David W Hoskin

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. pmc Studies on anticancer activities of antimicrobial peptides
    David W Hoskin
    Department of Pathology and Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Biochim Biophys Acta 1778:357-75. 2008
  2. ncbi request reprint Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
    David W Hoskin
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Int J Oncol 32:527-35. 2008
  3. ncbi request reprint Contribution of reactive oxygen species and caspase-3 to apoptosis and attenuated ICAM-1 expression by paclitaxel-treated MDA-MB-435 breast carcinoma cells
    Helen Fawcett
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Int J Oncol 27:1717-26. 2005
  4. ncbi request reprint Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
    Ashley L Hilchie
    Dalhousie University, Halifax, Nova Scotia, Canada
    Nutr Cancer 62:379-89. 2010
  5. ncbi request reprint Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
    Jane L Watson
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Cancer Lett 297:1-8. 2010
  6. ncbi request reprint Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways
    Jared J Butler
    Department of Microbiology and Immunology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Cell Biochem 89:975-91. 2003
  7. ncbi request reprint Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor
    Asile El-Darahali
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Mol Pathol 79:249-58. 2005
  8. doi request reprint Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    Nicholas A Forward
    Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 87:117-25. 2010
  9. ncbi request reprint Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
    Jamie S Mader
    Department of Pathology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Cancer Ther 4:612-24. 2005
  10. doi request reprint Role of mitogen-activated protein kinases in Thy-1-induced T-lymphocyte activation
    David M Conrad
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H1X5, Canada
    Cell Signal 21:1298-307. 2009

Collaborators

  • Jonathan Blay
  • S M Mansour Haeryfar
  • Tong Jun Lin
  • Alexander S Easton
  • Hong Zhang
  • Jamie S Mader
  • Jordan Warford
  • Robert Anderson
  • Neale D Ridgway
  • Roy Duncan
  • Brent A Williams
  • Pei Lin Chen
  • Ayyalusamy Ramamoorthy
  • - Zhang Hong
  • Suzanne J Furlong
  • David M Conrad
  • Carolyn D Doucette
  • Ashley L Hilchie
  • Robert T M Boudreau
  • Nicholas A Forward
  • Jane L Watson
  • Carman A Giacomantonio
  • Carolyn J Macmillan
  • Kimberly M Sutton
  • Carrie L Watson
  • Susan Douglas
  • Paul B Yaffe
  • Angela Richardson
  • Patrick W Lee
  • Richard Hill
  • Michael G Brown
  • Bruce L Musgrave
  • Jared J Butler
  • Helen Fawcett
  • Melanie R Power Coombs
  • Mark Walsh
  • Anna Greenshields
  • Yongjun Yang
  • Matthew R J Robichaud
  • Max Morgan
  • S Y Velda Chan
  • Kenneth A West
  • Ernest Y Tan
  • Jean S Marshall
  • Asile El-Darahali
  • Osama Loubani
  • Vineet Bhan
  • Jillian P Tarrant
  • Sandra J Gallagher
  • Chuanli Zhao
  • Monther M Al-Alwan
  • Anna L Greenshields
  • Willena M MacKenzie
  • Tyler S Zemlak
  • Rachel Vale
  • Robert Liwski
  • Aleksander Patrzykat
  • Devanand M Pinto
  • Ashley Hilchie
  • Kimberly Sutton
  • Christine A King
  • Roberto de Antueno
  • Yan Y Huang
  • Angela M Richardson
  • Cynthia L Richard
  • Matthew Robichaud
  • Carman Giacomantonio
  • Mark J Walsh
  • Mark C Blanchard
  • Christine A Barnes
  • Timothy D G Lee
  • Elyisha A Hanniman
  • William H Baldridge
  • Geoffrey Rowden
  • Robert S Liwski
  • Natalie Ward
  • Jennifer Cochran

Detail Information

Publications58

  1. pmc Studies on anticancer activities of antimicrobial peptides
    David W Hoskin
    Department of Pathology and Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Biochim Biophys Acta 1778:357-75. 2008
    ..In this article, we review various studies on different AMPs that exhibit cytotoxic activity against cancer cells. The suitability of cancer cell-targeting AMPs as cancer therapeutics is also discussed...
