- LKB1, the multitasking tumour suppressor kinaseP A Marignani
Dallhousie University, Faculty of Medicine, Department of Biochemistry and Molecular Biology, Halifax, Nova Scotia, Canada
J Clin Pathol 58:15-9. 2005....
- Novel splice isoforms of STRADalpha differentially affect LKB1 activity, complex assembly and subcellular localizationP A Marignani
Department of Biochemistry and Molecular Biology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Cancer Biol Ther 6:1627-31. 2007..We report herein the discovery of several novel splice isoforms of STRADalpha that differentially affect the kinase activity, complex assembly, subcellular localization of LKB1 and the activation of the LKB1-dependent AMPK pathway...
- LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrestP A Marignani
Department of Medicine, Division of Signal Transduction, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Biol Chem 276:32415-8. 2001..The inability of mutants of LKB1 to mediate Brg1-dependent growth arrest may explain the manifestations of Peutz-Jeghers syndrome...