Joanne M Langley

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc Respiratory syncytial virus - associated intensive care unit admission in children in Southern China
    Qingli Zhang
    Department of Pediatrics, Canadian Center for Vaccinology, IWK Health Centre and Capital Health District, Dalhousie University, 5850 University Ave, Halifax, Nova Scotia B3K 6R8, Canada
    BMC Res Notes 6:447. 2013
  2. doi request reprint Randomized, multicenter trial of a single dose of AS03-adjuvanted or unadjuvanted H1N1 2009 pandemic influenza vaccine in children 6 months to <9 years of age: safety and immunogenicity
    Joanne M Langley
    Canadian Center for Vaccinology and the Departments of Pediatrics and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 31:848-58. 2012
  3. ncbi request reprint Safety and immunogenicity of 2 mixed primary infant immunization schedules of pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, and Haemophilus influenzae Type B vaccines at 2, 4, and 6 months of age: a randomized controlled
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre and Capital Health, Halifax, Canada
    Pediatr Infect Dis J 31:189-92. 2012
  4. pmc Pneumococcal and influenza immunization in asplenic persons: a retrospective population-based cohort study 1990-2002
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax Nova Scotia B3K6R8, Canada
    BMC Infect Dis 10:219. 2010
  5. doi request reprint A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults > or =65 years of age
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, NS, Canada
    Vaccine 27:5913-9. 2009
  6. doi request reprint Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, Canada
    J Infect Dis 201:1644-53. 2010
  7. doi request reprint Immunization: a global challenge for the 21st Century
    Joanne M Langley
    Department of Pediatrics, Canadian Centre for Vaccinology, Halifax, NS, Canada
    Expert Rev Vaccines 10:429-31. 2011
  8. pmc Empyema associated with community-acquired pneumonia: a Pediatric Investigator's Collaborative Network on Infections in Canada (PICNIC) study
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, Canada
    BMC Infect Dis 8:129. 2008
  9. ncbi request reprint Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adults
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
    Vaccine 25:3464-74. 2007
  10. ncbi request reprint Safety and immunogenicity of two formulations of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae conjugate-hepatitis B vaccine in 15 to 18-month-old children
    Scott A Halperin
    Clinical Trials Research Center, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Hum Vaccin 1:245-50. 2005

Detail Information

Publications48

  1. pmc Respiratory syncytial virus - associated intensive care unit admission in children in Southern China
    Qingli Zhang
    Department of Pediatrics, Canadian Center for Vaccinology, IWK Health Centre and Capital Health District, Dalhousie University, 5850 University Ave, Halifax, Nova Scotia B3K 6R8, Canada
    BMC Res Notes 6:447. 2013
    ..There are incomplete data on the global burden of viral lower respiratory tract infection, in particular the role of Respiratory Syncytial Virus, in children requiring health services...
  2. doi request reprint Randomized, multicenter trial of a single dose of AS03-adjuvanted or unadjuvanted H1N1 2009 pandemic influenza vaccine in children 6 months to <9 years of age: safety and immunogenicity
    Joanne M Langley
    Canadian Center for Vaccinology and the Departments of Pediatrics and Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 31:848-58. 2012
    ....
  3. ncbi request reprint Safety and immunogenicity of 2 mixed primary infant immunization schedules of pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliomyelitis, and Haemophilus influenzae Type B vaccines at 2, 4, and 6 months of age: a randomized controlled
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre and Capital Health, Halifax, Canada
    Pediatr Infect Dis J 31:189-92. 2012
    ..The safety and immunogenicity of mixed primary infant schedules is unknown...
  4. pmc Pneumococcal and influenza immunization in asplenic persons: a retrospective population-based cohort study 1990-2002
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax Nova Scotia B3K6R8, Canada
    BMC Infect Dis 10:219. 2010
    ....
  5. doi request reprint A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults > or =65 years of age
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, NS, Canada
    Vaccine 27:5913-9. 2009
    ....
