M W Gray

Summary

Affiliation: Dalhousie University
Country: Canada

Publications

  1. ncbi Evolutionary origin of RNA editing
    Michael W Gray
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3M 4R2, Canada
    Biochemistry 51:5235-42. 2012
  2. ncbi Mitochondrial evolution
    Michael W Gray
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3M 4R2, Canada
    Cold Spring Harb Perspect Biol 4:a011403. 2012
  3. ncbi U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis
    J Michael Charette
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Genomics 10:528. 2009
  4. ncbi A complex and punctate distribution of three eukaryotic genes derived by lateral gene transfer
    Matthew B Rogers
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Evol Biol 7:89. 2007
  5. ncbi An ancient spliceosomal intron in the ribosomal protein L7a gene (Rpl7a) of Giardia lamblia
    Anthony G Russell
    Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Evol Biol 5:45. 2005
  6. ncbi Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I
    Ryan M R Gawryluk
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Evol Biol 10:176. 2010
  7. ncbi Broad genomic and transcriptional analysis reveals a highly derived genome in dinoflagellate mitochondria
    Christopher J Jackson
    School of Botany, The University of Melbourne, Victoria 3010, Australia
    BMC Biol 5:41. 2007
  8. ncbi AutoFACT: an automatic functional annotation and classification tool
    Liisa B Koski
    Robert Cedergren Center for Bioinformatics and Genomics, Universite de Montreal, Montreal, Quebec, Canada
    BMC Bioinformatics 6:151. 2005
  9. ncbi Mitochondrial evolution
    M W Gray
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 283:1476-81. 1999
  10. ncbi A split and rearranged nuclear gene encoding the iron-sulfur subunit of mitochondrial succinate dehydrogenase in Euglenozoa
    Ryan Mr Gawryluk
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Res Notes 2:16. 2009

Collaborators

Detail Information

Publications59

  1. ncbi Evolutionary origin of RNA editing
    Michael W Gray
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3M 4R2, Canada
    Biochemistry 51:5235-42. 2012
    ....
  2. ncbi Mitochondrial evolution
    Michael W Gray
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3M 4R2, Canada
    Cold Spring Harb Perspect Biol 4:a011403. 2012
    ....
  3. ncbi U3 snoRNA genes are multi-copy and frequently linked to U5 snRNA genes in Euglena gracilis
    J Michael Charette
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    BMC Genomics 10:528. 2009
    ....
  4. ncbi A complex and punctate distribution of three eukaryotic genes derived by lateral gene transfer
    Matthew B Rogers
    Department of Botany, University of British Columbia, Vancouver, British Columbia, Canada
    BMC Evol Biol 7:89. 2007
    ..Ideally such an observation would involve a single eukaryote or a small group of related eukaryotes encoding a gene from a specific bacterial lineage...
  5. ncbi An ancient spliceosomal intron in the ribosomal protein L7a gene (Rpl7a) of Giardia lamblia
    Anthony G Russell
    Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Evol Biol 5:45. 2005
    ..This intron is only 35 nucleotides in length and is unusual in possessing a non-canonical 5' intron boundary sequence, CT, instead of GT...
  6. ncbi Evidence for an early evolutionary emergence of gamma-type carbonic anhydrases as components of mitochondrial respiratory complex I
    Ryan M R Gawryluk
    Centre for Comparative Genomics and Evolutionary Bioinformatics, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Evol Biol 10:176. 2010
    ..However, relatively little is known about CI composition in the unicellular protists, the characterizations of which are essential to our understanding of CI evolution...
  7. ncbi Broad genomic and transcriptional analysis reveals a highly derived genome in dinoflagellate mitochondria
    Christopher J Jackson
    School of Botany, The University of Melbourne, Victoria 3010, Australia
    BMC Biol 5:41. 2007
    ..Here, we investigate structure, content and expression of dinoflagellate mitochondrial genomes...
  8. ncbi AutoFACT: an automatic functional annotation and classification tool
    Liisa B Koski
    Robert Cedergren Center for Bioinformatics and Genomics, Universite de Montreal, Montreal, Quebec, Canada
    BMC Bioinformatics 6:151. 2005
    ..Assignment of function to new molecular sequence data is an essential step in genomics projects. The usual process involves similarity searches of a given sequence against one or more databases, an arduous process for large datasets...
  9. ncbi Mitochondrial evolution
    M W Gray
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Science 283:1476-81. 1999
    ....
