Research Topics
| Anne DuffySummaryAffiliation: Dalhousie University Country: Canada Publications
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Detail Information
Publications
The early natural history of bipolar disorder: what we have learned from longitudinal high-risk researchAnne Duffy
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia
Can J Psychiatry 55:477-85. 2010..In this regard, the development of specialty psychiatric programs aiming to identify youth in the early stages of evolving psychosis are substantially ahead of services for youth in the early stages of evolving major mood disorders...
Early stages in the development of bipolar disorderAnne Duffy
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
J Affect Disord 121:127-35. 2010..We tested the hypothesis that in high risk offspring, bipolar disorder evolves in a predictable clinical sequence from non-specific (non-mood) to specific (mood) psychopathology...- Findings from bipolar offspring studies: methodology mattersAnne Duffy
Department of Psychiatry, Faculty of Medicine, Dalhousie University, Nova Scotia, Canada
Early Interv Psychiatry 5:181-91. 2011..In this review, we compare different methods of ascertainment and assessment, and their impact on study findings... - Biological indicators of illness risk in offspring of bipolar parents: targeting the hypothalamic-pituitary-adrenal axis and immune systemAnne Duffy
Departments of Psychiatry, Dalhousie University, Halifax, Nova Scotia
Early Interv Psychiatry 6:128-37. 2012..The study aims to provide a selective review of the literature pertaining to the hypothalamic-pituitary-adrenal (HPA) axis and immune abnormalities as informative biological indicators of vulnerability in bipolar disorder (BD)... 
Maintenance treatment of adolescent bipolar disorder: open study of the effectiveness and tolerability of quetiapineAnne Duffy
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
BMC Psychiatry 9:4. 2009..The purpose of the study was to determine the effectiveness and tolerability of quetiapine as a maintenance treatment preventing against relapse or recurrence of acute mood episodes in adolescent patients diagnosed with bipolar disorder...- Early course of bipolar disorder in high-risk offspring: prospective studyAnne Duffy
MD, Department of Psychiatry, Dalhousie University IWK Health Centre, 5850 5980 University Avenue, P O Box 9700, Halifax, Nova Scotia, Canada B3K 6R8
Br J Psychiatry 195:457-8. 2009..We did not find evidence of pre-pubertal mania. In summary, adolescence marks the beginning of the high-risk period for major mood episodes related to bipolar disorder... - Neurocognitive functioning in the early stages of bipolar disorder: visual backward masking performance in high risk subjectsAnne Duffy
Department of Psychiatry, Dalhousie University, Halifax, NS, Canada
Eur Arch Psychiatry Clin Neurosci 259:263-9. 2009..The current study investigated whether or not deficits in early information processing were present before the onset and/or during the early stages of bipolar disorder... - Pituitary volumes in relatives of bipolar patients: high-risk studyTomas Hajek
Department of Psychiatry, Dalhousie University, Room 3089, QEII HSC, A J Lane Bldg 5909 Veteran s Memorial Lane, B3H 2E2, Halifax, NS, Canada
Eur Arch Psychiatry Clin Neurosci 258:357-62. 2008..To address this question, we performed the first high-risk study of pituitary volumes in affected and unaffected relatives of bipolar subjects... - Striatal volumes in affected and unaffected relatives of bipolar patients--high-risk studyTomas Hajek
Department of Psychiatry, Dalhousie University, 5909 Veteran s Memorial Lane, Halifax, Canada
J Psychiatr Res 43:724-9. 2009..We conducted volumetric high-risk study to investigate whether striatal volume changes represent primary biological risk factor for bipolar disorders... - Prophylactic treatment response in bipolar disorder: results of a naturalistic observation studyJulie Garnham
Department of Psychiatry, Capital District Health Authority, Halifax, Canada
J Affect Disord 104:185-90. 2007..The objective of this study was to evaluate effectiveness of commonly used prophylactic treatments for bipolar disorder in a naturalistic setting and to explore factors associated with treatment response... - The early manifestations of bipolar disorder: a longitudinal prospective study of the offspring of bipolar parentsAnne Duffy
Department of Psychiatry, McGill University, Montreal, QC, Canada
Bipolar Disord 9:828-38. 2007..A major aim of this longitudinal high-risk study is to identify reliable early indicators of emerging bipolar disorder (BD) among offspring from well-characterized parents... - Amygdala and hippocampal volumes in relatives of patients with bipolar disorder: a high-risk studyTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia
