Research Topics
| J M LangleySummaryAffiliation: Dalhousie University Country: Canada Publications
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Publications
A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccineJoanne M Langley
Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
BMC Infect Dis 12:279. 2012..At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred...
Safety and immunogenicity of 2010-2011 H1N12009-containing trivalent inactivated influenza vaccine in children 12-59 months of age previously given AS03-adjuvanted H1N12009 pandemic vaccine: a PHAC/CIHR Influenza Research Network (PCIRN) studyJoanne M Langley
Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, B3K 6R8, Canada
Vaccine 30:3389-94. 2012..We conducted a pre-season study of 2010-2011 TIV safety and immunogenicity in children 12-59 months of age to inform public health decision making...- Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) study of aseptic meningitisBonita E Lee
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
BMC Infect Dis 6:68. 2006..The seasonality, clinical and radiographic features and outcome of aseptic meningitis have been described for regional outbreaks but data from a wider geographic area is necessary to delineate the epidemiology of this condition... 
Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussisJoanne M Langley
Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Canada
Pediatrics 114:e96-101. 2004..We compared the safety and efficacy of erythromycin with azithromycin for treatment of pertussis in a large, randomized, controlled trial that enrolled children from primary care practices in 1 American and 11 Canadian urban centers...- A pilot study to quantify parental anxiety associated with enrollment of an infant or toddler in a phase III vaccine trialJoanne M Langley
Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Canada NS B3J 3G9
Vaccine 21:3863-6. 2003..These factors should be considered by vaccine researchers in the recruitment process of clinical trials... - Dose-sparing H5N1 A/Indonesia/05/2005 pre-pandemic influenza vaccine in adults and elderly adults: a phase III, placebo-controlled, randomized studyJoanne M Langley
Canadian Center for Vaccinology, Departments of Pediatrics and Community Health and Epidemiology, IWK Health Centre and Dalhousie University, Halifax, Canada
J Infect Dis 203:1729-38. 2011..Highly pathogenic avian influenza H5N1 viruses remain a threat to human health, with potential to become pandemic agents... - Prevention of influenza in the general populationJoanne M Langley
Department of Pediatrics, Dalhousie University and IWK Health Center, Halifax, NS
CMAJ 171:1213-22. 2004..Use of chemotherapy (amantidine, neuraminidase inhibitors) to prevent influenza varies among provinces. We sought to systematically review the evidence for the prevention of influenza infection in the general population... - A nasally administered trivalent inactivated influenza vaccine is well tolerated, stimulates both mucosal and systemic immunity, and potentially protects against influenza illnessJ M Langley
Canadian Centre for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, Canada
Vaccine 29:1921-8. 2011..An OMP-TIV vaccine was well tolerated and reduced risk of symptomatic culture confirmed influenza. Vaccine efficacy will need to be validated in a season with a higher attack rate... - Racemic epinephrine compared to salbutamol in hospitalized young children with bronchiolitis; a randomized controlled clinical trial [ISRCTN46561076]Joanne M Langley
Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
BMC Pediatr 5:7. 2005..Trials of racemic epinephrine have shown conflicting results. We sought to determine if administration of racemic epinephrine during hospital stay for bronchiolitis improved respiratory distress, was safe, and shortened length of stay... - Safety and immunogenicity of a Proteosome -trivalent inactivated influenza vaccine, given nasally to healthy adultsJoanne M Langley
Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
Vaccine 24:1601-8. 2006..Further testing of this nasal influenza vaccine is warranted to determine its safety and immunogenicity in these populations and its efficacy in the prevention of clinical illness... - Study of cerebrospinal fluid shunt-associated infections in the first year following placement, by the Canadian Nosocomial Infection Surveillance ProgramJoanne M Langley
Department of Pediatrics, Dalhousie University, Canada
Infect Control Hosp Epidemiol 30:285-8. 2009..85% vs 3.24%; P=.04) and occurred sooner after surgery in children than in adults. A wide variation in compliance with antimicrobial prophylaxis was observed between 21 participating medical centers... - Increasing incidence of hospitalization for bronchiolitis among Canadian children, 1980-2000Joanne M Langley
