J S Marshall

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc Local and systemic immunological parameters associated with remission of asthma symptoms in children
    Susan Waserman
    Departments of Medicine, McMaster University, Hamilton, ON, Canada
    Allergy Asthma Clin Immunol 8:16. 2012
  2. pmc IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis
    Steven Maltby
    The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada
    Allergy Asthma Clin Immunol 8:15. 2012
  3. doi request reprint Virus stimulation of human mast cells results in the recruitment of CD56⁺ T cells by a mechanism dependent on CCR5 ligands
    Sarah M McAlpine
    Dalhousie Inflammation Group, Dalhousie University, 5850 College St, Halifax, NS B3H 1X5, Canada
    FASEB J 26:1280-9. 2012
  4. ncbi request reprint Mast-cell responses to pathogens
    Jean S Marshall
    Dalhousie Inflammation Group, Department of Microbiology and Immunology, Dalhousie University, Sir Charles Tupper Medical Building, College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Nat Rev Immunol 4:787-99. 2004
  5. ncbi request reprint Mast cells in innate immunity
    Jean S Marshall
    Dalhousie Inflammation Group, the Departments of Pathology and Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Allergy Clin Immunol 114:21-7. 2004
  6. ncbi request reprint Toll-like receptor-mediated activation of mast cells: implications for allergic disease?
    Jean S Marshall
    Dalhousie Inflammation Group, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Arch Allergy Immunol 132:87-97. 2003
  7. ncbi request reprint Mast cell cytokine and chemokine responses to bacterial and viral infection
    Jean S Marshall
    Depts of Microbiology and Immunology and Pathology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
    Curr Pharm Des 9:11-24. 2003
  8. ncbi request reprint Nerve growth factor modifies the expression of inflammatory cytokines by mast cells via a prostanoid-dependent mechanism
    J S Marshall
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 162:4271-6. 1999
  9. ncbi request reprint Toll-like receptor 4-mediated activation of murine mast cells
    J D McCurdy
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 70:977-84. 2001
  10. pmc The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice
    M R Power
    Department of Microbiology and Immunology, Dalhousie University, Canada
    Clin Exp Immunol 146:323-9. 2006

Collaborators

  • Tong Jun Lin
  • R Anderson
  • S Akira
  • D W Hoskin
  • Wojciech Dawicki
  • Michael G Brown
  • Dunia M Jawdat
  • Christine A King
  • Timothy J Olynych
  • Steven Maltby
  • Susan Waserman
  • Sarah M McAlpine
  • Thomas B Issekutz
  • Sarah M Burke
  • Yong jun Yang
  • M R Power
  • Geoffrey Rowden
  • Melanie R Power
  • Raja M Abdel-Majid
  • Sandra J Gallagher
  • Jeffrey D McCurdy
  • Erin J Debruin
  • Denis Snider
  • Kelly M McNagny
  • Mary Conway
  • Frederick E Hargreave
  • T B Issekutz
  • Lynn M McCleary
  • Zhiqi Jian
  • Jami Bennett
  • Matthew C Tunis
  • Matthew J Gold
  • Lata Jayaram
  • Parameswaran Nair
  • Jerry Dolovich
  • J D McCurdy
  • C A King
  • Dunia W Jawdat
  • Nong Xu
  • Yan Y Huang
  • Wei Chen
  • Wei Min Chen
  • Karkada Mohan
  • Jun ichiro Inoue
  • Jason N Berman
  • Kristy Roth
  • Maya Shmulevitz
  • Svetlana O Carrigan
  • Patrick W K Lee
  • Taishin Akiyama
  • Christine Sherren
  • M Yamamoto
  • David L Jakeman
  • Yongde Peng
  • Ian D Haidl
  • Elana Maydanski
  • Eric J Albert
  • Lauren H Maher
  • U Kadela-Stolarz
  • A Palecanda
  • H Alshurafa

