I Mendez

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: a tracer study using fluorogold and horseradish peroxidase
    I Mendez
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain Res 778:194-205. 1997
  2. ncbi Neural transplantation cannula and microinjector system: experimental and clinical experience. Technical note
    I Mendez
    Department of Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 92:493-9. 2000
  3. ncbi Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease
    I Mendez
    Neural Transplantation Laboratory, Departments of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain Res Brain Res Rev 32:328-39. 2000
  4. ncbi Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considera
    I Mendez
    Department of Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 92:863-9. 2000
  5. ncbi Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases
    Ivar Mendez
    Department of Surgery Neurosurgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 96:589-96. 2002
  6. ncbi Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants
    K Mukhida
    Neural Transplantation Laboratory, Departments of Anatomy and Neurobiology and Surgery (Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Neurosci 21:3521-30. 2001
  7. ncbi Adjunctive use of the non-ionic surfactant Poloxamer 188 improves fetal dopaminergic cell survival and reinnervation in a neural transplantation strategy for Parkinson's disease
    M Quinn
    Cell Restoration Laboratory, Departments of Anatomy and Neurobiology and Surgery Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Eur J Neurosci 27:43-52. 2008
  8. ncbi Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats
    A Y Alemdar
    Neural Transplantation Laboratory, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Neurol 172:416-24. 2001
  9. ncbi A sequential intrastriatal dopaminergic graft strategy in the rodent model for Parkinson's disease: implications for graft survival and targeting
    K A Baker
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Transplant 11:185-93. 2002
  10. ncbi A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats
    K Mukhida
    Departments of Anatomy and Neurobiology and Surgery Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain 131:2106-26. 2008

Collaborators

  • M McLeod
  • A Dagher
  • A Sen
  • Ole Isacson
  • H Robertson
  • S Darvesh
  • Michael Hutchinson
  • Anthony E Lang
  • J Desrosiers
  • J Q Trojanowski
  • K Mukhida
  • Karim Mukhida
  • D Sadi
  • Murray Hong
  • Matthew O Hebb
  • A Y Alemdar
  • M Hong
  • Adam O Hebb
  • K A Baker
  • Damaso Sadi
  • M Quinn
  • Leo A Behie
  • L Borgal
  • Zubin Master
  • Matthew Lewington
  • K Adam Baker
  • L E Bartlett
  • Aylin Y Alemdar
  • Lynsey E Bartlett
  • Sean Dennis Christie
  • P Daniel McNeely
  • Arun C Ramachandran
  • Kari Hebb
  • S D Christie
  • T Phillips
  • B A Baghbaderani
  • Timothy Phillips
  • G B Miles
  • L A Behie
  • Behnam A Baghbaderani
  • N Kobayashi
  • R M Brownstone
  • Paula Chiasson
  • Christopher Haughn
  • Nao Kobayashi
  • Brian Milne
  • Behnam Baghbaderani
  • V McAlister
  • Robert M Brownstone
  • Paula Gaudet
  • N R Kobayashi
  • Ron Hill
  • Steve W Smith
  • Vivian C McAlister
  • M B Purdy
  • V C McAlister