  6. doi request reprint Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, Canada
    J Infect Dis 201:1644-53. 2010
    ..1) prepandemic candidate vaccines produced at 2 separate manufacturing sites...
  7. doi request reprint Immunization: a global challenge for the 21st Century
    Joanne M Langley
    Department of Pediatrics, Canadian Centre for Vaccinology, Halifax, NS, Canada
    Expert Rev Vaccines 10:429-31. 2011
    ..In this article, we summarize some of the key presentations from the six plenary sessions, 36 concurrent symposia and workshops, podium and poster presentations...
  8. pmc Empyema associated with community-acquired pneumonia: a Pediatric Investigator's Collaborative Network on Infections in Canada (PICNIC) study
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, Canada
    BMC Infect Dis 8:129. 2008
    ..We reviewed the epidemiology and clinical management of empyema at 8 pediatric hospitals in a period before the widespread implementation of universal infant heptavalent pneumococcal vaccine programs in Canada...
  9. ncbi request reprint Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adults
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
    Vaccine 25:3464-74. 2007
    ....
  10. ncbi request reprint Safety and immunogenicity of two formulations of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae conjugate-hepatitis B vaccine in 15 to 18-month-old children
    Scott A Halperin
    Clinical Trials Research Center, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Hum Vaccin 1:245-50. 2005
    ..8 microg/mL in PRP-T/HBV10 recipients and 9.4 microg/mL in PRP-OMPC/HBV15 recipients. We conclude that the hexavalent formulations appear generally well tolerated and immunogenic as a booster dose in these toddlers...
  11. pmc A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine
    Joanne M Langley
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
    BMC Infect Dis 12:279. 2012
    ..At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred...
  12. doi request reprint Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, B3K 6R8, Canada
    Vaccine 30:3389-94. 2012
    ..We conducted a pre-season study of 2010-2011 TIV safety and immunogenicity in children 12-59 months of age to inform public health decision making...
  13. doi request reprint Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Nova Scotia, Canada
    Vaccine 30:5445-8. 2012
    ..A more rapid schedule with a 4-week interval could provide earlier protection and potentially greater compliance...
  14. doi request reprint Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adul
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Canada
    Vaccine 30:2556-63. 2012
    ....
  15. ncbi request reprint An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine an
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 25:1121-5. 2007
    ..Fever and injection site reactions are less common in 4-6 year-old-children who receive a dTap vaccine compared to DTaP-IPV, without inferior immunogenicity...
  16. ncbi request reprint Safety and immunogenicity of a Proteosome -trivalent inactivated influenza vaccine, given nasally to healthy adults
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 24:1601-8. 2006
    ..Further testing of this nasal influenza vaccine is warranted to determine its safety and immunogenicity in these populations and its efficacy in the prevention of clinical illness...
  17. ncbi request reprint Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
    Vaccine 24:4017-23. 2006
    ..Recently, another DTaP-IPV-Hib (Infanrix-IPV-Hib) became available. Data on the interchangeability of these products was lacking...
  18. ncbi request reprint Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, The IWK Health Centre, Halifax, NS, Canada
    Vaccine 25:450-7. 2007
    ....
  19. pmc Immunogenicity and safety of an inactivated quadrivalent influenza vaccine candidate: a phase III randomized controlled trial in children
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada
    J Infect Dis 208:544-53. 2013
    ..Mismatch between circulating influenza B viruses (Yamagata and Victoria lineages) and vaccine strains occurs frequently...
  20. doi request reprint Immunogenicity of 2 doses of HPV vaccine in younger adolescents vs 3 doses in young women: a randomized clinical trial
    Simon R M Dobson
    Department of Pediatrics, University of British Columbia, Vancouver, Canada
    JAMA 309:1793-802. 2013
    ..Global use of human papillomavirus (HPV) vaccines to prevent cervical cancer is impeded by cost. A 2-dose schedule for girls may be possible...
  21. pmc Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]
    Joanne M Langley
    Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
    BMC Pediatr 5:7. 2005
    ..Trials of racemic epinephrine have shown conflicting results. We sought to determine if administration of racemic epinephrine during hospital stay for bronchiolitis improved respiratory distress, was safe, and shortened length of stay...
