S A Halperin

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. doi request reprint Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial
    Matthew D Snape
    Oxford Vaccine Group, University of Oxford, England
    JAMA 299:173-84. 2008
  2. pmc A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine
    Joanne M Langley
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
    BMC Infect Dis 12:279. 2012
  3. pmc Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals
    Andrew McDermid
    National Microbiology Laboratory, Winnipeg, Canada
    BMC Infect Dis 12:306. 2012
  4. doi request reprint Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Nova Scotia, Canada
    Vaccine 30:5445-8. 2012
  5. pmc Challenges to immunization: the experiences of homeless youth
    Alexander Doroshenko
    Department of Pediatrics, Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Public Health 12:338. 2012
  6. doi request reprint The changing and dynamic epidemiology of meningococcal disease
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, The IWK Health Centre, and Capital Health, Halifax, Canada
    Vaccine 30:B26-36. 2012
  7. doi request reprint Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adul
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Canada
    Vaccine 30:2556-63. 2012
  8. doi request reprint Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, NS, Canada
    Vaccine 30:974-82. 2012
  9. pmc Has the change to acellular pertussis vaccine improved or worsened pertussis control?
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, NS
    CMAJ 175:1227. 2006
  10. ncbi request reprint Canadian Association for Immunization Research and Evaluation (CAIRE) guidelines for industry-sponsored clinical trial and epidemiology contract research
    Scott A Halperin
    CAIRE Research Sponsor Advisory Board, Halifax, Nova Scotia
    Hum Vaccin 1:140-2. 2005

Detail Information

Publications91

  1. doi request reprint Immunogenicity of a tetravalent meningococcal glycoconjugate vaccine in infants: a randomized controlled trial
    Matthew D Snape
    Oxford Vaccine Group, University of Oxford, England
    JAMA 299:173-84. 2008
    ..However, the currently licensed vaccine is poorly immunogenic in infancy, when the highest rates of disease are observed...
  2. pmc A randomized, controlled non-inferiority trial comparing A(H1N1)pmd09 vaccine antigen, with and without AS03 adjuvant system, co-administered or sequentially administered with an inactivated trivalent seasonal influenza vaccine
    Joanne M Langley
    Canadian Center for Vaccinology, IWK Health Centre, Capital District Health Authority and Dalhousie University, 5850 University Avenue, Halifax, NS, Canada
    BMC Infect Dis 12:279. 2012
    ..At the time of the influenza A(H1N1)pmd09 pandemic it was not known if concurrent or sequential administration of seasonal trivalent influenza vaccine (TIV) with pandemic vaccine was preferred...
  3. pmc Molecular characterization of rotavirus isolates from select Canadian pediatric hospitals
    Andrew McDermid
    National Microbiology Laboratory, Winnipeg, Canada
    BMC Infect Dis 12:306. 2012
    ..Secondly we identified rotavirus strains that differed genetically from those included in the vaccines and which could affect vaccine effectiveness...
  4. doi request reprint Safety and immunogenicity of different two-dose regimens of an investigational hepatitis B vaccine (hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide) in healthy young adults
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Nova Scotia, Canada
    Vaccine 30:5445-8. 2012
    ..A more rapid schedule with a 4-week interval could provide earlier protection and potentially greater compliance...
  5. pmc Challenges to immunization: the experiences of homeless youth
    Alexander Doroshenko
    Department of Pediatrics, Canadian Center for Vaccinology, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Public Health 12:338. 2012
    ..Early departure from school and limited access to public health services makes them a particularly vulnerable high-risk group. This study explores challenges to obtaining essential vaccines experienced by homeless youth...
  6. doi request reprint The changing and dynamic epidemiology of meningococcal disease
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, The IWK Health Centre, and Capital Health, Halifax, Canada
    Vaccine 30:B26-36. 2012
    ..Continued surveillance of meningococcal disease is essential; ongoing global efforts to improve the completeness of reporting are required...
  7. doi request reprint Comparison of safety and immunogenicity of two doses of investigational hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligodeoxyribonucleotide and three doses of a licensed hepatitis B vaccine in healthy adul
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, Canada
    Vaccine 30:2556-63. 2012
    ....
  8. doi request reprint Immune responses in adults to revaccination with a tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine 10 years after a previous dose
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, IWK Health Centre, and Capital Health, Halifax, NS, Canada
    Vaccine 30:974-82. 2012
    ..Although decennial adult boosters of tetanus and diphtheria toxoids are recommended in Canada and the United States, a second dose of pertussis vaccine during adulthood is not currently recommended...
  9. pmc Has the change to acellular pertussis vaccine improved or worsened pertussis control?