Detail Information

Publications33

  1. ncbi Reconstruction of the striato-nigro-striatal circuitry by simultaneous double dopaminergic grafts: a tracer study using fluorogold and horseradish peroxidase
    I Mendez
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain Res 778:194-205. 1997
    ....
  2. ncbi Neural transplantation cannula and microinjector system: experimental and clinical experience. Technical note
    I Mendez
    Department of Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 92:493-9. 2000
    ..The device presented here has proved to be of value in maximizing the number of graft deposits while minimizing implantation-related trauma to the host brain...
  3. ncbi Simultaneous intrastriatal and intranigral grafting (double grafts) in the rat model of Parkinson's disease
    I Mendez
    Neural Transplantation Laboratory, Departments of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain Res Brain Res Rev 32:328-39. 2000
    ..This double graft strategy may have potential implications in clinical neural transplantation for Parkinson's disease...
  4. ncbi Enhancement of survival of stored dopaminergic cells and promotion of graft survival by exposure of human fetal nigral tissue to glial cell line--derived neurotrophic factor in patients with Parkinson's disease. Report of two cases and technical considera
    I Mendez
    Department of Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 92:863-9. 2000
    ..A mean increase of 107% in putaminal fluorodopa uptake from baseline values was observed 12 months postgrafting...
  5. ncbi Simultaneous intrastriatal and intranigral fetal dopaminergic grafts in patients with Parkinson disease: a pilot study. Report of three cases
    Ivar Mendez
    Department of Surgery Neurosurgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    J Neurosurg 96:589-96. 2002
    ..The authors demonstrate the feasibility of reinnervating the SN and striatum by using a double transplant strategy in humans...
  6. ncbi Enhancement of sensorimotor behavioral recovery in hemiparkinsonian rats with intrastriatal, intranigral, and intrasubthalamic nucleus dopaminergic transplants
    K Mukhida
    Neural Transplantation Laboratory, Departments of Anatomy and Neurobiology and Surgery (Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    J Neurosci 21:3521-30. 2001
    ..A multitarget transplant strategy aimed at optimizing dopaminergic reinnervation of the basal ganglia may be crucial in improving clinical outcomes in PD patients...
  7. ncbi Adjunctive use of the non-ionic surfactant Poloxamer 188 improves fetal dopaminergic cell survival and reinnervation in a neural transplantation strategy for Parkinson's disease
    M Quinn
    Cell Restoration Laboratory, Departments of Anatomy and Neurobiology and Surgery Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Eur J Neurosci 27:43-52. 2008
    ..Use of P188 may thus be an important adjunct to improve the clinical efficacy of neural transplantation for Parkinson's disease...
  8. ncbi Liposomal tacrolimus administered systemically and within the donor cell suspension improves xenograft survival in hemiparkinsonian rats
    A Y Alemdar
    Neural Transplantation Laboratory, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Neurol 172:416-24. 2001
    ..This strategy may have important implications for clinical neural transplantation...
  9. ncbi A sequential intrastriatal dopaminergic graft strategy in the rodent model for Parkinson's disease: implications for graft survival and targeting
    K A Baker
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Transplant 11:185-93. 2002
    ..These results are further discussed in relation to their important clinical implication for neural transplantation in PD...
  10. ncbi A multitarget basal ganglia dopaminergic and GABAergic transplantation strategy enhances behavioural recovery in parkinsonian rats
    K Mukhida
    Departments of Anatomy and Neurobiology and Surgery Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Brain 131:2106-26. 2008
    ....
  11. ncbi Erythropoietin and GDNF enhance ventral mesencephalic fiber outgrowth and capillary proliferation following neural transplantation in a rodent model of Parkinson's disease
    M McLeod
    Cell Restoration Laboratory, Brain Repair Centre, 12th Floor, Department of Anatomy and Neurobiology and Surgery, Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Eur J Neurosci 24:361-70. 2006
    ..These findings suggest that the hibernation of FVM tissue in a combination of GDNF and EPO can enhance graft efficacy and may have important implications for tissue preparation protocols for clinical neural transplantation in PD...
  12. ncbi Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro
    L Borgal
    Cell Restoration Laboratory, Brain Repair Centre, Dalhousie University, Halifax, NS, Canada
    Neuroscience 147:712-9. 2007
    ..These results may have important implications for clinical neural transplantation in PD...
  13. ncbi Intracerebral co-transplantation of liposomal tacrolimus improves xenograft survival and reduces graft rejection in the hemiparkinsonian rat
    A Y Alemdar
    Neural Transplantation Laboratory, Department of Anatomy and Neurobiology, Dalhousie University, Halifax Infirmary, Nova Scotia, Canada B3H 3A7
    Neuroscience 146:213-24. 2007
    ..These findings may be useful in optimizing immunosuppression in experimental neural transplantation in the laboratory and its translation into the clinical setting...
  14. ncbi Transplantation of bioreactor-produced neural stem cells into the rodent brain
    M McLeod
    Cell Restoration Laboratory, Brain Repair Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Cell Transplant 15:689-97. 2006
    ..Future studies should focus on predifferentiating NSC towards specific neuronal phenotypes prior to transplantation in order to restore behavioral function in rodent models of neurodegenerative disease...
  15. ncbi Dopaminergic reinnervation of the globus pallidus by fetal nigral grafts in the rodent model of Parkinson's disease
    L E Bartlett
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
    Cell Transplant 14:119-27. 2005
    ..These observations suggest that functional recovery was the result of dopaminergic reinnervation of the GP and that this nucleus may be a potential target for neural transplantation in clinical PD...
  16. pmc Cell type analysis of functional fetal dopamine cell suspension transplants in the striatum and substantia nigra of patients with Parkinson's disease
    Ivar Mendez