  22. ncbi request reprint Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, Halifax, NS, Canada B3K 6R8
    Vaccine 24:20-6. 2006
    ..Many individuals do not respond to a three-dose series of hepatitis B vaccine (HBV) and most do not achieve a protective antibody response until after dose 2 or 3...
  23. doi request reprint Hepatitis A and travel amongst Nova Scotia postsecondary students: evidence for a targeted vs. universal immunization strategy
    Katherine Matheson
    Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Vaccine 28:8105-11. 2010
    ..Canadian guidelines recommend hepatitis A virus (HAV) vaccination for high-risk persons, such as travelers to HAV-endemic areas. The US CDC advocates universal immunization...
  24. doi request reprint Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, NS, Canada
    Vaccine 30:974-82. 2012
    ..Although decennial adult boosters of tetanus and diphtheria toxoids are recommended in Canada and the United States, a second dose of pertussis vaccine during adulthood is not currently recommended...
  25. pmc Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study
    Joan L Robinson
    Department of Pediatrics, Alberta Children s Hospital Calgary, Alberta, Canada
    BMC Infect Dis 9:183. 2009
    ..There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU)...
  26. pmc Optimizing the delivery and use of a new monoclonal antibody in children with congenital heart disease: a successful provincial respiratory syncytial virus prophylaxis program
    Andrew Warren
    Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Canada
    Can J Cardiol 23:463-6. 2007
    ..To describe a program for passive immunization against respiratory syncytial virus infection in infants with hemodynamically significant congenital heart disease (CHD) in accordance with the Canadian Paediatric Society recommendations...
  27. pmc Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study
    Joanne M Langley
    Canadian Center for Vaccinology, Departments of Pediatrics and Community Health and Epidemiology, IWK Health Centre and Dalhousie University, Halifax, Canada
    J Infect Dis 203:1729-38. 2011
    ..Highly pathogenic avian influenza H5N1 viruses remain a threat to human health, with potential to become pandemic agents...
  28. ncbi request reprint History of penicillin allergy and referral for skin testing: evaluation of a pediatric penicillin allergy testing program
    Joanne M Langley
    Clin Invest Med 25:181-4. 2002
    ..Penicillin allergy, commonly reported in children, leads to use of more expensive, broad-spectrum drugs. The results and effectiveness of a skin testing program for immediate hypersensitivity to penicillin in children were studied...
  29. ncbi request reprint Coxiella burnetii seropositivity in parturient women is associated with adverse pregnancy outcomes
    Joanne M Langley
    Izaak Walton Killam Health Centre, Departments of Pediatrics, Dalhousie University, Halifax, Canada
    Am J Obstet Gynecol 189:228-32. 2003
    ..We conducted a cohort study of parturient women in an area with endemic Q fever infection to determine whether those seropositive for Coxiella burnetii had evidence of adverse birth outcomes...
  30. ncbi request reprint Commentary: Waterless hand hygiene--if there's a will, there's a way
    Joanne M Langley
    Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
    Pediatr Infect Dis J 21:496-7. 2002
  31. doi request reprint Study of cerebrospinal fluid shunt-associated infections in the first year following placement, by the Canadian Nosocomial Infection Surveillance Program
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Canada
    Infect Control Hosp Epidemiol 30:285-8. 2009
    ..85% vs 3.24%; P=.04) and occurred sooner after surgery in children than in adults. A wide variation in compliance with antimicrobial prophylaxis was observed between 21 participating medical centers...
  32. pmc Highlights of the National Advisory Committee on Immunization statement on influenza for the 2006-2007 season
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS
    CMAJ 175:742. 2006
  33. ncbi request reprint An incremental economic evaluation of targeted and universal influenza vaccination in pregnant women
    Chris Skedgel
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, Halifax, NS
    Can J Public Health 102:445-50. 2011
    ..Although vaccination is expected to reduce influenza-related events, the economic implications are unclear. We developed an economic model to estimate the cost-effectiveness (CE) of different vaccination strategies in Nova Scotia...
