
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Mol Med 11:39-47. 2005
    ..Our results suggest that AEBP1 plays a key functional role in in vivo modulation of adiposity via fat-cell proliferation and is involved in a sex-specific susceptibility to diet-induced obesity by the estrogen signaling pathway...
  9. pmc Lactation defect with impaired secretory activation in AEBP1-null mice
    Lei Zhang
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 6:e27795. 2011
    ..Our studies suggest that AEBP1 is critical in the maintenance of normal tissue architecture and function of the mammary gland tissue and controls stromal-epithelial crosstalk in mammary gland development...
  10. ncbi request reprint The trans-10, cis-12 isomer of conjugated linoleic acid decreases adiponectin assembly by PPARgamma-dependent and PPARgamma-independent mechanisms
    Jessica R Miller
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    J Lipid Res 49:550-62. 2008
    ..Therefore, the t-10, c-12 CLA isomer appears to alter adipocyte adiponectin metabolism through PPARgamma-dependent and PPARgamma-independent mechanisms...
  11. doi request reprint LPS-induced suppression of macrophage cholesterol efflux is mediated by adipocyte enhancer-binding protein 1
    Amin Majdalawieh
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia, Canada
    Int J Biochem Cell Biol 41:1518-25. 2009
    ..We speculate that AEBP1 may serve as a potential therapeutic target for the prevention/treatment of bacterial infection-induced atherosclerosis...