J M Langley

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine
    Joanne M Langley
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
    BMC Infect Dis 12:279. 2012
  2. doi request reprint Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, B3K 6R8, Canada
    Vaccine 30:3389-94. 2012
  3. pmc Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis
    Bonita E Lee
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Infect Dis 6:68. 2006
  4. ncbi request reprint Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis
    Joanne M Langley
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Canada
    Pediatrics 114:e96-101. 2004
  5. ncbi request reprint A pilot study to quantify parental anxiety associated with enrollment of an infant or toddler in a phase III vaccine trial
    Joanne M Langley
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Canada NS B3J 3G9
    Vaccine 21:3863-6. 2003
  6. pmc Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study
    Joanne M Langley
    Canadian Center for Vaccinology, Departments of Pediatrics and Community Health and Epidemiology, IWK Health Centre and Dalhousie University, Halifax, Canada
    J Infect Dis 203:1729-38. 2011
  7. pmc Prevention of influenza in the general population
    Joanne M Langley
    Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, NS
    CMAJ 171:1213-22. 2004
  8. doi request reprint A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness
    J M Langley
    Canadian Centre for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, Canada
    Vaccine 29:1921-8. 2011
  9. pmc Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]
    Joanne M Langley
    Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
    BMC Pediatr 5:7. 2005
  10. ncbi request reprint Safety and immunogenicity of a Proteosome -trivalent inactivated influenza vaccine, given nasally to healthy adults
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 24:1601-8. 2006

Detail Information

Publications53

  1. pmc A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine
    Joanne M Langley
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
    BMC Infect Dis 12:279. 2012
    ..At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred...
  2. doi request reprint Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) study
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, B3K 6R8, Canada
    Vaccine 30:3389-94. 2012
    ..We conducted a pre-season study of 2010-2011 TIV safety and immunogenicity in children 12-59 months of age to inform public health decision making...
  3. pmc Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitis
    Bonita E Lee
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    BMC Infect Dis 6:68. 2006
    ..The seasonality, clinical and radiographic features and outcome of aseptic meningitis have been described for regional outbreaks but data from a wider geographic area is necessary to delineate the epidemiology of this condition...
  4. ncbi request reprint Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis
    Joanne M Langley
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Canada
    Pediatrics 114:e96-101. 2004
    ..We compared the safety and efficacy of erythromycin with azithromycin for treatment of pertussis in a large, randomized, controlled trial that enrolled children from primary care practices in 1 American and 11 Canadian urban centers...
  5. ncbi request reprint A pilot study to quantify parental anxiety associated with enrollment of an infant or toddler in a phase III vaccine trial
    Joanne M Langley
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Canada NS B3J 3G9
    Vaccine 21:3863-6. 2003
    ..These factors should be considered by vaccine researchers in the recruitment process of clinical trials...
  6. pmc Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized study
    Joanne M Langley
    Canadian Center for Vaccinology, Departments of Pediatrics and Community Health and Epidemiology, IWK Health Centre and Dalhousie University, Halifax, Canada
    J Infect Dis 203:1729-38. 2011
    ..Highly pathogenic avian influenza H5N1 viruses remain a threat to human health, with potential to become pandemic agents...
  7. pmc Prevention of influenza in the general population
    Joanne M Langley
    Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, NS
    CMAJ 171:1213-22. 2004
    ..Use of chemotherapy (amantidine, neuraminidase inhibitors) to prevent influenza varies among provinces. We sought to systematically review the evidence for the prevention of influenza infection in the general population...
  8. doi request reprint A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illness
    J M Langley
    Canadian Centre for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, Canada
    Vaccine 29:1921-8. 2011
    ..An OMP-TIV vaccine was well tolerated and reduced risk of symptomatic culture confirmed influenza. Vaccine efficacy will need to be validated in a season with a higher attack rate...
  9. pmc Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]
    Joanne M Langley
    Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
    BMC Pediatr 5:7. 2005
    ..Trials of racemic epinephrine have shown conflicting results. We sought to determine if administration of racemic epinephrine during hospital stay for bronchiolitis improved respiratory distress, was safe, and shortened length of stay...