Detail Information

Publications28

  1. pmc Local and systemic immunological parameters associated with remission of asthma symptoms in children
    Susan Waserman
    Departments of Medicine, McMaster University, Hamilton, ON, Canada
    Allergy Asthma Clin Immunol 8:16. 2012
    ..These findings suggest that decreased type 1 cytokine expression as well as decreased eosinophilic inflammation is associated with the resolution of asthma symptoms...
  2. pmc IL-7Rα and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis
    Steven Maltby
    The Biomedical Research Centre, University of British Columbia, Vancouver, BC, Canada
    Allergy Asthma Clin Immunol 8:15. 2012
    ..abstract:..
  3. doi request reprint Virus stimulation of human mast cells results in the recruitment of CD56⁺ T cells by a mechanism dependent on CCR5 ligands
    Sarah M McAlpine
    Dalhousie Inflammation Group, Dalhousie University, 5850 College St, Halifax, NS B3H 1X5, Canada
    FASEB J 26:1280-9. 2012
    ..These findings could be exploited to enhance local T-cell responses in chronic viral infection and malignancies at mast cell-rich sites...
  4. ncbi request reprint Mast-cell responses to pathogens
    Jean S Marshall
    Dalhousie Inflammation Group, Department of Microbiology and Immunology, Dalhousie University, Sir Charles Tupper Medical Building, College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Nat Rev Immunol 4:787-99. 2004
    ..Studies of this intriguing immune-effector cell provide important insights into the complex mechanisms by which appropriate innate and acquired immune responses are initiated...
  5. ncbi request reprint Mast cells in innate immunity
    Jean S Marshall
    Dalhousie Inflammation Group, the Departments of Pathology and Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Allergy Clin Immunol 114:21-7. 2004
    ....
  6. ncbi request reprint Toll-like receptor-mediated activation of mast cells: implications for allergic disease?
    Jean S Marshall
    Dalhousie Inflammation Group, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    Int Arch Allergy Immunol 132:87-97. 2003
    ..The unusual ability of Toll-like receptor 2 activators to selectively induce leukotriene production by mast cells opens up new possibilities concerning mechanisms of disease exacerbation during infection...
  7. ncbi request reprint Mast cell cytokine and chemokine responses to bacterial and viral infection
    Jean S Marshall
    Depts of Microbiology and Immunology and Pathology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
    Curr Pharm Des 9:11-24. 2003
    ....
  8. ncbi request reprint Nerve growth factor modifies the expression of inflammatory cytokines by mast cells via a prostanoid-dependent mechanism
    J S Marshall
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 162:4271-6. 1999
    ..These results suggest a role for mast cell-derived prostanoids in the regulation of local inflammatory responses and neuronal degeneration after tissue injury involving induction of NGF production...
  9. ncbi request reprint Toll-like receptor 4-mediated activation of murine mast cells
    J D McCurdy
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 70:977-84. 2001
    ..These findings have important implications for the mechanism of mast cell responses to pathogens and their products and suggest that different TLR4-expressing cells might have different thresholds for activation with LPS...
  10. pmc The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice
    M R Power
    Department of Microbiology and Immunology, Dalhousie University, Canada
    Clin Exp Immunol 146:323-9. 2006
    ..Thus, the full development of host responses to P. aeruginosa lung infection involves, in a sequential, stepwise fashion, a MyD88-dependent early response and a MyD88-independent delayed mechanism...
  11. ncbi request reprint Blockade of either alpha-4 or beta-7 integrins selectively inhibits intestinal mast cell hyperplasia and worm expulsion in response to Nippostrongylus brasiliensis infection
    T B Issekutz
    Department of Pediatrics, Dalhousie University, Halifax, Canada
    Eur J Immunol 31:860-8. 2001
    ..These data suggest a role for alpha4 integrins, in particular alpha4beta7, in the regulation of mast cell precursor migration to the intestine...
  12. ncbi request reprint Cutting edge: distinct Toll-like receptor 2 activators selectively induce different classes of mediator production from human mast cells
    Jeffrey D McCurdy
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7 Canada
    J Immunol 170:1625-9. 2003
    ..These data demonstrate highly selective production of different classes of mast cell mediators in response to distinct TLR activators of potential importance to the host response to bacterial or fungal pathogens...
  13. ncbi request reprint SDF-1 induces IL-8 production and transendothelial migration of human cord blood-derived mast cells
    T J Lin
    Departments of Pathology, Microbiology and Immunology and Pediatrics, Dalhousie University, Halifax, Canada
    Int Arch Allergy Immunol 124:142-5. 2001
    ..CONCLUSION: Human mast cells can both migrate across vascular endothelium and produce the pro-angiogenic chemokine IL-8 in response to SDF-1. These responses may be important in angiogenic processes...
  14. pmc Release of vasoactive cytokines by antibody-enhanced dengue virus infection of a human mast cell/basophil line
    C A King
    Departments of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Virol 74:7146-50. 2000
    ..The results suggest a potential role for mast cells/basophils in the pathogenesis of dengue virus-induced disease...
  15. ncbi request reprint The development of early host response to Pseudomonas aeruginosa lung infection is critically dependent on myeloid differentiation factor 88 in mice