  2. ncbi request reprint Inhibition of T cell and natural killer cell function by adenosine and its contribution to immune evasion by tumor cells (Review)
    David W Hoskin
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Int J Oncol 32:527-35. 2008
    ....
  3. ncbi request reprint Contribution of reactive oxygen species and caspase-3 to apoptosis and attenuated ICAM-1 expression by paclitaxel-treated MDA-MB-435 breast carcinoma cells
    Helen Fawcett
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Int J Oncol 27:1717-26. 2005
    ....
  4. ncbi request reprint Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria
    Ashley L Hilchie
    Dalhousie University, Halifax, Nova Scotia, Canada
    Nutr Cancer 62:379-89. 2010
    ..We conclude that curcumin-induced cytotoxicity was due to cellular ceramide accumulation and damage to mitochondria that resulted in apoptosis mediated by AIF and other caspase-independent processes...
  5. ncbi request reprint Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
    Jane L Watson
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Cancer Lett 297:1-8. 2010
    ..Curcumin may therefore have therapeutic potential in the management of colon cancer, especially in tumorsthatare resistant to conventional chemotherapydue todefects inp53 expression or function...
  6. ncbi request reprint Adenosine inhibits activation-induced T cell expression of CD2 and CD28 co-stimulatory molecules: role of interleukin-2 and cyclic AMP signaling pathways
    Jared J Butler
    Department of Microbiology and Immunology, Faculty of Medicine, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Cell Biochem 89:975-91. 2003
    ..We conclude that adenosine interferes with IL-2-dependent T cell expression of co-stimulatory molecules via a mechanism that does not involve the accumulation of intracellular cAMP...
  7. ncbi request reprint Adenosine-induced apoptosis in EL-4 thymoma cells is caspase-independent and mediated through a non-classical adenosine receptor
    Asile El-Darahali
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Mol Pathol 79:249-58. 2005
    ..Adenosine therefore acts through a non-classical receptor at the cell surface to trigger caspase-independent apoptosis in mouse thymoma cells...
  8. doi request reprint Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    Nicholas A Forward
    Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 87:117-25. 2010
    ..We speculate that TLR7-stimulated enhancement of T(reg) cell suppressor function may modulate host T cell responses against ssRNA viruses...
  9. ncbi request reprint Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
    Jamie S Mader
    Department of Pathology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, Canada B3H 1X5
    Mol Cancer Ther 4:612-24. 2005
    ..We conclude that LfcinB kills cancer cells by triggering the mitochondrial pathway of apoptosis at least in part through the generation of reactive oxygen species...
  10. doi request reprint Role of mitogen-activated protein kinases in Thy-1-induced T-lymphocyte activation
    David M Conrad
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H1X5, Canada
    Cell Signal 21:1298-307. 2009
    ..MAPKs are therefore essential signalling intermediates for the Thy-1-driven proliferation of mouse T-lymphocytes...
  11. ncbi request reprint Apoptosis induced by protein phosphatase 2A (PP2A) inhibition in T leukemia cells is negatively regulated by PP2A-associated p38 mitogen-activated protein kinase
    Robert T M Boudreau
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 University Ave, Halifax, Nova Scotia, Canada B3H 1X5
    Cell Signal 19:139-51. 2007
    ..Collectively, these findings indicate that PP2A and p38 MAPK have coordinate effects on signaling pathways that regulate the survival of T leukemia cells...
  12. doi request reprint Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling
    Jane L Watson
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada
    Mol Carcinog 49:13-24. 2010
    ..These data provide a mechanistic rationale for the potential use of curcumin in the treatment of ovarian cancer...
  13. ncbi request reprint Differential involvement of reactive oxygen species in apoptosis caused by the inhibition of protein phosphatase 2A in Jurkat and CCRF-CEM human T-leukemia cells
    Robert T M Boudreau
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Exp Mol Pathol 83:347-56. 2007
    ....
  14. ncbi request reprint Antibody blockade of Thy-1 (CD90) impairs mouse cytotoxic T lymphocyte induction by anti-CD3 monoclonal antibody
    S M Mansour Haeryfar
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Canada
    Immunol Cell Biol 83:352-63. 2005
    ..In contrast, Fas ligand expression and function was not affected by Thy-1 blockade. We conclude that Thy-1 signalling promotes the in vitro generation of CTL that kill in a granule-dependent fashion...