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, NS
    CMAJ 175:1227. 2006
  10. ncbi request reprint Canadian Association for Immunization Research and Evaluation (CAIRE) guidelines for industry-sponsored clinical trial and epidemiology contract research
    Scott A Halperin
    CAIRE Research Sponsor Advisory Board, Halifax, Nova Scotia
    Hum Vaccin 1:140-2. 2005
    ..Topics addressed include definition of investigators, data ownership, protocol development, data management, data analysis, producing a study report and publication of the results of the study...
  11. doi request reprint Safety and immunogenicity of an investigational quadrivalent meningococcal conjugate vaccine after one or two doses given to infants and toddlers
    S A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, NS, B3K 6R8, Canada
    Eur J Clin Microbiol Infect Dis 29:259-67. 2010
    ..Serogroup C titers were comparable following a single dose of MenACWY-CRM or MenC at 12 months. MenACWY-CRM is well tolerated and immunogenic given at 12 months, or two doses at 6 and 12 months of age...
  12. ncbi request reprint Safety and immunogenicity of two formulations of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae conjugate-hepatitis B vaccine in 15 to 18-month-old children
    Scott A Halperin
    Clinical Trials Research Center, IWK Health Centre and Dalhousie University, Halifax, Nova Scotia, Canada
    Hum Vaccin 1:245-50. 2005
    ..8 microg/mL in PRP-T/HBV10 recipients and 9.4 microg/mL in PRP-OMPC/HBV15 recipients. We conclude that the hexavalent formulations appear generally well tolerated and immunogenic as a booster dose in these toddlers...
  13. ncbi request reprint Phase I, randomized, controlled trial to study the reactogenicity and immunogenicity of a nasal, inactivated trivalent influenza virus vaccine in healthy adults
    Scott A Halperin
    Dalhousie University, Halifax, Nova Scotia, Canada
    Hum Vaccin 1:37-42. 2005
    ..We conclude that this trivalent, split virion, inactivated nasal influenza vaccine formulated with lipid/polysaccharide molecule carriers is well tolerated and modestly immunogenic in healthy adults...
  14. ncbi request reprint Phase 1 first-in-human studies of the reactogenicity and immunogenicity of a recombinant meningococcal NspA vaccine in healthy adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, The IWK Health Centre, Halifax, NS, Canada
    Vaccine 25:450-7. 2007
    ....
  15. ncbi request reprint Canadian experience with implementation of an acellular pertussis vaccine booster-dose program in adolescents: implications for the United States
    Scott A Halperin
    Dalhousie University, IWK Health Centre, Halifax, Nova Scotia B3K 6R8, Canada
    Pediatr Infect Dis J 24:S141-6. 2005
    ..In Canada, the epidemiology of pertussis has changed during the past decade such that more cases occur in adolescents than in any other age cohort...
  16. ncbi request reprint Comparison of the safety and immunogenicity of hepatitis B virus surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide and a licensed hepatitis B vaccine in healthy young adults
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 5980 University Avenue, Halifax, NS, Canada B3K 6R8
    Vaccine 24:20-6. 2006
    ..Many individuals do not respond to a three-dose series of hepatitis B vaccine (HBV) and most do not achieve a protective antibody response until after dose 2 or 3...
  17. doi request reprint Safety and immunogenicity of a measles-mumps-rubella-varicella vaccine given as a second dose in children up to six years of age
    Scott A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
    Vaccine 27:2701-6. 2009
    ..In children primed with MMR and varicella vaccine, MMRV had non-inferior immunogenicity and similar safety profiles as a second dose of licensed MMR and varicella vaccine administered concomitantly...
  18. doi request reprint Safety and immunogenicity of a hexavalent diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae b conjugate-hepatitis B vaccine at 2, 3, 4, and 12-14 months of age
    Scott A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada
    Vaccine 27:2540-7. 2009
    ..All vaccine formulations were well tolerated. The three PRP-OMPC formulations met prespecified immunogenicity criteria, and the one with the lowest PRP-OMPC concentration was selected for further optimization of immunogenicity...
  19. doi request reprint Comparison of the safety and immunogenicity of an investigational and a licensed quadrivalent meningococcal conjugate vaccine in children 2-10 years of age
    Scott A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
    Vaccine 28:7865-72. 2010
    ....
  20. ncbi request reprint Prevention of pertussis across the age spectrum through the use of the combination vaccines PENTACEL and ADACEL
    Scott A Halperin
    Dalhousie University, Canadian Centre for Vaccinology, Departments of Pediatrics and Microbiology and Immunology, IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, B3K 6R8, Canada
    Expert Opin Biol Ther 6:807-21. 2006
    ..These products have been demonstrated to be safe, immunogenic and effective for the control of pertussis and the other included diseases...
