Research Topics
| G R FerrierSummaryAffiliation: Dalhousie University Country: Canada Publications
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Detail Information
Publications
Differential effects of docosahexaenoic acid on contractions and L-type Ca2+ current in adult cardiac myocytesGregory R Ferrier
Department of Pharmacology, Sir Charles Tupper Medical Bldg, Dalhousie University, Nova Scotia, Halifax, Canada
Cardiovasc Res 54:601-10. 2002..Beneficial effects of n-3 polyunsaturated fatty acids in Ca2+ overload have been attributed to blockade of L-type Ca2+ current (I(Ca-L)). However, cardiac contractions may be maintained despite block of I(Ca-L)...- Role of cAMP-dependent protein kinase A in activation of a voltage-sensitive release mechanism for cardiac contraction in guinea-pig myocytesG R Ferrier
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Physiol 513:185-201. 1998..Intracellular dialysis with solutions that do not maintain phosphorylation levels inhibits a major mechanism in cardiac excitation- contraction coupling... - Regulation of contraction and relaxation by membrane potential in cardiac ventricular myocytesG R Ferrier
Cardiovascular Research Laboratories, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Am J Physiol Heart Circ Physiol 278:H1618-26. 2000..Our study indicates that the VSRM includes both a phasic inactivating and a sustained noninactivating component. The sustained component contributes both to initiation and relaxation of contraction... - Cardiac excitation-contraction coupling: role of membrane potential in regulation of contractionG R Ferrier
Cardiovascular Research Laboratories, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, B3H 4H7, Canada
Am J Physiol Heart Circ Physiol 280:H1928-44. 2001..This review explores the operation and characteristics of the VSRM and CICR and discusses the impact of the VSRM on our understanding of cardiac excitation-contraction coupling... - Calcium sparks in mouse ventricular myocytes at physiological temperatureGregory R Ferrier
Department of Pharmacology, Sir Charles Tupper Medical Bldg, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Am J Physiol Heart Circ Physiol 285:H1495-505. 2003..Thus effects of temperature on spark frequency may reflect changes in SR stores, whereas changes in spark amplitude and rise time may reflect known effects of temperature on ryanodine receptor function... - Pretreatment with pinacidil promotes arrhythmias in an isolated tissue model of cardiac ischemia and reperfusionGregory R Ferrier
Cardiovascular Research Laboratories, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
J Pharmacol Exp Ther 313:823-30. 2005..Thus, pinacidil pretreatment enhanced the effects of ischemia and reperfusion on action potential duration, effective refractory period, and transmural conduction, and it promoted re-entrant arrhythmias... - Changes in excitation-contraction coupling in an isolated ventricular myocyte model of cardiac stunningWilliam E Louch
Cardiovascular Research Laboratories, Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Am J Physiol Heart Circ Physiol 283:H800-10. 2002..Our observations suggest that stunning is associated with reduced L-type Ca(2+) current but that alterations in Ca(2+) homeostasis and release are not directly responsible for stunning... - In contrast to forskolin and 3-isobutyl-1-methylxanthine, amrinone stimulates the cardiac voltage-sensitive release mechanism without increasing calcium-induced calcium releaseW Xiong
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
J Pharmacol Exp Ther 298:954-63. 2001..Increases in CICR induced by forskolin and IBMX were proportional to caffeine contractures. Thus, positive inotropic effects of cAMP on VSRM contractions may be compartmentalized separately from effects on Ca(2+) current and CICR... - Increases in diastolic [Ca2+] can contribute to positive inotropy in guinea pig ventricular myocytes in the absence of changes in amplitudes of Ca2+ transientsRobin H Shutt
Dept. of Pharmacology, Sir Charles Tupper Medical Bldg, Dalhousie Univ, 5850 College St, Halifax, NS, Canada
Am J Physiol Heart Circ Physiol 291:H1623-34. 2006..These data suggest that increased diastolic [Ca(2+)] contributes to positive inotropy following rest or with increasing extracellular [Ca(2+)] in guinea pig ventricular myocytes... - Overexpression of human beta2-adrenergic receptors increases gain of excitation-contraction coupling in mouse ventricular myocytesScott A Grandy
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Am J Physiol Heart Circ Physiol 287:H1029-38. 2004..Increased gain counteracts the effects of decreased amplitude of I(Ca-L) in voltage-clamped myocytes and likely contributes to increased contraction amplitudes in field-stimulated TG4 myocytes... - Attentuation of cardiac stunning by losartan in a cellular model of ischemia and reperfusion is accompanied by increased sarcoplasmic reticulum Ca2+ stores and prevention of cytosolic Ca2+ elevationWilliam E Louch
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Pharmacol Exp Ther 312:238-47. 2005..We conclude that losartan abolishes stunning in reperfusion by preserving normal diastolic Ca(2+) in ischemia and by increasing Ca(2+) transients through elevation of releasable SR Ca(2+)... - L-Arginine ameliorates effects of ischemia and reperfusion in isolated cardiac myocytesAdrian Au
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
Eur J Pharmacol 476:45-54. 2003..Thus, NO contributes to beneficial effects of L-arginine in reperfusion, although effects on I(Ca-L) are independent of NO. Further, L-arginine effects differ under normoxic and ischemic conditions... - Differential effects of phosphodiesterase-sensitive and -resistant analogs of cAMP on initiation of contraction in cardiac ventricular myocytesGregory R Ferrier
Department of Pharmacology, Sir Charles Tupper Medical Bldg, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4H7
J Pharmacol Exp Ther 306:166-78. 2003..Furthermore, PDE can play a major role in modulating cardiac contraction by altering the relationship between membrane potential and Ca2+ release... - Calcium spark properties in ventricular myocytes are altered in aged miceSusan E Howlett
Dept of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 1X5
Am J Physiol Heart Circ Physiol 290:H1566-74. 2006.... - In Memoriam: Gregory R. Ferrier, PhD, 1943-2005Susan E Howlett
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
Heart Rhythm 3:497. 2006 - Diminished inotropic response to amrinone in ventricular myocytes from myopathic hamsters is linked to depression of high-gain Ca2+-induced Ca2+ releaseWei Xiong
Department of Pharmacology, Sir Charles Tupper Medical Building, Dalhousie University, Halifax, Nova Scotia Canada B3H 4H7
J Pharmacol Exp Ther 310:761-73. 2004..This positive inotropic effect of amrinone may reflect increased SR Ca(2+) stores because increased stores accompanied the positive inotropic effect in normal myocytes but were absent in CM myocytes... - Effects of alpha-adrenergic agents on generation of oscillatory afterpotentials and triggered activity in rabbit Purkinje fibersX Q Han
Department of Pharmacology, Dalhousie University, Halifax, Nova Scotia, Canada
J Mol Cell Cardiol 22:871-82. 1990..The alpha 1- and alpha 2-antagonists prazosin and yohimbine both exert direct antiarrhythmic effects in addition to their adrenergic blocking actions... - Characterization of membrane N-glycan binding sites of lysozyme for cardiac depression in sepsisHans Jacobs
Department of Biochemistry and Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada
Intensive Care Med 31:129-37. 2005..We further localize its binding site to a variant of the chitotriose structure in the tri-mannosyl core of the membrane glycoprotein...