Clinical Trials Research Centre, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
J Infect Dis 188:1764-7. 2003.... - An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine anJoanne M Langley
Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
Vaccine 25:1121-5. 2007..Fever and injection site reactions are less common in 4-6 year-old-children who receive a dTap vaccine compared to DTaP-IPV, without inferior immunogenicity... - Evaluation of the notification of hepatitis C risk to children who received unscreened blood or blood productsJ M Langley
Clinical Trials Research Centre Infectious Diseases, IWK Health Centre, Halifax, Nova Scotia, Canada
Commun Dis Public Health 4:288-92. 2001..Awareness of transfusion history or risk of HCV was not universal, indicating the need to address notification to individuals, rather than through public education campaigns alone... - Variation in risk for nosocomial chickenpox after inadvertent exposureJ M Langley
Izaak Walton Killam Grace Health Centre for Children, Women and Families, Dalhousie University, Halifax, Nova Scotia
J Hosp Infect 44:224-6. 2000..02). Occupational exposures present a lesser transmission risk than those in households. Definition of those exposure variables that increase risk of transmission in the occupational setting should be explored in future studies... - Commentary: Waterless hand hygiene--if there's a will, there's a wayJoanne M Langley
Clinical Trials Research Centre, Dalhousie University, Halifax, Canada
Pediatr Infect Dis J 21:496-7. 2002 - History of penicillin allergy and referral for skin testing: evaluation of a pediatric penicillin allergy testing programJoanne M Langley
Clin Invest Med 25:181-4. 2002..Penicillin allergy, commonly reported in children, leads to use of more expensive, broad-spectrum drugs. The results and effectiveness of a skin testing program for immediate hypersensitivity to penicillin in children were studied... - Coxiella burnetii seropositivity in parturient women is associated with adverse pregnancy outcomesJoanne M Langley
Izaak Walton Killam Health Centre, Departments of Pediatrics, Dalhousie University, Halifax, Canada
Am J Obstet Gynecol 189:228-32. 2003..We conducted a cohort study of parturient women in an area with endemic Q fever infection to determine whether those seropositive for Coxiella burnetii had evidence of adverse birth outcomes... - Case report: Molluscum contagiosum. Toxic shock syndrome following cantharidin treatmentJ M Langley
Department of Pediatrics, Dalhousie University in Halifax, NS, USA
Can Fam Physician 49:887-9. 2003 - Seven days of erythromycin estolate is as effective as fourteen days for the treatment of Bordetella pertussis infectionsS A Halperin
Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, Canada
Pediatrics 100:65-71. 1997..99% at the 5% level to detect a difference in failure rates of 10% and a power of 80% to detect a difference of 5%. We conclude that 7 days of erythromycin estolate is as effective as 14 days for the eradication of B pertussis... - A randomized, placebo-controlled trial of erythromycin estolate chemoprophylaxis for household contacts of children with culture-positive bordetella pertussis infectionS A Halperin
Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, B3J 3G9 Canada E mail
Pediatrics 104:e42. 1999..Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxis in preventing secondary cases of pertussis... - Demand for isolation beds in a pediatric hospitalJ M Langley
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
Am J Infect Control 22:207-11. 1994..An increasing need for single-bed rooms is identified. Isolation requirements must be considered during the design of new hospitals or renovation of existing ones... - Unique epidemiology of nosocomial urinary tract infection in childrenJ M Langley
Infection Control Services, Izaak Walton Killam Grace Health Centre for Children, Women and Families, Halifax, Nova Scotia
Am J Infect Control 29:94-8. 2001..Although E coli remains the most common cause of pediatric NUTI, fungi have become the second most common pathogen in this tertiary care population. Risk factors for NUTI in noncatheterized children remain to be delineated... - Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adultsShelly A McNeil
Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
Vaccine 25:3464-74. 2007.... - Evaluation of a tuberculosis screening program at a children's hospitalS A Halperin
Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