  21. doi request reprint Tolerability and antibody response in adolescents and adults revaccinated with tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis vaccine adsorbed (Tdap) 4-5 years after a previous dose
    Scott A Halperin
    Canadian Center for Vaccinology, Dalhousie University, Halifax, NS, Canada
    Vaccine 29:8459-65. 2011
    ..Although decennial adult boosters of tetanus and diphtheria toxoids are recommended in Canada and the United States, a second dose of pertussis vaccine is not currently recommended for adults...
  22. ncbi request reprint Is pertussis immune globulin efficacious for the treatment of hospitalized infants with pertussis? No answer yet
    Scott A Halperin
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 26:79-81. 2007
    ..Although well tolerated, there was no difference in the number or rate of improvement of symptoms (paroxysmal cough, whoop, apnea, bradycardia, oxygen desaturations) in P-IGIV recipients compared with placebo...
  23. ncbi request reprint Interchangeability of two diphtheria and tetanus toxoids, acellular pertussis, inactivated poliovirus, Haemophilus influenzae type b conjugate vaccines as a fourth dose in 15-20-month-old toddlers
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 5980 University Avenue, Halifax, Nova Scotia, Canada B3K 6R8
    Vaccine 24:4017-23. 2006
    ..Recently, another DTaP-IPV-Hib (Infanrix-IPV-Hib) became available. Data on the interchangeability of these products was lacking...
  24. ncbi request reprint How soon after a prior tetanus-diphtheria vaccination can one give adult formulation tetanus-diphtheria-acellular pertussis vaccine?
    Scott A Halperin
    Department of Pediatrics, Dalhousie University, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 25:195-200. 2006
    ....
  25. ncbi request reprint Comparison of a fifth dose of a five-component acellular or a whole cell pertussis vaccine in children four to six years of age
    S A Halperin
    Dalhousie University, Halifax, Canada
    Pediatr Infect Dis J 18:772-9. 1999
    ..This study compared a fifth dose of an acellular and a whole cell pertussis vaccine in 4- to 6-year-old children previously immunized with four doses of acellular or whole cell pertussis vaccine...
  26. pmc Immunogenicity and protective efficacy of a recombinant filamentous haemagglutinin from Bordetella pertussis
    J B Knight
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada
    Clin Exp Immunol 144:543-51. 2006
    ..pertussis in BALB/c mice. These data indicate that the type I domain of FHA is a protective antigen in mice and may serve as a candidate for inclusion in new acellular pertussis vaccines...
  27. ncbi request reprint Expression of a pertussis toxin S1 fragment by inducible promoters in oral Streptococcus and the induction of immune responses during oral colonization in mice
    P P Mallaley
    Department of Microbiology and Immunology, Faculty of Medicine, Halifax, Canada
    Can J Microbiol 52:436-44. 2006
    ..mutans PM14 showed a decreased in B. pertussis lung colony count (P = 0.03) on day 3 compared with control mice colonized by the parent S. mutans 834...
  28. ncbi request reprint An adult formulation of a five-component acellular pertussis vaccine combined with diphtheria and tetanus toxoids is safe and immunogenic in adolescents and adults
    S A Halperin
    Departments of Pediatrics, Clinical Trials Research Center, Dalhousie University and the IWK Grace Health Centre, 5850 University Avenue, Halifax, Canada
    Vaccine 18:1312-9. 2000
    ..We conclude that this adult formulation 5-component acellular pertussis vaccine is safe and immunogenic in adolescents and adults and is a candidate vaccine for adolescent and adult immunization programs...
  29. ncbi request reprint Safety and immunogenicity of Haemophilus influenzae-tetanus toxoid conjugate vaccine given separately or in combination with a three-component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine for
    S A Halperin
    Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, Canada
    Clin Infect Dis 28:995-1001. 1999
    ..influenzae type b polysaccharide after the primary three-dose series, mixing of the vaccines in a single syringe likely induced immunologic priming, as suggested by the high antibody levels after the booster dose...
  30. ncbi request reprint Seven days of erythromycin estolate is as effective as fourteen days for the treatment of Bordetella pertussis infections
    S A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, Canada
    Pediatrics 100:65-71. 1997
    ..B pertussis-specific antibodies were measured before treatment and 1 month later. Information about clinical symptoms, adverse reactions, and compliance were collected at each scheduled contact...
  31. pmc Surface expression of a protective recombinant pertussis toxin S1 subunit fragment in Streptococcus gordonii
    S F Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Infect Immun 67:1511-6. 1999
    ..In conclusion, a fragment of the S1 subunit of PT was successfully surface expressed in S. gordonii; the recombinant S1 fragment was found to be immunogenic and could induce protection against the toxic effect of PT in mice...