Can J Psychiatry 54:726-33. 2009..To test whether amygdala or hippocampal volumes represent an endophenotype for BD, we measured mesiotemporal volumes in young affected and unaffected relatives of patients with BD (high-risk design)... - A comparison of affected and unaffected relatives of patients with bipolar disorder using proton magnetic resonance spectroscopyTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, NS
J Psychiatry Neurosci 33:531-40. 2008..We searched for biological vulnerability markers using proton magnetic resonance spectroscopy (MRS) in both affected and unaffected participants at high genetic risk for bipolar disorder... - Phenotypic spectra of bipolar disorder in responders to lithium versus lamotrigineMichael J Passmore
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
Bipolar Disord 5:110-4. 2003..CONCLUSIONS: These findings suggest that lithium- and lamotrigine-responsive patients differ with respect to course of illness, comorbidity and family history and may represent distinct subtypes of bipolar disorder... - Temperament, life events, and psychopathology among the offspring of bipolar parentsAnne Duffy
Department of Psychiatry, Montreal Children s Hospital, 4018 St Catherine St West, Montreal, Quebec, Canada
Eur Child Adolesc Psychiatry 16:222-8. 2007..The present study examines the relationship between temperament, recent and remote life events, and psychopathology among the offspring of parents with bipolar disorder and well comparisons... - White matter hyperintensities in affected and unaffected late teenage and early adulthood offspring of bipolar parents: a two-center high-risk studyEva Gunde
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada
J Psychiatr Res 45:76-82. 2011..It is not clear whether these lesions are an artifact of comorbid conditions, or whether they are directly associated with the disorder, or even represent biological risk factor for BD... - A prospective study of the offspring of bipolar parents responsive and nonresponsive to lithium treatmentAnne Duffy
Department of Psychiatry, University of Ottawa, Royal Ottawa Hospital, Ottawa, Ontario, Canada
J Clin Psychiatry 63:1171-8. 2002..Among the offspring of lithium-responsive bipolar parents, an early-onset subgroup with a classical episodic clinical course can be identified... - Subgenual cingulate volumes in affected and unaffected offspring of bipolar parentsTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, Nova Scotia, Canada
J Affect Disord 108:263-9. 2008..This is the first study of SGC volumes in affected and unaffected subjects at familial risk for mood disorders... - Brain structural signature of familial predisposition for bipolar disorder: replicable evidence for involvement of the right inferior frontal gyrusTomas Hajek
Department of Psychiatry, Dalhousie University, Halifax, Canada
Biol Psychiatry 73:144-52. 2013..Thus, we examined the associations among genetic risk, illness burden, lithium treatment, and brain structure in BD... - Adolescent substance use disorder during the early stages of bipolar disorder: A prospective high-risk studyAnne Duffy
Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada Department of Community Health and Epidemiology, Halifax, Nova Scotia, Canada Electronic address
J Affect Disord 142:57-64. 2012..We studied this relationship in a prospectively assessed cohort of high-risk offspring... - Is response to prophylactic lithium a familial trait?Paul Grof
Department of Psychiatry, University of Ottawa, Ontario, Canada
J Clin Psychiatry 63:942-7. 2002..However, this recommendation has not been adequately substantiated in the literature. We tested the hypothesis that response to long-term lithium treatment is a familial trait... - Salivary cortisol secretion in remitted bipolar patients and offspring of bipolar parentsDorian Deshauer
Department of Psychiatry, University of Ottawa, Ottawa, Ontario, Canada
Bipolar Disord 8:345-9. 2006..The purpose of this study is to replicate findings of increased cortisol secretion during clinical remission in bipolar patients and in the offspring of bipolar parents, rigorously controlling for known confounders... - The nature of the association between childhood ADHD and the development of bipolar disorder: a review of prospective high-risk studiesAnne Duffy
Department of Psychiatry, University of Calgary, Alberta, Canada
Am J Psychiatry 169:1247-55. 2012.... - Does bipolar disorder exist in children? A selected reviewAnne Duffy
Department of Psychiatry, McGill University, Montreal Children s Hospital, Quebec, Canada
Can J Psychiatry 52:409-17. 2007..Some children manifest antecedent nonspecific psychopathology in early childhood. Therefore, as currently diagnosed, BD does not manifest as such typically until at least adolescence...