    Melanie R Power
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3J 3G9, Canada
    J Biol Chem 279:49315-22. 2004
    ..aeruginosa infection, leading to the clearance of this bacterium, and that TLR2 and TLR4 are involved in this process...
  16. pmc Dengue virus selectively induces human mast cell chemokine production
    Christine A King
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Virol 76:8408-19. 2002
    ..These results suggest a role for mast cells in the initiation of chemokine-dependent host responses to dengue virus infection...
  17. doi request reprint Mast cells, histamine, and IL-6 regulate the selective influx of dendritic cell subsets into an inflamed lymph node
    Wojciech Dawicki
    Dalhousie Inflammation Group, Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 184:2116-23. 2010
    ..These findings provide novel opportunities for the selective mobilization of specific DC subsets to lymph nodes and demonstrate critical roles for both histamine and IL-6 in this process...
  18. doi request reprint Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells
    Michael G Brown
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Leukoc Biol 85:71-80. 2009
    ..Transfection of KU812 cells with L-SIGN/DC-SIGNR was able to overcome the requirement for antibody enhancement with regard to dengue virus infection and apoptosis...
  19. doi request reprint TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation
    Yong jun Yang
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3K 6R8, Canada
    J Biol Chem 283:32110-8. 2008
    ..These results identified TRAF6 as an important signal transducer in FcepsilonRI-mediated signaling in mast cells. Our findings implicate TRAF6 as a new adaptor/regulator molecule for allergen-mediated inflammation in allergy...
  20. ncbi request reprint Human mast cells induce caspase-independent DNA fragmentation in leukemic T cells
    Sandra J Gallagher
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Oncol Rep 10:1019-23. 2003
    ..Collectively, these data indicate that mast cells trigger caspase-independent apoptosis in leukemic cells via a novel cell-surface molecule, and are consistent with a role for mast cells as anti-tumor effector cells...
  21. ncbi request reprint New and emerging roles for mast cells in host defence
    Wojciech Dawicki
    Dalhousie University, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Curr Opin Immunol 19:31-8. 2007
    ..Understanding the mechanisms and scope of the contribution of mast cells to host defence will be crucial to regulating their activity therapeutically...
  22. doi request reprint Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism
    Sarah M Burke
    Dalhousie Inflammation Group, Dalhousie University, Halifax, NS
    Blood 111:5467-76. 2008
    ..These results suggest a novel role for mast cells in the recruitment of human NK cells to sites of early viral infection via CXCL8...
  23. ncbi request reprint Fungal zymosan induces leukotriene production by human mast cells through a dectin-1-dependent mechanism
    Timothy J Olynych
    Department of Pathology, Dalhousie Inflammation Group, Canada
    J Allergy Clin Immunol 118:837-43. 2006
    ..The coreceptor dectin-1, through a Syk tyrosine kinase-dependent pathway, can mediate some responses to fungal challenge, but its expression by mast cells and its involvement in lipid mediator responses have not been assessed...
  24. ncbi request reprint A dominant role for FcgammaRII in antibody-enhanced dengue virus infection of human mast cells and associated CCL5 release
    Michael G Brown
    Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Leukoc Biol 80:1242-50. 2006
    ..3 was found to significantly abrogate dengue virus binding to KU812 cells and CBMC in the presence of dengue-specific antibody. Dengue virus infection and the production of CCL5 by KU812 cells were also inhibited by FcgammaRII blockade...
  25. ncbi request reprint Mast cells have a pivotal role in TNF-independent lymph node hypertrophy and the mobilization of Langerhans cells in response to bacterial peptidoglycan
    Dunia M Jawdat
    Dalhousie Inflammation Group, Department of Pathology and Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 177:1755-62. 2006
    ..These data demonstrate a critical role for mast cells and complement in LN responses to PGN and illustrate a novel TNF-independent mechanism whereby mast cells participate in the initiation of immunity...
  26. ncbi request reprint IgE-mediated mast cell activation induces Langerhans cell migration in vivo
    Dunia M Jawdat
    Dalhousie Inflammation Group, Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 173:5275-82. 2004
    ..These data directly demonstrate the ability of mast cells to induce dendritic cell migration to lymph nodes following IgE-mediated activation in vivo by a histamine-dependent mechanism...
  27. ncbi request reprint Prostaglandin E2 induces degranulation-independent production of vascular endothelial growth factor by human mast cells
    Raja M Abdel-Majid
    Department of Pathology, Dalhousie University, College Street, Halifax, Nova Scotia B3H 4H7, Canada
    J Immunol 172:1227-36. 2004
    ..These data suggest a role for human mast cells as a potent source of VEGF(121/165) in the absence of degranulation, and may provide new opportunities to regulate angiogenesis at mast cell-rich sites...
  28. pmc Selective early production of CCL20, or macrophage inflammatory protein 3alpha, by human mast cells in response to Pseudomonas aeruginosa
    Tong Jun Lin
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7 Canada
    Infect Immun 71:365-73. 2003
    ..These results support a role for human mast cells in the initiation of immune responses to P. aeruginosa infection...