Tomas Hajek

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi request reprint Functional neuroanatomy of response inhibition in bipolar disorders--combined voxel based and cognitive performance meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada Prague Psychiatric Centre, Department of Psychiatry and Medical Psychology, 3rd School of Medicine, Charles University, Prague, Czech Republic Electronic address
    J Psychiatr Res 47:1955-66. 2013
  2. doi request reprint Why negative meta-analyses may be false?
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic Electronic address
    Eur Neuropsychopharmacol 23:1307-9. 2013
  3. doi request reprint Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Biol Psychiatry 73:144-52. 2013
  4. pmc Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    J Psychiatry Neurosci 37:333-43. 2012
  5. pmc Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Bipolar Disord 14:261-70. 2012
  6. pmc Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 37:185-92. 2012
  7. pmc Reduced subgenual cingulate volumes in mood disorders: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:91-9. 2008
  8. doi request reprint Striatal volumes in affected and unaffected relatives of bipolar patients--high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, 5909 Veteran s Memorial Lane, Halifax, Canada
    J Psychiatr Res 43:724-9. 2009
  9. doi request reprint Amygdala volumes in mood disorders--meta-analysis of magnetic resonance volumetry studies
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 115:395-410. 2009
  10. doi request reprint Subgenual cingulate volumes in offspring of bipolar parents and in sporadic bipolar patients
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 260:297-304. 2010

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Functional neuroanatomy of response inhibition in bipolar disorders--combined voxel based and cognitive performance meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada Prague Psychiatric Centre, Department of Psychiatry and Medical Psychology, 3rd School of Medicine, Charles University, Prague, Czech Republic Electronic address
    J Psychiatr Res 47:1955-66. 2013
    ..Thus, we performed the first combined meta-analysis of fMRI activations and neurocognitive performance in studies investigating response inhibition in BD...
  2. doi request reprint Why negative meta-analyses may be false?
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada Prague Psychiatric Center, Department of Psychiatry and Medical Psychology, 3 rd Faculty of Medicine, Charles University, Prague, Czech Republic Electronic address
    Eur Neuropsychopharmacol 23:1307-9. 2013
    ..Over reliance on such meta-analyses may falsely identify certain potentially fruitful research avenues as blind alleys. ..
  3. doi request reprint Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrus
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Biol Psychiatry 73:144-52. 2013
    ..Thus, we examined the associations among genetic risk, illness burden, lithium treatment, and brain structure in BD...
  4. pmc Smaller hippocampal volumes in patients with bipolar disorder are masked by exposure to lithium: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    J Psychiatry Neurosci 37:333-43. 2012
    ..Preserved hippocampal volumes in most studies of participants with bipolar disorder may reflect potential neuroprotective effects of lithium (Li)...
  5. pmc Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Bipolar Disord 14:261-70. 2012
    ..The absence of hippocampal volume changes in most studies of individuals with bipolar disorder (BD) may reflect neuroprotective effects of lithium (Li)...
  6. pmc Large positive effect of lithium on prefrontal cortex N-acetylaspartate in patients with bipolar disorder: 2-centre study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 37:185-92. 2012
    ..Previous studies investigating the association between Li treatment and brain N-acetylaspartate (NAA), a putative neuronal marker, showed mixed results because of methodological heterogeneity...
  7. pmc Reduced subgenual cingulate volumes in mood disorders: a meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:91-9. 2008
    ..Our objective was to carry out the first meta-analysis of SGC volumes in patients with mood disorders...
  8. doi request reprint Striatal volumes in affected and unaffected relatives of bipolar patients--high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, 5909 Veteran s Memorial Lane, Halifax, Canada
    J Psychiatr Res 43:724-9. 2009
    ..We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders...
  9. doi request reprint Amygdala volumes in mood disorders--meta-analysis of magnetic resonance volumetry studies
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 115:395-410. 2009
    ..We present the largest meta-analysis of amygdala volumes in mood disorders and the first one to investigate modifying effects of clinical, demographic and methodological variables...
  10. doi request reprint Subgenual cingulate volumes in offspring of bipolar parents and in sporadic bipolar patients
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 260:297-304. 2010
    ..In conclusion, SGC volume abnormalities were absent in unaffected, affected relatives of bipolar patients as well as sporadic bipolar patients and thus did not meet criteria for endophenotype...
  11. doi request reprint Reduced hippocampal volumes in healthy carriers of brain-derived neurotrophic factor Val66Met polymorphism: meta-analysis
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    World J Biol Psychiatry 13:178-87. 2012
    ..Yet the majority of studies have shown no effect of this polymorphism on hippocampal volumes, perhaps due to small effect size...
  12. ncbi request reprint Neuroanatomical abnormalities as risk factors for bipolar disorder
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Bipolar Disord 7:393-403. 2005
    ..Some of the abnormalities may represent biological risk factors conveying vulnerability for the disease. This paper aims to identify neuroanatomical risk factors for bipolar disorder (BD)...
  13. doi request reprint Pituitary volumes in relatives of bipolar patients: high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Room 3089, QEII HSC, A J Lane Bldg 5909 Veteran s Memorial Lane, B3H 2E2, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 258:357-62. 2008
    ..To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects...
  14. doi request reprint White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: a two-center high-risk study
    Eva Gunde
    Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Psychiatr Res 45:76-82. 2011
    ..It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD...
  15. ncbi request reprint Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk study
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia
    Can J Psychiatry 54:726-33. 2009
    ..To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design)...