  15. ncbi request reprint CD2-CD48 interactions promote interleukin-2 and interferon-gamma synthesis by stabilizing cytokine mRNA
    Bruce L Musgrave
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS B3H 1X5, Canada
    Cell Immunol 229:1-12. 2004
    ..CD2, therefore, costimulates T cell activation by stabilizing cytokine mRNA transcripts, albeit with less efficiency than CD28...
  16. ncbi request reprint Exposure to paclitaxel or vinblastine down-regulates CD11a and CD54 expression by P815 mastocytoma cells and renders the tumor cells resistant to killing by nonspecific cytotoxic T lymphocytes induced with anti-CD3 antibody
    Chuanli Zhao
    Department of Microbiology and Immunology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Cancer Immunol Immunother 52:185-93. 2003
    ..A similar effect by these drugs on tumor cells and/or leukocytes in cancer patients might compromise tumor-specific cell-mediated immune responses...
  17. ncbi request reprint CD2-CD48 interactions promote cytotoxic T lymphocyte induction and function: anti-CD2 and anti-CD48 antibodies impair cytokine synthesis, proliferation, target recognition/adhesion, and cytotoxicity
    Bruce L Musgrave
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Interferon Cytokine Res 23:67-81. 2003
    ..We conclude that CD2-CD48 interactions during T cell activation are critical for the synthesis of sufficient IL-2 and IFN-gamma to drive CD8(+) T cells to differentiate into functional cytotoxic effector cells...
  18. ncbi request reprint Impaired interleukin-2 synthesis and T cell proliferation following antibody-mediated CD3 and CD2 or CD28 cross-linking in trans: evidence that T cell activation requires the engagement of costimulatory molecules within the immunological synapse
    Carrie L Watson
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Immunol Invest 37:63-78. 2008
    ....
  19. doi request reprint Piperine impairs cell cycle progression and causes reactive oxygen species-dependent apoptosis in rectal cancer cells
    Paul B Yaffe
    Department of Surgery, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Exp Mol Pathol 94:109-14. 2013
    ..The cytostatic and cytotoxic effects of piperine on rectal cancer cells suggest that this dietary phytochemical may be useful in cancer treatment...
  20. ncbi request reprint Ryanodine receptor signaling is required for anti-CD3-induced T cell proliferation, interleukin-2 synthesis, and interleukin-2 receptor signaling
    David M Conrad
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, B3H 1X5 Canada
    J Cell Biochem 92:387-99. 2004
    ..We conclude that RyR-associated Ca(++) signaling regulates T cell proliferation by promoting both IL-2 synthesis and IL-2-dependent cell cycle progression...
  21. doi request reprint Intracellular delivery of bovine lactoferricin's antimicrobial core (RRWQWR) kills T-leukemia cells
    Angela Richardson
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Biochem Biophys Res Commun 388:736-41. 2009
    ..We suggest that LfcinB6, in combination with a fusogenic liposome delivery system that selectively targets malignant cells, has potential as a novel anticancer agent...
  22. ncbi request reprint Adenosine acts through A2 receptors to inhibit IL-2-induced tyrosine phosphorylation of STAT5 in T lymphocytes: role of cyclic adenosine 3',5'-monophosphate and phosphatases
    Hong Zhang
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 173:932-44. 2004
    ....
  23. ncbi request reprint Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria
    Jamie S Mader
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Cell Res 313:2634-50. 2007
    ..We conclude that LfcinB-induced apoptosis in Jurkat T-leukemia cells resulted from cell membrane damage and the subsequent disruption of mitochondrial membranes by internalized LfcinB...
  24. ncbi request reprint Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin
    Suzanne J Furlong
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Int J Oncol 32:537-44. 2008
    ..We conclude that manipulation of cellular ceramide levels in combination with LfcinB therapy warrants further investigation as a novel strategy for the treatment of T cell-derived leukemias...
  25. ncbi request reprint The Ca(2+) channel blocker flunarizine induces caspase-10-dependent apoptosis in Jurkat T-leukemia cells
    David M Conrad
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Apoptosis 15:597-607. 2010
    ..Flunarizine warrants further investigation as a potential anti-cancer agent for the treatment of hematological malignancies...