  10. ncbi request reprint Safety and immunogenicity of a Proteosome -trivalent inactivated influenza vaccine, given nasally to healthy adults
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 24:1601-8. 2006
    ..Further testing of this nasal influenza vaccine is warranted to determine its safety and immunogenicity in these populations and its efficacy in the prevention of clinical illness...
  11. doi request reprint Study of cerebrospinal fluid shunt-associated infections in the first year following placement, by the Canadian Nosocomial Infection Surveillance Program
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Canada
    Infect Control Hosp Epidemiol 30:285-8. 2009
    ..85% vs 3.24%; P=.04) and occurred sooner after surgery in children than in adults. A wide variation in compliance with antimicrobial prophylaxis was observed between 21 participating medical centers...
  12. ncbi request reprint Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980-2000
    Joanne M Langley
    Clinical Trials Research Centre, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    J Infect Dis 188:1764-7. 2003
    ....
  13. ncbi request reprint An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine an
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 25:1121-5. 2007
    ..Fever and injection site reactions are less common in 4-6 year-old-children who receive a dTap vaccine compared to DTaP-IPV, without inferior immunogenicity...
  14. ncbi request reprint Evaluation of the notification of hepatitis C risk to children who received unscreened blood or blood products
    J M Langley
    Clinical Trials Research Centre Infectious Diseases, IWK Health Centre, Halifax, Nova Scotia, Canada
    Commun Dis Public Health 4:288-92. 2001
    ..Awareness of transfusion history or risk of HCV was not universal, indicating the need to address notification to individuals, rather than through public education campaigns alone...
  15. ncbi request reprint Variation in risk for nosocomial chickenpox after inadvertent exposure
    J M Langley
    Izaak Walton Killam Grace Health Centre for Children, Women and Families, Dalhousie University, Halifax, Nova Scotia
    J Hosp Infect 44:224-6. 2000
    ..02). Occupational exposures present a lesser transmission risk than those in households. Definition of those exposure variables that increase risk of transmission in the occupational setting should be explored in future studies...
  16. ncbi request reprint Commentary: Waterless hand hygiene--if there's a will, there's a way
    Joanne M Langley
    Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
    Pediatr Infect Dis J 21:496-7. 2002
  17. ncbi request reprint History of penicillin allergy and referral for skin testing: evaluation of a pediatric penicillin allergy testing program
    Joanne M Langley
    Clin Invest Med 25:181-4. 2002
    ..Penicillin allergy, commonly reported in children, leads to use of more expensive, broad-spectrum drugs. The results and effectiveness of a skin testing program for immediate hypersensitivity to penicillin in children were studied...
  18. ncbi request reprint Coxiella burnetii seropositivity in parturient women is associated with adverse pregnancy outcomes
    Joanne M Langley
    Izaak Walton Killam Health Centre, Departments of Pediatrics, Dalhousie University, Halifax, Canada
    Am J Obstet Gynecol 189:228-32. 2003
    ..We conducted a cohort study of parturient women in an area with endemic Q fever infection to determine whether those seropositive for Coxiella burnetii had evidence of adverse birth outcomes...
  19. pmc Case report: Molluscum contagiosum. Toxic shock syndrome following cantharidin treatment
    J M Langley
    Department of Pediatrics, Dalhousie University in Halifax, NS, USA
    Can Fam Physician 49:887-9. 2003
  20. ncbi request reprint Seven days of erythromycin estolate is as effective as fourteen days for the treatment of Bordetella pertussis infections
    S A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, Canada
    Pediatrics 100:65-71. 1997
    ..B pertussis-specific antibodies were measured before treatment and 1 month later. Information about clinical symptoms, adverse reactions, and compliance were collected at each scheduled contact...
  21. ncbi request reprint A randomized, placebo-controlled trial of erythromycin estolate chemoprophylaxis for household contacts of children with culture-positive bordetella pertussis infection
    S A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, B3J 3G9 Canada E mail
    Pediatrics 104:e42. 1999
    ..Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxis in preventing secondary cases of pertussis...
  22. ncbi request reprint Demand for isolation beds in a pediatric hospital
    J M Langley
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Infect Control 22:207-11. 1994
    ..An increasing need for single-bed rooms is identified. Isolation requirements must be considered during the design of new hospitals or renovation of existing ones...