  32. ncbi request reprint Adult formulation of a five component acellular pertussis vaccine combined with diphtheria and tetanus toxoids and inactivated poliovirus vaccine is safe and immunogenic in adolescents and adults
    S A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 19:276-83. 2000
    ..Pertussis is increasingly recognized as an important cause of cough illness in adolescents and adults...
  33. ncbi request reprint Simultaneous administration of meningococcal C conjugate vaccine and diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate vaccine in children: a randomized double-blind study
    Scott A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, NS
    Clin Invest Med 25:243-51. 2002
    ..The objective of this study was to measure the safety and immunogenicity of a meningococcal C conjugate vaccine when given with routine childhood vaccines...
  34. doi request reprint Pediatric combined formulation DTaP-IPV/Hib vaccine
    Craig White
    Canadian Center for Vaccinology, Canada
    Expert Rev Vaccines 8:831-40. 2009
    ..This article summarizes the available safety, immunogenicity and effectiveness data of this combination vaccine and provides a brief review of future trends in combination vaccine use...
  35. pmc Improved efficacy of a licensed acellular pertussis vaccine, reformulated in an adjuvant emulsion of liposomes in oil, in a murine model
    Marc Mansour
    ImmunoVaccine Technologies Inc, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Vaccine Immunol 14:1381-3. 2007
    ....
  36. ncbi request reprint The control of pertussis--2007 and beyond
    Scott A Halperin
    Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    N Engl J Med 356:110-3. 2007
  37. ncbi request reprint Epidemiological features of pertussis in hospitalized patients in Canada, 1991-1997: report of the Immunization Monitoring Program--Active (IMPACT)
    S A Halperin
    Department of Pediatrics, Dalhousie University, IWK Grace Health Centre, Halifax, Nova Scotia, Canada
    Clin Infect Dis 28:1238-43. 1999
    ..2% vs. 4.9%; P = .001) in infants under <6 months of age than in those > or =6 months. Pertussis continues to cause significant morbidity and occasional mortality in Canada, particularly in young infants...
  38. ncbi request reprint A randomized, placebo-controlled trial of erythromycin estolate chemoprophylaxis for household contacts of children with culture-positive bordetella pertussis infection
    S A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Grace Health Centre, Halifax, Nova Scotia, B3J 3G9 Canada E mail
    Pediatrics 104:e42. 1999
    ..Although epidemiologic investigations of outbreaks have suggested a benefit, there have been no prospective studies evaluating the efficacy of chemoprophylaxis in preventing secondary cases of pertussis...
  39. ncbi request reprint Nature, evolution, and appraisal of adverse events and antibody response associated with the fifth consecutive dose of a five-component acellular pertussis-based combination vaccine
    Scott A Halperin
    Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 University Avenue, 8 West Research, Halifax, NS, Canada B3J 3G9
    Vaccine 21:2298-306. 2003
    ..However, parents will still need to be aware of the high rates of injection site reactions expected after a fifth dose of acellular pertussis vaccine...
  40. ncbi request reprint Comparison of the safety and immunogenicity of concomitant and sequential administration of an adult formulation tetanus and diphtheria toxoids adsorbed combined with acellular pertussis (Tdap) vaccine and trivalent inactivated influenza vaccine in adults
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre and QEII Health Sciences Centre, Dalhousie University, 5850 5980 University Avenue, Halifax, NS B3K 6R8, Canada
    Vaccine 25:3464-74. 2007
    ....
  41. doi request reprint Kinetics of the antibody response to tetanus-diphtheria-acellular pertussis vaccine in women of childbearing age and postpartum women
    B A Halperin
    Clinical Trials Research Center, Canadian Center for Vaccinology, Canada
    Clin Infect Dis 53:885-92. 2011
    ..We sought to determine whether the antibody response to tetanus-diphtheria-acellular pertussis vaccine (Tdap) is sufficiently rapid to support the cocoon strategy...
  42. ncbi request reprint Expression of diphtheria toxin in Streptococcus mutans and induction of toxin-neutralizing antisera
    C W Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, NS, Canada
    Can J Microbiol 51:841-6. 2005
    ..The potential of using S. gordonii as a live vaccine against diphtheria faces major challenges in the expression of DTX in this organism and in the induction of high-titer toxin-neutralizing antibodies...
  43. doi request reprint Overcoming codon-usage bias in heterologous protein expression in Streptococcus gordonii
    Song F Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, NS, Canada
    Microbiology 155:3581-8. 2009
    ..and the limitation of heterologous protein expression caused by codon-usage bias can be overcome by tRNA supplementation...