  26. ncbi request reprint Assessment of antimicrobial (host defense) peptides as anti-cancer agents
    Susan Douglas
    Department of Microbiology and Immunology, Dalhousie University, Halifax, NS, Canada
    Methods Mol Biol 1088:159-70. 2014
    ..In addition the clonogenic assay, which assesses the ability of single transformed cells to multiply and produce colonies, is described...
  27. pmc Pleurocidin-family cationic antimicrobial peptides are cytolytic for breast carcinoma cells and prevent growth of tumor xenografts
    Ashley L Hilchie
    Department of Microbiology and Immunology, Dalhousie University, 5850 College St, Halifax, B3H 4R2, Canada
    Breast Cancer Res 13:R102. 2011
    ..The purpose of this investigation was to determine the effect of the pleurocidin-family CAPs, NRC-03 and NRC-07, on breast cancer cells...
  28. ncbi request reprint 2-Chloro-2'-deoxyadenosine-induced apoptosis in T leukemia cells is mediated via a caspase-3-dependent mitochondrial feedback amplification loop
    David M Conrad
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    Int J Oncol 32:1325-33. 2008
    ..Agents that inhibit p38 MAPK might therefore increase the effectiveness of CdA-based chemotherapy...
  29. ncbi request reprint Cutting edge: dendritic cell actin cytoskeletal polarization during immunological synapse formation is highly antigen-dependent
    Monther M Al-Alwan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 171:4479-83. 2003
    ..Our findings suggest that a high Ag specificity is required for DC IS formation and that MHC class II signaling plays a central role in this process...
  30. ncbi request reprint Thy-1 signaling in the context of costimulation provided by dendritic cells provides signal 1 for T cell proliferation and cytotoxic effector molecule expression, but fails to trigger delivery of the lethal hit
    S M Mansour Haeryfar
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 171:69-77. 2003
    ....
  31. doi request reprint Curcumin blocks interleukin (IL)-2 signaling in T-lymphocytes by inhibiting IL-2 synthesis, CD25 expression, and IL-2 receptor signaling
    Nicholas A Forward
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Biochem Biophys Res Commun 407:801-6. 2011
    ..We conclude that curcumin inhibits IL-2 signaling by reducing available IL-2 and high affinity IL-2R, as well as interfering with IL-2R signaling...
  32. ncbi request reprint In vitro exposure to paclitaxel modulates integrin expression by human T lymphocytes and inhibits T cell adhesion to breast carcinoma cells
    Vineet Bhan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Oncol Rep 11:893-7. 2004
    ..A similar effect by paclitaxel on T lymphocytes of breast cancer patients may compromise cell-mediated anti-tumor immune responses...
  33. doi request reprint Generation of a hematologic malignancy-selective membranolytic peptide from the antimicrobial core (RRWQWR) of bovine lactoferricin
    Ashley L Hilchie
    Department of Microbiology and Immunology, Dalhousie University, P O Box 15000, Halifax, Nova Scotia, B3H 4R2, Canada
    Exp Mol Pathol 95:192-8. 2013
    ..We conclude that MPLfcinB6 selectively kills human T-leukemia and B-lymphoma cells by causing extensive and irreparable damage to the cell membrane. ..
  34. doi request reprint Dramatic caspase-dependent apoptosis in antibody-enhanced dengue virus infection of human mast cells
    Michael G Brown
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Leukoc Biol 85:71-80. 2009
    ..Transfection of KU812 cells with L-SIGN/DC-SIGNR was able to overcome the requirement for antibody enhancement with regard to dengue virus infection and apoptosis...
  35. ncbi request reprint Adenosine acts through an A3 receptor to prevent the induction of murine anti-CD3-activated killer T cells
    David W Hoskin
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Int J Cancer 99:386-95. 2002
    ..Adenosine, therefore, acts through an A(3) receptor to prevent AK-T cell induction. Tumor-associated adenosine may act through the same mechanism to impair the development of tumor-reactive T cells in cancer patients...
  36. pmc Bovine lactoferricin inhibits basic fibroblast growth factor- and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells
    Jamie S Mader
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5 Canada
    Am J Pathol 169:1753-66. 2006
    ..These findings suggest that LfcinB may have utility as an antiangiogenic agent for the treatment of human cancers...