  34. pmc Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis
    Bonita E Lee
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Infect Dis 6:68. 2006
    ..The seasonality, clinical and radiographic features and outcome of aseptic meningitis have been described for regional outbreaks but data from a wider geographic area is necessary to delineate the epidemiology of this condition...
  35. pmc Release of the statement on influenza for the 2007 2008 season from the National Advisory Committee on Immunization
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS
    CMAJ 177:1025-6. 2007
  36. doi request reprint Serratia marcescens outbreak in a neonatal intensive care unit related to the exit port of an oscillator
    Tracy M Macdonald
    Department of Infection Prevention and Control Services, IWK Health Center, Halifax, Canada
    Pediatr Crit Care Med 12:e282-6. 2011
    ..To interrupt transmission of Serratia marcescens colonization in a neonatal intensive care unit and determine the source of ongoing transmission...
  37. ncbi request reprint Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980-2000
    Joanne M Langley
    Clinical Trials Research Centre, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Infect Dis 188:1764-7. 2003
    ....
  38. pmc Prevention of influenza in the general population
    Joanne M Langley
    Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, NS
    CMAJ 171:1213-22. 2004
    ..Use of chemotherapy (amantidine, neuraminidase inhibitors) to prevent influenza varies among provinces. We sought to systematically review the evidence for the prevention of influenza infection in the general population...
  39. ncbi request reprint A pilot study to quantify parental anxiety associated with enrollment of an infant or toddler in a phase III vaccine trial
    Joanne M Langley
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Canada NS B3J 3G9
    Vaccine 21:3863-6. 2003
    ..These factors should be considered by vaccine researchers in the recruitment process of clinical trials...
  40. ncbi request reprint Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis
    Joanne M Langley
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Canada
    Pediatrics 114:e96-101. 2004
    ..We compared the safety and efficacy of erythromycin with azithromycin for treatment of pertussis in a large, randomized, controlled trial that enrolled children from primary care practices in 1 American and 11 Canadian urban centers...
  41. ncbi request reprint Prospects for defined epitope vaccines for respiratory syncytial virus
    Robert Anderson
    Department of Microbiology and Immunology, Pediatrics and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Future Microbiol 5:585-602. 2010
    ..Identification and characterization of RSV epitopes is a rapidly expanding topic of research with potential contributions to the tailored design of improved safe and effective vaccines...
  42. pmc Influenza and the influenza vaccine
    Noni MacDonald
    Division of Infectious Diseases, Department of Paediatrics, Dalhousie University, Halifax, NS
    CMAJ 177:1028. 2007
  43. ncbi request reprint Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  44. doi request reprint Human challenge studies: a review of adequacy of reporting methods and results
    Jennifer A Kalil
    Canadian Center for Vaccinology, Sanofi Pasteur Vaccine Challenge Unit, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    Future Microbiol 7:481-95. 2012
    ..An unofficial extension of the Consolidated Standards of Reporting Trials (CONSORT) statement is proposed...
  45. ncbi request reprint Defining pneumonia in critically ill infants and children
    Joanne M Langley
    Clinical Trials Research Centre, IWK Health Center, and the Department of Pediatrics, Dalhousie University, Halifax, Canada
    Pediatr Crit Care Med 6:S9-S13. 2005
    ....
  46. pmc Dermacase. Dermatobia hominis infestation
    Joanne M Langley
    IWK Health Centre and Dalhousie University in Halifax, NS, Canada
    Can Fam Physician 53:1443, 1455. 2007
  47. ncbi request reprint Defining urinary tract infection in the critically ill child
    Joanne M Langley
    Clinical Trials Research Centre, the IWK Health Centre and Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Crit Care Med 6:S25-9. 2005
    ..To define urinary tract infections in critically ill children in the intensive care unit setting for the purpose of surveillance of infection, enrollment of children in sepsis trials, and for trials of therapy and prevention...