  44. ncbi request reprint Outbreak of atypical pertussis detected by polymerase chain reaction in immunized preschool-aged children
    Valerie Waters
    Division of Infectious Diseases, Department of Pediatrics, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Pediatr Infect Dis J 28:582-7. 2009
    ..A case-control study in children was done to identify the risk factors for being positive for Bordetella pertussis by polymerase chain reaction (PCR)...
  45. ncbi request reprint An adolescent-adult formulation tetanus and diptheria toxoids adsorbed combined with acellular pertussis vaccine has comparable immunogenicity but less reactogenicity in children 4-6 years of age than a pediatric formulation acellular pertussis vaccine an
    Joanne M Langley
    Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 25:1121-5. 2007
    ..Fever and injection site reactions are less common in 4-6 year-old-children who receive a dTap vaccine compared to DTaP-IPV, without inferior immunogenicity...
  46. ncbi request reprint Use of lidocaine-prilocaine patch to decrease intramuscular injection pain does not adversely affect the antibody response to diphtheria-tetanus-acellular pertussis-inactivated poliovirus-Haemophilus influenzae type b conjugate and hepatitis B vaccines in
    Beth A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, Nova Scotia, Canada
    Pediatr Infect Dis J 21:399-405. 2002
    ....
  47. ncbi request reprint Safety and immunogenicity of a Proteosome -trivalent inactivated influenza vaccine, given nasally to healthy adults
    Joanne M Langley
    Division of Infectious Diseases, Department of Pediatrics, Dalhousie University, Halifax, NS, Canada
    Vaccine 24:1601-8. 2006
    ..Further testing of this nasal influenza vaccine is warranted to determine its safety and immunogenicity in these populations and its efficacy in the prevention of clinical illness...
  48. pmc Safety and immunoenhancing effect of a Chlorella-derived dietary supplement in healthy adults undergoing influenza vaccination: randomized, double-blind, placebo-controlled trial
    Scott A Halperin
    Department of Pediatrics, Dalhousie University and the IWK Health Centre, Halifax, NS
    CMAJ 169:111-7. 2003
    ..We evaluated the effect of an oral dietary supplement derived from the edible microalga Chlorella pyrenoidosa on immune response after influenza vaccination...
  49. ncbi request reprint A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    Scott A Halperin
    Department of Pediatrics, Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 University Avenue, Halifax, NS, Canada B3J 3G9
    Vaccine 21:2461-7. 2003
    ....
  50. ncbi request reprint Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis
    Joanne M Langley
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Canada
    Pediatrics 114:e96-101. 2004
    ..We compared the safety and efficacy of erythromycin with azithromycin for treatment of pertussis in a large, randomized, controlled trial that enrolled children from primary care practices in 1 American and 11 Canadian urban centers...
  51. pmc Expression and immunogenicity of a recombinant diphtheria toxin fragment A in Streptococcus gordonii
    Chiang W Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia B3H 3J5, Canada
    Appl Environ Microbiol 70:4569-74. 2004
    ..The antisera failed to neutralize diphtheria toxin cytotoxicity in a Vero cell assay...
  52. pmc Mucosal immunization with a genetically engineered pertussis toxin S1 fragment-cholera toxin subunit B chimeric protein
    Song F Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Infect Immun 71:2272-5. 2003
    ..01) from that of the sham control group. Thus, a divalent S1 fragment CtxA2B chimera is an immunogenic antigen and can elicit a protective immunity...
  53. pmc Purification and immunogenicity of a recombinant Bordetella pertussis S1S3FHA fusion protein expressed by Streptococcus gordonii
    Song F Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Appl Environ Microbiol 68:4253-8. 2002
    ..gordonii and that the fusion protein is immunogenic. This multivalent fusion protein approach may be used in designing a new generation of acellular pertussis vaccines...
  54. ncbi request reprint A pilot study to quantify parental anxiety associated with enrollment of an infant or toddler in a phase III vaccine trial
    Joanne M Langley
    Clinical Trials Research Center, Dalhousie University and the IWK Health Centre, 5850 University Avenue, Halifax, Canada NS B3J 3G9
    Vaccine 21:3863-6. 2003
    ..These factors should be considered by vaccine researchers in the recruitment process of clinical trials...
  55. ncbi request reprint History of penicillin allergy and referral for skin testing: evaluation of a pediatric penicillin allergy testing program
    Joanne M Langley
    Clin Invest Med 25:181-4. 2002
    ..Penicillin allergy, commonly reported in children, leads to use of more expensive, broad-spectrum drugs. The results and effectiveness of a skin testing program for immediate hypersensitivity to penicillin in children were studied...