  10. ncbi A split and rearranged nuclear gene encoding the iron-sulfur subunit of mitochondrial succinate dehydrogenase in Euglenozoa
    Ryan Mr Gawryluk
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    BMC Res Notes 2:16. 2009
    ..Our results pose questions about the origin and timing of this novel gene arrangement and the structure and function of euglenozoan SdhB...
  11. ncbi Mitochondria of protists
    Michael W Gray
    Robert Cedergren Center, Program in Evolutionary Biology, Canadian Institute for Advanced Research, Canada
    Annu Rev Genet 38:477-524. 2004
    ..This comparative genomics approach has also revealed unique and fascinating aspects of mitochondrial gene expression, highlighting the mitochondrion as an evolutionary playground par excellence...
  12. ncbi Diversity and evolution of mitochondrial RNA editing systems
    Michael W Gray
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada
    IUBMB Life 55:227-33. 2003
    ..The derived nature of RNA editing raises intriguing questions about how and why RNA editing systems arise, and how they become fixed as additional, essential steps in genetic information transfer...
  13. ncbi RNA editing in plant mitochondria: 20 years later
    Michael W Gray
    Department of Biochemistry and Molecular Biology, Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, Canada
    IUBMB Life 61:1101-4. 2009
    ..Essential background information pertaining to RNA editing in general and RNA editing in plant organelles in particular is provided in this overview...
  14. ncbi The path to RNA editing in plant mitochondria: the Halifax chapter
    Michael W Gray
    Department of Biochemistry and Molecular Biology, Centre for Comparative Genomics and Evolutionary Bioinformatics, Dalhousie University, 5850 College Street, Halifax, Nova Scotia, Canada
    IUBMB Life 61:1114-7. 2009
    ..Further investigations of RNA editing in plant mitochondria led to the subsequent discovery of a case of mitochondrion-to-nucleus gene (cox2) transfer in soybean, mediated by reverse transcription of edited cox2 mRNA...
  15. ncbi The origin and early evolution of mitochondria
    M W Gray
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Genome Biol 2:REVIEWS1018. 2001
    ..These data confirm that the mitochondrial genome originated from a eubacterial (specifically alpha-proteobacterial) ancestor but raise questions about the evolutionary antecedents of the mitochondrial proteome...
  16. ncbi Genome structure and gene content in protist mitochondrial DNAs
    M W Gray
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Nucleic Acids Res 26:865-78. 1998
    ..Comparative analysis of protist mtDNAs is providing a new perspective on mtDNA evolution: how the original mitochondrial genome was organized, what genes it contained, and in what ways it must have changed in different eukaryotic phyla...
  17. ncbi Evolution of organellar genomes
    M W Gray
    Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Canadian Institute for Advanced Research, Dalhousie University, Halifax, B3H 4H7, Canada
    Curr Opin Genet Dev 9:678-87. 1999
    ..The 'single-gene circle' arrangement recently reported for dinoflagellate chloroplast genomes is a notable example of a highly derived organellar genome...
  18. ncbi The ribosomal RNA gene region in Acanthamoeba castellanii mitochondrial DNA. A case of evolutionary transfer of introns between mitochondria and plastids?
    K M Lonergan
    Canadian Institute for Advanced Research, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
    J Mol Biol 239:476-99. 1994
    ..castellanii and C. reinhardtii or, more recently, as a result of an intercellular exchange of genetic information...
  19. ncbi Complete sequence of the mitochondrial DNA of the red alga Porphyra purpurea. Cyanobacterial introns and shared ancestry of red and green algae
    G Burger
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, 180 Dundas Street West, Toronto, Ontario M5G 1Z8, Canada
    Plant Cell 11:1675-94. 1999
    ..Finally, phylogenetic analyses provide strong evidence that red algae share a common ancestry with green algae and plants...
  20. ncbi The complete mitochondrial DNA sequences of Nephroselmis olivacea and Pedinomonas minor. Two radically different evolutionary patterns within green algae
    M Turmel
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Quebec, Quebec G1K 7P4, Canada
    Plant Cell 11:1717-30. 1999
    ..Our results confirm the existence of two radically different patterns of mitochondrial genome evolution within the green algae...
  21. ncbi Identification and characterization of T3/T7 bacteriophage-like RNA polymerase sequences in wheat
    T M Ikeda
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Plant Mol Biol 40:567-78. 1999
    ....
  22. ncbi The complete mitochondrial DNA sequence of Scenedesmus obliquus reflects an intermediate stage in the evolution of the green algal mitochondrial genome
    A M Nedelcu
    Department of Biology, Dalhousie University, Halifax, Nova Scotia B3H 4J1, Canada
    Genome Res 10:819-31. 2000
    ..Furthermore, the gene content and the fragmentation pattern of the rRNA genes suggest that this genome represents an intermediate stage in the evolutionary process of mitochondrial genome streamlining in green algae...