  37. ncbi request reprint Adenosine downregulates DPPIV on HT-29 colon cancer cells by stimulating protein tyrosine phosphatase(s) and reducing ERK1/2 activity via a novel pathway
    Ernest Y Tan
    Department of Pharmacology, Faculty of Medicine, Sir Charles Tupper Medical Bldg, Dalhousie University, 1459 Oxford St, Halifax, Nova Scotia, Canada B3H 1X5
    Am J Physiol Cell Physiol 291:C433-44. 2006
    ..This novel action of adenosine has implications for our ability to manipulate adenosine-dependent events within the solid tumor microenvironment...
  38. pmc Piperine, a dietary phytochemical, inhibits angiogenesis
    Carolyn D Doucette
    Department of Pathology, Dalhousie University, Halifax, PO Box 15000, Nova Scotia, Canada
    J Nutr Biochem 24:231-9. 2013
    ..Taken together, these data support the further investigation of piperine as an angiogenesis inhibitor for use in cancer treatment...
  39. ncbi request reprint Bovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing B-lymphoma xenografts
    Suzanne J Furlong
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Mol Pathol 88:371-5. 2010
    ....
  40. ncbi request reprint Paclitaxel inhibits natural killer cell binding to target cells by down-regulating adhesion molecule expression
    Osama Loubani
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Anticancer Res 25:735-41. 2005
    ..Chemotherapy with paclitaxel is associated with impaired natural killer (NK) cell function. The purpose of this study was to determine the effect of paclitaxel treatment on NK cell adherence to target cells...
  41. doi request reprint Murine T cell activation is regulated by surfen (bis-2-methyl-4-amino-quinolyl-6-carbamide)
    Jordan Warford
    Department of Pathology, Dalhousie University, Tupper Building, 5850 College Street, Halifax, Nova Scotia B3H 4R2, Canada Electronic address
    Biochem Biophys Res Commun 443:524-30. 2014
    ..The results imply that endogenous GAGs and proteoglycans play a complex role in promoting or inhibiting different aspects of T cell activation...
  42. ncbi request reprint Apoptosis induced by intracellular ceramide accumulation in MDA-MB-435 breast carcinoma cells is dependent on the generation of reactive oxygen species
    S Y Velda Chan
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Exp Mol Pathol 82:1-11. 2007
    ..Collectively, these findings indicate that strategies to enhance intracellular ceramide accumulation in malignant cells might offer a novel approach to the treatment of breast cancer...
  43. doi request reprint Induction of CD4(+)CD25(+)Foxp3(-) regulatory T cells by Thy-1 stimulation of CD4(+) T cells
    David M Conrad
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Immunol Cell Biol 90:248-52. 2012
    ..We suggest that T(reg) cells induced by Thy-1 ligation in vivo may contribute to the maintenance of T-cell homeostasis...
  44. ncbi request reprint Chemosensitization of T-47D breast carcinoma cells to TRAIL and Fas receptor-induced killing
    Max Morgan
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    Anticancer Res 22:673-6. 2002
    ....
  45. doi request reprint Mast cells down-regulate CD4+CD25+ T regulatory cell suppressor function via histamine H1 receptor interaction
    Nicholas A Forward
    Department of Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Immunol 183:3014-22. 2009
    ..We suggest that histamine released as a result of mast cell activation by microbial products might cause a transient decrease in T(reg) cell suppressor function, thereby enhancing the development of protective immunity...
  46. ncbi request reprint Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen
    Suzanne J Furlong
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Oncol Rep 15:1385-90. 2006
    ..We conclude that combination therapy with LfcinB and tamoxifen warrants further investigation for possible use in the treatment of breast cancer...
  47. ncbi request reprint The use of okadaic acid to elucidate the intracellular role(s) of protein phosphatase 2A: lessons from the mast cell model system
    Robert T M Boudreau
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 University Ave, Halifax, NS B3H 1X5, Canada
    Int Immunopharmacol 5:1507-18. 2005
    ..Results of these studies have contributed to the current recognition that PP2A plays a crucial role in the biology of mast cells and other cell types...
