Andrea L O Hebb

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi Intracerebroventricular D-Pen2, D-Pen5-enkephalin administration soon after stressor imposition influences behavioral responsivity to a subsequent stressor encounter in CD-1 mice
    Andrea L O Hebb
    Laboratory of Molecular Neurobiology, Dalhousie University, Halifax, NS, Canada
    Pharmacol Biochem Behav 82:453-69. 2005
  2. ncbi Central D-Ala2-Met5-enkephalinamide mu/delta-opioid receptor activation reverses the anxiogenic-like properties of cholecystokinin on locomotor and rearing activity in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 970:9-19. 2003
  3. ncbi Central D-Ala2-Met5-enkephalinamide mu/delta-opioid receptor activation blocks behavioral sensitization to cholecystokinin in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Brain Res 970:20-34. 2003
  4. ncbi Exposure of mice to a predator odor increases acoustic startle but does not disrupt the rewarding properties of VTA intracranial self-stimulation
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 982:195-210. 2003
  5. ncbi Differential startle reactivity following central CCK-8S and systemic Boc CCK-4 administration in mice: antecedent stressor history and testing condition
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Neurosci 117:704-15. 2003
  6. ncbi Cholecystokinin and endogenous opioid peptides: interactive influence on pain, cognition, and emotion
    Andrea L O Hebb
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, NS, Canada B3H 1X5
    Prog Neuropsychopharmacol Biol Psychiatry 29:1225-38. 2005
  7. ncbi Human kallikrein 6 cerebrospinal levels are elevated in multiple sclerosis
    Andrea L O Hebb
    Department of Pharmacology, Dalhousie University, Halifax, NS B3H 1X5, Canada
    Curr Drug Discov Technol 7:137-40. 2010
  8. ncbi Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Eur J Neurosci 20:2415-29. 2004
  9. doi Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE)
    Craig S Moore
    Department of Pharmacology, Dalhousie University, Faculty of Medicine, Sir Charles Tupper Building, 5850 College Street, Halifax, NS, Canada B3H 1X5
    J Neuroimmunol 203:79-93. 2008
  10. ncbi Odor-induced variation in anxiety-like behavior in mice is associated with discrete and differential effects on mesocorticolimbic cholecystokinin mRNA expression
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Neuropsychopharmacology 27:744-55. 2002