  23. ncbi A complex organization of the gene encoding cytochrome oxidase subunit 1 in the mitochondrial genome of the dinoflagellate, Crypthecodinium cohnii: homologous recombination generates two different cox1 open reading frames
    J E Norman
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Room 8F-2, Tupper Medical Building, 5859 University Avenue, Halifax, Nova Scotia B3H 4H7, Canada
    J Mol Evol 53:351-63. 2001
    ..Such recombining repeats are a characteristic feature of plant (angiosperm) mtDNA, but they have not previously been described in the mitochondrial genomes of protists...
  24. ncbi Identification and structural characterization of nucleus-encoded transfer RNAs imported into wheat mitochondria
    K E Glover
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    J Biol Chem 276:639-48. 2001
    ....
  25. ncbi Nucleotide sequence of a region encoding subunit 6 of NADH dehydrogenase (ND6) and tRNA(Trp) in Chlamydomonas reinhardtii mitochondrial DNA
    P H Boer
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Nucleic Acids Res 17:3993. 1989
  26. ncbi Genes encoding the same three subunits of respiratory complex II are present in the mitochondrial DNA of two phylogenetically distant eukaryotes
    G Burger
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Departement de Biochimie, Universite de Montreal, Quebec, Canada
    Proc Natl Acad Sci U S A 93:2328-32. 1996
    ..The data presented here are consistent with the view that mitochondria constitute a monophyletic lineage...
  27. ncbi Genes encoding a subunit of respiratory NADH dehydrogenase (ND1) and a reverse transcriptase-like protein (RTL) are linked to ribosomal RNA gene pieces in Chlamydomonas reinhardtii mitochondrial DNA
    P H Boer
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    EMBO J 7:3501-8. 1988
    ..We suggest a model, involving reverse transcription of rRNAs and insertion of the resulting cDNAs into the mitochondrial genome, that might account for the pattern of dispersed rRNA gene pieces in C. reinhardtii mitochondrial DNA...
  28. ncbi Evolution of the mitochondrial genome: protist connections to animals, fungi and plants
    Charles E Bullerwell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Room 8F-2, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Curr Opin Microbiol 7:528-34. 2004
    ....
  29. ncbi Abundant 5S rRNA-like transcripts encoded by the mitochondrial genome in amoebozoa
    Charles E Bullerwell
    Department of Biochemistry and Molecular Biology, Room 8 F2, Sir Charles Tupper Medical Building, Dalhousie University, 5840 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Eukaryot Cell 9:762-73. 2010
    ..We posit that currently unrecognized 5S-like RNAs may exist in other mitochondrial systems in which a conventional 5S rRNA cannot be identified...
  30. ncbi Sequences homologous to yeast mitochondrial and bacteriophage T3 and T7 RNA polymerases are widespread throughout the eukaryotic lineage
    N Cermakian
    Canadian Institute for Advanced Research, Department de Biochimie, Universite de Montreal, Quebec, Canada
    Nucleic Acids Res 24:648-54. 1996
    ....
  31. ncbi An early evolutionary origin for the minor spliceosome
    Anthony G Russell
    Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    Nature 443:863-6. 2006
    ..In addition, our results reveal marked evolutionary conservation of functionally important sequence elements contained within U12-type introns and snRNAs...
  32. ncbi Homologs of mitochondrial transcription factor B, sparsely distributed within the eukaryotic radiation, are likely derived from the dimethyladenosine methyltransferase of the mitochondrial endosymbiont
    Timothy E Shutt
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
    Mol Biol Evol 23:1169-79. 2006
    ..Phylogenetic analysis further demonstrates that the mtTFB is most likely derived from the DMT of the mitochondrial endosymbiont...
  33. ncbi Analysis of intergenic spacer transcripts suggests 'read-around' transcription of the extrachromosomal circular rDNA in Euglena gracilis
    S J Greenwood
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 4H7, Canada
    Nucleic Acids Res 29:2191-8. 2001
    ..This result suggests the possibility of 'read-around' transcription, i.e. transcription that proceeds multiple times around the rDNA circle without termination...
  34. ncbi Silent mitochondrial and active nuclear genes for subunit 2 of cytochrome c oxidase (cox2) in soybean: evidence for RNA-mediated gene transfer
    P S Covello
    Canadian Institute for Advanced Research, Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia
    EMBO J 11:3815-20. 1992
    ..Comparison of soybean mitochondrial and nuclear cox2 sequences clearly indicates that in an ancestor of soybean, cox2 was transferred from the mitochondrion to the nucleus via a C-to-U edited RNA intermediate...