  56. pmc Role of the cell wall microenvironment in expression of a heterologous SpaP-S1 fusion protein by Streptococcus gordonii
    Elisabeth Davis
    Dept of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Appl Environ Microbiol 77:1660-6. 2011
    ..gordonii and that this modulation is mediated by the level of PrsA, whose expression is regulated by the LiaSR two-component regulatory system...
  57. ncbi request reprint Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers
    Shelly A McNeil
    Clinical Trials Research Center, IWK Health Centre, Dalhousie University, Halifax, Nova Scotia, Canada
    Clin Infect Dis 41:1114-22. 2005
    ..New molecular techniques have allowed the previous obstacles to be largely overcome...
  58. doi request reprint Differential activation of dendritic cells by Toll-like receptor agonists isolated from the Gram-positive vaccine vector Streptococcus gordonii
    M L Mayer
    Canadian Center for Vaccinology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Scand J Immunol 69:351-6. 2009
    ..gordonii activates DC predominantly through a MyD88-dependent and TRIF-independent pathway. This activation can be attributed to multiple immunostimulatory components present within S. gordonii bacterial cells...
  59. doi request reprint Expression of the Streptococcus mutans essential two-component regulatory system VicRK is pH and growth-phase dependent and controlled by the LiaFSR three-component regulatory system
    Yannick D N Tremblay
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada
    Microbiology 155:2856-65. 2009
    ..In conclusion, the expression of vicRKX is influenced by culture pH, growth phase and antibiotic stress, and is regulated by LiaFRS...
  60. ncbi request reprint Safety and immunogenicity of a trivalent, inactivated, mammalian cell culture-derived influenza vaccine in healthy adults, seniors, and children
    Scott A Halperin
    Department of Pediatrics, Clinical Trials Research Center, Dalhousie University, IWK Health Centre, 5850 University Avenue, NS, B3J 3G9, Halifax, Canada
    Vaccine 20:1240-7. 2002
    ..We conclude that the cell culture-derived vaccine was safe and immunogenic in children, healthy adults and seniors...
  61. doi request reprint Pertussis immunization in paediatric healthcare workers: knowledge, attitudes, beliefs, and behaviour
    Karina A Top
    Department of Pediatrics, Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada
    Vaccine 28:2169-73. 2010
    ..There is a widespread acceptance of pertussis immunization among paediatric HCWs. Stated intentions may be poorly predictive of behaviour. Education and institutional or public funding may improve vaccine uptake...
  62. ncbi request reprint Oral colonization and immune responses to Streptococcus gordonii expressing a pertussis toxin S1 fragment in mice
    Song F Lee
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    FEMS Microbiol Lett 208:175-8. 2002
    ..In conclusion, long-term oral colonization of BALB/c mice with our recombinant S. gordonii was established and the colonization elicited mucosal antibodies against PT and SpaP...
  63. ncbi request reprint Expression and purification of a trivalent pertussis toxin-diphtheria toxin-tetanus toxin fusion protein in Escherichia coli
    Mahdi Aminian
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, NS, Canada B3H 3J5
    Protein Expr Purif 51:170-8. 2007
    ..Antisera generated against the purified PDT protein recognized the native toxins indicating that some, if not all, of the native epitopes were conserved...
  64. pmc Role of D-alanylation of Streptococcus gordonii lipoteichoic acid in innate and adaptive immunity
    Karenn G Chan
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University, Halifax, Nova Scotia B3H 3J5, Canada
    Infect Immun 75:3033-42. 2007
    ..These results show that d-alanylation of LTA in S. gordonii plays a role in the interaction with the host immune system by contributing to the relative resistance to host defense peptides and by modulating cytokine production by DCs...
  65. pmc Expression of a functional single-chain variable-fragment antibody against complement receptor 1 in Streptococcus gordonii
    Jennifer B Knight
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada B3H 3J5
    Clin Vaccine Immunol 15:925-31. 2008
    ..Mice orally colonized by the anti-CR1-secreting S. gordonii produced an anti-HA IgG immune response, indicating that such an approach can be used to increase the immune response to antigens produced by this bacterium...
  66. doi request reprint Trivalent MDCK cell culture-derived influenza vaccine Optaflu (Novartis Vaccines)
    Alexander Doroshenko
    Canadian Center for Vaccinology, Departments of Pediatrics, Dalhousie University and IWK Health Centre, Halifax, Nova Scotia, Canada
    Expert Rev Vaccines 8:679-88. 2009
    ....