  23. ncbi request reprint Unique epidemiology of nosocomial urinary tract infection in children
    J M Langley
    Infection Control Services, Izaak Walton Killam Grace Health Centre for Children, Women and Families, Halifax, Nova Scotia
    Am J Infect Control 29:94-8. 2001
    ..Although E coli remains the most common cause of pediatric NUTI, fungi have become the second most common pathogen in this tertiary care population. Risk factors for NUTI in noncatheterized children remain to be delineated...
  24. ncbi request reprint Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adults
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
    Vaccine 25:3464-74. 2007
    ....
  25. ncbi request reprint Evaluation of a tuberculosis screening program at a children's hospital
    S A Halperin
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Am J Infect Control 20:19-23. 1992
    ....
  26. doi request reprint A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults > or =65 years of age
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, NS, Canada
    Vaccine 27:5913-9. 2009
    ....
  27. doi request reprint Prospects for defined epitope vaccines for respiratory syncytial virus
    Robert Anderson
    Department of Microbiology and Immunology, Pediatrics and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Future Microbiol 5:585-602. 2010
    ..Identification and characterization of RSV epitopes is a rapidly expanding topic of research with potential contributions to the tailored design of improved safe and effective vaccines...
  28. doi request reprint Immunization: a global challenge for the 21st Century
    Joanne M Langley
    Department of Pediatrics, Canadian Centre for Vaccinology, Halifax, NS, Canada
    Expert Rev Vaccines 10:429-31. 2011
    ..In this article, we summarize some of the key presentations from the six plenary sessions, 36 concurrent symposia and workshops, podium and poster presentations...
  29. pmc Empyema associated with community-acquired pneumonia: a Pediatric Investigator's Collaborative Network on Infections in Canada (PICNIC) study
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, Canada
    BMC Infect Dis 8:129. 2008
    ..We reviewed the epidemiology and clinical management of empyema at 8 pediatric hospitals in a period before the widespread implementation of universal infant heptavalent pneumococcal vaccine programs in Canada...
  30. doi request reprint Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adults
    Joanne M Langley
    Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, Canada
    J Infect Dis 201:1644-53. 2010
    ..1) prepandemic candidate vaccines produced at 2 separate manufacturing sites...
  31. ncbi request reprint Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, The IWK Health Centre, Halifax, NS, Canada
    Vaccine 25:450-7. 2007
    ....
  32. ncbi request reprint Safety and immunogenicity of two formulations of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae conjugate-hepatitis B vaccine in 15 to 18-month-old children
    Scott A Halperin
    Clinical Trials Research Center, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Hum Vaccin 1:245-50. 2005
    ..8 microg/mL in PRP-T/HBV10 recipients and 9.4 microg/mL in PRP-OMPC/HBV15 recipients. We conclude that the hexavalent formulations appear generally well tolerated and immunogenic as a booster dose in these toddlers...
  33. ncbi request reprint Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, Halifax, NS, Canada B3K 6R8
    Vaccine 24:20-6. 2006
    ..Many individuals do not respond to a three-dose series of hepatitis B vaccine (HBV) and most do not achieve a protective antibody response until after dose 2 or 3...
  34. ncbi request reprint Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
    Vaccine 24:4017-23. 2006
    ..Recently, another DTaP-IPV-Hib (Infanrix-IPV-Hib) became available. Data on the interchangeability of these products was lacking...
  35. pmc Pneumococcal and influenza immunization in asplenic persons: a retrospective population-based cohort study 1990-2002
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax Nova Scotia B3K6R8, Canada
    BMC Infect Dis 10:219. 2010
    ....
  36. doi request reprint Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum women
    B A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Canada
    Clin Infect Dis 53:885-92. 2011
    ..We sought to determine whether the antibody response to tetanus-diphtheria-acellular pertussis vaccine (Tdap) is sufficiently rapid to support the cocoon strategy...