    Dalhousie University and Queen Elizabeth II Health Science Center, Division of Neurosurgery and Neuroscience, Halifax, Canada
    Brain 128:1498-510. 2005
    ....
  17. ncbi Neural transplantation in spinal cord injury
    S D Christie
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Neurol Sci 28:6-15. 2001
    ..This article presents the scientific basis of neural transplantation as a repair strategy and reviews the current status of neural transplantation in spinal cord injury...
  18. ncbi A novel role for parkin in trauma-induced central nervous system secondary injury
    K Mukhida
    Cell Restoration Laboratory, 12th Floor, Department of Anatomy, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 4H7
    Med Hypotheses 64:1120-3. 2005
    ....
  19. ncbi Liposomal formulations of tacrolimus and rapamycin increase graft survival and fiber outgrowth of dopaminergic grafts
    Aylin Y Alemdar
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Cell Transplant 13:263-71. 2004
    ..These compounds may play an important role in optimizing graft survival and host reinnervation in cell-mediated brain repair strategies for the treatment of neurological conditions...
  20. ncbi Glial cell line-derived neurotrophic factor-supplemented hibernation of fetal ventral mesencephalic neurons for transplantation in Parkinson disease: long-term storage
    Adam O Hebb
    Department of Anatomy, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neurosurg 98:1078-83. 2003
    ..The objective of this study was to evaluate the effects on fetal dopaminergic tissue of GDNF-supplemented hibernation for extended periods of 6 to 15 days...
  21. ncbi Glial cell line-derived neurotrophic factor-supplemented hibernation of fetal ventral mesencephalic neurons for transplantation in Parkinson disease: long-term storage
    Adam O Hebb
    Department of Anatomy and Neurobiology, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
    Neurosurg Focus 13:e4. 2002
    ..The objective of this study was to evaluate GDNF-supplemented hibernation of fetal dopaminergic tissue for extended periods of 6 to 15 days...
  22. pmc Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years
    Ivar Mendez
    Dalhousie University and Queen Elizabeth II Health Sciences Centre, Division of Neurosurgery and Department of Anatomy and Neurobiology, 1976 Summer Street, Halifax, Nova Scotia B3H 3A7, Canada
    Nat Med 14:507-9. 2008
    ..These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies...
  23. ncbi Functional improvement with low-dose dopaminergic grafts in hemiparkinsonian rats
    Lynsey E Bartlett
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Neurosurgery 55:405-12; discussion 412-5. 2004
    ..In this study, we explored the ability of low-dose dopaminergic grafts to produce functional benefits in the 6-hydroxydopamine rodent model of Parkinson's disease over a long period of observation...
  24. doi GDNF therapy for Parkinson's disease
    Murray Hong
    Cell Restoration Laboratory, Departments of Anatomy and Neurobiology and Surgery Neurosurgery, Dalhousie University, Room 12H1, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5
    Expert Rev Neurother 8:1125-39. 2008
    ..This review will examine the experimental and clinical evidence of GDNF use in PD with particular focus on its potential as an effective therapy in the treatment of PD...
  25. doi Survival, differentiation, and migration of bioreactor-expanded human neural precursor cells in a model of Parkinson disease in rats
    Karim Mukhida
    Division of Neurosurgery, Department of Surgery, Cell Restoration Laboratory, Dalhousie Medical School, Halifax, Nova Scotia, Canada
    Neurosurg Focus 24:E8. 2008
    ....
  26. ncbi Long distance selective fiber outgrowth of transplanted hNT neurons in white matter tracts of the adult rat brain
    K Adam Baker
    Neural Transplantation Laboratory, Department of Anatomy, Dalhousie University, Halifax, Nova Scotia, Canada
    J Comp Neurol 486:318-30. 2005
    ....
  27. ncbi Deep brain stimulation to treat hyperkinetic symptoms of Cockayne syndrome
    Matthew O Hebb
    Department of Surgery, Division of Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Mov Disord 21:112-5. 2006
    ..These results suggest that patients with Cockayne syndrome should be considered for deep brain stimulation to treat refractory movement disorders...
  28. ncbi Sustained relief of dystonia following cessation of deep brain stimulation
    Matthew O Hebb
    Division of Neurosurgery, Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Mov Disord 22:1958-62. 2007
    ....
  29. ncbi Spinal GABAergic transplants attenuate mechanical allodynia in a rat model of neuropathic pain
    Karim Mukhida
    Cell Restoration Laboratory, Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Stem Cells 25:2874-85. 2007
    ..In addition, HNPCs expanded in a standardized fashion in suspension bioreactors and differentiated into a GABAergic phenotype may be an alternative to fetal cells for cell-based therapies to treat chronic pain syndromes...
  30. ncbi Intraspinal transplantation of hNT neurons in the lesioned adult rat spinal cord
    Sean Dennis Christie
    Department of Surgery Neurosurgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Can J Neurol Sci 31:87-96. 2004
    ..We have studied the use of a commercially available cell line of cultured human neurons (hNT neurons) as a tissue source for neural transplantation in spinal cord injury...
  31. ncbi Robotic long-distance telementoring in neurosurgery
    Ivar Mendez
    Division of Neurosurgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    Neurosurgery 56:434-40; discussion 434-40. 2005
    ..To test the feasibility of long-distance telementoring in neurosurgery by providing subspecialized expertise in real time to another neurosurgeon performing a surgical procedure in a remote location...
  32. ncbi Stabilization clamp for insertion of deep brain stimulation electrodes: technical note
    P Daniel McNeely
    Division of Neurosurgery, Department of Surgery, Dalhousie University and Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
    Stereotact Funct Neurosurg 82:31-4. 2004
    ..In order to enhance accuracy of final lead placement and ease of insertion, we describe a useful and reliable DBS electrode lead stabilization device developed and used at our centre...
  33. pmc Benefits, risks and ethical considerations in translation of stem cell research to clinical applications in Parkinson's disease
    Zubin Master
    W Maurice Young Centre for Applied Ethics, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z2
    J Med Ethics 33:169-73. 2007
    ....