  67. doi request reprint Synergistic BM-DC activation and immune induction by the oral vaccine vector Streptococcus gordonii and exogenous tumor necrosis factor
    Matthew L Mayer
    Department of Microbiology and Immunology, Faculty of Medicine, Dalhousie University and the IWK Health Centre, Halifax, NS, Canada
    Mol Immunol 46:1883-91. 2009
    ..These findings collectively demonstrate that TNF is able to prime BM-DCs to better respond to S. gordonii, through a mechanism at least partially involving TLR-2 upregulation...
  68. ncbi request reprint Group B streptococcal testing during pregnancy: survey of postpartum women and audit of current prenatal screening practices
    Laura Youden
    Faculty of Medicine, Dalhousie University, Halifax NS
    J Obstet Gynaecol Can 27:1006-12. 2005
    ..The objective of this study was to determine the level of compliance with GBS testing recommendations and to determine women's knowledge of, attitudes towards, and beliefs about prenatal screening for this infection...
  69. ncbi request reprint Immunologic considerations for the timing of the booster dose of 7-valent pneumococcal conjugate vaccine in young children
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, BC, Canada
    Pediatr Infect Dis J 26:387-92. 2007
    ....
  70. ncbi request reprint Immunization Monitoring Program, Active: a model of active surveillance of vaccine safety
    David W Scheifele
    Immunization Monitoring Program, Active IMPACT, Ottawa, Ontario, Canada
    Semin Pediatr Infect Dis 14:213-9. 2003
    ..Concomitant disease surveillance has been important for sustaining the surveillance system because few postimmunization adverse events require hospital admission...
  71. doi request reprint Ongoing control of Haemophilus influenzae type B infections in Canadian children, 2004-2007
    David W Scheifele
    Division of Pediatric Infectious and Immunologic Diseases, University of British Columbia, Vancouver, British Columbia
    Pediatr Infect Dis J 27:755-7. 2008
    ..Surveillance at 12 pediatric centers in 2004-2007 indicates that vaccine failures remain rare and case totals approach an irreducible minimum, with no age shift...
  72. ncbi request reprint Population-based epidemiology of invasive pneumococcal infection in children in nine urban centers in Canada, 1994 through 1998
    Gordean L Bjornson
    Vaccine Evaluation Center, University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 21:947-50. 2002
    ..To describe the epidemiology of invasive pneumococcal infections in Canadian children 0 to 12 years old...
  73. pmc Pertussis control in Canada
    Scott A Halperin
    CMAJ 168:1389-90. 2003
  74. ncbi request reprint The changing age and seasonal profile of pertussis in Canada
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Epidemiology Services, Vancouver, British Columbia, Canada V5Z 4R4
    J Infect Dis 185:1448-53. 2002
    ....
  75. ncbi request reprint Predictors of death in infants hospitalized with pertussis: a case-control study of 16 pertussis deaths in Canada
    Lynda K Mikelova
    J Pediatr 143:576-81. 2003
    ..To describe the clinical course of fatal cases of pertussis and identify predictors of death at the time of presentation for medical care...
  76. ncbi request reprint Assessment of the compatibility of co-administered 7-valent pneumococcal conjugate, DTaP.IPV/PRP-T Hib and hepatitis B vaccines in infants 2-7 months of age
    David W Scheifele
    Vaccine Evaluation Center, BC Children s Hospital, 4500 Oak Street, Vancouver, BC, Canada V6H 3N1
    Vaccine 24:2057-64. 2006
    ..008) and HB responses were reduced (p=0.006) with concurrent dosing, the latter possibly from same thigh injection with DTaP.IPV/Hib. We conclude that PCV7, DTaP.IPV/Hib and HB are compatible with concurrent, separate injections...
  77. ncbi request reprint Surveillance for influenza admissions among children hospitalized in Canadian immunization monitoring program active centers, 2003-2004
    Dorothy L Moore
    Infectious Diseases Division, Montreal Children s Hospital, McGill University Health Centre, Montreal, Quebec, Canada
    Pediatrics 118:e610-9. 2006
    ....
  78. ncbi request reprint Pertussis--a disease and vaccine for all ages
    Scott A Halperin
    N Engl J Med 353:1615-7. 2005
  79. pmc Polymorphisms of the fimbria fim3 gene of Bordetella pertussis strains isolated in Canada
    Raymond S W Tsang
    National Microbiology Laboratory, Health Canada, Winnipeg, Manitoba, Canada R3E 3R2
    J Clin Microbiol 42:5364-7. 2004
    ..At least one of the novel mutations identified was found to involve a surface epitope that has been mapped by serum antibodies from infected or vaccinated subjects...