  35. ncbi Analysis of 5'- or 3'-terminal tRNA editing: mitochondrial 5' tRNA editing in Acanthamoeba castellanii as the exemplar
    Amanda J Lohan
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Methods Enzymol 424:223-42. 2007
    ....
  36. ncbi In vitro characterization of a tRNA editing activity in the mitochondria of Spizellomyces punctatus, a Chytridiomycete fungus
    Charles E Bullerwell
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    J Biol Chem 280:2463-70. 2005
    ..castellanii tRNA editing, suggesting that remarkably similar activities function in the mitochondria of these two organisms. The evolutionary origins of these activities are discussed...
  37. ncbi A large collection of compact box C/D snoRNAs and their isoforms in Euglena gracilis: structural, functional and evolutionary insights
    Anthony G Russell
    Department of Biochemistry and Molecular Biology Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    J Mol Biol 357:1548-65. 2006
    ....
  38. ncbi Twinkle, the mitochondrial replicative DNA helicase, is widespread in the eukaryotic radiation and may also be the mitochondrial DNA primase in most eukaryotes
    Timothy E Shutt
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, and Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    J Mol Evol 62:588-99. 2006
    ..Accordingly, we propose that Twinkle likely serves as the primase as well as the helicase for mtDNA replication in most eukaryotes whose genome encodes it, with the exception of Metazoa...
  39. ncbi Unusual features of fibrillarin cDNA and gene structure in Euglena gracilis: evolutionary conservation of core proteins and structural predictions for methylation-guide box C/D snoRNPs throughout the domain Eucarya
    Anthony G Russell
    Department of Biochemistry and Molecular Biology, Dalhousie University Halifax, Nova Scotia, Canada B3H 1X5
    Nucleic Acids Res 33:2781-91. 2005
    ....
  40. ncbi Unique mitochondrial genome architecture in unicellular relatives of animals
    Gertraud Burger
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Departement de Biochimie, Universite de Montreal, Succursale Centre Ville, Montreal, QC, Canada H3C 3J7
    Proc Natl Acad Sci U S A 100:892-7. 2003
    ....
  41. ncbi A phylogenomic investigation into the origin of metazoa
    Inaki Ruiz-Trillo
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
    Mol Biol Evol 25:664-72. 2008
    ..Understanding the function of "metazoan-specific" proteins we have identified in these protists will clarify the evolutionary steps that led to the emergence of the Metazoa...
  42. ncbi The origins of multicellularity: a multi-taxon genome initiative
    Iñaki Ruiz Trillo
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Trends Genet 23:113-8. 2007
    ..Here, we introduce this initiative and the biological questions that underpin it, summarize the rationale guiding the choice of organisms and discuss the anticipated benefits to the broader scientific community...
  43. ncbi Sampling gene diversity across the supergroup Amoebozoa: large EST data sets from Acanthamoeba castellanii, Hartmannella vermiformis, Physarum polycephalum, Hyperamoeba dachnaya and Hyperamoeba sp
    Russell F Watkins
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
    Protist 159:269-81. 2008
    ....
  44. ncbi Methods for analysis of mitochondrial tRNA editing in Acanthamoeba castellanii
    Amanda J Lohan
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    Methods Mol Biol 265:315-31. 2004
    ....
  45. ncbi Pseudouridine in RNA: what, where, how, and why
    M Charette
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
    IUBMB Life 49:341-51. 2000
    ..Such studies demonstrate that pseudouridylation of RNA confers an important selective advantage in a natural biological context...
  46. ncbi Short dispersed repeats localized in spacer regions of Chlamydomonas reinhardtii mitochondrial DNA
    P H Boer
    Department of Biochemistry, Dalhousie University, Halifax, Nova Scotia, Canada
    Curr Genet 19:309-12. 1991
    ..The location of these elements suggests that they could play a role in gene expression, e.g., post-transcriptional processing, in C. reinhardtii mitochondria...
  47. ncbi Pseudouridine-guide RNAs and other Cbf5p-associated RNAs in Euglena gracilis
    Anthony G Russell
    Department of Biochemistry and Molecular Biology, Sir Charles Tupper Medical Building, Room 8F-2, Dal-housie University, 5850 College Street, Halifax, Nova Scotia B3H 1X5, Canada
    RNA 10:1034-46. 2004
    ..Unexpectedly, we also found and have partially characterized a selenocysteine tRNA homolog in the anti-Cbf5p-immunoprecipitated sample...