  48. pmc Murine experimental autoimmune encephalomyelitis is diminished by treatment with the angiogenesis inhibitors B20-4.1.1 and angiostatin (K1-3)
    Carolyn J Macmillan
    Department of Pathology, Dalhousie University, Halifax, Nova Scotia, Canada
    PLoS ONE 9:e89770. 2014
    ..We conclude that these angiogenesis inhibitors mitigate EAE by both suppressing spinal cord angiogenesis and reducing peripheral T cell activation. ..
  49. ncbi request reprint Cationic antimicrobial peptides as novel cytotoxic agents for cancer treatment
    Jamie S Mader
    Dalhousie University, Department of Pathology, Faculty of Medicine, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Expert Opin Investig Drugs 15:933-46. 2006
    ..This article reviews the mechanisms by which CAPs exert anticancer activity and discusses the potential application of selected CAPs as therapeutic agents for the treatment of human cancers...
  50. doi request reprint NADPH quinone oxidoreductase 1 mediates breast cancer cell resistance to thymoquinone-induced apoptosis
    Kimberly M Sutton
    Department of Pathology, Dalhousie University, PO Box 15000, Halifax, Nova Scotia, Canada B3H 4R2
    Biochem Biophys Res Commun 426:421-6. 2012
    ..These findings may be clinically important when considering TQ as a possible adjunct treatment for breast cancer since a high percentage of breast tumors express NQO1...
  51. ncbi request reprint Activation-induced expression of cell surface CD28 on mouse T lymphocytes is inhibited by cyclosporine A
    Jared J Butler
    Department of Microbiology, Dalhousie University, Halifax, Canada
    Am J Transplant 2:215-22. 2002
    ....
  52. doi request reprint Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner
    Jane L Watson
    Department of Surgery, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Exp Mol Pathol 84:230-3. 2008
    ..We conclude that curcumin-induced apoptosis in HCT-116 colon cancer cells does not depend on p21 status...
  53. ncbi request reprint Human mast cells induce caspase-independent DNA fragmentation in leukemic T cells
    Sandra J Gallagher
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Oncol Rep 10:1019-23. 2003
    ..Collectively, these data indicate that mast cells trigger caspase-independent apoptosis in leukemic cells via a novel cell-surface molecule, and are consistent with a role for mast cells as anti-tumor effector cells...
  54. ncbi request reprint Reduced tumorigenicity of B16-F10 mouse melanoma cells transfected with mycobacterial antigen 85A
    Jillian P Tarrant
    Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    Int J Oncol 25:1693-9. 2004
    ..Reduced tumor progression by Ag85A-transfected B16-F10 melanoma cells suggests that immunotherapy based on the transient induction of Ag85A expression may be an effective approach for the treatment of cutaneous malignant melanoma...
  55. doi request reprint Bevacizumab diminishes experimental autoimmune encephalomyelitis by inhibiting spinal cord angiogenesis and reducing peripheral T-cell responses
    Carolyn J Macmillan
    Department of Pathology, Microbiology and Immunology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Neuropathol Exp Neurol 71:983-99. 2012
    ..These data indicate that bevacizumab ameliorates vascular and T-cell responses during EAE, but its effects on T cells may be indirect, possibly by suppressing angiogenesis...
  56. ncbi request reprint Phosphatase inhibition potentiates IL-6 production by mast cells in response to FcepsilonRI-mediated activation: involvement of p38 MAPK
    Robert T M Boudreau
    Department of Microbiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Leukoc Biol 76:1075-81. 2004
    ..These data support a role for PP2A through interaction with p38 MAPK in the regulation of IgE-dependent mast cell activation...
  57. ncbi request reprint Adenosine suppresses alpha(4)beta(7) integrin-mediated adhesion of T lymphocytes to colon adenocarcinoma cells
    Willena M MacKenzie
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Exp Cell Res 276:90-100. 2002
    ..We conclude that adenosine partially inhibits the interaction of T lymphocytes with tumor cells by blocking the function of integrin alpha(4)beta(7)...
  58. ncbi request reprint Thymoquinone, a bioactive component of black caraway seeds, causes G1 phase cell cycle arrest and apoptosis in triple-negative breast cancer cells with mutant p53
    Kimberly M Sutton
    a Department of Pathology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
    Nutr Cancer 66:408-18. 2014
    ..Finally, TQ enhanced cisplatin- and docetaxel-induced cytotoxicity. These findings suggest that TQ could be useful in the management of TNBC, even when functional p53 is absent. ..