  80. ncbi request reprint A modified vaccine reduces the rate of large injection site reactions to the preschool booster dose of diphtheria-tetanus-acellular pertussis vaccine: results of a randomized, controlled trial
    David W Scheifele
    Canadian Association for Immunization Research and Evaluation CAIRE and the Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 24:1059-66. 2005
    ..Large injection site reactions commonly follow booster doses of diphtheria-tetanus-acellular pertussis (DTaP) vaccines at 4-6 years of age. A vaccine with lower diphtheria and pertussis dosage (Tdap) might be better tolerated for this dose...
  81. ncbi request reprint Recommendation for an adolescent dose of tetanus and diphtheria toxoids and acellular pertussis vaccine: reassurance for the future
    Scott A Halperin
    J Pediatr 149:589-91. 2006
  82. ncbi request reprint The effect of changing from whole-cell to acellular pertussis vaccine on the epidemiology of hospitalized children with pertussis in Canada
    Julie A Bettinger
    Vaccine Evaluation Center, BC Children s Hospital and the University of British Columbia, Vancouver, British Columbia, Canada
    Pediatr Infect Dis J 26:31-5. 2007
    ..To assess effects on pertussis epidemiology of this nationwide change, we analyzed hospitalizations during 1991-2004 using the Canadian Immunization Monitoring Program, Active (IMPACT) pertussis database...
  83. ncbi request reprint Lack of evidence of encephalopathy related to pertussis vaccine: active surveillance by IMPACT, Canada, 1993-2002
    Dorothy L Moore
    Montreal Children s Hospital, McGill University Health Centre, Quebec, Canada
    Pediatr Infect Dis J 23:568-71. 2004
    ..Seven cases of encephalopathy began within 7 days after pertussis vaccination, but a more likely cause was found in each instance. No attributable case followed administration of >6.5 million doses of vaccine...
  84. ncbi request reprint Injection-site reactions to booster doses of acellular pertussis vaccine: rate, severity, and anticipated impact
    Danuta M Skowronski
    University of British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada
    Pediatrics 112:e453. 2003
    ....
  85. pmc Construction and characterization of single-chain variable fragment antibodies directed against the Bordetella pertussis surface adhesins filamentous hemagglutinin and pertactin
    Ahmad H Hussein
    Department of Applied Oral Sciences, Faculty of Dentistry, Dalhousie University Halifax, Nova Scotia B3H 3J5, Canada
    Infect Immun 75:5476-82. 2007
    ..BALB/c mice who received recombinant phage-treated B. pertussis had reduced bacterial counts in the nasal cavity, trachea, and lungs compared to the control groups...
  86. ncbi request reprint Nodule at injection site as an adverse event following immunization: case definition and guidelines for data collection, analysis, and presentation
    Edward Rothstein
    Pennridge Pediatric Associates, Sellersville, PA, USA
    Vaccine 22:575-85. 2004
  87. ncbi request reprint Invasive pneumococcal infections in Canadian children, 1998-2003: implications for new vaccination programs
    Julie A Bettinger
    Vaccine Evaluation Centre, BC Children s Hospital and the University of British Columbia, Vancouver, BC
    Can J Public Health 98:111-5. 2007
    ..We conducted active surveillance for invasive pneumococcal disease to assess the serotype and antibiotic resistance patterns in Canada prior to universal infant immunization programs, in most provinces...
  88. ncbi request reprint Comparative evaluation of safety and immunogenicity of two dosages of an oral live attenuated human rotavirus vaccine
    Penelope H Dennehy
    Division of Pediatric Infectious Diseases, Rhode Island Hospital and the Department of Pediatrics, Brown Medical School, Providence, 02903, USA
    Pediatr Infect Dis J 24:481-8. 2005
    ..Rotavirus is a major cause of gastroenteritis in children worldwide and is estimated to be responsible for more than 500,000 physician visits, 50,000 hospitalizations and 20 deaths in the United States each year...
  89. ncbi request reprint Outcome of penicillin-nonsusceptible Streptococcus pneumoniae meningitis: a nested case-control study
    James D Kellner
    Canadian Paediatric Society, Ottawa, Ontario, Canada
    Pediatr Infect Dis J 21:903-10. 2002
    ..There are few data comparing the clinical features, management and outcome of penicillin-nonsusceptible (PNSP) meningitis patients with penicillin-susceptible (PSSP) meningitis patients...
  90. pmc Conforming to ICMJE principles
    Scott A Halperin
    CMAJ 173:1358-9. 2005
  91. ncbi request reprint Carotid artery dissection as a possible severe complication of pertussis in an adult: clinical case report and review
    Danuta M Skowronski
    British Columbia Centre for Disease Control, St Paul s Hospital and University of British Columbia, Vancouver, British Columbia V5Z 4R4, Canada
    Clin Infect Dis 36:e1-4. 2003
    ..Adult booster immunization against pertussis should be considered to protect adults themselves from this illness and its potential complications...