  48. ncbi Bacteriophage origins of mitochondrial replication and transcription proteins
    Timothy E Shutt
    Program in Evolutionary Biology, Canadian Institute for Advanced Research, Department of Biochemistry and Molecular Biology, Dalhousie University, Sir Charles Tupper Medical Building, 5850 College Street, Halifax, NS, Canada, B3H 1X5
    Trends Genet 22:90-5. 2006
    ..We further propose that at a later stage the single-subunit RNA polymerase, originally acquired for mitochondrial DNA replication, was co-opted to serve in mitochondrial transcription...
  49. ncbi Discovery and characterization of Acanthamoeba castellanii mitochondrial 5S rRNA
    Charles E Bullerwell
    Canadian Institute for Advanced Research, Program in Evolutionary Biology, Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia B3H 1X5, Canada
    RNA 9:287-92. 2003
    ..These results emphasize the need for caution when interpreting negative results that suggest the absence of 5S rRNA and/or a mitochondrial DNA-encoded 5S rRNA sequence in other (particularly protist) mitochondrial systems...
  50. ncbi Toward resolving the eukaryotic tree: the phylogenetic positions of jakobids and cercozoans
    Naiara Rodriguez Ezpeleta
    Centre Robert Cedergren, Departement de Biochimie, Universite de Montreal, 2900 Boulevard Edouard Montpetit, Montreal, Quebec H3T 1J4, Canada
    Curr Biol 17:1420-5. 2007
    ..We discuss the implications of these results for the concept of "excavates" and for the elucidation of eukaryotic phylogeny in general...
  51. ncbi Widespread and extensive editing of mitochondrial mRNAS in dinoflagellates
    Senjie Lin
    Department of Marine Sciences, University of Connecticut, Groton, CT 06340, USA
    J Mol Biol 320:727-39. 2002
    ....
  52. ncbi Evolutionary biology: the hydrogenosome's murky past
    Michael W Gray
    Nature 434:29-31. 2005
  53. ncbi Mitochondrial genomes: anything goes
    Gertraud Burger
    Canadian Institute for Advanced Research, Programme in Evolutionary Biology, , , 2900 Boulevard Edouard-Montpetit, , , Canada H3T 1J4
    Trends Genet 19:709-16. 2003
  54. ncbi TBestDB: a taxonomically broad database of expressed sequence tags (ESTs)
    Emmet A O'Brien
    Departement de Biochimie, Canadian Institute for Advanced Research, Robert Cedergren Centre for Research in Bioinformatics and Genomics, Universite de Montreal, 2900 Edouard Montpetit, Montreal, QC, Canada H3T 1J4
    Nucleic Acids Res 35:D445-51. 2007
    ..For instructions on submission to TBestDB, contact tbestdb@bch.umontreal.ca. The database can be queried at http://tbestdb.bcm.umontreal.ca/...
  55. ncbi Analysis of Euglena gracilis plastid-targeted proteins reveals different classes of transit sequences
    Dion G Durnford
    Department of Biology, University of New Brunswick, Fredericton, New Brunswick, Canada E3B 5A3
    Eukaryot Cell 5:2079-91. 2006
    ..This work represents the most comprehensive description to date of transit peptides in Euglena and hints at the complex routes of plastid targeting that must exist in this organism...
  56. ncbi The frequency of eubacterium-to-eukaryote lateral gene transfers shows significant cross-taxa variation within amoebozoa
    Russell F Watkins
    Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, and Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V5Z 4H4, Canada
    J Mol Evol 63:801-14. 2006
    ..Our results indicate that there may be substantial inter-taxon variation in the number of LGT events that become fixed even between amoebozoan species that have similar feeding modalities...
  57. ncbi Exploring the mitochondrial proteome of the ciliate protozoon Tetrahymena thermophila: direct analysis by tandem mass spectrometry
    Daryl G S Smith
    Department of Chemistry and Centre for Research in Mass Spectrometry, York University, Toronto, Ontario, Canada
    J Mol Biol 374:837-63. 2007
    ....
  58. ncbi Gene discovery in the Acanthamoeba castellanii genome
    Iain J Anderson
    Department of Parasite Genomics, The Institute for Genomic Research, 9712 Medical Center Dr, Rockville, MD 20850, USA
    Protist 156:203-14. 2005
    ..histolytica. Serine, cysteine and metalloproteases were identified, some of which are likely involved in pathogenicity...
  59. ncbi Problems with co-funding in Canada
    Mike Tyers
    Science 308:1867. 2005