Collaborators

Detail Information

Publications15

  1. ncbi Intracerebroventricular D-Pen2, D-Pen5-enkephalin administration soon after stressor imposition influences behavioral responsivity to a subsequent stressor encounter in CD-1 mice
    Andrea L O Hebb
    Laboratory of Molecular Neurobiology, Dalhousie University, Halifax, NS, Canada
    Pharmacol Biochem Behav 82:453-69. 2005
    ..Finally, our investigation demonstrates that DPDPE administration alters the behavioral impact of future stressful encounters and emphasizes the importance of investigating opioid mechanisms in chronic stress disorders...
  2. ncbi Central D-Ala2-Met5-enkephalinamide mu/delta-opioid receptor activation reverses the anxiogenic-like properties of cholecystokinin on locomotor and rearing activity in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 970:9-19. 2003
    ..These data imply that while CCK induces relatively protracted behavioral disturbances, mu/delta receptor activation may change the course of psychopathology...
  3. ncbi Central D-Ala2-Met5-enkephalinamide mu/delta-opioid receptor activation blocks behavioral sensitization to cholecystokinin in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ont, Canada
    Brain Res 970:20-34. 2003
    ..These data imply that while CCK induces relatively protracted and exaggerated behavioral disturbances, mu/delta opioid-receptor activation may block CCK-induced behavioral sensitization and change the course of psychopathology...
  4. ncbi Exposure of mice to a predator odor increases acoustic startle but does not disrupt the rewarding properties of VTA intracranial self-stimulation
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Brain Res 982:195-210. 2003
    ..Moreover, the anxiogenic properties of psychogenic stressors can be separated from their anhedonic effects. The implications of these data for clinical psychopathology are discussed...
  5. ncbi Differential startle reactivity following central CCK-8S and systemic Boc CCK-4 administration in mice: antecedent stressor history and testing condition
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Behav Neurosci 117:704-15. 2003
    ..Results demonstrate that antecedent environmental experiences interact with subsequent pharmacological challenges in provoking the temporal expression of alterations in startle magnitude...
  6. ncbi Cholecystokinin and endogenous opioid peptides: interactive influence on pain, cognition, and emotion
    Andrea L O Hebb
    Department of Pharmacology, Faculty of Medicine, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, NS, Canada B3H 1X5
    Prog Neuropsychopharmacol Biol Psychiatry 29:1225-38. 2005
    ....
  7. ncbi Human kallikrein 6 cerebrospinal levels are elevated in multiple sclerosis
    Andrea L O Hebb
    Department of Pharmacology, Dalhousie University, Halifax, NS B3H 1X5, Canada
    Curr Drug Discov Technol 7:137-40. 2010
    ..5 ng/ml). Determining CSF concentrations of human kallikrein-related peptidase 6 may therefore have diagnostic value in MS...
  8. ncbi Brief exposure to predator odor and resultant anxiety enhances mesocorticolimbic activity and enkephalin expression in CD-1 mice
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Eur J Neurosci 20:2415-29. 2004
    ..Indeed, increased ENK availability in mesolimbic sites may promote behavioral responses that detract from the aversiveness of the stressor experience...
  9. doi Increased X-linked inhibitor of apoptosis protein (XIAP) expression exacerbates experimental autoimmune encephalomyelitis (EAE)
    Craig S Moore
    Department of Pharmacology, Dalhousie University, Faculty of Medicine, Sir Charles Tupper Building, 5850 College Street, Halifax, NS, Canada B3H 1X5
    J Neuroimmunol 203:79-93. 2008
    ..This work identifies XIAP is an important apoptotic regulator in EAE and a potential pharmacological target for treating autoimmune diseases such as MS...
  10. ncbi Odor-induced variation in anxiety-like behavior in mice is associated with discrete and differential effects on mesocorticolimbic cholecystokinin mRNA expression
    Andrea L O Hebb
    Institute of Neuroscience, Carleton University, Ottawa, Ontario, Canada
    Neuropsychopharmacology 27:744-55. 2002
    ..The differential pattern of CCK mRNA associated with discrete psychogenic stressor manipulations and the provocation of anxiety-like behavior associated with such experiences is discussed...
  11. ncbi Targeting apoptosis to treat multiple sclerosis
    Andrea L O Hebb
    Department of Pharmacology, Dalhousie University, 5850 College Street, Halifax, NS B3H 1X5, Canada
    Curr Drug Discov Technol 5:75-7. 2008
    ....
  12. ncbi PDEs as drug targets for CNS immune disorders
    Andrea L O Hebb
    Dalhousie University, Faculty of Medicine, Department of Pharmacology, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia, B3H 1X5, Canada
    Curr Opin Investig Drugs 9:744-53. 2008
    ....
  13. pmc Effects of IFN-B on TRAIL and Decoy Receptor Expression in Different Immune Cell Populations from MS Patients with Distinct Disease Subtypes
    Andrea L O Hebb
    Department of Pharmacology, Dalhousie University, Halifax, NS, Canada B3H 1X5
    Autoimmune Dis 2011:485752. 2010
    ..Although our findings suggest altered TRAIL signaling may play a role in MS pathogenesis and IFN-β therapy, they do not support use of TRAIL as a surrogate marker for clinical responsiveness to this therapeutic...
  14. ncbi Inhibitor of apoptosis protein (IAP) profiling in experimental autoimmune encephalomyelitis (EAE) implicates increased XIAP in T lymphocytes
    Craig S Moore
    Department of Pharmacology, Dalhousie University, Faculty of Medicine, Sir Charles Tupper Building, 5850 College Street, Halifax NS Canada B3H 1X5
    J Neuroimmunol 193:94-105. 2008
    ..Increased XIAP expression in T cells within areas of demyelination in the CNS suggests that XIAP may be enhancing cell survival and thereby contributing to disease pathology...
  15. ncbi Phosphodiesterase 10A inhibition is associated with locomotor and cognitive deficits and increased anxiety in mice
    Andrea L O Hebb
    Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
    Eur Neuropsychopharmacol 18:339-63. 2008
    ..The unique localization of PDE10A and its apparent role in basal ganglia function may underlie its role in psychiatric and neurological disorders involving the basal ganglia...