  16. pmc A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopy
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS
    J Psychiatry Neurosci 33:531-40. 2008
    ..We searched for biological vulnerability markers using proton magnetic resonance spectroscopy (MRS) in both affected and unaffected participants at high genetic risk for bipolar disorder...
  17. doi request reprint Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjects
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009
    ..The current study investigated whether or not deficits in early information processing were present before the onset and/or during the early stages of bipolar disorder...
  18. pmc Can body mass index help predict outcome in patients with bipolar disorder?
    Cynthia Calkin
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia B3H 2E2, Canada
    Bipolar Disord 11:650-6. 2009
    ....
  19. pmc Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 108:263-9. 2008
    ..This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders...
  20. pmc Rapid cycling bipolar disorders in primary and tertiary care treated patients
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Bipolar Disord 10:495-502. 2008
    ..Generalizability of these findings to primary care populations is thus questionable. We examined clinical and demographic factors associated with RC in both primary and tertiary care treated populations...
  21. doi request reprint Early course of bipolar disorder in high-risk offspring: prospective study
    Anne Duffy
    MD, Department of Psychiatry, Dalhousie University IWK Health Centre, 5850 5980 University Avenue, P O Box 9700, Halifax, Nova Scotia, Canada B3K 6R8
    Br J Psychiatry 195:457-8. 2009
    ..We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder...
  22. doi request reprint Findings from bipolar offspring studies: methodology matters
    Anne Duffy
    Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
    Early Interv Psychiatry 5:181-91. 2011
    ..In this review, we compare different methods of ascertainment and assessment, and their impact on study findings...
  23. doi request reprint Early stages in the development of bipolar disorder
    Anne Duffy
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 121:127-35. 2010
    ..We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology...
  24. doi request reprint An admixture analysis of the age at index episodes in bipolar disorder
    Abigail Ortiz
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Psychiatry Res 188:34-9. 2011
    ..Our results suggest the presence of a bimodal distribution of age at onset in BD according to the polarity of the index episode, and denote that an early onset BD, irrespective of polarity, may be a more serious subtype of the disorder...
  25. doi request reprint Genetic risk of suicidal behavior in bipolar spectrum disorder: analysis of 737 pedigrees
    Mirko Manchia
    Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
    Bipolar Disord 15:496-506. 2013
    ....
  26. ncbi request reprint Antidepressant monotherapy in pre-bipolar depression; predictive value and inherent risk
    Claire O'Donovan
    Queen Elizabeth II Health Sciences Centre, Mood Disorders Program, Department of Psychiatry, Abbie J Ln Memorial Bldg, 3rd Floor, Veterans Memorial Lane, Dalhousie University, Halifax, Nova Scotia, Canada
    J Affect Disord 107:293-8. 2008
    ..To identify specific treatment-emergent symptoms in response to antidepressant therapy in depression preceding bipolar disorder...
  27. doi request reprint White matter hyperintensities: from medical comorbidities to bipolar disorders and back
    Eva Gunde
    Department of Psychiatry, Dalhousie University, Halifax, Canada
    Ann Med 43:571-80. 2011
    ..With further research WMHs may enhance our knowledge about various pathological pathways involved in BD, help in decreasing the etiological heterogeneity of BD, and become useful as markers of severity or subtype of BD...
  28. doi request reprint Treatment of bipolar disorder: new perspectives
    Martin Alda
    Department of Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Halifax, Nova Scotia, Canada
    Ann Med 41:186-96. 2009
    ..Cognitive deficits, persistence of residual symptoms, and increased mortality of BD are recognized as important for outcome of BD, yet are not always adequately addressed by traditional treatments...
  29. ncbi request reprint Prospective study of hippocampal volume and function in human subjects treated with corticosteroids
    Tomas Hajek
    Prague Psychiatric Center and Charles University, 3rd School of Medicine, Prague, Czech Republic
    Eur Psychiatry 21:123-8. 2006
    ..This is the first prospective study of hippocampal volume and function in patients treated with corticosteroids...
  30. pmc Risk of mental illness in offspring of parents with schizophrenia, bipolar disorder, and major depressive disorder: a meta-analysis of family high-risk studies
    Daniel Rasic
    To whom correspondence should be addressed Department of Psychiatry, Canada Research Chair in Early Intervention in Psychiatry, Dalhousie University, 5909 Veterans Memorial Lane, Room 3089, Abbie J Lane Memorial Building, Halifax, Nova Scotia B3H 2E2, Canada fax 902 473 4877, E mail
    Schizophr Bull 40:28-38. 2014
    ..We aimed to quantify the risk of mental disorders in offspring and determine whether increased risk extends beyond the disorder present in the parent...
  31. ncbi request reprint Clinical correlates of current level of functioning in primary care-treated bipolar patients
    Tomas Hajek
    Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
    Bipolar Disord 7:286-91. 2005
    ..A number of studies, mostly from specialized programs, show that bipolar disorder often leads to occupational and social impairment. Here we report data from patients in a primary care setting...
  32. ncbi request reprint Subjective quality of life in psychiatric patients: diagnosis and illness-specific profiles
    Eva Goppoldova
    Maritime Psychiatry, IWK Health Centre, Halifax, Nova Scotia
    Can J Psychiatry 53:587-93. 2008
    ..This is the first study of psychiatric diagnosis and illness stage specific profiles of subjective quality of life (SQOL) impairment...
  33. ncbi request reprint Psychosis induced by low-dose bupropion: sensitization of dopaminergic system by past cocaine abuse?
    Margaret Hahn
    Dalhousie University, Halifax, Nova Scotia
    J Psychiatr Pract 13:336-8. 2007