  37. ncbi request reprint Health care epidemiology perspective on the October 2006 recommendations of the Subcommittee on Diagnosis and Management of Bronchiolitis
    Jo Ann S Harris
    Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA
    Pediatrics 120:890-2. 2007
  38. pmc Optimizing the delivery and use of a new monoclonal antibody in children with congenital heart disease: a successful provincial respiratory syncytial virus prophylaxis program
    Andrew Warren
    Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Canada
    Can J Cardiol 23:463-6. 2007
    ..To describe a program for passive immunization against respiratory syncytial virus infection in infants with hemodynamically significant congenital heart disease (CHD) in accordance with the Canadian Paediatric Society recommendations...
  39. ncbi request reprint Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  40. pmc Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study
    Joan L Robinson
    Department of Pediatrics, Alberta Children s Hospital Calgary, Alberta, Canada
    BMC Infect Dis 9:183. 2009
    ..There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU)...
  41. pmc Release of the statement on influenza for the 2007 2008 season from the National Advisory Committee on Immunization
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS
    CMAJ 177:1025-6. 2007
  42. pmc Highlights of the National Advisory Committee on Immunization statement on influenza for the 2006-2007 season
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS
    CMAJ 175:742. 2006
  43. pmc Influenza and the influenza vaccine
    Noni MacDonald
    Division of Infectious Diseases, Department of Paediatrics, Dalhousie University, Halifax, NS
    CMAJ 177:1028. 2007
  44. ncbi request reprint Defining pneumonia in critically ill infants and children
    Joanne M Langley
    Clinical Trials Research Centre, IWK Health Center, and the Department of Pediatrics, Dalhousie University, Halifax, Canada
    Pediatr Crit Care Med 6:S9-S13. 2005
    ....
  45. ncbi request reprint Encephalitis in the summer: a case of snowshoe hare (California serogroup) virus infection in Nova Scotia
    V Meier-Stephenson
    Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Can Commun Dis Rep 33:23-6. 2007
  46. ncbi request reprint Defining urinary tract infection in the critically ill child
    Joanne M Langley
    Clinical Trials Research Centre, the IWK Health Centre and Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Crit Care Med 6:S25-9. 2005
    ..To define urinary tract infections in critically ill children in the intensive care unit setting for the purpose of surveillance of infection, enrollment of children in sepsis trials, and for trials of therapy and prevention...
  47. pmc Prevention of influenza in the general population: recommendation statement from the Canadian Task Force on Preventive Health Care
    Joanne M Langley
    Canadian Task Force on Preventive Health Care, London, ON
    CMAJ 171:1169-70. 2004
  48. ncbi request reprint The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestation
    Barbara J Law
    Department of Pediatrics and Child Health, University of Manitoba and the Winnipeg Health Sciences Center, Winnipeg, Canada
    Pediatr Infect Dis J 23:806-14. 2004
    ..This study sought to identify independent risk factors for hospitalization for RSV infection...
  49. ncbi request reprint Hospitalization attributable to influenza and other viral respiratory illnesses in Canadian children
    Dena L Schanzer
    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Pediatr Infect Dis J 25:795-800. 2006
    ..We sought to estimate the incidence of hospitalization attributable to influenza virus infection in Canadian children while controlling for the impact of other respiratory viruses...
  50. ncbi request reprint Influenza-attributed hospitalization rates among pregnant women in Canada 1994-2000
    Dena L Schanzer
    Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa ON, Canada
    J Obstet Gynaecol Can 29:622-9. 2007
    ..We aimed to estimate the rate of hospitalization attributable to influenza for healthy pregnant women and for those with known co-morbidities...
  51. doi request reprint Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial
    Matthew D Snape
    Oxford Vaccine Group, University of Oxford, England
    JAMA 299:173-84. 2008
    ..However, the currently licensed vaccine is poorly immunogenic in infancy, when the highest rates of disease are observed...
  52. doi request reprint Co-morbidities associated with influenza-attributed mortality, 1994-2000, Canada
    Dena L Schanzer
    Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
    Vaccine 26:4697-703. 2008
    ..These estimates identify groups most in need of improved vaccines and for whom the use of additional strategies, such as immunization of household contacts or caregivers should be considered...
  53. ncbi request reprint The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in children
    Joanne M Langley
    Infect Control Hosp Epidemiol 23:660-4. 2002
    ..We report surveillance of nosocomial diarrhea in children at our institution during the past decade and note different epidemiology of diarrhea due to viruses and Clostridium difficile...