Am J Infect Control 20:19-23. 1992.... - A dose-ranging study of a subunit Respiratory Syncytial Virus subtype A vaccine with and without aluminum phosphate adjuvantation in adults > or =65 years of ageJoanne M Langley
Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre, Halifax, NS, Canada
Vaccine 27:5913-9. 2009.... - Prospects for defined epitope vaccines for respiratory syncytial virusRobert Anderson
Department of Microbiology and Immunology, Pediatrics and Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
Future Microbiol 5:585-602. 2010..Identification and characterization of RSV epitopes is a rapidly expanding topic of research with potential contributions to the tailored design of improved safe and effective vaccines... - Immunization: a global challenge for the 21st CenturyJoanne M Langley
Department of Pediatrics, Canadian Centre for Vaccinology, Halifax, NS, Canada
Expert Rev Vaccines 10:429-31. 2011..In this article, we summarize some of the key presentations from the six plenary sessions, 36 concurrent symposia and workshops, podium and poster presentations... - Empyema associated with community-acquired pneumonia: a Pediatric Investigator's Collaborative Network on Infections in Canada (PICNIC) studyJoanne M Langley
Department of Pediatrics, Dalhousie University, Halifax, Canada
BMC Infect Dis 8:129. 2008..We reviewed the epidemiology and clinical management of empyema at 8 pediatric hospitals in a period before the widespread implementation of universal infant heptavalent pneumococcal vaccine programs in Canada... - Safety and cross-reactive immunogenicity of candidate AS03-adjuvanted prepandemic H5N1 influenza vaccines: a randomized controlled phase 1/2 trial in adultsJoanne M Langley
Canadian Center for Vaccinology, Dalhousie University and IWK Health Centre Halifax, Halifax, Nova Scotia, Canada
J Infect Dis 201:1644-53. 2010..1) prepandemic candidate vaccines produced at 2 separate manufacturing sites... - Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adultsScott A Halperin
Clinical Trials Research Center, Dalhousie University, The IWK Health Centre, Halifax, NS, Canada
Vaccine 25:450-7. 2007.... - Safety and immunogenicity of two formulations of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae conjugate-hepatitis B vaccine in 15 to 18-month-old childrenScott A Halperin
Clinical Trials Research Center, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
Hum Vaccin 1:245-50. 2005..8 microg/mL in PRP-T/HBV10 recipients and 9.4 microg/mL in PRP-OMPC/HBV15 recipients. We conclude that the hexavalent formulations appear generally well tolerated and immunogenic as a booster dose in these toddlers... - Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adultsScott A Halperin
Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, Halifax, NS, Canada B3K 6R8
Vaccine 24:20-6. 2006..Many individuals do not respond to a three-dose series of hepatitis B vaccine (HBV) and most do not achieve a protective antibody response until after dose 2 or 3... - Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlersScott A Halperin
Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
Vaccine 24:4017-23. 2006..Recently, another DTaP-IPV-Hib (Infanrix-IPV-Hib) became available. Data on the interchangeability of these products was lacking... - Pneumococcal and influenza immunization in asplenic persons: a retrospective population-based cohort study 1990-2002Joanne M Langley
Department of Pediatrics, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax Nova Scotia B3K6R8, Canada
BMC Infect Dis 10:219. 2010.... - Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum womenB A Halperin
Clinical Trials Research Center, Canadian Center for Vaccinology, Canada
Clin Infect Dis 53:885-92. 2011..We sought to determine whether the antibody response to tetanus-diphtheria-acellular pertussis vaccine (Tdap) is sufficiently rapid to support the cocoon strategy... - Health care epidemiology perspective on the October 2006 recommendations of the Subcommittee on Diagnosis and Management of BronchiolitisJo-Ann S Harris
Department of Pediatrics, University of Kansas Medical Center, Kansas City, Kansas, USA
Pediatrics 120:890-2. 2007 - Optimizing the delivery and use of a new monoclonal antibody in children with congenital heart disease: a successful provincial respiratory syncytial virus prophylaxis programAndrew Warren
Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Canada
Can J Cardiol 23:463-6. 2007..To describe a program for passive immunization against respiratory syncytial virus infection in infants with hemodynamically significant congenital heart disease (CHD) in accordance with the Canadian Paediatric Society recommendations... - Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteersShelly A McNeil
Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
Clin Infect Dis 41:1114-22. 2005..New molecular techniques have allowed the previous obstacles to be largely overcome... - Characteristics and outcome of infants with candiduria in neonatal intensive care - a Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC) studyJoan L Robinson
Department of Pediatrics, Alberta Children s Hospital Calgary, Alberta, Canada
BMC Infect Dis 9:183. 2009..There is limited information in the literature on the presentation and prognosis of candidal urinary tract infection (UTI) in infants in the neonatal intensive care unit (NICU)... - Release of the statement on influenza for the 2007 2008 season from the National Advisory Committee on ImmunizationJoanne M Langley
Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS
CMAJ 177:1025-6. 2007 - Highlights of the National Advisory Committee on Immunization statement on influenza for the 2006-2007 seasonJoanne M Langley
Division of Infectious Diseases, Department of Pediatrics, Canadian Centre for Vaccinology, IWK Health Centre, Halifax, NS
CMAJ 175:742. 2006 - Influenza and the influenza vaccineNoni MacDonald
Division of Infectious Diseases, Department of Paediatrics, Dalhousie University, Halifax, NS
CMAJ 177:1028. 2007 - Defining pneumonia in critically ill infants and childrenJoanne M Langley
Clinical Trials Research Centre, IWK Health Center, and the Department of Pediatrics, Dalhousie University, Halifax, Canada
Pediatr Crit Care Med 6:S9-S13. 2005..Future research should determine the utility of these definitions in the critically ill child and adapt them accordingly... - Encephalitis in the summer: a case of snowshoe hare (California serogroup) virus infection in Nova ScotiaV Meier-Stephenson
Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
Can Commun Dis Rep 33:23-6. 2007 - Defining urinary tract infection in the critically ill childJoanne M Langley
Clinical Trials Research Centre, the IWK Health Centre and Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
Pediatr Crit Care Med 6:S25-9. 2005..Future research should determine the utility of these definitions in the critically ill child and adapt them accordingly... - Prevention of influenza in the general population: recommendation statement from the Canadian Task Force on Preventive Health CareJoanne M Langley
Canadian Task Force on Preventive Health Care, London, ON
CMAJ 171:1169-70. 2004 - The Pediatric Investigators Collaborative Network on Infections in Canada study of predictors of hospitalization for respiratory syncytial virus infection for infants born at 33 through 35 completed weeks of gestationBarbara J Law
Department of Pediatrics and Child Health, University of Manitoba and the Winnipeg Health Sciences Center, Winnipeg, Canada
Pediatr Infect Dis J 23:806-14. 2004..This study sought to identify independent risk factors for hospitalization for RSV infection... - Hospitalization attributable to influenza and other viral respiratory illnesses in Canadian childrenDena L Schanzer
Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
Pediatr Infect Dis J 25:795-800. 2006..We sought to estimate the incidence of hospitalization attributable to influenza virus infection in Canadian children while controlling for the impact of other respiratory viruses... - Influenza-attributed hospitalization rates among pregnant women in Canada 1994-2000Dena L Schanzer
Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada, Ottawa ON, Canada
J Obstet Gynaecol Can 29:622-9. 2007..We aimed to estimate the rate of hospitalization attributable to influenza for healthy pregnant women and for those with known co-morbidities... - Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trialMatthew D Snape
Oxford Vaccine Group, University of Oxford, England
JAMA 299:173-84. 2008..However, the currently licensed vaccine is poorly immunogenic in infancy, when the highest rates of disease are observed... - Co-morbidities associated with influenza-attributed mortality, 1994-2000, CanadaDena L Schanzer
Centre for Communicable Diseases and Infection Control, Public Health Agency of Canada, Ottawa, Ontario, Canada
Vaccine 26:4697-703. 2008..These estimates identify groups most in need of improved vaccines and for whom the use of additional strategies, such as immunization of household contacts or caregivers should be considered... - The role of Clostridium difficile and viruses as causes of nosocomial diarrhea in childrenJoanne M Langley
Infect Control Hosp Epidemiol 23:660-4. 2002..Further characterization of risk factors for, and morbidity associated with, nosocomial CDAD in children is warranted...